Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
-
Lung transplantation
-
Lung fibrosis
-
Stem cells
-
Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2009
Journal Article
Lung function in ex-preterm adults
Chambers, Daniel C. (2009). Lung function in ex-preterm adults. American Journal of Respiratory and Critical Care Medicine, 179 (6), 517-517. doi: 10.1164/ajrccm.179.6.517
2009
Conference Publication
Cells of Epithelial Lineage Are Detectable In Peripheral Blood and Are Increased in Lung Transplantation
Alay, LA, Kicic, A, Heel, K, Banerjee, B, Musk, A, Hopkins, PMA and Chambers, DC (2009). Cells of Epithelial Lineage Are Detectable In Peripheral Blood and Are Increased in Lung Transplantation. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC.
2009
Conference Publication
Calcineurin Inhibition Can Be Safely Maintained in Lung Transplantation Complicated by Reversible Posterior Leukoencephalopathy Syndrome
Tsang, Bkt, Kermeen, F, Hopkins, PMA and Chambers, DC (2009). Calcineurin Inhibition Can Be Safely Maintained in Lung Transplantation Complicated by Reversible Posterior Leukoencephalopathy Syndrome. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2008.11.654
2009
Conference Publication
Preceeding Respiratory Viral Infection Is a Strong Risk Factor for Fungal infection in Lung Transplant Recipients
Hopkins, Pma, Kermeen, FD, Tsang, B, Daniels, TWV, Seale, H, Bec, C and Chambers, DC (2009). Preceeding Respiratory Viral Infection Is a Strong Risk Factor for Fungal infection in Lung Transplant Recipients. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2008.11.277
2009
Conference Publication
A Polymorphism in the Hepatocyte Growth Factor (HGF) Gene Is Associated with Bronchiolitis Obliterans Syndrome (BOS)-Free Survival after Lung Transplantation
Chambers, DC, Musk, M, Wong, S, Temple, S, Liesfield, TM, Kermeen, F and Hopkins, PMA (2009). A Polymorphism in the Hepatocyte Growth Factor (HGF) Gene Is Associated with Bronchiolitis Obliterans Syndrome (BOS)-Free Survival after Lung Transplantation. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2008.11.314
2009
Conference Publication
Adenovirus Is Not Associated with Graft Drysfunction Post Lung Transplantation and Does Not Warrant Anti-Viral Therapy
Daniels, Twv, Chambers, DC, Tsang, BKT, Seale, HE, Leisbfield, TM, Kermeen, FD and Hopkins, PMA (2009). Adenovirus Is Not Associated with Graft Drysfunction Post Lung Transplantation and Does Not Warrant Anti-Viral Therapy. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC.
2009
Conference Publication
Intragam use for severe refractory paramyxoviral infection to lung transplant recipients
Hopkins, P. M. A., Kermeen, F. D., Tsang, B., Daniels, T. W. V., Walsh, J., Leisfield, T. M. and Chambers, D. C. (2009). Intragam use for severe refractory paramyxoviral infection to lung transplant recipients. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris, France, 22-25 April 2009. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.healun.2008.11.279
2009
Book Chapter
Leucocyte intracellular cytokines in lung transplant patients : A more physiological indicator of immunosuppression than plasma drug levels
Hodge, Greg, Hodge, S., reynolds, P., Chambers, D. and Holmes, M. (2009). Leucocyte intracellular cytokines in lung transplant patients : A more physiological indicator of immunosuppression than plasma drug levels. Immunosuppression : New research. (pp. 91-115) edited by Charles B. Taylor. New York, NY, United States: Nova Biomedical Books.
2009
Conference Publication
Epithelial Mesenchymal Transition (EMT) in Bronchiolitis Obliterans Syndrome (BOS) Is Not Restricted to Small Airways
Chambers, DC, Banerfee, B, Hodge, G, Hopkins, P, Kicic, A, Musk, M, Stick, S, Reynolds, P, Holmes, M and Hodger, S (2009). Epithelial Mesenchymal Transition (EMT) in Bronchiolitis Obliterans Syndrome (BOS) Is Not Restricted to Small Airways. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2008.11.528
2009
Conference Publication
Parainfluenza Infection after Lung Transplantation Is a Strong Predictor for Obliterative Bronchiolitis
Daniels, Twv, Tsang, BKT, Chambers, DC, Kermeen, FD, Walsh, JR and Beck, C (2009). Parainfluenza Infection after Lung Transplantation Is a Strong Predictor for Obliterative Bronchiolitis. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC.
2009
Conference Publication
Bronchiolitis Obliterans Syndrome: Do Uncultured Bacterial Species Play a Role?
Daniels, T.W. V., Rogers, G. B., Banarjee, B., Fraser, J. F., Hopkins, P. M. A., Kermeen, F. D., Musk, M., Corley, A., Bruce, K. D. and Chambers, D. C. (2009). Bronchiolitis Obliterans Syndrome: Do Uncultured Bacterial Species Play a Role?. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. New York, NY, United States: Elsevier. doi: 10.1016/j.healun.2008.11.159
2009
Conference Publication
Mucosal Integrin Expressing CD8 Lymphocytes infiltrate Small Airways during Episodes of Acute Lung Allograft Rejection - Link between Rejection and BOS?
Chambers, DC, Hopkins, PMA, Kermeen, F, Abern, J, Hodge, G, Reynolds, P, Holmes, M and Hodge, S (2009). Mucosal Integrin Expressing CD8 Lymphocytes infiltrate Small Airways during Episodes of Acute Lung Allograft Rejection - Link between Rejection and BOS?. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2008.11.838
2009
Conference Publication
Increased Levels of T-Cell Granzyme b in Bronchiolitis Obliterans Syndrome (BOS) Are Not Adequately Suppressed by Current Immunosuppressive Regimens
Hodge, S, Hodge, G, Ahern, J, Nairn, J, Liew, CL, Reynolds, PN, Hopkins, P, Chambers, D and Holmes, M (2009). Increased Levels of T-Cell Granzyme b in Bronchiolitis Obliterans Syndrome (BOS) Are Not Adequately Suppressed by Current Immunosuppressive Regimens. 29th Annual Meeting and Scientific Session of the International-Society-for-Heart-and-Lung-Transplantation, Paris France, Apr 22-25, 2009. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2008.11.312
2008
Journal Article
Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients
Shepherd, Kelly L., Chambers, Daniel C., Gabbay, Eli, Hillman, David R. and Eastwood, Peter R. (2008). Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients. Respirology, 13 (7), 1045-1052. doi: 10.1111/j.1440-1843.2008.01368.x
2008
Journal Article
Pulmonary hypertension complicating sarcoidosis
Rhodes, B., Chambers, D., Musk, M. and Gabbay, E. (2008). Pulmonary hypertension complicating sarcoidosis. Internal Medicine Journal, 38 (7), 613-U6. doi: 10.1111/j.1445-5994.2008.01682.x
2008
Journal Article
Meta-analysis of nebulized amphotericin B to prevent or treat pulmonary aspergillosis in immunosuppressed animals
Ho, K. M., Duff, O., Chambers, D. and Murray, R. (2008). Meta-analysis of nebulized amphotericin B to prevent or treat pulmonary aspergillosis in immunosuppressed animals. Transplant Infectious Disease, 10 (3), 168-176. doi: 10.1111/j.1399-3062.2007.00290.x
2008
Conference Publication
Lung disease in young adult survivors of moderate and severe bronchopulmonary dysplasia - A future indication for lung transplantation?
Chambers, D. C., Murray, C. P., Louw, J., French, N. and Wilson, A. (2008). Lung disease in young adult survivors of moderate and severe bronchopulmonary dysplasia - A future indication for lung transplantation?. 28th Annual Meeting of the International-Society-for-Heart-and-Lung-Transplantation, Boston Ma, Apr 09-12, 2008. Philadelphia United States: Elsevier. doi: 10.1016/j.healun.2007.11.142
2007
Journal Article
Acute lung transplant rejection is associated with localized increase in T-cell IFN gamma and TNF alpha proinflammatory cytokines in the airways
Hodge, Greg, Hodge, Sandra, Chambers, Daniel, Reynolds, Paul N. and Holmes, Mark (2007). Acute lung transplant rejection is associated with localized increase in T-cell IFN gamma and TNF alpha proinflammatory cytokines in the airways. Transplantation, 84 (11), 1452-1458. doi: 10.1097/01.tp.0000290679.94163.e1
2006
Journal Article
Successful treatment of disseminated Scedosporium infection in 2 lung transplant recipients: Review of the literature and recommendations for management
Musk, M, Chambers, D, Chin, W, Murray, R and Gabbay, E (2006). Successful treatment of disseminated Scedosporium infection in 2 lung transplant recipients: Review of the literature and recommendations for management. Journal of Heart and Lung Transplantation, 25 (10), 1268-1272. doi: 10.1016/j.healun.2006.06.002
2005
Journal Article
Factors associated with infection by Pseudomonas aeruginosa in adult cystic fibrosis
Chambers, D., Scott, F., Bangur, R., Davies, R., Lim, A., Walters, S., Smith, G., Pitt, T., Stableforth, D. and Honeybourne, D. (2005). Factors associated with infection by Pseudomonas aeruginosa in adult cystic fibrosis. European Respiratory Journal, 26 (4), 651-656. doi: 10.1183/09031936.05.00126704
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
-
Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
-
2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
-
-
2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: