Overview
Background
Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.
As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.
More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.
Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.
Pre-Eminent Staff Specialist, Department of Emergency Medicine
Prof, Queensland University of Technology
A/Prof, University of Queensland
Royal Brisbane and Women’s Hospital
Brisbane, Queensland 4029, AUSTRALIA.
Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.
Email: louise.cullen@health.qld.gov.au
Twitter: @louiseacullen
Qualifications: MBBS (Hon) FACEM PhD
Availability
- Professor Louise Cullen is:
- Available for supervision
Fields of research
Research impacts
Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.
Works
Search Professor Louise Cullen’s works on UQ eSpace
2016
Conference Publication
Rapid measurement of a single troponin I combined with negative ECG allow accurate rule-out of NSTEMI in patients with suspected AMI
Neumann, J. T., Soerensen, N., Schwemer, T., Ojeda, F., Keller, T., Renne, T., Than, M., Parsonage, W., Schnabel, R., Cullen, L., Greenslade, J., Zeller, T., Karakas, M., Blankenberg, S. and Westermann, D. (2016). Rapid measurement of a single troponin I combined with negative ECG allow accurate rule-out of NSTEMI in patients with suspected AMI. Congress of the European-Society-of-Cardiology (ESC), Rome Italy, Aug 27-31, 2016. OXFORD: OXFORD UNIV PRESS.
2016
Conference Publication
Direct comparison of the safety and efficacy of two rule-out strategies for acute myocardial infarction: 2-hour adp algorithm versus 2 hour algorithm
Wildi, K. S., Cullen, L., Gimenez, M. Rubini, Nestelberger, T., Puelacher, C., Boeddinghaus, J., Twerenbold, R. and Mueller, C. (2016). Direct comparison of the safety and efficacy of two rule-out strategies for acute myocardial infarction: 2-hour adp algorithm versus 2 hour algorithm. Congress of the European-Society-of-Cardiology (ESC), Rome Italy, Aug 27-31, 2016. OXFORD: OXFORD UNIV PRESS.
2016
Conference Publication
Translation of the ADAPT accelerated diagnostic protocol into clinical practice: impact on hospital length of stay and admission rates for possible cardiac chest pain
Parsonage, W. A., Ashover, S., Milburn, T., Skoien, W., Greenslade, J. and Cullen, L. (2016). Translation of the ADAPT accelerated diagnostic protocol into clinical practice: impact on hospital length of stay and admission rates for possible cardiac chest pain. Congress of the European-Society-of-Cardiology (ESC), Rome Italy, Aug 27-31, 2016. OXFORD: OXFORD UNIV PRESS.
2016
Journal Article
Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction
Pickering, John W., Greenslade, Jaimi H., Cullen, Louise, Flaws, Dylan, Parsonage, William, George, Peter, Worster, Andrew, Kavsak, Peter A. and Than, Martin P. (2016). Validation of presentation and 3 h high-sensitivity troponin to rule-in and rule-out acute myocardial infarction. Heart, 102 (16), 1270-1278. doi: 10.1136/heartjnl-2015-308505
2016
Conference Publication
Cardiac troponins, type II myocardial infarction and late mortality: a report from the Australian and New Zealand 2012 SNAPSHOT ACS study
Etaher, A., Chew, D., Redfern, J. K., Cullen, L., Lefkovits, J., Elis, C. J., Hammett, C. J. K., Elliott, J. M., Briffa, T., Brieger, D. and French, J. K. (2016). Cardiac troponins, type II myocardial infarction and late mortality: a report from the Australian and New Zealand 2012 SNAPSHOT ACS study. Congress of the European-Society-of-Cardiology (ESC), Rome Italy, Aug 27-31, 2016. OXFORD: OXFORD UNIV PRESS.
2016
Journal Article
Appropriate use of serum troponin testing in general practice: a narrative review
Aroney, Constantine N. and Cullen, Louise (2016). Appropriate use of serum troponin testing in general practice: a narrative review. Medical Journal of Australia, 205 (2), 91-94. doi: 10.5694/mja16.00263
2016
Journal Article
Evaluation of high-sensitivity cardiac troponin I levels in patients with suspected acute coronary syndrome
Carlton, Edward, Greenslade, Jaimi, Cullen, Louise, Body, Richard, Than, Martin, Pickering, John W., Aldous, Sally, Carley, Simon, Hammett, Christopher, Kendall, Jason, Keevil, Brian, Lord, Sarah, Parsonage, William and Greaves, Kim (2016). Evaluation of high-sensitivity cardiac troponin I levels in patients with suspected acute coronary syndrome. JAMA Cardiology, 1 (4), 405-412. doi: 10.1001/jamacardio.2016.1309
2016
Journal Article
Diagnosis of myocardial infarction using a high-sensitivity Troponin I 1-hour algorithm
Neumann, Johannes Tobias, Sörensen, Nils Arne, Schwemer, Tjark, Ojeda, Francisco, Bourry, Rafael, Sciacca, Vanessa, Schaefer, Sarina, Waldeyer, Christoph, Sinning, Christoph, Renné, Thomas, Than, Martin, Parsonage, William, Wildi, Karin, Makarova, Nataliya, Schnabel, Renate B., Landmesser, Ulf, Mueller, Christian, Cullen, Louise, Greenslade, Jaimi, Zeller, Tanja, Blankenberg, Stefan, Karakas, Mahir and Westermann, Dirk (2016). Diagnosis of myocardial infarction using a high-sensitivity Troponin I 1-hour algorithm. JAMA Cardiology, 1 (4), 397-404. doi: 10.1001/jamacardio.2016.0695
2016
Journal Article
Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice
Than, Martin P., Pickering, John W., Aldous, Sally J., Cullen, Louise, Frampton, Christopher M.A., Peacock, W. Frank, Jaffe, Allan S., Goodacre, Steve W., Richards, A. Mark, Ardagh, Michael W., Deely, Joanne M., Florkowski, Chris M., George, Peter, Hamilton, Gregory J., Jardine, David L., Troughton, Richard W., van Wyk, Pieter, Young, Joanna M., Bannister, Laura and Lord, Sally J. (2016). Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice. Annals of Emergency Medicine, 68 (1), 93-102.e1. doi: 10.1016/j.annemergmed.2016.01.001
2016
Journal Article
Outcome at 30 days for low-risk chest pain patients assessed using an accelerated diagnostic pathway in the emergency department : Clinical Outcome of an ADP for low Risk Chest Pain in ED
Meek, Robert, Braitberg, George, Cullen, Louise, Than, Martin, Graudins, Andis and Glynn, Deirdre (2016). Outcome at 30 days for low-risk chest pain patients assessed using an accelerated diagnostic pathway in the emergency department : Clinical Outcome of an ADP for low Risk Chest Pain in ED. Emergency Medicine Australasia, 28 (3), 279-286. doi: 10.1111/1742-6723.12570
2016
Journal Article
Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome
Cullen, Louise, Greenslade, Jaimi H., Menzies, Louven, Leong, Ashley, Than, Martin, Pemberton, Christopher, Aldous, Sally, Pickering, John, Dalton, Emily, Crosling, Bianca, Foreman, Rachelle and Parsonage, William A. (2016). Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome. Emergency Medicine Journal, 33 (6), 390-395. doi: 10.1136/emermed-2015-204978
2016
Journal Article
Relationship between physiological parameters and acute coronary syndrome in patients presenting to the emergency department with undifferentiated chest pain
Greenslade, Jaimi H., Beamish, Daniel, Parsonage, William, Hawkins, Tracey, Schluter, Jessica, Dalton, Emily, Parker, Kate, Than, Martin, Hammett, Christopher, Lamanna, Arvin and Cullen, Louise (2016). Relationship between physiological parameters and acute coronary syndrome in patients presenting to the emergency department with undifferentiated chest pain. Journal of Cardiovascular Nursing, 31 (3), 267-273. doi: 10.1097/JCN.0000000000000228
2016
Journal Article
Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I
Boeddinghaus, Jasper, Reichlin, Tobias, Cullen, Louise, Greenslade, Jaimi H., Parsonage, William A., Hammett, Christopher, Pickering, John W., Hawkins, Tracey, Aldous, Sally, Twerenbold, Raphael, Wildi, Karin, Nestelberger, Thomas, Grimm, Karin, Rubini-Gimenez, Maria, Puelacher, Christian, Kern, Vera, Rentsch, Katharina, Than, Martin and Mueller, Christian (2016). Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clinical Chemistry, 62 (3), 494-504. doi: 10.1373/clinchem.2015.249508
2016
Journal Article
The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis
Chuang, Anthony, Hancock, David G., Horsfall, Matthew, Alhammad, Nasser J., Zhou, Julia, Cullen, Louise, French, John and Chew, Derek P. (2016). The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis. International Journal of Cardiology, 204, 106-111. doi: 10.1016/j.ijcard.2015.11.132
2016
Journal Article
Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain
Cullen, Louise, Greenslade, Jaimi H., Carlton, Edward W., Than, Martin, Pickering, John W., Ho, Ariel, Greaves, Kim, Berndt, Sara L., Body, Richard, Ryan, Kimberley and Parsonagel, William A. (2016). Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain. Heart, 102 (2), 120-126. doi: 10.1136/heartjnl-2015-308506
2016
Journal Article
Change to costs and lengths of stay in the emergency department and the Brisbane protocol: an observational study
Cheng, Qinglu, Greenslade, Jaimi H., Parsonage, William A., Barnett, Adrian G., Merollini, Katharina, Graves, Nicholas, Peacock, W. Frank and Cullen, Louise (2016). Change to costs and lengths of stay in the emergency department and the Brisbane protocol: an observational study. BMJ Open, 6 (2) e009746, 1-11. doi: 10.1136/bmjopen-2015-009746
2015
Journal Article
Myocardial infarction: rapid ruling out in the emergency room
Cullen, Louise, Parsonage, William and Than, Martin (2015). Myocardial infarction: rapid ruling out in the emergency room. The Lancet, 386 (10012), 2449-2450. doi: 10.1016/s0140-6736(15)00449-3
2015
Journal Article
The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing
Aldous, Sally, Richards, A Mark, Cullen, Louise, Pickering, John W and Than, Martin (2015). The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing. Emergency Medicine Journal, 33 (5), 319-324. doi: 10.1136/emermed-2015-204823
2015
Journal Article
Factors associated with triage assignment of emergency department patients ultimately diagnosed with acute myocardial infarction
Ryan, Kimberley, Greenslade, Jaimi, Dalton, Emily, Chu, Kevin, Brown, Anthony F. T. and Cullen, Louise (2015). Factors associated with triage assignment of emergency department patients ultimately diagnosed with acute myocardial infarction. Australian Critical Care, 29 (1), 23-26. doi: 10.1016/j.aucc.2015.05.001
2015
Journal Article
'Chest pain typicality' in suspected acute coronary syndromes and the impact of clinical experience
Carlton, Edward W., Than, Martin, Cullen, Louise, Khattab, Ahmed and Greaves, Kim (2015). 'Chest pain typicality' in suspected acute coronary syndromes and the impact of clinical experience. American Journal of Medicine, 128 (10), 1109-1116.e2. doi: 10.1016/j.amjmed.2015.04.012
Funding
Current funding
Supervision
Availability
- Professor Louise Cullen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Automated data extraction of electronic health records using natural language processing for a statewide chest pain clinical data registry: The HER DECoDeR study
Principal Advisor
-
Doctor Philosophy
Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study
Principal Advisor
Completed supervision
-
2017
Doctor Philosophy
Decision Aid Derivation Methods for the Acute Coronary Syndrome Pathway
Principal Advisor
-
2024
Doctor Philosophy
Atrial Fibrillation in Critical Care
Associate Advisor
Other advisors: Associate Professor Robert Boots
Media
Enquiries
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