
Overview
Background
Alternate email address: Daniel.Chambers@health.qld.gov.au
Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.
Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.
Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.
Qualifications
MBBS(Hons1) UQ, 1993
MED University of Birmingham, UK
Availability
- Professor Dan Chambers is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Lung transplantation
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Lung fibrosis
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Stem cells
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Cellular therapy
Research impacts
Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.
His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.
Works
Search Professor Dan Chambers’s works on UQ eSpace
2016
Journal Article
Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres
Jo, Helen E., Corte, Tamera J., Moodley, Yuben, Levin, Kovi, Westall, Glen, Hopkins, Peter, Chambers, Daniel and Glaspole, Ian (2016). Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres. BMC Pulmonary Medicine, 16 (22) 22, 22. doi: 10.1186/s12890-016-0179-3
2016
Conference Publication
Human Lung-Derived Mesenchymal Stromal Cells Donate Cytoplasmic Content to Bronchial Epithelium Through Microtubules, Tunnelling Nanotubes, Gap Junctions and Microvesicles
Sinclair, K. A., Yerkovich, S., Hopkins, P. and Chambers, D. (2016). Human Lung-Derived Mesenchymal Stromal Cells Donate Cytoplasmic Content to Bronchial Epithelium Through Microtubules, Tunnelling Nanotubes, Gap Junctions and Microvesicles. 22nd Annual Scientific Meeting of the International Society for Cell Therapy (ISCT) , Singapore, May 2016. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2016.03.034
2016
Journal Article
Lung transplantation using controlled donation after circulatory death donors: trials and tribulations
Cypel, Marcelo, Levvey, Bronwyn, Van Raemdonck, Dirk, Erasmus, MichieL, Dark, John, Mason, David, Glanville, Allan R., Chambers, Daniel, Edwards, Leah, Stehlik, Josef, Hertz, Marshall, Whitson, Brian A., Yusen, Roger D., Hopkins, Peter, Snell, Greg and Keshavjee, Shaf (2016). Lung transplantation using controlled donation after circulatory death donors: trials and tribulations. Journal of Heart and Lung Transplantation, 35 (1), 146-147. doi: 10.1016/j.healun.2015.10.004
2016
Journal Article
Controlling cytomegalovirus in the age of personalized medicine
Chambers, Daniel C. (2016). Controlling cytomegalovirus in the age of personalized medicine. American Journal of Respiratory and Critical Care Medicine, 193 (1), 10-11. doi: 10.1164/rccm.201509-1897ED
2016
Conference Publication
Mesenchymal Stromal Cells Isolated From Pulmonary Transplant Recipients by Bronchoalveolar Lavage Are Profibrotic
Sinclair, K., Yerkovich, S., Hopkins, P. and Chambers, D. (2016). Mesenchymal Stromal Cells Isolated From Pulmonary Transplant Recipients by Bronchoalveolar Lavage Are Profibrotic. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science Annual Scientific Meeting, Perth, Western Australia, 1–6 April 2016. Malden MA United States: Wiley-Blackwell.
2015
Journal Article
Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor - anakinra
Divithotawela, Chandima, Garrett, Peter, Westall, Glen, Bhaskar, Balu, Tol, Maneesha and Chambers, Daniel C. (2015). Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor - anakinra. Respirology Case Reports, 4 (1), 4-6. doi: 10.1002/rcr2.137
2015
Journal Article
International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report
Cypel, Marcelo, Levvey, Bronwyn, Van Raemdonck, Dirk, Erasmus, Michiel, Dark, John, Love, Robert, Mason, David, Glanville, Allan R., Chambers, Daniel, Edwards, Leah B., Stehlik, Josef, Hertz, Marshall, Whitson, Brian A., Yusen, Roger D., Puri, Varun, Hopkins, Peter, Snell, Greg and Keshavjee, Shaf (2015). International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report. Journal of Heart and Lung Transplantation, 34 (10), 1278-1282. doi: 10.1016/j.healun.2015.08.015
2015
Journal Article
Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: The GLISTEN study - a randomised controlled trial
Frith, Peter A., Thompson, Philip J., Ratnavadivel, Rajeev, Chang, Catherina L., Bremner, Peter, Day, Peter, Frenzel, Christina, Kurstjens, Nicol, Waddell, Ainslie, Daniel, Alexander, Khoussousi, Alireza, Springfield, Andrew, Veale, Andrew, Graham, Anthony Neil, Gallagher, Brad, Pande, Braj Raj, O'Kane, Brendan, Jones, Christopher, Baldi, Claudio, Helm, Colin, O'Dochartaigh, Conor, Chambers, Daniel, Quinn, Dean, Yull, Derek, Karthigesu, Dhanalakshi, Then, Edward, Graham, Frank, Faigenbaum, Fred, Geddam, Geetha ... Hess, Zofia (2015). Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: The GLISTEN study - a randomised controlled trial. Thorax, 70 (6), 519-527. doi: 10.1136/thoraxjnl-2014-206670
2015
Journal Article
An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases
Weiss, Daniel J., Chambers, Daniel, Giangreco, Adam, Keating, Armand, Kotton, Darrell, Lelkes, Peter I., Wagner, Darcy E. and Prockop, Darwin J. (2015). An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases. Annals of the American Thoracic Society, 12 (4), S79-S97. doi: 10.1513/annalsats.201502-086st
2015
Journal Article
Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation
Holmes-Liew, Chien-Li, Holmes, Mark, Beagley, Leone, Hopkins, Peter, Chambers, Daniel, Smith, Corey and Khanna, Rajiv (2015). Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation. Clinical and Translational Immunology , 4 (3) e35, e35. doi: 10.1038/cti.2015.5
2015
Conference Publication
Prevalence of actinic keratosis and the risk factors for skin cancer in lung transplant recipients in Queensland, Australia
Sahebian, A., Morze, C., Grant, M., Hopkins, P., Yerkovich, S., Chambers, D. and Soyer, H. P. (2015). Prevalence of actinic keratosis and the risk factors for skin cancer in lung transplant recipients in Queensland, Australia. 48th Annual Scientific Meeting of the Australasian College of Dermatologists, Adelaide SA, Australia, 16 May 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12337
2015
Conference Publication
Transbronchial Brush (Tbbr) Reliably Quantifies Lymphocytic Bronchiolitis and Predicts Subsequent Chronic Lung Allograft Dysfunction
Yerkovich, S., Samson, L., Sinclair, K., Tan, M., Gallagher, H., Fiene, A., Hopkins, P. and Chambers, D. (2015). Transbronchial Brush (Tbbr) Reliably Quantifies Lymphocytic Bronchiolitis and Predicts Subsequent Chronic Lung Allograft Dysfunction. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.
2015
Book Chapter
Mesenchymal stromal cell-based therapies for lung disease
Chambers, Daniel (2015). Mesenchymal stromal cell-based therapies for lung disease. Stem Cells in the Lung: Development, Repair and Regeneration. (pp. 225-242) edited by Ivan Bertoncello. Heidelberg, Germany: Springer Spektrum. doi: 10.1007/978-3-319-21082-7_14
2015
Conference Publication
Adoptive T-Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cmv Disease After Lung Transplantation
Holmes-Liew, C., Holmes, M., Beagley, L., Hopkins, P., Chambers, D., Smith, C. and Khanna, R. (2015). Adoptive T-Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cmv Disease After Lung Transplantation. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.
2015
Conference Publication
Hyaluronan - the First New Biomarker of Donor Organ Quality Since Po2?
Sladden, T., Samson, L., Hopkins, P., Yerkovich, S. and Chambers, D. (2015). Hyaluronan - the First New Biomarker of Donor Organ Quality Since Po2?. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.
2015
Conference Publication
Effects of Human Rhinovirus Infection in Large and Small Airway of Lung Transplant Recipients
Ling, K., Lavendar, M., Musk, M., Wrobel, J., Garratt, L., Martinovich, K., Shaw, N., Iosifidis, T., Looi, K., Kicic-Starcevich, E., Lannigan, F., Hopkins, P., Chambers, D., Sutanto, E., Stick, S. and Kicic, A. (2015). Effects of Human Rhinovirus Infection in Large and Small Airway of Lung Transplant Recipients. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.
2015
Conference Publication
Physical Activity Level - a New Marker of Frailty in Lung Transplantation
Walsh, J., Chambers, D., Yerkovich, S., Hopkins, P. and Morris, N. (2015). Physical Activity Level - a New Marker of Frailty in Lung Transplantation. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.
2014
Journal Article
Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial
Bilton, Diana, Tino, Gregory, Barker, Alan F., Chambers, Daniel C., De Soyza, Anthony, Dupont, Lieven J. A., O'Dochartaigh, Conor, van Haren, Eric H. J., Vidal, Luis Otero, Welte, Tobias, Fox, Howard G., Wu, Jian and Charlton, Brett (2014). Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial. Thorax, 69 (12), 1073-1079. doi: 10.1136/thoraxjnl-2014-205587
2014
Journal Article
JTD special edition 'Hot Topics in COPD'- the microbiome in COPD
Chambers, Daniel C., Gellatly, Shaan L., Hugenholtz, Philip and Hansbro, Philip M. (2014). JTD special edition 'Hot Topics in COPD'- the microbiome in COPD. Journal of Thoracic Disease, 6 (11), 1525-1531. doi: 10.3978/j.issn.2072-1439.2014.11.08
2014
Conference Publication
DYSREGULATED REPAIR AND EPITHELIAL INJURY IN SMALL AND LARGE AIRWAYS OF LUNG TRANSPLANT PATIENTS IS AMELIORATED BY AZITHROMYCIN
Kicic, A., Lavender, M., Musk, M., Wrobel, J., Banerjee, B., Ling, K., Martinovich, K., Garratt, L., Iosifidis, T., Looi, K., Kicic-Starvevich, E., Lannigan, F., Hopkins, P., Yerkovich, S., Sutanto, E., Chambers, D. and Stick, S. (2014). DYSREGULATED REPAIR AND EPITHELIAL INJURY IN SMALL AND LARGE AIRWAYS OF LUNG TRANSPLANT PATIENTS IS AMELIORATED BY AZITHROMYCIN. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/resp.12264
Funding
Current funding
Supervision
Availability
- Professor Dan Chambers is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The human pulmonary fibrosis transcriptome at single cell resolution
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care
Associate Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Principal Advisor
Other advisors: Professor Jeffrey Lipman
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2023
Doctor Philosophy
Antibody-Dependent Serum Resistance of Intractable Lung Bacteria
Associate Advisor
Other advisors: Associate Professor Timothy Wells
Media
Enquiries
Contact Professor Dan Chambers directly for media enquiries about:
- Idiopathic pulmonary fibrosis
- Lung fibrosis
- Lung transplantation
- Silicosis
- Stem cell therapy
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