Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2012
Conference Publication
Risk factors for invasive fungal infection after lung transplantation
Chambers, D.C., Yerkovich, S.T., Maliyasena, V., Menon, M. and Hopkins, P.M. (2012). Risk factors for invasive fungal infection after lung transplantation. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.415
2012
Book Chapter
Pulmonary clinical applications for mesenchymal stem cells
Chambers, D. and Hopkins, P. (2012). Pulmonary clinical applications for mesenchymal stem cells. Mesenchymal stem cell therapy. (pp. 87-99) edited by Lucas G. Chase and Mohan C. Vemuri. Totowa, NJ USA: Humana Press. doi: 10.1007/978-1-62703-200-1_5
2012
Conference Publication
Rapid decline in six minute walk distance is associated with lower survival to transplant in the idiopathic pulmonary fibrosis patient
Walsh, J.R., Chambers, D.C., Yerkovich, S.T., Morris, N.R. and Hopkins, P.M.A. (2012). Rapid decline in six minute walk distance is associated with lower survival to transplant in the idiopathic pulmonary fibrosis patient. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.716
2012
Conference Publication
Direct Evidence of Chronic Epithelial Injury and Dysregulated Repair in Small and Large Airways of Lung Transplant Patients
Banerjee, B., Musk, M., Hopkins, P., Stick, S. M., Kicic, A. and Chambers, D. C. (2012). Direct Evidence of Chronic Epithelial Injury and Dysregulated Repair in Small and Large Airways of Lung Transplant Patients. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, 30 March–4 April 2012. Malden MA United States: Wiley-Blackwell.
2012
Conference Publication
Distinct microbial signatures of healthy and failing lung allografts
Willner, D., Hugenholtz, P., Tan, M.E., Yerkovich, S.T., Hopkins, P.M. and Chambers, D.C. (2012). Distinct microbial signatures of healthy and failing lung allografts. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.072
2012
Conference Publication
Neovascularity in patients with idiopathic pulmonary arterial hypertension
Tuppin, M.P., Chambers, D., Slaughter, R., Mohammed, O. and Kermeen, F. (2012). Neovascularity in patients with idiopathic pulmonary arterial hypertension. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.852
2012
Conference Publication
The transbronchial brush test circumvents sampling limitation associated with transbronchial biopsy and has superior reproducibility for assessment of lymphocytic bronchiolitis
Chambers, D.C., Yerkovich, S.T., Tan, M.E., Sinclair, K.A., Kermeen, F.D., Fiene, A. and Hopkins, P.M. (2012). The transbronchial brush test circumvents sampling limitation associated with transbronchial biopsy and has superior reproducibility for assessment of lymphocytic bronchiolitis. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2012.01.518
2011
Journal Article
The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome
Banerjee, Balarka, Ling, Kak-Ming, Sutanto, Erika N., Musk, Michael, Yerkovich, Stephanie T., Hopkins, Peter M. A., Stick, Stephen M., Kicic, Anthony and Chambers, Daniel. C. (2011). The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome. Journal of Heart and Lung Transplantation, 30 (10), 1175-1185. doi: 10.1016/j.healun.2011.06.007
2011
Journal Article
Adult bronchopulmonary dysplasia: Computed tomography pulmonary findings
Wong, Patrick, Murray, Conor, Louw, Jeanne and Chambers, Daniel (2011). Adult bronchopulmonary dysplasia: Computed tomography pulmonary findings. Journal of Medical Imaging and Radiation Oncology, 55 (4), 373-378. doi: 10.1111/j.1754-9485.2011.02285.x
2011
Journal Article
A novel approach to the assessment of lymphocytic bronchiolitis after lung transplantation - transbronchial brush
Chambers, Daniel C., Hodge, Sandra, Hodge, Greg, Yerkovich, Stephanie T., Kermeen, Fiona D., Reynolds, Paul, Holmes, Mark and Hopkins, Peter M.A. (2011). A novel approach to the assessment of lymphocytic bronchiolitis after lung transplantation - transbronchial brush. The Journal of Heart and Lung Transplantation, 30 (5), 544-551. doi: 10.1016/j.healun.2010.10.018
2011
Journal Article
Lung transplantation-associated leukoencephalopathy, not necessarily the posterior reversible encephalopathy syndrome? Reply
Tsang, B. K. T, Kermeen, F. D., Hopkins, P. M. A. and Chambers, D.C. (2011). Lung transplantation-associated leukoencephalopathy, not necessarily the posterior reversible encephalopathy syndrome? Reply. Internal Medicine Journal, 41 (4), 366-368. doi: 10.1111/j.1445-5994.2011.02463.x
2011
Journal Article
The Impact of Pandemic Influenza A H1N1 2009 on Australian Lung Transplant Recipients
Ng, B.J.H., Glanville, A.R., Snell, G., Musk, M., Holmes, M., Chambers, D.C. and Hopkins, P.M.A. (2011). The Impact of Pandemic Influenza A H1N1 2009 on Australian Lung Transplant Recipients. American Journal of Transplantation, 11 (3), 568-574. doi: 10.1111/j.1600-6143.2010.03422.x
2011
Journal Article
Survival after bronchiolitis obliterans syndrome
Yerkovich, Stephanie T., Hopkins, Peter M. A. and Chambers, Daniel C. (2011). Survival after bronchiolitis obliterans syndrome. American Journal of Respiratory and Critical Care Medicine, 183 (4), 554-554. doi: 10.1164/ajrccm.183.4.554
2011
Conference Publication
Azithromycin Inhibits Mesenchymal Transition of Allograft Epithelium
Banerjee, B, Musk, MM, Yerkovich, ST, Hopkins, PM, Stick, SM, Kicic, A and Chambers, DC (2011). Azithromycin Inhibits Mesenchymal Transition of Allograft Epithelium. 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation, San Diego Ca, Apr 13-16, 2011. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2011.01.349
2011
Conference Publication
Secretory IgA Is Reduced in Lung Transplant Recipients and Is Associated with Community Acquired Respiratory Viral Infection
Yerkovich, ST, Tan, ME, Dodt, WG, Enever, DL, Hopkins, PMA and Chambers, DC (2011). Secretory IgA Is Reduced in Lung Transplant Recipients and Is Associated with Community Acquired Respiratory Viral Infection. 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation, San Diego Ca, Apr 13-16, 2011. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2011.01.361
2011
Book Chapter
Mold infections in cardiothoracic transplantation
Chambers, Daniel C. and Sole, Amparo (2011). Mold infections in cardiothoracic transplantation. Diagnosis and Management of Infectious Diseases in Cardiothoracic Transplantation and Mechanical Circulatory Support. (pp. 195-209) edited by Martha L. Mooney, Margaret M. Hannan, Shahid Husain and James K. Kirklin. Addison, TX, United States: International Society of Heart and Lung Transplantation.
2011
Conference Publication
Community Acquired Respiratory Viral Infection Is a Risk Factor for Death after Lung Transplantation
Chambers, D. C., Burke, A., Daniels, T. W. V., Yerkovich, S. T. and Hopkins, P. M. A. (2011). Community Acquired Respiratory Viral Infection Is a Risk Factor for Death after Lung Transplantation. 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation, San Diego CA, United States, 13-16 April 2011. New York, NY, United States: Elsevier. doi: 10.1016/j.healun.2011.01.360
2011
Conference Publication
BOS Is Associated with Increased Expression of C4d on Airway Bronchial Epithelial Cells Using Flow Cytometry - Potential Use in Diagnosing AMR
Hodge, G, Hodge, S, Chambers, D, Hopkins, P, Reynolds, PN, Holmes, M and Liew, CL (2011). BOS Is Associated with Increased Expression of C4d on Airway Bronchial Epithelial Cells Using Flow Cytometry - Potential Use in Diagnosing AMR. 31st Annual Meeting and Scientific Sessions on International-Society-for-Heart-and-Lung-Transplantation, San Diego Ca, Apr 13-16, 2011. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2011.01.156
2010
Journal Article
Reversible posterior leukoencephalopathy syndrome: Diagnosis and management in the setting of lung transplantation
Tsang, B. K. T., Kermeen, F. D, Hopkins, P. M. A. and Chambers, D. C. (2010). Reversible posterior leukoencephalopathy syndrome: Diagnosis and management in the setting of lung transplantation. Internal Medicine Journal, 40 (10), 716-720. doi: 10.1111/j.1445-5994.2010.02314.x
2010
Journal Article
Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines
Hodge, G., Hodge, S., Li-Liew, C., Chambers, D., Hopkins, P., Reynolds, P. N. and Holmes, M. (2010). Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines. Clinical and Experimental Immunology, 161 (3), 584-590. doi: 10.1111/j.1365-2249.2010.04186.x
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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