
Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2022
Journal Article
Alveolar crystal burden in stone workers with artificial stone silicosis
Apte, Simon H., Tan, Maxine E., Lutzky, Viviana P., De Silva, Tharushi A., Fiene, Andreas, Hundloe, Justin, Deller, David, Sullivan, Clair, Bell, Peter T. and Chambers, Daniel C. (2022). Alveolar crystal burden in stone workers with artificial stone silicosis. Respirology, 27 (6), 437-446. doi: 10.1111/resp.14229
2022
Journal Article
Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies
Kusuma, Gina D., Li, Anqi, Zhu, Dandan, McDonald, Hannah, Inocencio, Ishmael M., Chambers, Daniel C., Sinclair, Kenneth, Fang, Haoyun, Greening, David W., Frith, Jessica E. and Lim, Rebecca (2022). Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies. Frontiers in Cell and Developmental Biology, 10 819726, 819726. doi: 10.3389/fcell.2022.819726
2022
Journal Article
Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis
Hua, Jeremy Tang, Zell-Baran, Lauren, Go, Leonard H. T., Kramer, Mordechai R., Van Bree, Johanna B., Chambers, Daniel, Deller, David, Newbigin, Katrina, Matula, Michael, Fireman, Elizabeth, Dahbash, Mor, Martinez-Gonzalez, Cristina, León-Jimenez, Antonio, Sack, Coralynn, Ferrer, Jaume, Villar, Ana, Almberg, Kirsten S., Cohen, Robert A. and Rose, Cecile S. (2022). Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis. Occupational and Environmental Medicine, 79 (9) 108190, 586-593. doi: 10.1136/oemed-2021-108190
2021
Journal Article
TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis
MacKintosh, John A., Pietsch, Maria, Lutzky, Viviana, Enever, Debra, Bancroft, Sandra, Apte, Simon H., Tan, Maxine, Yerkovich, Stephanie T., Dickinson, Joanne L., Pickett, Hilda A., Selvadurai, Hiran, Grainge, Christopher, Goh, Nicole S., Hopkins, Peter, Glaspole, Ian, Reynolds, Paul N., Wrobel, Jeremy, Jaffe, Adam, Corte, Tamera J. and Chambers, Daniel C. (2021). TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis. BMJ Open Respiratory Research, 8 (1) e001127, 1-8. doi: 10.1136/bmjresp-2021-001127
2021
Journal Article
The evolution of the ISHLT transplant registry : preparing for the future
Stehlik, Josef, Christie, Jason D, Goldstein, Daniel R, Amarelli, Cristiano, Bertolotti, Alejandro, Chambers, Daniel C., Dorent, Richard, Gonzalez-Vilchez, Francisco, Parameshwar, Jayan, Perch, Michael, Zuckermann, Andreas, Coll, Elisabeth, Levy, Robert D., Atik, Fernando A., Gomez-Mesa, Juan Esteban, Moayedi, Yasbanoo, Peled-Potashnik, Yael, Schultz, Greg, Cherikh, Wida and Danziger-Isakov, Lara (2021). The evolution of the ISHLT transplant registry : preparing for the future. Journal of Heart and Lung Transplantation, 40 (12), 1670-1681. doi: 10.1016/j.healun.2021.09.007
2021
Journal Article
High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial
Dowman, Leona M., May, Anthony K., Hill, Catherine J., Bondarenko, Janet, Spencer, Lissa, Morris, Norman R., Alison, Jennifer A., Walsh, James, Goh, Nicole S. L., Corte, Tamera, Glaspole, Ian, Chambers, Daniel C., McDonald, Christine F. and Holland, Anne E. (2021). High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial. BMC Pulmonary Medicine, 21 (1) 361, 361. doi: 10.1186/s12890-021-01704-2
2021
Journal Article
Donor to recipient matching for lung transplant candidates with interstitial lung disease: a sizeable problem
Eberlein, Michael and Chambers, Daniel C. (2021). Donor to recipient matching for lung transplant candidates with interstitial lung disease: a sizeable problem. Journal of Heart and Lung Transplantation, 40 (11), 1431-1432. doi: 10.1016/j.healun.2021.07.023
2021
Journal Article
Recent trends in pirfenidone and nintedanib use for idiopathic pulmonary fibrosis in Australia
Cox, Ingrid A., De Graaff, Barbara, Corte, Tamera J., Glaspole, Ian, Chambers, Daniel C., Moodley, Yuben, Teoh, Alan, Walters, E. Haydn and Palmer, Andrew J. (2021). Recent trends in pirfenidone and nintedanib use for idiopathic pulmonary fibrosis in Australia. Australian Health Review, 45 (6), 718-727. doi: 10.1071/AH20337
2021
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report-2021; focus on recipient characteristics
Khush, Kiran K., Hsich, Eileen, Potena, Luciano, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Perch, Michael, Sadavarte, Aparna, Toll, Alice, Singh, Tajinder P., Zuckermann, Andreas and Stehlik, Josef (2021). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report-2021; focus on recipient characteristics. Journal of Heart and Lung Transplantation, 40 (10), 1035-1049. doi: 10.1016/j.healun.2021.07.015
2021
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics
Chambers, Daniel C., Perch, Michael, Zuckermann, Andreas, Cherikh, Wida S., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Potena, Luciano, Sadavarte, Aparna, Lindblad, Kelsi, Singh, Tajinder P., Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2021). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. The Journal of Heart and Lung Transplantation, 40 (10), 1060-1072. doi: 10.1016/j.healun.2021.07.021
2021
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric lung transplantation report - 2021; Focus on recipient characteristics
Hayes, Don, Harhay, Michael O., Cherikh, Wida S., Chambers, Daniel C., Perch, Michael, Khush, Kiran K., Hsich, Eileen, Potena, Luciano, Sadavarte, Aparna, Booker, Sarah, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2021). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth pediatric lung transplantation report - 2021; Focus on recipient characteristics. The Journal of Heart and Lung Transplantation, 40 (10), 1023-1034. doi: 10.1016/j.healun.2021.07.018
2021
Journal Article
Combined heart-lung-liver transplantation for patients with cystic fibrosis: the Australian experience
Bell, P. T., Carew, A., Fiene, A., Divithotawela, C., Stuart, K. A., Hodgkinson, P., Chambers, D. C. and Hopkins, P. M. (2021). Combined heart-lung-liver transplantation for patients with cystic fibrosis: the Australian experience. Transplantation Proceedings, 53 (7), 2382-2389. doi: 10.1016/j.transproceed.2021.07.028
2021
Conference Publication
The Performance of RA Disease Activity and Patient-Reported Outcomes in Rheumatoid Arthritis-Associated Interstitial Lung Disease in a Prospective Trial Using Pirfenidone in RA ILD (TRAIL1)
Dellaripa, Paul, Doyle, Tracy, Danoff, Sonye, Goldberg, Hillary, Kolb, Martin, Chambers, Daniel, Woodhead, Felix, Spino, Cathy, Rosas, Ivan and Solomon, Joshua (2021). The Performance of RA Disease Activity and Patient-Reported Outcomes in Rheumatoid Arthritis-Associated Interstitial Lung Disease in a Prospective Trial Using Pirfenidone in RA ILD (TRAIL1). ACR Convergence Conference, Electr Network, Nov 05-09, 2021. HOBOKEN: WILEY.
2021
Journal Article
Inferior outcomes in lung transplant recipients with serum Pseudomonas aeruginosa specific cloaking antibodies
Divithotawela, Chandima, Pham, Amy, Bell, Peter T., Ledger, Emma L., Tan, Maxine, Yerkovich, Stephanie, Grant, Michelle, Hopkins, Peter M., Wells, Timothy J. and Chambers, Daniel C. (2021). Inferior outcomes in lung transplant recipients with serum Pseudomonas aeruginosa specific cloaking antibodies. The Journal of Heart and Lung Transplantation, 40 (9), 951-959. doi: 10.1016/j.healun.2021.05.016
2021
Conference Publication
A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease
Solomon, Joshua, Woodhead, Felix, Danoff, Sonye, Haynes-Harp, Shana, Naik, Tanvi, Spino, Cathie, Hurwitz, Shelley, Maurer, Rie, Chambers, Daniel, Kolb, Martin, Goldberg, Hiliary and Rosas, Ivan (2021). A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease. ACR Convergence Conference, Electr Network, Nov 05-09, 2021. HOBOKEN: WILEY.
2021
Journal Article
Covid-19 in recipients of heart and lung transplantation: learning from experience
Kittleson, Michelle M., Chambers, Daniel C., Cypel, Marcelo and Potena, Luciano (2021). Covid-19 in recipients of heart and lung transplantation: learning from experience. Journal of Heart and Lung Transplantation, 40 (9), 948-950. doi: 10.1016/j.healun.2021.05.021
2021
Journal Article
Benefits of a virtual interstitial lung disease multidisciplinary meeting in the face of COVID-19
Mackintosh, John A., Glenn, Laura, Barnes, Hayley, Dunn, Emily, Bancroft, Sandra, Reddy, Taryn, Teoh, Alan K. Y., Troy, Lauren, Jo, Helen, Geis, Monika, Glaspole, Ian, Grainge, Christopher, Corte, Tamera J., Chambers, Daniel C. and Hopkins, Peter (2021). Benefits of a virtual interstitial lung disease multidisciplinary meeting in the face of COVID-19. Respirology, 26 (6), 612-615. doi: 10.1111/resp.14062
2021
Journal Article
Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment
Seviiri, Mathias, Law, Matthew H., Ong, Jue Sheng, Gharahkhani, Puya, Nyholt, Dale R., Hopkins, Peter, Chambers, Daniel, Campbell, Scott, Isbel, Nicole M., Soyer, H. Peter, Olsen, Catherine M., Ellis, Jonathan J., Whiteman, David C., Green, Adele C. and MacGregor, Stuart (2021). Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment. Journal of Investigative Dermatology, 141 (12), 2866-2875.e2. doi: 10.1016/j.jid.2021.03.034
2021
Conference Publication
Progressive Fibrosing Interstitial Lung Disease in the Real World: A Retrospective Analysis of the Queensland Statewide Interstitial Lung Disease Multi-Disciplinary Meeting
Godfrey, E., Reddy, T., Navaratnam, V., Balzat, L., Watters, C., Bancroft, S., Divithotawela, C., Godbolt, D., Pauli, J., Goddard, J., Trotter, M., Hopkins, P., Chambers, D. and Mackintosh, J. (2021). Progressive Fibrosing Interstitial Lung Disease in the Real World: A Retrospective Analysis of the Queensland Statewide Interstitial Lung Disease Multi-Disciplinary Meeting. doi: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1835
2021
Journal Article
Radiological outcomes of whole lung lavage for artificial stone-associated silicosis
Chambers, Daniel C., Apte, Simon H., Deller, David, Masel, Philip J., Jones, Catherine M., Newbigin, Katrina, Matula, Michael and Rapchuk, Ivan L. (2021). Radiological outcomes of whole lung lavage for artificial stone-associated silicosis. Respirology, 26 (5), 501-503. doi: 10.1111/resp.14018
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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