Skip to menu Skip to content Skip to footer
Professor Dan Chambers
Professor

Dan Chambers

Email: 

Overview

Background

Alternate email address: Daniel.Chambers@health.qld.gov.au

Professor Dan Chambers is a thoracic transplant physician, interstitial lung disease expert, and translational clinician researcher. He is an internationally recognised authority in the fields of lung fibrosis, cell therapy for lung disease and lung transplantation. His research focuses on the mechanisms and treatments for lung fibrosis, silicosis, transplant rejection and post-transplant complications.

Graduating from UQ in 1993 with the William Nathaniel Robertson Medal and a University Medal, Dan’s career has continued to be recognised by being named one of Australia’s top 200 researchers in all fields and the most highly cited in the field of transplantation for the last three years. Dan was the immediate past Director of the International Lung and Heart-Lung Transplant Registry, the first Australian to be appointed to that role. The Registry remains the most important source of evidence to guide the practice of transplantation globally.

Dan is Executive Director of Research at Australia’s’ largest health service, Metro North Hospital and Health, and heads one of the world’s largest clinical trials programs in lung fibrosis. He is Chair of the Pulmonary Fibrosis Australiasian Clinical Trials Network (PACT). His research program, located at UQ Thoracic Research Centre at Prince Charles Hospital, has attracted over $20 million. He has authored over 150 original papers and book chapters. He is a regular reviewer for all the highest ranked journals in respiratory and transplantation medicine and is Deputy Editor of the Journal for Heart and Lung Transplantation, the highest impact journal in the field.

Qualifications

MBBS(Hons1) UQ, 1993

MED University of Birmingham, UK

Availability

Professor Dan Chambers is:
Available for supervision
Media expert

Research interests

  • Lung transplantation

  • Lung fibrosis

  • Stem cells

  • Cellular therapy

Research impacts

Professor Chambers is a recognised thought leader in the fields of lung fibrosis, lung cell therapy and lung transplantation. His contributions to these fields have translated into improvements in the management of a wide range of serious lung diseases including silicosis, lung transplant rejection, lung fibrosis and grown up neonatal lung disease. Dan pioneered the use of whole lung lavage to treat acute silicosis, work that has been featured in international media. He was a key member of the team which pioneered ex-vivo lung perfusion to resuscitate marginal donor organs in Australia in 2011. He has used this technology to improve the safety of early phase human trials, and in so doing conceived and developed guidelines for the use of donated human lungs for research in Australia, a document now endorsed by the Transplantation Society of Australia and New Zealand and utilised around the country.

His contribution to knowledge in these diverse areas has been recognised in his appointment to several governmental panels including the Biologicals Advisory Committee (Therapeutic Goods Administration, 2017-2019), the Interim Advisory Panel of the Notifiable Dust Lung Disease Register (Qld Government, 2020-2021), the Virtual Cross Match Working Group (Organ and Tissue Authority, 2020-2021) and the Registry Build Advisory Group for the National Occupational Lung Disease Registry (Australian Government Department of Health, 2020-). He has either chaired or contributed to committees and working groups which have developed international position statements or guidelines in diverse areas of advanced lung disease including the management of fungal infection, conduct of bronchoalveolar lavage, donor and recipient lung transplant management, and in the diagnosis and management of interstitial lung disease. He runs one of the world's largest clinical trial centres focussed on interstitial lung disease and has collaborated with multiple academic and industry partners to bring new treatments to patients with serious lung disease. His work is regularly featured in the Australian media.

Works

Search Professor Dan Chambers’s works on UQ eSpace

248 works between 1998 and 2025

141 - 160 of 248 works

2016

Journal Article

Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres

Jo, Helen E., Corte, Tamera J., Moodley, Yuben, Levin, Kovi, Westall, Glen, Hopkins, Peter, Chambers, Daniel and Glaspole, Ian (2016). Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres. BMC Pulmonary Medicine, 16 (22) 22, 22. doi: 10.1186/s12890-016-0179-3

Evaluating the interstitial lung disease multidisciplinary meeting: a survey of expert centres

2016

Conference Publication

Human Lung-Derived Mesenchymal Stromal Cells Donate Cytoplasmic Content to Bronchial Epithelium Through Microtubules, Tunnelling Nanotubes, Gap Junctions and Microvesicles

Sinclair, K. A., Yerkovich, S., Hopkins, P. and Chambers, D. (2016). Human Lung-Derived Mesenchymal Stromal Cells Donate Cytoplasmic Content to Bronchial Epithelium Through Microtubules, Tunnelling Nanotubes, Gap Junctions and Microvesicles. 22nd Annual Scientific Meeting of the International Society for Cell Therapy (ISCT) , Singapore, May 2016. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2016.03.034

Human Lung-Derived Mesenchymal Stromal Cells Donate Cytoplasmic Content to Bronchial Epithelium Through Microtubules, Tunnelling Nanotubes, Gap Junctions and Microvesicles

2016

Journal Article

Lung transplantation using controlled donation after circulatory death donors: trials and tribulations

Cypel, Marcelo, Levvey, Bronwyn, Van Raemdonck, Dirk, Erasmus, MichieL, Dark, John, Mason, David, Glanville, Allan R., Chambers, Daniel, Edwards, Leah, Stehlik, Josef, Hertz, Marshall, Whitson, Brian A., Yusen, Roger D., Hopkins, Peter, Snell, Greg and Keshavjee, Shaf (2016). Lung transplantation using controlled donation after circulatory death donors: trials and tribulations. Journal of Heart and Lung Transplantation, 35 (1), 146-147. doi: 10.1016/j.healun.2015.10.004

Lung transplantation using controlled donation after circulatory death donors: trials and tribulations

2016

Journal Article

Controlling cytomegalovirus in the age of personalized medicine

Chambers, Daniel C. (2016). Controlling cytomegalovirus in the age of personalized medicine. American Journal of Respiratory and Critical Care Medicine, 193 (1), 10-11. doi: 10.1164/rccm.201509-1897ED

Controlling cytomegalovirus in the age of personalized medicine

2016

Conference Publication

Mesenchymal Stromal Cells Isolated From Pulmonary Transplant Recipients by Bronchoalveolar Lavage Are Profibrotic

Sinclair, K., Yerkovich, S., Hopkins, P. and Chambers, D. (2016). Mesenchymal Stromal Cells Isolated From Pulmonary Transplant Recipients by Bronchoalveolar Lavage Are Profibrotic. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science Annual Scientific Meeting, Perth, Western Australia, 1–6 April 2016. Malden MA United States: Wiley-Blackwell.

Mesenchymal Stromal Cells Isolated From Pulmonary Transplant Recipients by Bronchoalveolar Lavage Are Profibrotic

2015

Journal Article

Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor - anakinra

Divithotawela, Chandima, Garrett, Peter, Westall, Glen, Bhaskar, Balu, Tol, Maneesha and Chambers, Daniel C. (2015). Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor - anakinra. Respirology Case Reports, 4 (1), 4-6. doi: 10.1002/rcr2.137

Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor - anakinra

2015

Journal Article

International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report

Cypel, Marcelo, Levvey, Bronwyn, Van Raemdonck, Dirk, Erasmus, Michiel, Dark, John, Love, Robert, Mason, David, Glanville, Allan R., Chambers, Daniel, Edwards, Leah B., Stehlik, Josef, Hertz, Marshall, Whitson, Brian A., Yusen, Roger D., Puri, Varun, Hopkins, Peter, Snell, Greg and Keshavjee, Shaf (2015). International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report. Journal of Heart and Lung Transplantation, 34 (10), 1278-1282. doi: 10.1016/j.healun.2015.08.015

International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report

2015

Journal Article

Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: The GLISTEN study - a randomised controlled trial

Frith, Peter A., Thompson, Philip J., Ratnavadivel, Rajeev, Chang, Catherina L., Bremner, Peter, Day, Peter, Frenzel, Christina, Kurstjens, Nicol, Waddell, Ainslie, Daniel, Alexander, Khoussousi, Alireza, Springfield, Andrew, Veale, Andrew, Graham, Anthony Neil, Gallagher, Brad, Pande, Braj Raj, O'Kane, Brendan, Jones, Christopher, Baldi, Claudio, Helm, Colin, O'Dochartaigh, Conor, Chambers, Daniel, Quinn, Dean, Yull, Derek, Karthigesu, Dhanalakshi, Then, Edward, Graham, Frank, Faigenbaum, Fred, Geddam, Geetha ... Hess, Zofia (2015). Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: The GLISTEN study - a randomised controlled trial. Thorax, 70 (6), 519-527. doi: 10.1136/thoraxjnl-2014-206670

Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: The GLISTEN study - a randomised controlled trial

2015

Journal Article

An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases

Weiss, Daniel J., Chambers, Daniel, Giangreco, Adam, Keating, Armand, Kotton, Darrell, Lelkes, Peter I., Wagner, Darcy E. and Prockop, Darwin J. (2015). An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases. Annals of the American Thoracic Society, 12 (4), S79-S97. doi: 10.1513/annalsats.201502-086st

An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases

2015

Journal Article

Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation

Holmes-Liew, Chien-Li, Holmes, Mark, Beagley, Leone, Hopkins, Peter, Chambers, Daniel, Smith, Corey and Khanna, Rajiv (2015). Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation. Clinical and Translational Immunology , 4 (3) e35, e35. doi: 10.1038/cti.2015.5

Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation

2015

Conference Publication

Prevalence of actinic keratosis and the risk factors for skin cancer in lung transplant recipients in Queensland, Australia

Sahebian, A., Morze, C., Grant, M., Hopkins, P., Yerkovich, S., Chambers, D. and Soyer, H. P. (2015). Prevalence of actinic keratosis and the risk factors for skin cancer in lung transplant recipients in Queensland, Australia. 48th Annual Scientific Meeting of the Australasian College of Dermatologists, Adelaide SA, Australia, 16 May 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12337

Prevalence of actinic keratosis and the risk factors for skin cancer in lung transplant recipients in Queensland, Australia

2015

Conference Publication

Transbronchial Brush (Tbbr) Reliably Quantifies Lymphocytic Bronchiolitis and Predicts Subsequent Chronic Lung Allograft Dysfunction

Yerkovich, S., Samson, L., Sinclair, K., Tan, M., Gallagher, H., Fiene, A., Hopkins, P. and Chambers, D. (2015). Transbronchial Brush (Tbbr) Reliably Quantifies Lymphocytic Bronchiolitis and Predicts Subsequent Chronic Lung Allograft Dysfunction. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.

Transbronchial Brush (Tbbr) Reliably Quantifies Lymphocytic Bronchiolitis and Predicts Subsequent Chronic Lung Allograft Dysfunction

2015

Book Chapter

Mesenchymal stromal cell-based therapies for lung disease

Chambers, Daniel (2015). Mesenchymal stromal cell-based therapies for lung disease. Stem Cells in the Lung: Development, Repair and Regeneration. (pp. 225-242) edited by Ivan Bertoncello. Heidelberg, Germany: Springer Spektrum. doi: 10.1007/978-3-319-21082-7_14

Mesenchymal stromal cell-based therapies for lung disease

2015

Conference Publication

Adoptive T-Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cmv Disease After Lung Transplantation

Holmes-Liew, C., Holmes, M., Beagley, L., Hopkins, P., Chambers, D., Smith, C. and Khanna, R. (2015). Adoptive T-Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cmv Disease After Lung Transplantation. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.

Adoptive T-Cell Immunotherapy for Treatment of Ganciclovir-Resistant Cmv Disease After Lung Transplantation

2015

Conference Publication

Hyaluronan - the First New Biomarker of Donor Organ Quality Since Po2?

Sladden, T., Samson, L., Hopkins, P., Yerkovich, S. and Chambers, D. (2015). Hyaluronan - the First New Biomarker of Donor Organ Quality Since Po2?. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.

Hyaluronan - the First New Biomarker of Donor Organ Quality Since Po2?

2015

Conference Publication

Effects of Human Rhinovirus Infection in Large and Small Airway of Lung Transplant Recipients

Ling, K., Lavendar, M., Musk, M., Wrobel, J., Garratt, L., Martinovich, K., Shaw, N., Iosifidis, T., Looi, K., Kicic-Starcevich, E., Lannigan, F., Hopkins, P., Chambers, D., Sutanto, E., Stick, S. and Kicic, A. (2015). Effects of Human Rhinovirus Infection in Large and Small Airway of Lung Transplant Recipients. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.

Effects of Human Rhinovirus Infection in Large and Small Airway of Lung Transplant Recipients

2015

Conference Publication

Physical Activity Level - a New Marker of Frailty in Lung Transplantation

Walsh, J., Chambers, D., Yerkovich, S., Hopkins, P. and Morris, N. (2015). Physical Activity Level - a New Marker of Frailty in Lung Transplantation. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Queensland, Australia, 27 March–1 April 2015. Malden MA United States: Wiley-Blackwell.

Physical Activity Level - a New Marker of Frailty in Lung Transplantation

2014

Journal Article

Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial

Bilton, Diana, Tino, Gregory, Barker, Alan F., Chambers, Daniel C., De Soyza, Anthony, Dupont, Lieven J. A., O'Dochartaigh, Conor, van Haren, Eric H. J., Vidal, Luis Otero, Welte, Tobias, Fox, Howard G., Wu, Jian and Charlton, Brett (2014). Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial. Thorax, 69 (12), 1073-1079. doi: 10.1136/thoraxjnl-2014-205587

Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial

2014

Journal Article

JTD special edition 'Hot Topics in COPD'- the microbiome in COPD

Chambers, Daniel C., Gellatly, Shaan L., Hugenholtz, Philip and Hansbro, Philip M. (2014). JTD special edition 'Hot Topics in COPD'- the microbiome in COPD. Journal of Thoracic Disease, 6 (11), 1525-1531. doi: 10.3978/j.issn.2072-1439.2014.11.08

JTD special edition 'Hot Topics in COPD'- the microbiome in COPD

2014

Conference Publication

DYSREGULATED REPAIR AND EPITHELIAL INJURY IN SMALL AND LARGE AIRWAYS OF LUNG TRANSPLANT PATIENTS IS AMELIORATED BY AZITHROMYCIN

Kicic, A., Lavender, M., Musk, M., Wrobel, J., Banerjee, B., Ling, K., Martinovich, K., Garratt, L., Iosifidis, T., Looi, K., Kicic-Starvevich, E., Lannigan, F., Hopkins, P., Yerkovich, S., Sutanto, E., Chambers, D. and Stick, S. (2014). DYSREGULATED REPAIR AND EPITHELIAL INJURY IN SMALL AND LARGE AIRWAYS OF LUNG TRANSPLANT PATIENTS IS AMELIORATED BY AZITHROMYCIN. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/resp.12264

DYSREGULATED REPAIR AND EPITHELIAL INJURY IN SMALL AND LARGE AIRWAYS OF LUNG TRANSPLANT PATIENTS IS AMELIORATED BY AZITHROMYCIN

Funding

Current funding

  • 2024 - 2025
    Targeting the Oxysterol/Gpr183 Axis to Treat Idiopathic Pulmonary Fibrosis
    Lung Foundation Australia
    Open grant
  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2023 - 2028
    Lung Diseases Research
    Research Donation Generic
    Open grant
  • 2023 - 2028
    A randomised clinical trial of a digital self-management package for people with Interstitial Lung Disease (the REBUILD-SM trial) (MRFF CRC led by USYD)
    University of Sydney
    Open grant
  • 2022 - 2027
    CRE for Interstitial Lung Disease - towards Individualised Care (NHMRC CRE led by University of Sydney)
    University of Sydney
    Open grant
  • 2022 - 2027
    The SiroSkin study: A multi-centre randomised double-blind placebo-controlled trial of 1% topical sirolimus in the chemoprevention of facial squamous cell carcinomas in solid organ... (Stream 7)
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2021 - 2025
    Silicosis - Harnessing new ideas to conquer the re-emergence of an ancient lung disease - The SHIELD Study
    NHMRC MRFF EPCDR Silicosis Research
    Open grant
  • 2020 - 2026
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant
  • 2016 - 2026
    Cell Therapy Facility at TPCH
    Mayne Bequest Fund
    Open grant

Past funding

  • 2018 - 2022
    Prevention and treatment of idiopathic and post-transplant pulmonary fibrosis
    Prince Charles Hospital Foundation
    Open grant
  • 2018 - 2023
    Ambulatory oxygen for interstitial lung disease (NHMRC Project Grant led by Monash University)
    Monash University
    Open grant
  • 2018 - 2023
    Modulation of lung regeneration and remodeling by the innate immune system (NHMRC Project Grant led by RMIT University)
    Royal Melbourne Institute of Technology University
    Open grant
  • 2017 - 2022
    Centre for Research Excellence in Pulmonary Fibrosis (NHMRC CRE administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2016 - 2023
    Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    Protecting the endothelial glycocalyx to improve transplant rates and outcomes
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Bronchopulmonary Dysplasia - A Regenerative Medicine Approach (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2015
    Optimising organ function during ex-vivo lung perfusion - role of the endothelial glycocalyx
    UQ Academic Title Holder Research Fund
    Open grant
  • 2011 - 2014
    Assessment of airway rejection in lung transplantation - no longer B grade?
    Roche Organ Transplant Resarch Foundation
    Open grant

Supervision

Availability

Professor Dan Chambers is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    The human pulmonary fibrosis transcriptome at single cell resolution

    Principal Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Development of Multimodal Machine Learning Tools for Precision Pulmonary Fibrosis Care

    Associate Advisor

    Other advisors: Dr Quan Nguyen

  • Doctor Philosophy

    Immune Regulation of Lung Injury: Pathways to Repair, Restoration and Fibrosis

    Associate Advisor

    Other advisors: Professor Gabrielle Belz

  • Doctor Philosophy

    What is the relationship between nutritional status of patients pre-lung transplant and their association with post-lung transplant outcomes

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Professor Dan Chambers directly for media enquiries about:

  • Idiopathic pulmonary fibrosis
  • Lung fibrosis
  • Lung transplantation
  • Silicosis
  • Stem cell therapy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au