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Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025

101 - 120 of 248 works

2020

Journal Article

Skin cancer multiplicity in lung transplant recipients: a prospective population‐based study

Way, M., Marquart, L., Chambers, D. C., Hopkins, P., Miura, K., Jiyad, Z., Plasmeijer, E. I., Ferguson, L. E., Davis, M., Whiteman, D. C., Soyer, H. P., O'Rourke, P. and Green, A. C. (2020). Skin cancer multiplicity in lung transplant recipients: a prospective population‐based study. British Journal of Dermatology, 183 (3) bjd.18812, 503-508. doi: 10.1111/bjd.18812

Skin cancer multiplicity in lung transplant recipients: a prospective population‐based study

2020

Journal Article

Silica-related diseases in the modern world

Hoy, Ryan F. and Chambers, Daniel C. (2020). Silica-related diseases in the modern world. Allergy: European Journal of Allergy and Clinical Immunology, 75 (11) all.14202, 2805-2817. doi: 10.1111/all.14202

Silica-related diseases in the modern world

2020

Journal Article

Erratum: The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth Adult Heart Transplantation Report - 2019; Focus Theme: Donor and Recipient Size Match (vol 38, pg 1056, 2019)

Khush, K. K., Cherikh, W. S., Chambers, D. C., Harhay, M. O., Hayes, D., Hsich, E., Meiser, B., Potena, L., Robinson, A., Rossano, J. W., Sadavarte, A., Singh, T. P., Zuckermann, A. and Stehlik, J. (2020). Erratum: The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth Adult Heart Transplantation Report - 2019; Focus Theme: Donor and Recipient Size Match (vol 38, pg 1056, 2019). Journal of Heart and Lung Transplantation, 39 (1), 91-91. doi: 10.1016/j.healun.2019.11.001

Erratum: The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth Adult Heart Transplantation Report - 2019; Focus Theme: Donor and Recipient Size Match (vol 38, pg 1056, 2019)

2019

Journal Article

Longevity of pulmonary rehabilitation benefit for chronic obstructive pulmonary disease - health care utilisation in the subsequent 2 years

Walsh, James R., Pegg, Jane, Yerkovich, Stephanie T., Morris, Norman, McKeough, Zoe J., Comans, Tracy, Paratz, Jenny D. and Chambers, Daniel C. (2019). Longevity of pulmonary rehabilitation benefit for chronic obstructive pulmonary disease - health care utilisation in the subsequent 2 years. BMJ Open Respiratory Research, 6 (1) e000500, e000500. doi: 10.1136/bmjresp-2019-000500

Longevity of pulmonary rehabilitation benefit for chronic obstructive pulmonary disease - health care utilisation in the subsequent 2 years

2019

Journal Article

The design and rationale of the Trail1 trial: A randomized double-blind phase 2 clinical trial of pirfenidone in rheumatoid arthritis-associated interstitial lung disease

Solomon, Joshua J., Danoff, Sonye K., Goldberg, Hilary J., Woodhead, Felix, Kolb, Martin, Chambers, Daniel C., DiFranco, Donna, Spino, Cathy, Haynes-Harp, Shana, Hurwitz, Shelley, Peters, Elizabeth B., Dellaripa, Paul F. and Rosas, Ivan O. (2019). The design and rationale of the Trail1 trial: A randomized double-blind phase 2 clinical trial of pirfenidone in rheumatoid arthritis-associated interstitial lung disease. Advances in Therapy, 36 (11), 3279-3287. doi: 10.1007/s12325-019-01086-2

The design and rationale of the Trail1 trial: A randomized double-blind phase 2 clinical trial of pirfenidone in rheumatoid arthritis-associated interstitial lung disease

2019

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match

Khush, Kiran K., Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Meiser, Bruno, Potena, Luciano, Robinson, Amanda, Rossano, Joseph W., Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and International Society for Heart and Lung Transplantation (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match. The Journal of Heart and Lung, 38 (10), 1056-1066. doi: 10.1016/j.healun.2019.08.004

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match

2019

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match

Chambers, Daniel C., Cherikh, Wida S., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Meiser, Bruno, Potena, Luciano, Rossano, Joseph W., Toll, Alice E., Singh, Tajinder P., Sadavarte, Aparna, Zuckermann, Andreas and Stehlik, Josef (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match. Journal of Heart and Lung Transplantation, 38 (10), 1042-1055. doi: 10.1016/j.healun.2019.08.001

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult lung and heart-lung transplantation Report-2019; Focus theme: Donor and recipient size match

2019

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report-2019; Focus theme: Donor and recipient size match

Rossano, Joseph W., Singh, Tajinder P., Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Hayes, Don, Hsich, Eileen, Khush, Kiran K., Meiser, Bruno, Potena, Luciano, Toll, Alice E., Sadavarte, Aparna, Zuckermann, Andreas and Stehlik, Josef (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report-2019; Focus theme: Donor and recipient size match. Journal of Heart and Lung Transplantation, 38 (10), 1028-1041. doi: 10.1016/j.healun.2019.08.002

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric heart transplantation report-2019; Focus theme: Donor and recipient size match

2019

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric lung and heart-lung transplantation report-2019; Focus theme: Donor and recipient size match

Hayes, Don, Cherikh, Wida S., Chambers, Daniel C., Harhay, Michael O., Khush, Kiran K., Lehman, Rebecca R., Meiser, Bruno, Rossano, Joseph W., Hsich, Eileen, Potena, Luciano, Sadavarte, Aparna, Singh, Tajinder P., Zuckermann, Andreas, Stehlik, Josef and for the International Society for Heart and Lung Transplantation (2019). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric lung and heart-lung transplantation report-2019; Focus theme: Donor and recipient size match. The Journal of Heart and Lung Transplantation, 38 (10), 1015-1027. doi: 10.1016/j.healun.2019.08.003

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-second pediatric lung and heart-lung transplantation report-2019; Focus theme: Donor and recipient size match

2019

Journal Article

Endothelial glycocalyx shedding occurs during ex vivo lung perfusion: a pilot study

Sladden, Timothy M., Yerkovich, Stephanie, Wall, Douglas, Tan, Maxine, Hunt, William, Hill, Jonathan, Smith, Ian, Hopkins, Peter and Chambers, Daniel C. (2019). Endothelial glycocalyx shedding occurs during ex vivo lung perfusion: a pilot study. Journal of Transplantation, 2019 6748242, 6748242-12. doi: 10.1155/2019/6748242

Endothelial glycocalyx shedding occurs during ex vivo lung perfusion: a pilot study

2019

Journal Article

T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response

Smith, Corey, Corvino, Dillon, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Matthews, Katherine K., Solomon, Matthew, Le Texier, Laetitia, Campbell, Scott, Francis, Ross S., Chambers, Daniel and Khanna, Rajiv (2019). T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response. Journal of Clinical Investigation, 129 (11), 5020-5032. doi: 10.1172/jci128323

T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response

2019

Journal Article

Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients

Sladden, Timothy M., Yerkovich, Stephanie, Grant, Michelle, Zhang, Fuming, Liu, Xinyue, Trotter, Michael, Hopkins, Peter, Linhardt, Robert J. and Chambers, Daniel C. (2019). Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients. Transplantation, 103 (6), 1277-1285. doi: 10.1097/TP.0000000000002539

Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients

2019

Journal Article

Bronchiolitis obliterans syndrome ‘endotypes’ in haematopoietic stem cell transplantation

Chambers, Daniel C. (2019). Bronchiolitis obliterans syndrome ‘endotypes’ in haematopoietic stem cell transplantation. Respirology, 24 (5) resp.13498, 408-409. doi: 10.1111/resp.13498

Bronchiolitis obliterans syndrome ‘endotypes’ in haematopoietic stem cell transplantation

2019

Journal Article

Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: experience of the Australian Lung Transplant Collaborative

Mackintosh, John A., Munsif, Maitri, Ranzenbacher, Lucy, Thomson, Claire, Musk, Michael, Snell, Gregory, Glanville, Allan, Chambers, Daniel C. and Hopkins, Peter (2019). Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: experience of the Australian Lung Transplant Collaborative. Journal of Heart and Lung Transplantation, 38 (5), 553-559. doi: 10.1016/j.healun.2019.02.005

Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: experience of the Australian Lung Transplant Collaborative

2019

Journal Article

Special delivery: engineered endothelial cells for pulmonary arterial hypertension

Chambers, Daniel C. (2019). Special delivery: engineered endothelial cells for pulmonary arterial hypertension. Respirology, 24 (11) resp.13686, 1042-1043. doi: 10.1111/resp.13686

Special delivery: engineered endothelial cells for pulmonary arterial hypertension

2019

Journal Article

Bronchiolitis obliterans syndrome–free survival after lung transplantation: an International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis

Kulkarni, Hrishikesh S., Cherikh, Wida S., Chambers, Daniel C., Garcia, Victoria C., Hachem, Ramsey R., Kreisel, Daniel E., Puri, Varun, Kozower, Benjamin D., Byers, Derek E., Witt, Chad A., Alexander-Brett, Jennifer, Aguilar, Patrick R., Tague, Laneshia K., Furuya, Yuka, Patterson, G. Alec, Trulock, Elbert P. and Yusen, Roger D. (2019). Bronchiolitis obliterans syndrome–free survival after lung transplantation: an International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis. Journal of Heart and Lung Transplantation, 38 (1), 5-16. doi: 10.1016/j.healun.2018.09.016

Bronchiolitis obliterans syndrome–free survival after lung transplantation: an International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis

2019

Conference Publication

Reconstruction of Transcriptional Programs of Monocyte to Macrophage Sequential Cell Fate Transition Using Single Cell RNA Sequencing in Sex Mis-Matched Lung Transplantation

O'Sullivan, B., Powell, J., Lukowski, S., Tan, M., Hopkins, P. and Chambers, D. (2019). Reconstruction of Transcriptional Programs of Monocyte to Macrophage Sequential Cell Fate Transition Using Single Cell RNA Sequencing in Sex Mis-Matched Lung Transplantation. 39th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), Orlando, FL, United States, 3-6 April 2019. Philadelphia, PA, United States: Elsevier . doi: 10.1016/j.healun.2019.01.375

Reconstruction of Transcriptional Programs of Monocyte to Macrophage Sequential Cell Fate Transition Using Single Cell RNA Sequencing in Sex Mis-Matched Lung Transplantation

2018

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first Pediatric Lung and Heart‒Lung Transplantation Report—2018; Focus Theme: Multiorgan Transplantation

Goldfarb, Samuel B., Hayes, Don, Levvey, Bronwyn J., Cherikh, Wida S., Chambers, Daniel C., Khush, Kiran K., Kucheryavaya, Anna Y., Meiser, Bruno, Rossano, Joseph W. and Stehlik, Josef (2018). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first Pediatric Lung and Heart‒Lung Transplantation Report—2018; Focus Theme: Multiorgan Transplantation. Journal of Heart and Lung Transplantation, 37 (10), 1196-1206. doi: 10.1016/j.healun.2018.07.021

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first Pediatric Lung and Heart‒Lung Transplantation Report—2018; Focus Theme: Multiorgan Transplantation

2018

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first pediatric heart transplantation report—2018; Focus theme: Multiorgan Transplantation

Rossano, Joseph W., Cherikh, Wida S., Chambers, Daniel C., Goldfarb, Samuel, Hayes, Don, Khush, Kiran K., Kucheryavaya, Anna Y., Toll, Alice E., Levvey, Bronwyn J., Meiser, Bruno and Stehlik, Josef (2018). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first pediatric heart transplantation report—2018; Focus theme: Multiorgan Transplantation. Journal of Heart and Lung Transplantation, 37 (10), 1184-1195. doi: 10.1016/j.healun.2018.07.018

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Twenty-first pediatric heart transplantation report—2018; Focus theme: Multiorgan Transplantation

2018

Journal Article

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report-2018; Focus Theme: Multiorgan Transplantation

Khush, Kiran K., Cherikh, Wida S., Chambers, Daniel C., Goldfarb, Samuel, Hayes, Don, Kucheryavaya, Anna Y., Levvey, Bronwyn J., Meiser, Bruno, Rossano, Joseph W. and Stehlik, Josef (2018). The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report-2018; Focus Theme: Multiorgan Transplantation. Journal of Heart and Lung Transplantation, 37 (10), 1155-1168. doi: 10.1016/j.healun.2018.07.022

The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report-2018; Focus Theme: Multiorgan Transplantation

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au