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Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025

21 - 40 of 248 works

2024

Journal Article

Silicosis—Where to from here?

Barnes, Hayley and Chambers, Daniel C. (2024). Silicosis—Where to from here?. Respirology, 29 (12), 1020-1022. doi: 10.1111/resp.14853

Silicosis—Where to from here?

2024

Journal Article

Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis

Aloe, Christian Anthony, Goh, Nicole Soo Leng, Wang, Hao, McQualter, Jonathan Luke, Doomun, Sheik Nadeem Elahee, De Souza, David, Pujari, Reshma, Papagianis, Paris Claris, Apte, Simon Hall, Barnes, Hayley, Vlahos, Ross, McDonald, Christine Faye, Hoy, Ryan Francis, Chambers, Daniel Charles, Leong, Tracy Li-Tsein and Bozinovski, Steven (2024). Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis. American Journal of Respiratory Cell and Molecular Biology, 71 (5), 617-621. doi: 10.1165/rcmb.2024-0181le

Iron Alters the Transcriptome and Volatile Organic Compounds in the BAL of Patients with Silicosis

2024

Journal Article

Closing the Loop on Diagnostic Testing in Interstitial Lung Disease

Chambers, Daniel C. and Mackintosh, John A. (2024). Closing the Loop on Diagnostic Testing in Interstitial Lung Disease. Chest, 166 (5), 909-910. doi: 10.1016/j.chest.2024.08.001

Closing the Loop on Diagnostic Testing in Interstitial Lung Disease

2024

Journal Article

Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers

Bell, Peter T and Chambers, Daniel C (2024). Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers. The Journal of Heart and Lung Transplantation, 44 (3), 329-330. doi: 10.1016/j.healun.2024.11.001

Towards Early Prediction of Chronic Allograft Dysfunction using Molecular Biomarkers

2024

Journal Article

Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease

Li, Andrew, Teoh, Alan, Troy, Lauren, Glaspole, Ian, Wilsher, Margaret L., de Boer, Sally, Wrobel, Jeremy, Moodley, Yuben P., Thien, Francis, Gallagher, Henry, Galbraith, Michelle, Chambers, Daniel C., Mackintosh, John, Goh, Nicole, Khor, Yet Hong, Edwards, Adrienne, Royals, Karen, Grainge, Christopher, Kwan, Benjamin, Keir, Gregory J., Ong, Chong, Reynolds, Paul N., Veitch, Elizabeth, Chai, Gin Tsen, Ng, Ziqin, Tan, Geak Poh, Jackson, Dan, Corte, Tamera and Jo, Helen (2024). Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease. Thorax, 79 (11), 1-9. doi: 10.1136/thorax-2024-221813

Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease

2024

Journal Article

Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing

Pham, Amy, Tan, Kellynn K. Y., Ledger, Emma L., Smith, Daniel J., Reid, David W., Burr, Lucy, Chambers, Daniel C. and Wells, Timothy J. (2024). Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing. Frontiers in Cellular and Infection Microbiology, 14 1426773. doi: 10.3389/fcimb.2024.1426773

Cloaking antibodies are prevalent in Burkholderia cepacia complex infection and their removal restores serum killing

2024

Journal Article

Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel

Luong, Me‐Linh, Nakamachi, Yoshiko, Silveira, Fernanda P., Morrissey, Catherine O., Danziger‐Isakov, Lara, Verschuuren, Erik A. M, Wolfe, Cameron R., Hadjiliadis, Denis, Chambers, Daniel C., Patel, Jignesh K., Dellgren, Goran, So, Miranda, Verleden, Geert M., Blumberg, Emily A., Vos, Robin, Perch, Michael, Holm, Are M., Mueller, Nicholas J., Chaparro, Cecilia and Husain, Shahid (2024). Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel. Transplant Infectious Disease, 26 (3) e14251, 1-16. doi: 10.1111/tid.14251

Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel

2024

Conference Publication

Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis

Zhang, L.-Y., Apte, S., Lutzky, V., Groves, P., Tan, M., de Silva, T.A., Nguyen, Q., Powell, J., Chambers, D. and O'Sullivan, B. (2024). Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2580

Cellular Genomics of Bronchoalveolar Lavage Reveals Insight into Mechanisms of Human Pulmonary Fibrosis

2024

Journal Article

Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease

Hoffman, Mariana, Burge, Angela T., Wong, Nick, McDonald, Christine F., Chambers, Daniel C., Glaspole, Ian, Mackintosh, John A., Ekstrom, Magnus, Sköld, Magnus, Goh, Nicole SL., Corte, Tamera J. and Holland, Anne E. (2024). Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease. CHEST, 165 (3), 632-635. doi: 10.1016/j.chest.2023.08.024

Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease

2024

Journal Article

Immunological landscapes in lung transplantation: Insights from T cell profiling in BAL and PBMC

de Silva, Tharushi Ayanthika, Apte, Simon, Voisey, Joanne, Spann, Kirsten, Tan, Maxine, Chambers, Daniel and O’Sullivan, Brendan (2024). Immunological landscapes in lung transplantation: Insights from T cell profiling in BAL and PBMC. International Journal of Molecular Sciences, 25 (5) 2476, 1-16. doi: 10.3390/ijms25052476

Immunological landscapes in lung transplantation: Insights from T cell profiling in BAL and PBMC

2024

Journal Article

Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes

Walters, Samuel, Yerkovich, Stephanie, Hopkins, Peter M., Leisfield, Trish, Winks, Lesleigh, Chambers, Daniel C. and Divithotawela, Chandima (2024). Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes. JHLT Open, 3 100043, 1-7. doi: 10.1016/j.jhlto.2023.100043

Erratic tacrolimus levels at 6 to 12 months post-lung transplant predicts poor outcomes

2024

Journal Article

Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision

Mackintosh, John A., Keir, Gregory, Troy, Lauren K., Holland, Anne E., Grainge, Christopher, Chambers, Daniel C., Sandford, Debra, Jo, Helen E., Glaspole, Ian, Wilsher, Margaret, Goh, Nicole S. L., Reynolds, Paul N., Chapman, Sally, Mutsaers, Steven E., de Boer, Sally, Webster, Susanne, Moodley, Yuben and Corte, Tamera J. (2024). Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision. Respirology, 29 (2), 105-135. doi: 10.1111/resp.14656

Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision

2024

Journal Article

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

Mackintosh, John A. and Chambers, Daniel C. (2024). Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease. European Respiratory Journal, 63 (1) 2301806, 2301806. doi: 10.1183/13993003.01806-2023

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

2023

Journal Article

Genomic analyses of Burkholderia respiratory isolates indicates two evolutionarily distinct B. anthina clades

Pham, Amy, Volmer, James G., Chambers, Daniel C., Smith, Daniel J., Reid, David W., Burr, Lucy and Wells, Timothy J. (2023). Genomic analyses of Burkholderia respiratory isolates indicates two evolutionarily distinct B. anthina clades. Frontiers in Microbiology, 14 1274280, 1-14. doi: 10.3389/fmicb.2023.1274280

Genomic analyses of Burkholderia respiratory isolates indicates two evolutionarily distinct B. anthina clades

2023

Journal Article

A methodological approach to identify natural compounds with antifibrotic activity and the potential to treat pulmonary fibrosis using single-cell sequencing and primary human lung macrophages

Apte, Simon H., Groves, Penny L., Tan, Maxine E., Lutzky, Viviana P., de Silva, Tharushi, Monteith, Joshua N., Yerkovich, Stephanie T., O’Sullivan, Brendan J., Davis, Rohan A. and Chambers, Daniel C. (2023). A methodological approach to identify natural compounds with antifibrotic activity and the potential to treat pulmonary fibrosis using single-cell sequencing and primary human lung macrophages. International Journal of Molecular Sciences, 24 (20) 15104, 1-14. doi: 10.3390/ijms242015104

A methodological approach to identify natural compounds with antifibrotic activity and the potential to treat pulmonary fibrosis using single-cell sequencing and primary human lung macrophages

2023

Journal Article

Contribution of skin cancer to overall healthcare costs of lung transplantation in Queensland, Australia

Gordon, L.G., Hopkins, P., Chambers, D. and Green, A.C. (2023). Contribution of skin cancer to overall healthcare costs of lung transplantation in Queensland, Australia. The Journal of Heart and Lung Transplantation, 42 (10), 1437-1444. doi: 10.1016/j.healun.2023.05.014

Contribution of skin cancer to overall healthcare costs of lung transplantation in Queensland, Australia

2023

Journal Article

Single-cell profiling of cells in the lung of a patient with chronic hypersensitivity pneumonitis reveals inflammatory niche with abundant CD39+ T cells with functional ATPase phenotype: A case study

de Silva, Tharushi Ayanthika, Apte, Simon, Voisey, Joanne, Spann, Kirsten, Tan, Maxine, Divithotawela, Chandima, Chambers, Daniel and O’Sullivan, Brendan (2023). Single-cell profiling of cells in the lung of a patient with chronic hypersensitivity pneumonitis reveals inflammatory niche with abundant CD39+ T cells with functional ATPase phenotype: A case study. International Journal of Molecular Sciences, 24 (19) 14442, 1-16. doi: 10.3390/ijms241914442

Single-cell profiling of cells in the lung of a patient with chronic hypersensitivity pneumonitis reveals inflammatory niche with abundant CD39+ T cells with functional ATPase phenotype: A case study

2023

Conference Publication

Late Breaking Abstract - Transcriptomic profiling identifies pro-fibrotic macrophages under ferroptotic stress in silicosis

Aloe, Christian, Goh, Nicole Soo Leng, Mcqualter, Jonathan, Pujari, Reshma, Cameron, Rhoda, Teague, Julie, Papagianis, Paris, Apte, Simon Hall, O'Sullivan, Brendan, Vlahos, Ross, Mcdonald, Christine Faye, Hoy, Ryan Francis, Chambers, Daniel Charles, Leong, Tracy Li-Tsein and Bozinovski, Steven (2023). Late Breaking Abstract - Transcriptomic profiling identifies pro-fibrotic macrophages under ferroptotic stress in silicosis. Annual Congress of the European-Respiratory-Society (ERS), Milan Ia, Sep 09-13, 2023. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2023.PA2233

Late Breaking Abstract - Transcriptomic profiling identifies pro-fibrotic macrophages under ferroptotic stress in silicosis

2023

Journal Article

High-risk prognostic tumor features of squamous cell carcinomas in organ transplant recipients compared with the general population

Pandeya, Nirmala, Isbel, Nicole, Campbell, Scott, Chambers, Daniel C., Hopkins, Peter, Soyer, H. Peter, Jiyad, Zainab, Plasmeijer, Elsemieke I., Whiteman, David C., Olsen, Catherine M. and Green, Adele C. (2023). High-risk prognostic tumor features of squamous cell carcinomas in organ transplant recipients compared with the general population. JAMA Dermatology, 159 (8), 854-858. doi: 10.1001/jamadermatol.2023.1574

High-risk prognostic tumor features of squamous cell carcinomas in organ transplant recipients compared with the general population

2023

Journal Article

Multimodal transplant-clinic–based skin cancer prevention education for organ transplant recipients: feasibility study

Yu, Regina, Miura, Kyoko, Chambers, Daniel C., Hopkins, Peter M., Proby, Charlotte M., Bibee, Kristin, Plasmeijer, Elsemieke I. and Green, Adele C. (2023). Multimodal transplant-clinic–based skin cancer prevention education for organ transplant recipients: feasibility study. Transplantation Direct, 9 (7) e1492, 1-5. doi: 10.1097/txd.0000000000001492

Multimodal transplant-clinic–based skin cancer prevention education for organ transplant recipients: feasibility study

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au