Overview
Background
Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.
As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.
More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.
Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.
Pre-Eminent Staff Specialist, Department of Emergency Medicine
Prof, Queensland University of Technology
A/Prof, University of Queensland
Royal Brisbane and Women’s Hospital
Brisbane, Queensland 4029, AUSTRALIA.
Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.
Email: louise.cullen@health.qld.gov.au
Twitter: @louiseacullen
Qualifications: MBBS (Hon) FACEM PhD
Availability
- Professor Louise Cullen is:
- Available for supervision
Fields of research
Research impacts
Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.
Works
Search Professor Louise Cullen’s works on UQ eSpace
2016
Journal Article
Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice
Than, Martin P., Pickering, John W., Aldous, Sally J., Cullen, Louise, Frampton, Christopher M.A., Peacock, W. Frank, Jaffe, Allan S., Goodacre, Steve W., Richards, A. Mark, Ardagh, Michael W., Deely, Joanne M., Florkowski, Chris M., George, Peter, Hamilton, Gregory J., Jardine, David L., Troughton, Richard W., van Wyk, Pieter, Young, Joanna M., Bannister, Laura and Lord, Sally J. (2016). Effectiveness of EDACS Versus ADAPT Accelerated Diagnostic Pathways for Chest Pain: A Pragmatic Randomized Controlled Trial Embedded Within Practice. Annals of Emergency Medicine, 68 (1), 93-102.e1. doi: 10.1016/j.annemergmed.2016.01.001
2016
Journal Article
Outcome at 30 days for low-risk chest pain patients assessed using an accelerated diagnostic pathway in the emergency department : Clinical Outcome of an ADP for low Risk Chest Pain in ED
Meek, Robert, Braitberg, George, Cullen, Louise, Than, Martin, Graudins, Andis and Glynn, Deirdre (2016). Outcome at 30 days for low-risk chest pain patients assessed using an accelerated diagnostic pathway in the emergency department : Clinical Outcome of an ADP for low Risk Chest Pain in ED. Emergency Medicine Australasia, 28 (3), 279-286. doi: 10.1111/1742-6723.12570
2016
Journal Article
Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome
Cullen, Louise, Greenslade, Jaimi H., Menzies, Louven, Leong, Ashley, Than, Martin, Pemberton, Christopher, Aldous, Sally, Pickering, John, Dalton, Emily, Crosling, Bianca, Foreman, Rachelle and Parsonage, William A. (2016). Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome. Emergency Medicine Journal, 33 (6), 390-395. doi: 10.1136/emermed-2015-204978
2016
Journal Article
Relationship between physiological parameters and acute coronary syndrome in patients presenting to the emergency department with undifferentiated chest pain
Greenslade, Jaimi H., Beamish, Daniel, Parsonage, William, Hawkins, Tracey, Schluter, Jessica, Dalton, Emily, Parker, Kate, Than, Martin, Hammett, Christopher, Lamanna, Arvin and Cullen, Louise (2016). Relationship between physiological parameters and acute coronary syndrome in patients presenting to the emergency department with undifferentiated chest pain. Journal of Cardiovascular Nursing, 31 (3), 267-273. doi: 10.1097/JCN.0000000000000228
2016
Journal Article
Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I
Boeddinghaus, Jasper, Reichlin, Tobias, Cullen, Louise, Greenslade, Jaimi H., Parsonage, William A., Hammett, Christopher, Pickering, John W., Hawkins, Tracey, Aldous, Sally, Twerenbold, Raphael, Wildi, Karin, Nestelberger, Thomas, Grimm, Karin, Rubini-Gimenez, Maria, Puelacher, Christian, Kern, Vera, Rentsch, Katharina, Than, Martin and Mueller, Christian (2016). Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clinical Chemistry, 62 (3), 494-504. doi: 10.1373/clinchem.2015.249508
2016
Journal Article
The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis
Chuang, Anthony, Hancock, David G., Horsfall, Matthew, Alhammad, Nasser J., Zhou, Julia, Cullen, Louise, French, John and Chew, Derek P. (2016). The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis. International Journal of Cardiology, 204, 106-111. doi: 10.1016/j.ijcard.2015.11.132
2016
Journal Article
Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain
Cullen, Louise, Greenslade, Jaimi H., Carlton, Edward W., Than, Martin, Pickering, John W., Ho, Ariel, Greaves, Kim, Berndt, Sara L., Body, Richard, Ryan, Kimberley and Parsonagel, William A. (2016). Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain. Heart, 102 (2), 120-126. doi: 10.1136/heartjnl-2015-308506
2016
Journal Article
Change to costs and lengths of stay in the emergency department and the Brisbane protocol: an observational study
Cheng, Qinglu, Greenslade, Jaimi H., Parsonage, William A., Barnett, Adrian G., Merollini, Katharina, Graves, Nicholas, Peacock, W. Frank and Cullen, Louise (2016). Change to costs and lengths of stay in the emergency department and the Brisbane protocol: an observational study. BMJ Open, 6 (2) e009746, 1-11. doi: 10.1136/bmjopen-2015-009746
2015
Journal Article
Myocardial infarction: rapid ruling out in the emergency room
Cullen, Louise, Parsonage, William and Than, Martin (2015). Myocardial infarction: rapid ruling out in the emergency room. The Lancet, 386 (10012), 2449-2450. doi: 10.1016/s0140-6736(15)00449-3
2015
Journal Article
The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing
Aldous, Sally, Richards, A Mark, Cullen, Louise, Pickering, John W and Than, Martin (2015). The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing. Emergency Medicine Journal, 33 (5), 319-324. doi: 10.1136/emermed-2015-204823
2015
Journal Article
Factors associated with triage assignment of emergency department patients ultimately diagnosed with acute myocardial infarction
Ryan, Kimberley, Greenslade, Jaimi, Dalton, Emily, Chu, Kevin, Brown, Anthony F. T. and Cullen, Louise (2015). Factors associated with triage assignment of emergency department patients ultimately diagnosed with acute myocardial infarction. Australian Critical Care, 29 (1), 23-26. doi: 10.1016/j.aucc.2015.05.001
2015
Journal Article
'Chest pain typicality' in suspected acute coronary syndromes and the impact of clinical experience
Carlton, Edward W., Than, Martin, Cullen, Louise, Khattab, Ahmed and Greaves, Kim (2015). 'Chest pain typicality' in suspected acute coronary syndromes and the impact of clinical experience. American Journal of Medicine, 128 (10), 1109-1116.e2. doi: 10.1016/j.amjmed.2015.04.012
2015
Journal Article
A Clinical Decision Rule to Identify Emergency Department Patients at Low Risk for Acute Coronary Syndrome Who Do Not Need Objective Coronary Artery Disease Testing: The No Objective Testing Rule
Greenslade, Jaimi H., Parsonage, William, Than, Martin, Scott, Adam, Aldous, Sally, Pickering, John W., Hammett, Christopher J. and Cullen, Louise (2015). A Clinical Decision Rule to Identify Emergency Department Patients at Low Risk for Acute Coronary Syndrome Who Do Not Need Objective Coronary Artery Disease Testing: The No Objective Testing Rule. Annals of Emergency Medicine, 67 (4), 478-489.e2. doi: 10.1016/j.annemergmed.2015.08.006
2015
Journal Article
The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department
Pickering, John W., Young, Joanna M., George, Peter, Aldous, Sally, Cullen, Louise, Greenslade, Jaimi H., Richards, A. Mark, Troughton, Richard, Ardagh, Michael, Frampton, Christopher M. and Than, Martin P. (2015). The utility of presentation and 4-hour high sensitivity troponin I to rule-out acute myocardial infarction in the emergency department. Clinical Biochemistry, 48 (18), 1219-1224. doi: 10.1016/j.clinbiochem.2015.07.033
2015
Journal Article
High-Sensitivity Cardiac Troponin T Concentrations below the Limit of Detection to Exclude Acute Myocardial Infarction: A Prospective Evaluation
Body, Richard, Burrows, Gillian, Carley, Simon, Cullen, Louise, Than, Martin, Jaffe, Allan S and Lewis, Philip S (2015). High-Sensitivity Cardiac Troponin T Concentrations below the Limit of Detection to Exclude Acute Myocardial Infarction: A Prospective Evaluation. Clinical Chemistry, 61 (7), 983-989. doi: 10.1373/clinchem.2014.231530
2015
Journal Article
Two-hour diagnostic algorithms for early assessment of patients with acute chest pain - Implications of lowering the cardiac troponin I cut-off to the 97.5th percentile
Eggers, Kai M, Aldous, Sally, Greenslade, Jaimi H, Johnston, Nina, Lindahl, Bertil, Parsonage, William A, Pickering, John W, Than, Martin and Cullen, Louise (2015). Two-hour diagnostic algorithms for early assessment of patients with acute chest pain - Implications of lowering the cardiac troponin I cut-off to the 97.5th percentile. Clinica Chimica Acta, 445, 19-24. doi: 10.1016/j.cca.2015.03.002
2015
Journal Article
Cost and outcomes of assessing patients with chest pain in an Australian emergency department
Cullen, Louise, Greenslade, Jaimi, Merollini, Katharina, Graves, Nicholas, Hammett, Christopher J. K., Hawkins, Tracey, Than, Martin P., Brown, Anthony F. T., Huang, Christopher B., Panahi, Seyed E., Dalton, Emily and Parsonage, William A. (2015). Cost and outcomes of assessing patients with chest pain in an Australian emergency department. Medical Journal of Australia, 202 (8), 427-432. doi: 10.5694/mja14.00472
2015
Journal Article
Utility of Routine Exercise Stress Testing among Intermediate Risk Chest Pain Patients Attending an Emergency Department
Greenslade, Jaimi H, Parsonage, William, Ho, Ariel, Scott, Adam, Dalton, Emily, Hammett, Christopher, Brown, Anthony F.T, Parker, Kate and Cullen, Louise (2015). Utility of Routine Exercise Stress Testing among Intermediate Risk Chest Pain Patients Attending an Emergency Department. Heart Lung and Circulation, 24 (9), 879-884. doi: 10.1016/j.hlc.2015.03.025
2015
Journal Article
Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients
Meller, Bernadette, Cullen, Louise, Parsonage, William A., Greenslade, Jaimi H., Aldous, Sally, Reichlin, Tobias, Wildi, Karin, Twerenbold, Raphael, Jaeger, Cedric, Hillinger, Petra, Haaf, Philip, Puelacher, Christian, Kern, Vera, Rentsch, Katharina, Stallone, Fabio, Rubini Gimenez, Maria, Ballarino, Paola, Bassetti, Stefano, Walukiewicz, Astrid, Troughton, Richard, Pemberton, Christopher J., Richards, A. Mark, Chu, Kevin, Reid, Christopher M., Than, Martin and Mueller, Christian (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184 (1), 208-15. doi: 10.1016/j.ijcard.2015.02.006
2015
Journal Article
Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T
Reichlin, Tobias, Cullen, Louise, Parsonage, William A., Greenslade, Jaimi, Twerenbold, Raphael, Moehring, Berit, Wildi, Karin, Mueller, Sandra, Zellweger, Christa, Mosimann, Tamina, Rubini Gimenez, Maria, Rentsch, Katharina, Osswald, Stefan and Muller, Christian (2015). Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. American Journal of Medicine, 128 (4), 369-379.e4. doi: 10.1016/j.amjmed.2014.10.032
Funding
Current funding
Supervision
Availability
- Professor Louise Cullen is:
- Available for supervision
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Supervision history
Completed supervision
-
2017
Doctor Philosophy
Decision Aid Derivation Methods for the Acute Coronary Syndrome Pathway
Principal Advisor
-
2024
Doctor Philosophy
Atrial Fibrillation in Critical Care
Associate Advisor
Other advisors: Associate Professor Robert Boots
Media
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