Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2014
Journal Article
Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire
Smith, Corey, Gras, Stephanie, Brennan, Rebekah M., Bird, Nicola L., Valkenburg, Sophie A., Twist, Kelly-Anne, Burrows, Jacqueline M., Miles, John J., Chambers, Daniel, Bell, Scott, Campbell, Scott, Kedzierska, Katherine, Burrows, Scott R., Rossjohn, Jamie and Khanna, Rajiv (2014). Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire. Scientific Reports, 4 (1) 3993, 3993.1-3993.10. doi: 10.1038/srep03993
2014
Conference Publication
A Phase 1B Study of Mesenchymal Stromal Cell Therapy for Idiopathic Pulmonary Fibrosis
Chambers, D. C., Enever, D., Ilic, N., Sparks, L., Ayres, J., Yerkovich, S. T., Khalil, D., Atkinson, K. and Hopkins, P. M. (2014). A Phase 1B Study of Mesenchymal Stromal Cell Therapy for Idiopathic Pulmonary Fibrosis. ISCT 2014 Annual Meeting, Paris France, April 23-26 2014. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2014.01.029
2013
Journal Article
Impaired exercise capacity after lung transplantation is related to delayed recovery of muscle strength
Walsh, James R., Chambers, Daniel C., Davis, Rebecca J., Morris, Norman R., Seale, Helen E., Yerkovich, Stephanie T. and Hopkins, Peter M. A. (2013). Impaired exercise capacity after lung transplantation is related to delayed recovery of muscle strength. Clinical Transplantation, 27 (4), E504-E511. doi: 10.1111/ctr.12163
2013
Journal Article
Australia’s experience with ex-vivo lung perfusion of highly marginal donors
Hopkins, P. M., Chambers, D. C., Naidoo, R., Wall, D. A., Smith, I. J. and Hunt, W. G. (2013). Australia’s experience with ex-vivo lung perfusion of highly marginal donors. The Journal of Heart and Lung Transplantation, 32 (4), S154. doi: 10.1016/j.healun.2013.01.355
2013
Journal Article
Mesenchymal stem cells and the lung
Sinclair, Kenneth, Yerkovich, Stephanie T. and Chambers, Daniel C. (2013). Mesenchymal stem cells and the lung. Respirology, 18 (3), 397-411. doi: 10.1111/resp.12050
2013
Conference Publication
Poor adherence to photoprotection and skin surveillance: Recommendations in lung transplant recipients
Morze, C., Sahebian, A., Grant, M., Hopkins, P. M. A., Yerkovich, S. T., Chambers, D. C. C. and Soyer, H. P. (2013). Poor adherence to photoprotection and skin surveillance: Recommendations in lung transplant recipients. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, New South Wales, 19–22 May 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12051
2013
Conference Publication
Longitudinal holistic profiling of the lung transplant microbiome
Willner, D., Ab-Ghani, N. A., Yerkovich, S., Tan, M. E., Hopkins, P. M., Chambers, D. C. and Hugenholtz, P. (2013). Longitudinal holistic profiling of the lung transplant microbiome. 33rd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation, Montreal, Canada, 24-27 April 2013. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2013.01.004
2013
Conference Publication
Poor adherence to photoprotection and skin surveillance: recommendations for lung transplant recipients
Morze, Conrad, Sahebian, Azadeh, Grant, Michelle, Hopkins, Peter, Yerkovich, Stephanie, Chambers, Daniel and Soyer, Peter H. (2013). Poor adherence to photoprotection and skin surveillance: recommendations for lung transplant recipients. 31st Annual Scientific Meeting of the Transplantation-Society-of-Australia-and-New-Zealand, Canberra, ACT, Australia, 26-28 June 2013. London, United Kingdom: Nature Publishing. doi: 10.1038/icb.2013.39
2013
Conference Publication
Prevalence and risk factors for actinic keratosis in lung transplantation
Morze, C., Sahebian, A., Grant, M., Hopkins, P. M. A., Yerkovich, S. T., Chambers, D. C. C. and Soyer, H. P. (2013). Prevalence and risk factors for actinic keratosis in lung transplantation. The Australasian College of Dermatologists 46th Annual Scientific Meeting, Sydney, New South Wales, 19–22 May 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12051
2013
Conference Publication
Hypogammaglobulinaemia Post-Lung Transplant Is Associated with Deficent B Cell Function
Yerkovich, S., Franz, L., Grant, M., Hopkins, P. and Chambers, D. (2013). Hypogammaglobulinaemia Post-Lung Transplant Is Associated with Deficent B Cell Function. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, 22 - 27 March 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12045
2013
Conference Publication
Prevalence of actinic keratosis in lung transplant recipients
Morze, Conrad, Sahebian, Azadeh, Grant, Michelle, Hopkins, Peter, Yerkovich, Stephanie, Chambers, Daniel and Soyer, Peter H. (2013). Prevalence of actinic keratosis in lung transplant recipients. 31st Annual Scientific Meeting of the Transplantation-Society-of-Australia-and-New-Zealand, Canberra, ACT, Australia, 26-28 June 2013. London, United Kingdom: Nature Publishing. doi: 10.1038/icb.2013.39
2013
Journal Article
Bronchiolitis obliterans syndrome, hypogammaglobulinemia, and infectious complications of lung transplantation
Chambers, Daniel C., Davies, Belinda, Mathews, Ann, Yerkovich, Stephanie T. and Hopkins, Peter M. (2013). Bronchiolitis obliterans syndrome, hypogammaglobulinemia, and infectious complications of lung transplantation. Journal of Heart and Lung Transplantation, 32 (1), 36-43. doi: 10.1016/j.healun.2012.10.006
2012
Journal Article
Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin
Banerjee, Balarka, Musk, Michael, Sutanto, Erika N., Yerkovich, Stephanie T., Hopkins, Peter, Knight, Darryl A., Lindsey-Temple, Suzanna, Stick, Stephen M., Kicic, Anthony and Chambers, Daniel C. (2012). Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin. PLoS One, 7 (12) e52309, e52309.1-e52309.12. doi: 10.1371/journal.pone.0052309
2012
Journal Article
Lung fibrosis, premature graying, and macrocytosis
Chambers, Daniel Charles, Clarke, Belinda Edith, McGaughran, Julie and Garcia, Christine Kim (2012). Lung fibrosis, premature graying, and macrocytosis. American Journal of Respiratory and Critical Care Medicine, 186 (5), e8-e9. doi: 10.1164/rccm.201112-2175IM
2012
Journal Article
Increased expression of graft intraepithelial T-Cell pro-inflammatory cytokines compared with native lung during episodes of acute rejection
Hodge, Greg, Hodge, Sandra, Chambers, Daniel C., Reynolds, Paul N. and Holmes, Mark (2012). Increased expression of graft intraepithelial T-Cell pro-inflammatory cytokines compared with native lung during episodes of acute rejection. Journal of Heart and Lung Transplantation, 31 (5), 538-544. doi: 10.1016/j.healun.2012.02.004
2012
Conference Publication
Delayed recovery in exercise capacity post lung transplantation bears no association with age or preoperative functional status
Walsh, J.R., Chambers, D.C., Yerkovich, S.T., Morris, N.R., Seale, H.E. and Hopkins, P.M.A. (2012). Delayed recovery in exercise capacity post lung transplantation bears no association with age or preoperative functional status. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.734
2012
Conference Publication
Mesenchymal Stromal cell therapy for Bronchiolitis Obliterans Syndrome - Preliminary data in humans
Chambers, D.C., Hopkins, P.M., Sturm, M., Lawrence, S., Enever, D., Sparks, L., Whitelaw, K., Herrmann, R. and Musk, M. (2012). Mesenchymal Stromal cell therapy for Bronchiolitis Obliterans Syndrome - Preliminary data in humans. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.181
2012
Conference Publication
Bone-marrow derived CCSP+ epithelial cells reside in the airway epithelium after lung transplantation
Yerkovich, S.T., Gilpin, S., Sinclair, K.A., Tan, M.E., Fiene, A., Hopkins, P.M., Waddell, T. and Chambers, D.C. (2012). Bone-marrow derived CCSP+ epithelial cells reside in the airway epithelium after lung transplantation. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.543
2012
Conference Publication
The pro-inflammatory cytokine IL-17 acts directly on bronchiolar epithelium - Implications for chronic lung allograft dysfunction pathogenesis
Yerkovich, S.T., Tan, M.E., Sinclair, K.A., Fiene, A., Hopkins, P.M. and Chambers, D.C. (2012). The pro-inflammatory cytokine IL-17 acts directly on bronchiolar epithelium - Implications for chronic lung allograft dysfunction pathogenesis. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.018
2012
Conference Publication
Predictors of six-minute walk distance in patients with systemic sclerosis associated pulmonary hypertension
Tuppin, M.P., Chambers, D., Slaughter, R., Mohammed, O. and Kermeen, F. (2012). Predictors of six-minute walk distance in patients with systemic sclerosis associated pulmonary hypertension. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.842
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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