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Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025

81 - 100 of 248 works

2021

Journal Article

Airway Telomere Length in Lung Transplant Recipients

Mackintosh, John A., Yerkovich, Stephanie T., Tan, Maxine E., Samson, Luke, Hopkins, Peter M.A. and Chambers, Daniel C. (2021). Airway Telomere Length in Lung Transplant Recipients. Frontiers in Immunology, 12 658062, 1-7. doi: 10.3389/fimmu.2021.658062

Airway Telomere Length in Lung Transplant Recipients

2021

Journal Article

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

Wong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

2021

Journal Article

Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand*

Jee, Adelle S., Sheehy, Robert, Hopkins, Peter, Corte, Tamera J., Grainge, Christopher, Troy, Lauren K., Symons, Karen, Spencer, Lissa M., Reynolds, Paul N., Chapman, Sally, de Boer, Sally, Reddy, Taryn, Holland, Anne E., Chambers, Daniel C., Glaspole, Ian N., Jo, Helen E., Bleasel, Jane F., Wrobel, Jeremy P., Dowman, Leona, Parker, Matthew J.S., Wilsher, Margaret L., Goh, Nicole S.L., Moodley, Yuben and Keir, Gregory J. (2021). Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand*. Respirology, 26 (1), 23-51. doi: 10.1111/resp.13977

Diagnosis and management of connective tissue disease-associated interstitial lung disease in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand*

2021

Journal Article

The autotaxin-lysophosphatidic acid pathway mediates mesenchymal cell recruitment and fibrotic contraction in lung transplant fibrosis

Sinclair, Kenneth Andrew, Yerkovich, Stephanie Terase, Hopkins, Peter Mark-Anthony, Fieuw, Ann M., Ford, Paul, Powell, Joseph Edwin, O'Sullivan, Brendan and Chambers, Daniel Charles (2021). The autotaxin-lysophosphatidic acid pathway mediates mesenchymal cell recruitment and fibrotic contraction in lung transplant fibrosis. Journal of Heart and Lung Transplantation, 40 (1), 12-23. doi: 10.1016/j.healun.2020.10.005

The autotaxin-lysophosphatidic acid pathway mediates mesenchymal cell recruitment and fibrotic contraction in lung transplant fibrosis

2020

Journal Article

Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial

Holland, Anne E., Corte, Tamera, Chambers, Daniel C., Palmer, Andrew J., Ekström, Magnus Per, Glaspole, Ian, Goh, Nicole S.L., Hepworth, Graham, Khor, Yet H., Hoffman, Mariana, Vlahos, Ross, Sköld, Magnus, Dowman, Leona, Troy, Lauren K., Prasad, Jyotika D., Walsh, James and McDonald, Christine F. (2020). Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial. BMJ Open, 10 (12) e040798, e040798. doi: 10.1136/bmjopen-2020-040798

Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial

2020

Journal Article

Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study

Altaf, Mohammed, Lineburg, Katie E., Crooks, Pauline, Rehan, Sweera, Matthews, Katherine K., Neller, Michelle A, Ambalathingal, George R., Sinha, Debottam, Grant, Michelle, Hopkins, Peter M. A., Chambers, Daniel, Khanna, Rajiv and Smith, Corey (2020). Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study. The Journal of infectious diseases, 224 (2), 312-317. doi: 10.1093/infdis/jiaa750

Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study

2020

Journal Article

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells

Abreu, Soraia C., Hampton, Thomas H., Hoffman, Evan, Dearborn, Jacob, Ashare, Alix, Sidhu, Karatatiwant Singh, Matthews, Dwight E., McKenna, David H., Amiel, Eyal, Barua, Jayita, Krasnodembskaya, Anna, English, Karen, Mahon, Bernard, Santos, Claudia Dos, Cruz, Fernanda F., Chambers, Daniel C., Liu, Kathleen D., Matthay, Michael A., Cramer, Robert A., Stanton, Bruce A., Rocco, Patricia R.M., Wargo, Matthew J., Weiss, Daniel J. and Enes, Sara Rolandsson (2020). Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. American Journal of Physiology - Lung Cellular and Molecular Physiology, 319 (6), L908-L925. doi: 10.1152/AJPLUNG.00218.2020

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells

2020

Journal Article

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

Martinu, Tereza, Koutsokera, Angela, Benden, Christian, Cantu, Edward, Chambers, Daniel, Cypel, Marcelo, Edelman, Jeffrey, Emtiazjoo, Amir, Fisher, Andrew J, Greenland, John R, Hayes, Don, Hwang, David, Keller, Brian C, Lease, Erika D, Perch, Michael, Sato, Masaaki, Todd, Jamie L, Verleden, Stijn, von der Thüsen, Jan, Weigt, S Samuel, Keshavjee, Shaf and Bronchoalveolar Lavage Standardization Workgroup (2020). International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation. The Journal of Heart and Lung Transplantation, 39 (11), 1171-1190. doi: 10.1016/j.healun.2020.07.006

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation

2020

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-third pediatric lung transplantation report - 2020; focus on deceased donor characteristics

Hayes, Don, Harhay, Michael O., Cherikh, Wida S., Chambers, Daniel C., Khush, Kiran K., Hsich, Eileen, Potena, Luciano, Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-third pediatric lung transplantation report - 2020; focus on deceased donor characteristics. The Journal of Heart and Lung Transplantation, 39 (10), 1038-1049. doi: 10.1016/j.healun.2020.07.007

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-third pediatric lung transplantation report - 2020; focus on deceased donor characteristics

2020

Journal Article

Itaconate controls the severity of pulmonary fibrosis

Ogger, Patricia P., Albers, Gesa J., Hewitt, Richard J., O’Sullivan, Brendan J., Powell, Joseph E., Calamita, Emily, Ghai, Poonam, Walker, Simone A., McErlean, Peter, Saunders, Peter, Kingston, Shaun, Molyneaux, Philip L., Halket, John M., Gray, Robert, Chambers, Daniel C., Maher, Toby M., Lloyd, Clare M. and Byrne, Adam J. (2020). Itaconate controls the severity of pulmonary fibrosis. Science Immunology, 5 (52) eabc1884, 1-14. doi: 10.1126/SCIIMMUNOL.ABC1884

Itaconate controls the severity of pulmonary fibrosis

2020

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics

Singh, Tajinder P., Hsich, Eileen, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Khush, Kiran K., Potena, Luciano, Sadavarte, Aparna, Zuckermann, Andreas and Stehlik, Josef (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics. Journal of Heart and Lung Transplantation, 39 (10), 1028-1037. doi: 10.1016/j.healun.2020.07.008

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics

2020

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics

Chambers, Daniel C., Zuckermann, Andreas, Cherikh, Wida S, Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Potena, Luciano, Sadavarte, Aparna, Singh, Tajinder P., Stehlik, Josef and International Society for Heart and Lung Transplantation (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics. The Journal of Heart and Lung Transplantation, 39 (10), 1016-1027. doi: 10.1016/j.healun.2020.07.009

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult lung transplantation report - 2020; focus on deceased donor characteristics

2020

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics

Khush, Kiran K., Potena, Luciano, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2020). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics. The Journal of Heart and Lung Transplantation, 39 (10), 1003-1015. doi: 10.1016/j.healun.2020.07.010

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 37th adult heart transplantation report-2020; focus on deceased donor characteristics

2020

Journal Article

The ongoing quest for a fountain of youth: cell therapy for pulmonary fibrosis

Chambers, Daniel C. (2020). The ongoing quest for a fountain of youth: cell therapy for pulmonary fibrosis. Respirology, 26 (2) resp.13938, 136-137. doi: 10.1111/resp.13938

The ongoing quest for a fountain of youth: cell therapy for pulmonary fibrosis

2020

Journal Article

Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer

Green, Adele C., Way, Mandy, Oster, Mariella, Plasmeijer, Elsemieke I., Jiyad, Zainab, O’Rourke, Peter, Miura, Kyoko, Campbell, Scott, Isbel, Nicole, Chambers, Daniel C., Hopkins, Peter, Ferguson, Lisa E., Davis, Marcia Batista, Whiteman, David C., Soyer, H. Peter and Marquart, Louise (2020). Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer. Archives of Dermatological Research, 314 (2), 203-206. doi: 10.1007/s00403-020-02136-4

Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer

2020

Journal Article

Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol

Chambers, Daniel C., Lutzky, Viviana P., Apte, Simon H., Godbolt, David, Feenstra, John and Mackintosh, John (2020). Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol. Respirology Case Reports, 8 (6) e00607, 1-3. doi: 10.1002/rcr2.607

Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol

2020

Journal Article

Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium

Ling, Kak-Ming, Garratt, Luke W., Banerjee, Balarka, Lavender, Melanie A., Wrobel, Jeremy P., Musk, Michael, Martinovich, Kelly M., Shaw, Nicole C., Iosifidis, Thomas, Looi, Kevin, Kicic-Starcevich, Elizabeth, Sutanto, Erika N., Yerkovich, Stephanie T., Chambers, Daniel C., Stick, Stephen M. and Kicic, Anthony (2020). Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium. Transplantation, 104 (6), 1166-1176. doi: 10.1097/TP.0000000000003134

Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium

2020

Journal Article

Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry

Zaffiri, Lorenzo, Long, Alex, Neely, Megan L., Cherikh, Wida S., Chambers, Daniel C. and Snyder, Laurie D. (2020). Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry. Journal of Heart and Lung Transplantation, 39 (10), 1089-1099. doi: 10.1016/j.healun.2020.06.010

Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry

2020

Conference Publication

A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation

Divithotawela, C., Pham, A., Ledger, E. L., Hopkins, P., Tan, M., Yerkovich, S., Wells, T. J. and Chambers, D. C. (2020). A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation. 40th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Montreal, Canada, 22-25 April 2020. New York, NY United States: Elsevier.

A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation

2020

Journal Article

Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry

Teoh, Alan K. Y., Jo, Helen E., Chambers, Daniel C., Symons, Karen, Walters, Eugene H., Goh, Nicole S., Glaspole, Ian, Cooper, Wendy, Reynolds, Paul, Moodley, Yuben and Corte, Tamera J. (2020). Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry. European Respiratory Journal, 55 (4) 1901855, 1901855. doi: 10.1183/13993003.01855-2019

Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au