
Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2024
Journal Article
Silicosis—Where to from here?
Barnes, Hayley and Chambers, Daniel C. (2024). Silicosis—Where to from here?. Respirology, 29 (12), 1020-1022. doi: 10.1111/resp.14853
2024
Journal Article
Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis
Aloe, Christian Anthony, Goh, Nicole Soo Leng, Wang, Hao, McQualter, Jonathan Luke, Doomun, Sheik Nadeem Elahee, De Souza, David, Pujari, Reshma, Papagianis, Paris Claris, Apte, Simon Hall, Barnes, Hayley, Vlahos, Ross, McDonald, Christine Faye, Hoy, Ryan Francis, Chambers, Daniel Charles, Leong, Tracy Li-Tsein and Bozinovski, Steven (2024). Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis. American Journal of Respiratory Cell and Molecular Biology, 71 (5), 617-621. doi: 10.1165/rcmb.2024-0181le
2024
Journal Article
Closing the Loop on Diagnostic Testing in Interstitial Lung Disease
Chambers, Daniel C. and Mackintosh, John A. (2024). Closing the Loop on Diagnostic Testing in Interstitial Lung Disease. Chest, 166 (5), 909-910. doi: 10.1016/j.chest.2024.08.001
2024
Journal Article
Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers
Bell, Peter T and Chambers, Daniel C (2024). Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers. The Journal of Heart and Lung Transplantation, 44 (3), 329-330. doi: 10.1016/j.healun.2024.11.001
2024
Journal Article
Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease
Li, Andrew, Teoh, Alan, Troy, Lauren, Glaspole, Ian, Wilsher, Margaret L., de Boer, Sally, Wrobel, Jeremy, Moodley, Yuben P., Thien, Francis, Gallagher, Henry, Galbraith, Michelle, Chambers, Daniel C., Mackintosh, John, Goh, Nicole, Khor, Yet Hong, Edwards, Adrienne, Royals, Karen, Grainge, Christopher, Kwan, Benjamin, Keir, Gregory J., Ong, Chong, Reynolds, Paul N., Veitch, Elizabeth, Chai, Gin Tsen, Ng, Ziqin, Tan, Geak Poh, Jackson, Dan, Corte, Tamera and Jo, Helen (2024). Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease. Thorax, 79 (11), 1-9. doi: 10.1136/thorax-2024-221813
2024
Journal Article
Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing
Pham, Amy, Tan, Kellynn K. Y., Ledger, Emma L., Smith, Daniel J., Reid, David W., Burr, Lucy, Chambers, Daniel C. and Wells, Timothy J. (2024). Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing. Frontiers in Cellular and Infection Microbiology, 14 1426773. doi: 10.3389/fcimb.2024.1426773
2024
Journal Article
Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel
Luong, Me‐Linh, Nakamachi, Yoshiko, Silveira, Fernanda P., Morrissey, Catherine O., Danziger‐Isakov, Lara, Verschuuren, Erik A. M, Wolfe, Cameron R., Hadjiliadis, Denis, Chambers, Daniel C., Patel, Jignesh K., Dellgren, Goran, So, Miranda, Verleden, Geert M., Blumberg, Emily A., Vos, Robin, Perch, Michael, Holm, Are M., Mueller, Nicholas J., Chaparro, Cecilia and Husain, Shahid (2024). Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel. Transplant Infectious Disease, 26 (3) e14251, 1-16. doi: 10.1111/tid.14251
2024
Conference Publication
Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis
Zhang, L.-Y., Apte, S., Lutzky, V., Groves, P., Tan, M., de Silva, T.A., Nguyen, Q., Powell, J., Chambers, D. and O'Sullivan, B. (2024). Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2580
2024
Journal Article
Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease
Hoffman, Mariana, Burge, Angela T., Wong, Nick, McDonald, Christine F., Chambers, Daniel C., Glaspole, Ian, Mackintosh, John A., Ekstrom, Magnus, Sköld, Magnus, Goh, Nicole SL., Corte, Tamera J. and Holland, Anne E. (2024). Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease. CHEST, 165 (3), 632-635. doi: 10.1016/j.chest.2023.08.024
2024
Journal Article
Immunological landscapes in lung transplantation: Insights from T cell profiling in BAL and PBMC
de Silva, Tharushi Ayanthika, Apte, Simon, Voisey, Joanne, Spann, Kirsten, Tan, Maxine, Chambers, Daniel and O’Sullivan, Brendan (2024). Immunological landscapes in lung transplantation: Insights from T cell profiling in BAL and PBMC. International Journal of Molecular Sciences, 25 (5) 2476, 1-16. doi: 10.3390/ijms25052476
2024
Journal Article
Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes
Walters, Samuel, Yerkovich, Stephanie, Hopkins, Peter M., Leisfield, Trish, Winks, Lesleigh, Chambers, Daniel C. and Divithotawela, Chandima (2024). Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes. JHLT Open, 3 100043, 1-7. doi: 10.1016/j.jhlto.2023.100043
2024
Journal Article
Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision
Mackintosh, John A., Keir, Gregory, Troy, Lauren K., Holland, Anne E., Grainge, Christopher, Chambers, Daniel C., Sandford, Debra, Jo, Helen E., Glaspole, Ian, Wilsher, Margaret, Goh, Nicole S. L., Reynolds, Paul N., Chapman, Sally, Mutsaers, Steven E., de Boer, Sally, Webster, Susanne, Moodley, Yuben and Corte, Tamera J. (2024). Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision. Respirology, 29 (2), 105-135. doi: 10.1111/resp.14656
2024
Journal Article
Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease
Mackintosh, John A. and Chambers, Daniel C. (2024). Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease. European Respiratory Journal, 63 (1) 2301806, 2301806. doi: 10.1183/13993003.01806-2023
2023
Journal Article
Genomic analyses of Burkholderia respiratory isolates indicates two evolutionarily distinct B. anthina clades
Pham, Amy, Volmer, James G., Chambers, Daniel C., Smith, Daniel J., Reid, David W., Burr, Lucy and Wells, Timothy J. (2023). Genomic analyses of Burkholderia respiratory isolates indicates two evolutionarily distinct B. anthina clades. Frontiers in Microbiology, 14 1274280, 1-14. doi: 10.3389/fmicb.2023.1274280
2023
Journal Article
A methodological approach to identify natural compounds with antifibrotic activity and the potential to treat pulmonary fibrosis using single-cell sequencing and primary human lung macrophages
Apte, Simon H., Groves, Penny L., Tan, Maxine E., Lutzky, Viviana P., de Silva, Tharushi, Monteith, Joshua N., Yerkovich, Stephanie T., O’Sullivan, Brendan J., Davis, Rohan A. and Chambers, Daniel C. (2023). A methodological approach to identify natural compounds with antifibrotic activity and the potential to treat pulmonary fibrosis using single-cell sequencing and primary human lung macrophages. International Journal of Molecular Sciences, 24 (20) 15104, 1-14. doi: 10.3390/ijms242015104
2023
Journal Article
Contribution of skin cancer to overall healthcare costs of lung transplantation in Queensland, Australia
Gordon, L.G., Hopkins, P., Chambers, D. and Green, A.C. (2023). Contribution of skin cancer to overall healthcare costs of lung transplantation in Queensland, Australia. The Journal of Heart and Lung Transplantation, 42 (10), 1437-1444. doi: 10.1016/j.healun.2023.05.014
2023
Journal Article
Single-cell profiling of cells in the lung of a patient with chronic hypersensitivity pneumonitis reveals inflammatory niche with abundant CD39+ T cells with functional ATPase phenotype: A case study
de Silva, Tharushi Ayanthika, Apte, Simon, Voisey, Joanne, Spann, Kirsten, Tan, Maxine, Divithotawela, Chandima, Chambers, Daniel and O’Sullivan, Brendan (2023). Single-cell profiling of cells in the lung of a patient with chronic hypersensitivity pneumonitis reveals inflammatory niche with abundant CD39+ T cells with functional ATPase phenotype: A case study. International Journal of Molecular Sciences, 24 (19) 14442, 1-16. doi: 10.3390/ijms241914442
2023
Conference Publication
Late Breaking Abstract - Transcriptomic profiling identifies pro-fibrotic macrophages under ferroptotic stress in silicosis
Aloe, Christian, Goh, Nicole Soo Leng, Mcqualter, Jonathan, Pujari, Reshma, Cameron, Rhoda, Teague, Julie, Papagianis, Paris, Apte, Simon Hall, O'Sullivan, Brendan, Vlahos, Ross, Mcdonald, Christine Faye, Hoy, Ryan Francis, Chambers, Daniel Charles, Leong, Tracy Li-Tsein and Bozinovski, Steven (2023). Late Breaking Abstract - Transcriptomic profiling identifies pro-fibrotic macrophages under ferroptotic stress in silicosis. Annual Congress of the European-Respiratory-Society (ERS), Milan Ia, Sep 09-13, 2023. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2023.PA2233
2023
Journal Article
High-risk prognostic tumor features of squamous cell carcinomas in organ transplant recipients compared with the general population
Pandeya, Nirmala, Isbel, Nicole, Campbell, Scott, Chambers, Daniel C., Hopkins, Peter, Soyer, H. Peter, Jiyad, Zainab, Plasmeijer, Elsemieke I., Whiteman, David C., Olsen, Catherine M. and Green, Adele C. (2023). High-risk prognostic tumor features of squamous cell carcinomas in organ transplant recipients compared with the general population. JAMA Dermatology, 159 (8), 854-858. doi: 10.1001/jamadermatol.2023.1574
2023
Journal Article
Multimodal transplant-clinic–based skin cancer prevention education for organ transplant recipients: feasibility study
Yu, Regina, Miura, Kyoko, Chambers, Daniel C., Hopkins, Peter M., Proby, Charlotte M., Bibee, Kristin, Plasmeijer, Elsemieke I. and Green, Adele C. (2023). Multimodal transplant-clinic–based skin cancer prevention education for organ transplant recipients: feasibility study. Transplantation Direct, 9 (7) e1492, 1-5. doi: 10.1097/txd.0000000000001492
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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