
Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2020
Journal Article
Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
Green, Adele C., Way, Mandy, Oster, Mariella, Plasmeijer, Elsemieke I., Jiyad, Zainab, O’Rourke, Peter, Miura, Kyoko, Campbell, Scott, Isbel, Nicole, Chambers, Daniel C., Hopkins, Peter, Ferguson, Lisa E., Davis, Marcia Batista, Whiteman, David C., Soyer, H. Peter and Marquart, Louise (2020). Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer. Archives of Dermatological Research, 314 (2), 203-206. doi: 10.1007/s00403-020-02136-4
2020
Journal Article
Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol
Chambers, Daniel C., Lutzky, Viviana P., Apte, Simon H., Godbolt, David, Feenstra, John and Mackintosh, John (2020). Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol. Respirology Case Reports, 8 (6) e00607, 1-3. doi: 10.1002/rcr2.607
2020
Journal Article
Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium
Ling, Kak-Ming, Garratt, Luke W., Banerjee, Balarka, Lavender, Melanie A., Wrobel, Jeremy P., Musk, Michael, Martinovich, Kelly M., Shaw, Nicole C., Iosifidis, Thomas, Looi, Kevin, Kicic-Starcevich, Elizabeth, Sutanto, Erika N., Yerkovich, Stephanie T., Chambers, Daniel C., Stick, Stephen M. and Kicic, Anthony (2020). Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium. Transplantation, 104 (6), 1166-1176. doi: 10.1097/TP.0000000000003134
2020
Journal Article
Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry
Zaffiri, Lorenzo, Long, Alex, Neely, Megan L., Cherikh, Wida S., Chambers, Daniel C. and Snyder, Laurie D. (2020). Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: analysis of ISHLT Registry. Journal of Heart and Lung Transplantation, 39 (10), 1089-1099. doi: 10.1016/j.healun.2020.06.010
2020
Conference Publication
A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation
Divithotawela, C., Pham, A., Ledger, E. L., Hopkins, P., Tan, M., Yerkovich, S., Wells, T. J. and Chambers, D. C. (2020). A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation. 40th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Montreal, Canada, 22-25 April 2020. New York, NY United States: Elsevier.
2020
Journal Article
Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry
Teoh, Alan K. Y., Jo, Helen E., Chambers, Daniel C., Symons, Karen, Walters, Eugene H., Goh, Nicole S., Glaspole, Ian, Cooper, Wendy, Reynolds, Paul, Moodley, Yuben and Corte, Tamera J. (2020). Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry. European Respiratory Journal, 55 (4) 1901855, 1901855. doi: 10.1183/13993003.01855-2019
2020
Journal Article
Skin cancer multiplicity in lung transplant recipients: a prospective population‐based study
Way, M., Marquart, L., Chambers, D. C., Hopkins, P., Miura, K., Jiyad, Z., Plasmeijer, E. I., Ferguson, L. E., Davis, M., Whiteman, D. C., Soyer, H. P., O'Rourke, P. and Green, A. C. (2020). Skin cancer multiplicity in lung transplant recipients: a prospective population‐based study. British Journal of Dermatology, 183 (3) bjd.18812, 503-508. doi: 10.1111/bjd.18812
2020
Journal Article
Silica-related diseases in the modern world
Hoy, Ryan F. and Chambers, Daniel C. (2020). Silica-related diseases in the modern world. Allergy: European Journal of Allergy and Clinical Immunology, 75 (11) all.14202, 2805-2817. doi: 10.1111/all.14202
2020
Journal Article
Erratum: The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth Adult Heart Transplantation Report - 2019; Focus Theme: Donor and Recipient Size Match (vol 38, pg 1056, 2019)
Khush, K. K., Cherikh, W. S., Chambers, D. C., Harhay, M. O., Hayes, D., Hsich, E., Meiser, B., Potena, L., Robinson, A., Rossano, J. W., Sadavarte, A., Singh, T. P., Zuckermann, A. and Stehlik, J. (2020). Erratum: The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth Adult Heart Transplantation Report - 2019; Focus Theme: Donor and Recipient Size Match (vol 38, pg 1056, 2019). Journal of Heart and Lung Transplantation, 39 (1), 91-91. doi: 10.1016/j.healun.2019.11.001
2019
Journal Article
Longevity of pulmonary rehabilitation benefit for chronic obstructive pulmonary disease - health care utilisation in the subsequent 2 years
Walsh, James R., Pegg, Jane, Yerkovich, Stephanie T., Morris, Norman, McKeough, Zoe J., Comans, Tracy, Paratz, Jenny D. and Chambers, Daniel C. (2019). Longevity of pulmonary rehabilitation benefit for chronic obstructive pulmonary disease - health care utilisation in the subsequent 2 years. BMJ Open Respiratory Research, 6 (1) e000500, e000500. doi: 10.1136/bmjresp-2019-000500
2019
Journal Article
The design and rationale of the Trail1 trial: A randomized double-blind phase 2 clinical trial of pirfenidone in rheumatoid arthritis-associated interstitial lung disease
Solomon, Joshua J., Danoff, Sonye K., Goldberg, Hilary J., Woodhead, Felix, Kolb, Martin, Chambers, Daniel C., DiFranco, Donna, Spino, Cathy, Haynes-Harp, Shana, Hurwitz, Shelley, Peters, Elizabeth B., Dellaripa, Paul F. and Rosas, Ivan O. (2019). The design and rationale of the Trail1 trial: A randomized double-blind phase 2 clinical trial of pirfenidone in rheumatoid arthritis-associated interstitial lung disease. Advances in Therapy, 36 (11), 3279-3287. doi: 10.1007/s12325-019-01086-2
2019
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match
Khush, Kiran K., Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Meiser, Bruno, Potena, Luciano, Robinson, Amanda, Rossano, Joseph W., Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and International Society for Heart and Lung Transplantation (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match. The Journal of Heart and Lung, 38 (10), 1056-1066. doi: 10.1016/j.healun.2019.08.004
2019
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match
Chambers, Daniel C., Cherikh, Wida S., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Meiser, Bruno, Potena, Luciano, Rossano, Joseph W., Toll, Alice E., Singh, Tajinder P., Sadavarte, Aparna, Zuckermann, Andreas and Stehlik, Josef (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match. Journal of Heart and Lung Transplantation, 38 (10), 1042-1055. doi: 10.1016/j.healun.2019.08.001
2019
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report-2019; Focus theme: Donor and recipient size match
Rossano, Joseph W., Singh, Tajinder P., Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Meiser, Bruno, Potena, Luciano, Toll, Alice E., Sadavarte, Aparna, Zuckermann, Andreas and Stehlik, Josef (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report-2019; Focus theme: Donor and recipient size match. Journal of Heart and Lung Transplantation, 38 (10), 1028-1041. doi: 10.1016/j.healun.2019.08.002
2019
Journal Article
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric lung and heart-lung transplantation report-2019; Focus theme: Donor and recipient size match
Hayes, Don, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Khush, Kiran K., Lehman, Rebecca R., Meiser, Bruno, Rossano, Joseph W., Hsich, Eileen, Potena, Luciano, Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric lung and heart-lung transplantation report-2019; Focus theme: Donor and recipient size match. The Journal of Heart and Lung Transplantation, 38 (10), 1015-1027. doi: 10.1016/j.healun.2019.08.003
2019
Journal Article
Endothelial glycocalyx shedding occurs during ex vivo lung perfusion: a pilot study
Sladden, Timothy M., Yerkovich, Stephanie, Wall, Douglas, Tan, Maxine, Hunt, William, Hill, Jonathan, Smith, Ian, Hopkins, Peter and Chambers, Daniel C. (2019). Endothelial glycocalyx shedding occurs during ex vivo lung perfusion: a pilot study. Journal of Transplantation, 2019 6748242, 6748242-12. doi: 10.1155/2019/6748242
2019
Journal Article
T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response
Smith, Corey, Corvino, Dillon, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Matthews, Katherine K., Solomon, Matthew, Le Texier, Laetitia, Campbell, Scott, Francis, Ross S., Chambers, Daniel and Khanna, Rajiv (2019). T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response. Journal of Clinical Investigation, 129 (11), 5020-5032. doi: 10.1172/jci128323
2019
Journal Article
Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients
Sladden, Timothy M., Yerkovich, Stephanie, Grant, Michelle, Zhang, Fuming, Liu, Xinyue, Trotter, Michael, Hopkins, Peter, Linhardt, Robert J. and Chambers, Daniel C. (2019). Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients. Transplantation, 103 (6), 1277-1285. doi: 10.1097/TP.0000000000002539
2019
Journal Article
Bronchiolitis obliterans syndrome ‘endotypes’ in haematopoietic stem cell transplantation
Chambers, Daniel C. (2019). Bronchiolitis obliterans syndrome ‘endotypes’ in haematopoietic stem cell transplantation. Respirology, 24 (5) resp.13498, 408-409. doi: 10.1111/resp.13498
2019
Journal Article
Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: experience of the Australian Lung Transplant Collaborative
Mackintosh, John A., Munsif, Maitri, Ranzenbacher, Lucy, Thomson, Claire, Musk, Michael, Snell, Gregory, Glanville, Allan, Chambers, Daniel C. and Hopkins, Peter (2019). Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: experience of the Australian Lung Transplant Collaborative. Journal of Heart and Lung Transplantation, 38 (5), 553-559. doi: 10.1016/j.healun.2019.02.005
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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