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Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025

61 - 80 of 248 works

2022

Journal Article

Alveolar crystal burden in stone workers with artificial stone silicosis

Apte, Simon H., Tan, Maxine E., Lutzky, Viviana P., De Silva, Tharushi A., Fiene, Andreas, Hundloe, Justin, Deller, David, Sullivan, Clair, Bell, Peter T. and Chambers, Daniel C. (2022). Alveolar crystal burden in stone workers with artificial stone silicosis. Respirology, 27 (6), 437-446. doi: 10.1111/resp.14229

Alveolar crystal burden in stone workers with artificial stone silicosis

2022

Journal Article

Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies

Kusuma, Gina D., Li, Anqi, Zhu, Dandan, McDonald, Hannah, Inocencio, Ishmael M., Chambers, Daniel C., Sinclair, Kenneth, Fang, Haoyun, Greening, David W., Frith, Jessica E. and Lim, Rebecca (2022). Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies. Frontiers in Cell and Developmental Biology, 10 819726, 819726. doi: 10.3389/fcell.2022.819726

Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies

2022

Journal Article

Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis

Hua, Jeremy Tang, Zell-Baran, Lauren, Go, Leonard H. T., Kramer, Mordechai R., Van Bree, Johanna B., Chambers, Daniel, Deller, David, Newbigin, Katrina, Matula, Michael, Fireman, Elizabeth, Dahbash, Mor, Martinez-Gonzalez, Cristina, León-Jimenez, Antonio, Sack, Coralynn, Ferrer, Jaume, Villar, Ana, Almberg, Kirsten S., Cohen, Robert A. and Rose, Cecile S. (2022). Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis. Occupational and Environmental Medicine, 79 (9) 108190, 586-593. doi: 10.1136/oemed-2021-108190

Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis

2021

Journal Article

TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis

MacKintosh, John A., Pietsch, Maria, Lutzky, Viviana, Enever, Debra, Bancroft, Sandra, Apte, Simon H., Tan, Maxine, Yerkovich, Stephanie T., Dickinson, Joanne L., Pickett, Hilda A., Selvadurai, Hiran, Grainge, Christopher, Goh, Nicole S., Hopkins, Peter, Glaspole, Ian, Reynolds, Paul N., Wrobel, Jeremy, Jaffe, Adam, Corte, Tamera J. and Chambers, Daniel C. (2021). TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis. BMJ Open Respiratory Research, 8 (1) e001127, 1-8. doi: 10.1136/bmjresp-2021-001127

TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis

2021

Journal Article

The evolution of the ISHLT transplant registry : preparing for the future

Stehlik, Josef, Christie, Jason D, Goldstein, Daniel R, Amarelli, Cristiano, Bertolotti, Alejandro, Chambers, Daniel C., Dorent, Richard, Gonzalez-Vilchez, Francisco, Parameshwar, Jayan, Perch, Michael, Zuckermann, Andreas, Coll, Elisabeth, Levy, Robert D., Atik, Fernando A., Gomez-Mesa, Juan Esteban, Moayedi, Yasbanoo, Peled-Potashnik, Yael, Schultz, Greg, Cherikh, Wida and Danziger-Isakov, Lara (2021). The evolution of the ISHLT transplant registry : preparing for the future. Journal of Heart and Lung Transplantation, 40 (12), 1670-1681. doi: 10.1016/j.healun.2021.09.007

The evolution of the ISHLT transplant registry : preparing for the future

2021

Journal Article

High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial

Dowman, Leona M., May, Anthony K., Hill, Catherine J., Bondarenko, Janet, Spencer, Lissa, Morris, Norman R., Alison, Jennifer A., Walsh, James, Goh, Nicole S. L., Corte, Tamera, Glaspole, Ian, Chambers, Daniel C., McDonald, Christine F. and Holland, Anne E. (2021). High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial. BMC Pulmonary Medicine, 21 (1) 361, 361. doi: 10.1186/s12890-021-01704-2

High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial

2021

Journal Article

Donor to recipient matching for lung transplant candidates with interstitial lung disease: a sizeable problem

Eberlein, Michael and Chambers, Daniel C. (2021). Donor to recipient matching for lung transplant candidates with interstitial lung disease: a sizeable problem. Journal of Heart and Lung Transplantation, 40 (11), 1431-1432. doi: 10.1016/j.healun.2021.07.023

Donor to recipient matching for lung transplant candidates with interstitial lung disease: a sizeable problem

2021

Journal Article

Recent trends in pirfenidone and nintedanib use for idiopathic pulmonary fibrosis in Australia

Cox, Ingrid A., De Graaff, Barbara, Corte, Tamera J., Glaspole, Ian, Chambers, Daniel C., Moodley, Yuben, Teoh, Alan, Walters, E. Haydn and Palmer, Andrew J. (2021). Recent trends in pirfenidone and nintedanib use for idiopathic pulmonary fibrosis in Australia. Australian Health Review, 45 (6), 718-727. doi: 10.1071/AH20337

Recent trends in pirfenidone and nintedanib use for idiopathic pulmonary fibrosis in Australia

2021

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report-2021; focus on recipient characteristics

Khush, Kiran K., Hsich, Eileen, Potena, Luciano, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Perch, Michael, Sadavarte, Aparna, Toll, Alice, Singh, Tajinder P., Zuckermann, Andreas and Stehlik, Josef (2021). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report-2021; focus on recipient characteristics. Journal of Heart and Lung Transplantation, 40 (10), 1035-1049. doi: 10.1016/j.healun.2021.07.015

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report-2021; focus on recipient characteristics

2021

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics

Chambers, Daniel C., Perch, Michael, Zuckermann, Andreas, Cherikh, Wida S., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Potena, Luciano, Sadavarte, Aparna, Lindblad, Kelsi, Singh, Tajinder P., Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2021). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. The Journal of Heart and Lung Transplantation, 40 (10), 1060-1072. doi: 10.1016/j.healun.2021.07.021

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics

2021

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric lung transplantation report - 2021; Focus on recipient characteristics

Hayes, Don, Harhay, Michael O., Cherikh, Wida S., Chambers, Daniel C., Perch, Michael, Khush, Kiran K., Hsich, Eileen, Potena, Luciano, Sadavarte, Aparna, Booker, Sarah, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2021). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric lung transplantation report - 2021; Focus on recipient characteristics. The Journal of Heart and Lung Transplantation, 40 (10), 1023-1034. doi: 10.1016/j.healun.2021.07.018

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric lung transplantation report - 2021; Focus on recipient characteristics

2021

Journal Article

Combined heart-lung-liver transplantation for patients with cystic fibrosis: the Australian experience

Bell, P. T., Carew, A., Fiene, A., Divithotawela, C., Stuart, K. A., Hodgkinson, P., Chambers, D. C. and Hopkins, P. M. (2021). Combined heart-lung-liver transplantation for patients with cystic fibrosis: the Australian experience. Transplantation Proceedings, 53 (7), 2382-2389. doi: 10.1016/j.transproceed.2021.07.028

Combined heart-lung-liver transplantation for patients with cystic fibrosis: the Australian experience

2021

Conference Publication

The Performance of RA Disease Activity and Patient-Reported Outcomes in Rheumatoid Arthritis-Associated Interstitial Lung Disease in a Prospective Trial Using Pirfenidone in RA ILD (TRAIL1)

Dellaripa, Paul, Doyle, Tracy, Danoff, Sonye, Goldberg, Hillary, Kolb, Martin, Chambers, Daniel, Woodhead, Felix, Spino, Cathy, Rosas, Ivan and Solomon, Joshua (2021). The Performance of RA Disease Activity and Patient-Reported Outcomes in Rheumatoid Arthritis-Associated Interstitial Lung Disease in a Prospective Trial Using Pirfenidone in RA ILD (TRAIL1). ACR Convergence Conference, Electr Network, Nov 05-09, 2021. HOBOKEN: WILEY.

The Performance of RA Disease Activity and Patient-Reported Outcomes in Rheumatoid Arthritis-Associated Interstitial Lung Disease in a Prospective Trial Using Pirfenidone in RA ILD (TRAIL1)

2021

Journal Article

Inferior outcomes in lung transplant recipients with serum Pseudomonas aeruginosa specific cloaking antibodies

Divithotawela, Chandima, Pham, Amy, Bell, Peter T., Ledger, Emma L., Tan, Maxine, Yerkovich, Stephanie, Grant, Michelle, Hopkins, Peter M., Wells, Timothy J. and Chambers, Daniel C. (2021). Inferior outcomes in lung transplant recipients with serum Pseudomonas aeruginosa specific cloaking antibodies. The Journal of Heart and Lung Transplantation, 40 (9), 951-959. doi: 10.1016/j.healun.2021.05.016

Inferior outcomes in lung transplant recipients with serum Pseudomonas aeruginosa specific cloaking antibodies

2021

Conference Publication

A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease

Solomon, Joshua, Woodhead, Felix, Danoff, Sonye, Haynes-Harp, Shana, Naik, Tanvi, Spino, Cathie, Hurwitz, Shelley, Maurer, Rie, Chambers, Daniel, Kolb, Martin, Goldberg, Hiliary and Rosas, Ivan (2021). A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease. ACR Convergence Conference, Electr Network, Nov 05-09, 2021. HOBOKEN: WILEY.

A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease

2021

Journal Article

Covid-19 in recipients of heart and lung transplantation: learning from experience

Kittleson, Michelle M., Chambers, Daniel C., Cypel, Marcelo and Potena, Luciano (2021). Covid-19 in recipients of heart and lung transplantation: learning from experience. Journal of Heart and Lung Transplantation, 40 (9), 948-950. doi: 10.1016/j.healun.2021.05.021

Covid-19 in recipients of heart and lung transplantation: learning from experience

2021

Journal Article

Benefits of a virtual interstitial lung disease multidisciplinary meeting in the face of COVID-19

Mackintosh, John A., Glenn, Laura, Barnes, Hayley, Dunn, Emily, Bancroft, Sandra, Reddy, Taryn, Teoh, Alan K. Y., Troy, Lauren, Jo, Helen, Geis, Monika, Glaspole, Ian, Grainge, Christopher, Corte, Tamera J., Chambers, Daniel C. and Hopkins, Peter (2021). Benefits of a virtual interstitial lung disease multidisciplinary meeting in the face of COVID-19. Respirology, 26 (6), 612-615. doi: 10.1111/resp.14062

Benefits of a virtual interstitial lung disease multidisciplinary meeting in the face of COVID-19

2021

Journal Article

Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment

Seviiri, Mathias, Law, Matthew H., Ong, Jue Sheng, Gharahkhani, Puya, Nyholt, Dale R., Hopkins, Peter, Chambers, Daniel, Campbell, Scott, Isbel, Nicole M., Soyer, H. Peter, Olsen, Catherine M., Ellis, Jonathan J., Whiteman, David C., Green, Adele C. and MacGregor, Stuart (2021). Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment. Journal of Investigative Dermatology, 141 (12), 2866-2875.e2. doi: 10.1016/j.jid.2021.03.034

Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment

2021

Conference Publication

Progressive Fibrosing Interstitial Lung Disease in the Real World: A Retrospective Analysis of the Queensland Statewide Interstitial Lung Disease Multi-Disciplinary Meeting

Godfrey, E., Reddy, T., Navaratnam, V., Balzat, L., Watters, C., Bancroft, S., Divithotawela, C., Godbolt, D., Pauli, J., Goddard, J., Trotter, M., Hopkins, P., Chambers, D. and Mackintosh, J. (2021). Progressive Fibrosing Interstitial Lung Disease in the Real World: A Retrospective Analysis of the Queensland Statewide Interstitial Lung Disease Multi-Disciplinary Meeting. doi: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1835

Progressive Fibrosing Interstitial Lung Disease in the Real World: A Retrospective Analysis of the Queensland Statewide Interstitial Lung Disease Multi-Disciplinary Meeting

2021

Journal Article

Radiological outcomes of whole lung lavage for artificial stone-associated silicosis

Chambers, Daniel C., Apte, Simon H., Deller, David, Masel, Philip J., Jones, Catherine M., Newbigin, Katrina, Matula, Michael and Rapchuk, Ivan L. (2021). Radiological outcomes of whole lung lavage for artificial stone-associated silicosis. Respirology, 26 (5), 501-503. doi: 10.1111/resp.14018

Radiological outcomes of whole lung lavage for artificial stone-associated silicosis

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au