Professor Dan Chambers
Professor

Dan Chambers

Email: 

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Cardiovascular medicine and haematology Clinical sciences Immunology

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025
All (248) Journal Article (178) Book Chapter (5) Conference Publication (65)

201 - 220 of 248 works

2010

Journal Article

Oil red O stain of alveolar macrophages is an effective screening test for gastroesophageal reflux disease in lung transplant recipients

Hopkins, Peter M., Kermeen, Fiona, Duhig, Edwina, Fletcher, Linda, Gradwell, Judith, Whitfield, Lenore, Godinez, Coral, Musk, Michael, Chambers, Daniel, Gotley, David and McNeil, Keith (2010). Oil red O stain of alveolar macrophages is an effective screening test for gastroesophageal reflux disease in lung transplant recipients. Journal of Heart and Lung Transplantation, 29 (8), 859-864. doi: 10.1016/j.healun.2010.03.015

Oil red O stain of alveolar macrophages is an effective screening test for gastroesophageal reflux disease in lung transplant recipients

2010

Journal Article

Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha

Hodge, Greg, Hodge, Sandra, Li-Liew, Chien, Chambers, Daniel, Hopkins, Peter, Reynolds, Paul N. and Holmes, Mark (2010). Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha. Transplantation, 89 (10), 1283-1289. doi: 10.1097/TP.0b013e3181d75971

Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha

2010

Conference Publication

Serum IgA Deficiency Is Common in Lung Transplantation and Is Independently Associated with Bronchiolitis Obliterans Syndrome (BOS)

Chambers, DC, Davies, B, Yerkovich, S and Hopkins, PM (2010). Serum IgA Deficiency Is Common in Lung Transplantation and Is Independently Associated with Bronchiolitis Obliterans Syndrome (BOS). 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.368

Serum IgA Deficiency Is Common in Lung Transplantation and Is Independently Associated with Bronchiolitis Obliterans Syndrome (BOS)

2010

Conference Publication

The Australian Experience with Combined Heart-Lung-Liver Transplantation

Fiene, A, McNeil, KD, Kermeen, FD, Chambers, DC, Stuart, K, Fawcett, J, Tam, R, Hart, GJ and Hopkins, PMA (2010). The Australian Experience with Combined Heart-Lung-Liver Transplantation. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.042

The Australian Experience with Combined Heart-Lung-Liver Transplantation

2010

Conference Publication

Lymphocytic Bronchiolitis Is Associated with Inadequate Suppression of Blood T-Cell Granzyme B, IFN gamma and TNF alpha

Liew, CL, Hodge, G, Hodge, S, Chambers, D, Hopkins, P, Reynolds, PN and Holmes, MD (2010). Lymphocytic Bronchiolitis Is Associated with Inadequate Suppression of Blood T-Cell Granzyme B, IFN gamma and TNF alpha. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.312

Lymphocytic Bronchiolitis Is Associated with Inadequate Suppression of Blood T-Cell Granzyme B, IFN gamma and TNF alpha

2010

Conference Publication

A Novel Approach to the Assessment of Lymphocytic Bronchiolitis - The 'B Score'

Chambers, DC, Hodge, S, Hodge, G, Kermeen, F, Reynolds, P, Holmes, M and Hopkins, P (2010). A Novel Approach to the Assessment of Lymphocytic Bronchiolitis - The 'B Score'. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.314

A Novel Approach to the Assessment of Lymphocytic Bronchiolitis - The 'B Score'

2010

Journal Article

Successful management of Aspergillus fuumigatus osteomyelitis in a lung transplant recipient

Allsopp, T., Chandratilleke, M. G., Kermeen, F., Chambers, D. C. and Hopkins, P. (2010). Successful management of Aspergillus fuumigatus osteomyelitis in a lung transplant recipient. The Internet Journal of Pulmonary Medicine, 12 (1).

Successful management of Aspergillus fuumigatus osteomyelitis in a lung transplant recipient

2010

Conference Publication

Achieving Therapeutic Levels of Cyciosporin C2 Early Post Transplant Has No Impact on Rejection Burden

Leong, SC, Chambers, DC, Kermeen, FD and Hopkins, PMA (2010). Achieving Therapeutic Levels of Cyciosporin C2 Early Post Transplant Has No Impact on Rejection Burden. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.163

Achieving Therapeutic Levels of Cyciosporin C2 Early Post Transplant Has No Impact on Rejection Burden

2010

Conference Publication

Antibiotic desensitisation in cystic fibrosis patients with a history of hypersensitivity undergoing lung transplantation is not mandatory

Tse, T., Hopkins, P. M. A., France, M. W., Masel, P. J., Bell, S. C., Kermeen, F. D. and Chambers, D. C. (2010). Antibiotic desensitisation in cystic fibrosis patients with a history of hypersensitivity undergoing lung transplantation is not mandatory. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. ELSEVIER SCIENCE INC.

Antibiotic desensitisation in cystic fibrosis patients with a history of hypersensitivity undergoing lung transplantation is not mandatory

2010

Conference Publication

Are DCD Lungs Superior? Excellent Intermediate Results from a Donation after Cardiac Death Lung Transplant National Collaborative

Levvey, B, Harkess, M, Chambers, D, Granger, E, Ahmed, I, Hopkins, P, Glanville, A and Snell, G (2010). Are DCD Lungs Superior? Excellent Intermediate Results from a Donation after Cardiac Death Lung Transplant National Collaborative. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.365

Are DCD Lungs Superior? Excellent Intermediate Results from a Donation after Cardiac Death Lung Transplant National Collaborative

2010

Conference Publication

Significant side effect burden of voriconazole curtails clinical utility in lung transplantation

Beck, C. A., Chambers, D. C., Kermeen, F. D., Tse, T. and Hopkins, P. M. A. (2010). Significant side effect burden of voriconazole curtails clinical utility in lung transplantation. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago, IL, United States, 21-24 April 2010. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2009.11.434

Significant side effect burden of voriconazole curtails clinical utility in lung transplantation

2010

Conference Publication

Explaining the Bronchiolitis Obliterans Syndrome (BOS) Phenotype-Epithelial-Mesenchymal Transition (EMT) Occurs More Readily in Small Airway Epithelium

Banerjee, B, Kicic, A, Musk, MM, Stick, SM and Chambers, DC (2010). Explaining the Bronchiolitis Obliterans Syndrome (BOS) Phenotype-Epithelial-Mesenchymal Transition (EMT) Occurs More Readily in Small Airway Epithelium. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. ELSEVIER SCIENCE INC.

Explaining the Bronchiolitis Obliterans Syndrome (BOS) Phenotype-Epithelial-Mesenchymal Transition (EMT) Occurs More Readily in Small Airway Epithelium

2010

Conference Publication

RSV and Human Metapneumovirus Are Not Associated with Obliterative Bronchiolitis or Inferior Survival Post Lung Transplantation

Hopkins, Pma, Kermeen, FD, Seale, H, Leisfield, TM, Yerkovich, ST and Chambers, DC (2010). RSV and Human Metapneumovirus Are Not Associated with Obliterative Bronchiolitis or Inferior Survival Post Lung Transplantation. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.200

RSV and Human Metapneumovirus Are Not Associated with Obliterative Bronchiolitis or Inferior Survival Post Lung Transplantation

2010

Conference Publication

First Year Body Mass Index Trajectory Predicts Subsequent Survival in Lung Transplant Recipients

McMillan, JL, Hopkins, PMA, Yerkovich, ST, Herd, KM and Chambers, DC (2010). First Year Body Mass Index Trajectory Predicts Subsequent Survival in Lung Transplant Recipients. 30th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation, Chicago Il, Apr 21-24, 2010. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2009.11.437

First Year Body Mass Index Trajectory Predicts Subsequent Survival in Lung Transplant Recipients

2009

Journal Article

Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens

Hodge, S., Hodge, G., Ahern, J., Liew, C. L., Hopkins, P., Chambers, D. C., Reynolds, P. N. and Holmes, M. (2009). Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens. Clinical and Experimental Immunology, 158 (2), 230-236. doi: 10.1111/j.1365-2249.2009.04008.x

Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens

2009

Journal Article

Adverse outcomes of labour in public and private hospitals in Australia

Chambers, Daniel C. (2009). Adverse outcomes of labour in public and private hospitals in Australia. Medical Journal of Australia, 191 (10), 578-579.

Adverse outcomes of labour in public and private hospitals in Australia

2009

Journal Article

Successful establishment of primary small airway cell cultures in human lung transplantation

Banerjee, Balarka, Kicic, Anthony, Musk, Michael, Sutanto, Erika N., Stick, Stephen M. and Chambers, Daniel C. (2009). Successful establishment of primary small airway cell cultures in human lung transplantation. Respiratory Research, 10 (1) 99, 99.1-99.10. doi: 10.1186/1465-9921-10-99

Successful establishment of primary small airway cell cultures in human lung transplantation

2009

Journal Article

Bronchiolitis obliterans syndrome is associated with absence of suppression of peripheral blood Th1 proinflammatory cytokines

Hodge, Greg, Hodge, Sandra, Chambers, Daniel, Reynolds, Paul N. and Holmes, Mark (2009). Bronchiolitis obliterans syndrome is associated with absence of suppression of peripheral blood Th1 proinflammatory cytokines. Transplantation, 88 (2), 211-218. doi: 10.1097/TP.0b013e3181ac170f

Bronchiolitis obliterans syndrome is associated with absence of suppression of peripheral blood Th1 proinflammatory cytokines

2009

Journal Article

Cells of Epithelial Lineage Are Present in Blood, Engraft the Bronchial Epithelium, and Are Increased in Human Lung Transplantation

May, Leigh A., Kicic, Anthony, Rigby, Paul, Heel, Kathryn, Pullen, Tracey-Lee, Crook, Maxine, Charles, Adrian, Banerjee, Balarka, Ravine, David, Saxena, Alka, Musk, Michael, Stick, Stephen M. and Chambers, Daniel C. (2009). Cells of Epithelial Lineage Are Present in Blood, Engraft the Bronchial Epithelium, and Are Increased in Human Lung Transplantation. Journal of Heart and Lung Transplantation, 28 (6), 550-557. doi: 10.1016/j.healun.2009.03.013

Cells of Epithelial Lineage Are Present in Blood, Engraft the Bronchial Epithelium, and Are Increased in Human Lung Transplantation

2009

Journal Article

Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition

Hodge, S., Holmes, M., Banerjee, B., Musk, M., Kicic, A., Waterer, G., Reynolds, P. N., Hodge, G. and Chambers, D. C. (2009). Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition. American Journal of Transplantation, 9 (4), 727-733. doi: 10.1111/j.1600-6143.2009.02558.x

Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Availability

Professor Dan Chambers is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

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