
Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2021
Journal Article
Airway Telomere Length in Lung Transplant Recipients
Mackintosh, John A., Yerkovich, Stephanie T., Tan, Maxine E., Samson, Luke, Hopkins, Peter M.A. and Chambers, Daniel C. (2021). Airway Telomere Length in Lung Transplant Recipients. Frontiers in Immunology, 12 658062, 1-7. doi: 10.3389/fimmu.2021.658062
2021
Journal Article
Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism
Wong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182
2021
Journal Article
Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand*
Jee, Adelle S., Sheehy, Robert, Hopkins, Peter, Corte, Tamera J., Grainge, Christopher, Troy, Lauren K., Symons, Karen, Spencer, Lissa M., Reynolds, Paul N., Chapman, Sally, de Boer, Sally, Reddy, Taryn, Holland, Anne E., Chambers, Daniel C., Glaspole, Ian N., Jo, Helen E., Bleasel, Jane F., Wrobel, Jeremy P., Dowman, Leona, Parker, Matthew J.S., Wilsher, Margaret L., Goh, Nicole S.L., Moodley, Yuben and Keir, Gregory J. (2021). Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand*. Respirology, 26 (1), 23-51. doi: 10.1111/resp.13977
2021
Journal Article
The autotaxin-lysophosphatidic acid pathway mediates mesenchymal cell recruitment and fibrotic contraction in lung transplant fibrosis
Sinclair, Kenneth Andrew, Yerkovich, Stephanie Terase, Hopkins, Peter Mark-Anthony, Fieuw, Ann M., Ford, Paul, Powell, Joseph Edwin, O'Sullivan, Brendan and Chambers, Daniel Charles (2021). The autotaxin-lysophosphatidic acid pathway mediates mesenchymal cell recruitment and fibrotic contraction in lung transplant fibrosis. Journal of Heart and Lung Transplantation, 40 (1), 12-23. doi: 10.1016/j.healun.2020.10.005
2020
Journal Article
Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial
Holland, Anne E., Corte, Tamera, Chambers, Daniel C., Palmer, Andrew J., Ekström, Magnus Per, Glaspole, Ian, Goh, Nicole S.L., Hepworth, Graham, Khor, Yet H., Hoffman, Mariana, Vlahos, Ross, Sköld, Magnus, Dowman, Leona, Troy, Lauren K., Prasad, Jyotika D., Walsh, James and McDonald, Christine F. (2020). Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial. BMJ Open, 10 (12) e040798, e040798. doi: 10.1136/bmjopen-2020-040798
2020
Journal Article
Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study
Altaf, Mohammed, Lineburg, Katie E., Crooks, Pauline, Rehan, Sweera, Matthews, Katherine K., Neller, Michelle A, Ambalathingal, George R., Sinha, Debottam, Grant, Michelle, Hopkins, Peter M. A., Chambers, Daniel, Khanna, Rajiv and Smith, Corey (2020). Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study. The Journal of infectious diseases, 224 (2), 312-317. doi: 10.1093/infdis/jiaa750
2020
Journal Article
Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells
Abreu, Soraia C., Hampton, Thomas H., Hoffman, Evan, Dearborn, Jacob, Ashare, Alix, Sidhu, Karatatiwant Singh, Matthews, Dwight E., McKenna, David H., Amiel, Eyal, Barua, Jayita, Krasnodembskaya, Anna, English, Karen, Mahon, Bernard, Santos, Claudia Dos, Cruz, Fernanda F., Chambers, Daniel C., Liu, Kathleen D., Matthay, Michael A., Cramer, Robert A., Stanton, Bruce A., Rocco, Patricia R.M., Wargo, Matthew J., Weiss, Daniel J. and Enes, Sara Rolandsson (2020). Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. American Journal of Physiology - Lung Cellular and Molecular Physiology, 319 (6), L908-L925. doi: 10.1152/AJPLUNG.00218.2020
2020
Journal Article
International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation
Martinu, Tereza, Koutsokera, Angela, Benden, Christian, Cantu, Edward, Chambers, Daniel, Cypel, Marcelo, Edelman, Jeffrey, Emtiazjoo, Amir, Fisher, Andrew J, Greenland, John R, Hayes, Don, Hwang, David, Keller, Brian C, Lease, Erika D, Perch, Michael, Sato, Masaaki, Todd, Jamie L, Verleden, Stijn, von der Thüsen, Jan, Weigt, S Samuel, Keshavjee, Shaf and Bronchoalveolar Lavage Standardization Workgroup (2020). International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation. The Journal of Heart and Lung Transplantation, 39 (11), 1171-1190. doi: 10.1016/j.healun.2020.07.006
2020
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-third pediatric lung transplantation report - 2020; focus on deceased donor characteristics
Hayes, Don, Harhay, Michael O., Cherikh, Wida S., Chambers, Daniel C., Khush, Kiran K., Hsich, Eileen, Potena, Luciano, Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-third pediatric lung transplantation report - 2020; focus on deceased donor characteristics. The Journal of Heart and Lung Transplantation, 39 (10), 1038-1049. doi: 10.1016/j.healun.2020.07.007
2020
Journal Article
Itaconate controls the severity of pulmonary fibrosis
Ogger, Patricia P., Albers, Gesa J., Hewitt, Richard J., O’Sullivan, Brendan J., Powell, Joseph E., Calamita, Emily, Ghai, Poonam, Walker, Simone A., McErlean, Peter, Saunders, Peter, Kingston, Shaun, Molyneaux, Philip L., Halket, John M., Gray, Robert, Chambers, Daniel C., Maher, Toby M., Lloyd, Clare M. and Byrne, Adam J. (2020). Itaconate controls the severity of pulmonary fibrosis. Science Immunology, 5 (52) eabc1884, 1-14. doi: 10.1126/SCIIMMUNOL.ABC1884
2020
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics
Singh, Tajinder P., Hsich, Eileen, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Khush, Kiran K., Potena, Luciano, Sadavarte, Aparna, Zuckermann, Andreas and Stehlik, Josef (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics. Journal of Heart and Lung Transplantation, 39 (10), 1028-1037. doi: 10.1016/j.healun.2020.07.008
2020
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics
Chambers, Daniel C., Zuckermann, Andreas, Cherikh, Wida S, Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Potena, Luciano, Sadavarte, Aparna, Singh, Tajinder P., Stehlik, Josef and International Society for Heart and Lung Transplantation (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics. The Journal of Heart and Lung Transplantation, 39 (10), 1016-1027. doi: 10.1016/j.healun.2020.07.009
2020
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics
Khush, Kiran K., Potena, Luciano, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics. The Journal of Heart and Lung Transplantation, 39 (10), 1003-1015. doi: 10.1016/j.healun.2020.07.010
2020
Journal Article
The ongoing quest for a fountain of youth: cell therapy for pulmonary fibrosis
Chambers, Daniel C. (2020). The ongoing quest for a fountain of youth: cell therapy for pulmonary fibrosis. Respirology, 26 (2) resp.13938, 136-137. doi: 10.1111/resp.13938
2020
Journal Article
Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
Green, Adele C., Way, Mandy, Oster, Mariella, Plasmeijer, Elsemieke I., Jiyad, Zainab, O’Rourke, Peter, Miura, Kyoko, Campbell, Scott, Isbel, Nicole, Chambers, Daniel C., Hopkins, Peter, Ferguson, Lisa E., Davis, Marcia Batista, Whiteman, David C., Soyer, H. Peter and Marquart, Louise (2020). Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer. Archives of Dermatological Research, 314 (2), 203-206. doi: 10.1007/s00403-020-02136-4
2020
Journal Article
Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol
Chambers, Daniel C., Lutzky, Viviana P., Apte, Simon H., Godbolt, David, Feenstra, John and Mackintosh, John (2020). Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol. Respirology Case Reports, 8 (6) e00607, 1-3. doi: 10.1002/rcr2.607
2020
Journal Article
Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium
Ling, Kak-Ming, Garratt, Luke W., Banerjee, Balarka, Lavender, Melanie A., Wrobel, Jeremy P., Musk, Michael, Martinovich, Kelly M., Shaw, Nicole C., Iosifidis, Thomas, Looi, Kevin, Kicic-Starcevich, Elizabeth, Sutanto, Erika N., Yerkovich, Stephanie T., Chambers, Daniel C., Stick, Stephen M. and Kicic, Anthony (2020). Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium. Transplantation, 104 (6), 1166-1176. doi: 10.1097/TP.0000000000003134
2020
Journal Article
Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry
Zaffiri, Lorenzo, Long, Alex, Neely, Megan L., Cherikh, Wida S., Chambers, Daniel C. and Snyder, Laurie D. (2020). Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry. Journal of Heart and Lung Transplantation, 39 (10), 1089-1099. doi: 10.1016/j.healun.2020.06.010
2020
Conference Publication
A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation
Divithotawela, C., Pham, A., Ledger, E. L., Hopkins, P., Tan, M., Yerkovich, S., Wells, T. J. and Chambers, D. C. (2020). A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation. 40th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Montreal, Canada, 22-25 April 2020. New York, NY United States: Elsevier.
2020
Journal Article
Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry
Teoh, Alan K. Y., Jo, Helen E., Chambers, Daniel C., Symons, Karen, Walters, Eugene H., Goh, Nicole S., Glaspole, Ian, Cooper, Wendy, Reynolds, Paul, Moodley, Yuben and Corte, Tamera J. (2020). Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry. European Respiratory Journal, 55 (4) 1901855, 1901855. doi: 10.1183/13993003.01855-2019
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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