Overview
Background
Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.
As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.
More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.
Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.
Pre-Eminent Staff Specialist, Department of Emergency Medicine
Prof, Queensland University of Technology
A/Prof, University of Queensland
Royal Brisbane and Women’s Hospital
Brisbane, Queensland 4029, AUSTRALIA.
Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.
Email: louise.cullen@health.qld.gov.au
Twitter: @louiseacullen
Qualifications: MBBS (Hon) FACEM PhD
Availability
- Professor Louise Cullen is:
- Available for supervision
Fields of research
Research impacts
Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.
Works
Search Professor Louise Cullen’s works on UQ eSpace
2015
Journal Article
A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin
Carlton, Edward W, Cullen, Louise, Than, Martin, Gamble, James, Khattab, Ahmed and Greaves, Kim (2015). A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin. Heart, 101 (13), 1041-1046. doi: 10.1136/heartjnl-2014-307288
2015
Journal Article
Polylactide Bioabsorbable Struts for Chest Wall Reconstruction in a Pediatric Patient
Makarawo, Tafadzwa P., Reynolds, Richard A. and Cullen, Marc L. (2015). Polylactide Bioabsorbable Struts for Chest Wall Reconstruction in a Pediatric Patient. Annals of Thoracic Surgery, 99 (2), 689-691. doi: 10.1016/j.athoracsur.2014.03.052
2015
Journal Article
Admission glycaemia and its association with acute coronary syndrome in Emergency Department patients with chest pain
Gardner, Logan S, Nguyen-Pham, Sallyanne, Greenslade, Jaimi H, Parsonage, William, D'Emden, Michael, Than, Martin, Aldous, Sally, Brown, Anthony and Cullen, Louise (2015). Admission glycaemia and its association with acute coronary syndrome in Emergency Department patients with chest pain. Emergency Medicine Journal, 32 (8), 608-612. doi: 10.1136/emermed-2014-204046
2015
Journal Article
Availability of highly sensitive troponin assays and acute coronary syndrome care: insights from the SNAPSHOT registry
Cullen, Louise, French, John K, Briffa, Tom G, Redfern, Julie, Hammett, Christopher J K, Brieger, David B, Parsonage, William A, Lefkovits, Jeffrey, Ellis, Chris, Astley, Carolyn, Howell, Tegwen Eleanor, Elliott, John M and Chew, Derek P B (2015). Availability of highly sensitive troponin assays and acute coronary syndrome care: insights from the SNAPSHOT registry. Medical Journal of Australia, 202 (1), 36-39. doi: 10.5694/mja13.00275
2014
Journal Article
Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction
Aldous, Sally, Richards, A. Mark, George, Peter M., Cullen, Louise, Parsonage, William A., Flaws, Dylan, Florkowski, Christopher M., Troughton, Richard W., O'Sullivan, Jack W., Reid, Christopher M., Bannister, Laura and Than, Martin (2014). Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction. International Journal of Cardiology, 177 (1), 182-186. doi: 10.1016/j.ijcard.2014.09.026
2014
Journal Article
Decision limits and the reporting of cardiac troponin: Meeting the needs of both the cardiologist and the ED physician
Hickman, Peter E., Lindahl, Bertil, Cullen, Louise, Koerbin, Gus, Tate, Jill and Potter, Julia M. (2014). Decision limits and the reporting of cardiac troponin: Meeting the needs of both the cardiologist and the ED physician. Critical Reviews in Clinical Laboratory Sciences, 52 (1), 28-44. doi: 10.3109/10408363.2014.972497
2014
Journal Article
The promise of high‐sensitivity troponin testing
Chew, Derek P B and Cullen, Louise (2014). The promise of high‐sensitivity troponin testing. Medical Journal of Australia, 201 (3), 125-126. doi: 10.5694/mja14.00858
2014
Journal Article
Undetectable hs-cTnT in the Emergency Department and Risk of Myocardial Infarction
Cullen, Louise, Than, Martin and Peacock, W. Frank (2014). Undetectable hs-cTnT in the Emergency Department and Risk of Myocardial Infarction. Journal of the American College of Cardiology, 64 (6), 632-633. doi: 10.1016/j.jacc.2014.04.061
2014
Journal Article
Towards a consistent definition of a significant delta troponin with z-scores: a way out of chaos?
Pretorius, Carel J., Cullen, Louise, Parsonage, William A., Greenslade, Jaimi H., Tate, Jillian R., Wilgen, Urs and Ungerer, Jacobus P. J. (2014). Towards a consistent definition of a significant delta troponin with z-scores: a way out of chaos?. European Heart Journal: Acute Cardiovascular Care, 3 (2), 149-157. doi: 10.1177/2048872613517084
2014
Journal Article
Use of Observed Within-Person Variation of Cardiac Troponin in Emergency Department Patients for Determination of Biological Variation and Percentage and Absolute Reference Change Values
Simpson, Aaron J, Potter, Julia M, Koerbin, Gus, Oakman, Carmen, Cullen, Louise, Wilkes, Garry J, Scanlan, Samuel L, Parsonage, William and Hickman, Peter E (2014). Use of Observed Within-Person Variation of Cardiac Troponin in Emergency Department Patients for Determination of Biological Variation and Percentage and Absolute Reference Change Values. Clinical Chemistry, 60 (6), 848-854. doi: 10.1373/clinchem.2013.219410
2014
Journal Article
Limited utility of exercise stress testing in the evaluation of suspected acute coronary syndrome in patients aged less than 40 years with intermediate risk features
Scott, Adam C., Bilesky, Jennifer, Lamanna, Arvin, Cullen, Louise, Brown, Anthony F. T., Denaro, Charles and Parsonage, William (2014). Limited utility of exercise stress testing in the evaluation of suspected acute coronary syndrome in patients aged less than 40 years with intermediate risk features. EMA - Emergency Medicine Australasia, 26 (2), 170-176. doi: 10.1111/1742-6723.12222
2014
Conference Publication
A MODIFIED GOLDMAN RISK SCORE IN COMBINATION WITH HIGH-SENSITIVITY TROPONIN PROVES SUPERIOR TO TIMI IN THE EVALUATION OF SUSPECTED ACUTE CARDIAC CHEST PAIN
Carlton, Edward Watts, Cullen, Louise, Than, Martin and Greaves, Kim (2014). A MODIFIED GOLDMAN RISK SCORE IN COMBINATION WITH HIGH-SENSITIVITY TROPONIN PROVES SUPERIOR TO TIMI IN THE EVALUATION OF SUSPECTED ACUTE CARDIAC CHEST PAIN. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/S0735-1097(14)60080-2
2014
Journal Article
In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days
Cullen, L. and Carpenter, Christopher R. (2014). In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days. Annals of Internal Medicine, 160 (6), JC13. doi: 10.7326/0003-4819-160-6-201403180-02013
2014
Journal Article
Implementation of a chest pain management service improves patient care and reduces length of stay
Scott, Adam C., O'Dwyer, Kristina M., Cullen, Louise, Brown, Anthony, Denaro, Charles and Parsonage, William (2014). Implementation of a chest pain management service improves patient care and reduces length of stay. Critical Pathways in Cardiology, 13 (1), 9-13. doi: 10.1097/01.hpc.0000441082.64971.54
2014
Journal Article
Effect of recalibration of the hs-TnT assay on diagnostic performance
Parsonage, William A., Tate, Jillian R., Greenslade, Jaimi H., Hammett, Christopher J., Ungerer, Jacobus P. J., Pretorius, Carel J., Brown, Anthony F. T. and Cullen, Louise (2014). Effect of recalibration of the hs-TnT assay on diagnostic performance. Clinical Chemistry and Laboratory Medicine, 52 (2), E25-E27. doi: 10.1515/cclm-2013-0490
2014
Journal Article
Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain
Parsonage, William A, Greenslade, Jaimi H, Hammett, Christopher J, Lamanna, Arvin, Tate, Jillian R, Ungerer, Jacobus P, Chu, Kevin, Than, Martin, Brown, Anthony F T and Cullen, Louise (2014). Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain. Medical Journal of Australia, 200 (3), 161-165. doi: 10.5694/mja13.10466
2014
Journal Article
The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study
Cullen, L., Greenslade, J.H., Than, M., Brown, A.F.T., Hammett, C.J., Lamanna, A., Flaws, D.F., Chu, K., Fowles, L.F. and Parsonage, W.A. (2014). The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study. American Journal of Emergency Medicine, 32 (2), 129-134. doi: 10.1016/j.ajem.2013.10.021
2014
Journal Article
Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol
Than, Martin, Flaws, Dylan, Sanders, Sharon, Doust, Jenny, Glasziou, Paul, Kline, Jeffery, Aldous, Sally, Troughton, Richard, Reid, Christopher, Parsonage, William A., Frampton, Christopher, Greenslade, Jaimi H., Deely, Joanne M., Hess, Erik, Sadiq, Amr Bin, Singleton, Rose, Shopland, Rosie, Vercoe, Laura, Woolhouse-Williams, Morgana, Ardagh, Michael, Bossuyt, Patrick, Bannister, Laura and Cullen, Louise (2014). Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol. EMA - Emergency Medicine Australasia, 26 (1), 34-44. doi: 10.1111/1742-6723.12164
2014
Journal Article
Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain
Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., Hammett, C. J., Richards, A. M., Ungerer, J. P. J., Troughton, R. W., Brown, A. F. T., Flaws, D. F., Lamanna, A., Pemberton, C. J., Florkowski, C., Pretorius, C. J., Chu, K. and Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47 (6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019
2014
Journal Article
A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial
Than, Martin, Aldous, Sally, Lord, Sarah Jane, Goodacre, Stephen, Frampton, Christopher M. A., Troughton, Richard, George, Peter, Florkowski, Christopher Michael, Ardagh, Michael, Smyth, David, Jardine, David Lewis, Peacock, William Frank, Young, Joanna, Hamilton, Gregory, Deely, Joanne M., Cullen, Louise and Richards, A. Mark (2014). A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial. JAMA Internal Medicine, 174 (1), 51-58. doi: 10.1001/jamainternmed.2013.11362
Funding
Current funding
Supervision
Availability
- Professor Louise Cullen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study
Principal Advisor
Completed supervision
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2017
Doctor Philosophy
Decision Aid Derivation Methods for the Acute Coronary Syndrome Pathway
Principal Advisor
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2024
Doctor Philosophy
Atrial Fibrillation in Critical Care
Associate Advisor
Other advisors: Associate Professor Robert Boots
Media
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