Overview
Background
Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.
As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.
More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.
Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.
Pre-Eminent Staff Specialist, Department of Emergency Medicine
Prof, Queensland University of Technology
A/Prof, University of Queensland
Royal Brisbane and Women’s Hospital
Brisbane, Queensland 4029, AUSTRALIA.
Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.
Email: louise.cullen@health.qld.gov.au
Twitter: @louiseacullen
Qualifications: MBBS (Hon) FACEM PhD
Availability
- Professor Louise Cullen is:
- Available for supervision
Fields of research
Research impacts
Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.
Works
Search Professor Louise Cullen’s works on UQ eSpace
2014
Conference Publication
A MODIFIED GOLDMAN RISK SCORE IN COMBINATION WITH HIGH-SENSITIVITY TROPONIN PROVES SUPERIOR TO TIMI IN THE EVALUATION OF SUSPECTED ACUTE CARDIAC CHEST PAIN
Carlton, Edward Watts, Cullen, Louise, Than, Martin and Greaves, Kim (2014). A MODIFIED GOLDMAN RISK SCORE IN COMBINATION WITH HIGH-SENSITIVITY TROPONIN PROVES SUPERIOR TO TIMI IN THE EVALUATION OF SUSPECTED ACUTE CARDIAC CHEST PAIN. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/S0735-1097(14)60080-2
2014
Journal Article
In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days
Cullen, L. and Carpenter, Christopher R. (2014). In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days. Annals of Internal Medicine, 160 (6), JC13. doi: 10.7326/0003-4819-160-6-201403180-02013
2014
Journal Article
Implementation of a chest pain management service improves patient care and reduces length of stay
Scott, Adam C., O'Dwyer, Kristina M., Cullen, Louise, Brown, Anthony, Denaro, Charles and Parsonage, William (2014). Implementation of a chest pain management service improves patient care and reduces length of stay. Critical Pathways in Cardiology, 13 (1), 9-13. doi: 10.1097/01.hpc.0000441082.64971.54
2014
Journal Article
Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol
Than, Martin, Flaws, Dylan, Sanders, Sharon, Doust, Jenny, Glasziou, Paul, Kline, Jeffery, Aldous, Sally, Troughton, Richard, Reid, Christopher, Parsonage, William A., Frampton, Christopher, Greenslade, Jaimi H., Deely, Joanne M., Hess, Erik, Sadiq, Amr Bin, Singleton, Rose, Shopland, Rosie, Vercoe, Laura, Woolhouse-Williams, Morgana, Ardagh, Michael, Bossuyt, Patrick, Bannister, Laura and Cullen, Louise (2014). Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol. EMA - Emergency Medicine Australasia, 26 (1), 34-44. doi: 10.1111/1742-6723.12164
2014
Journal Article
Effect of recalibration of the hs-TnT assay on diagnostic performance
Parsonage, William A., Tate, Jillian R., Greenslade, Jaimi H., Hammett, Christopher J., Ungerer, Jacobus P. J., Pretorius, Carel J., Brown, Anthony F. T. and Cullen, Louise (2014). Effect of recalibration of the hs-TnT assay on diagnostic performance. Clinical Chemistry and Laboratory Medicine, 52 (2), E25-E27. doi: 10.1515/cclm-2013-0490
2014
Journal Article
Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain
Parsonage, William A, Greenslade, Jaimi H, Hammett, Christopher J, Lamanna, Arvin, Tate, Jillian R, Ungerer, Jacobus P, Chu, Kevin, Than, Martin, Brown, Anthony F T and Cullen, Louise (2014). Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain. Medical Journal of Australia, 200 (3), 161-165. doi: 10.5694/mja13.10466
2014
Journal Article
The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study
Cullen, L., Greenslade, J.H., Than, M., Brown, A.F.T., Hammett, C.J., Lamanna, A., Flaws, D.F., Chu, K., Fowles, L.F. and Parsonage, W.A. (2014). The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study. American Journal of Emergency Medicine, 32 (2), 129-134. doi: 10.1016/j.ajem.2013.10.021
2014
Journal Article
Performance of Risk Stratification for Acute Coronary Syndrome with Two-hour Sensitive Troponin Assay Results
Cullen, L., Greenslade, J., Than, M., Tate, J., Ungerer, J. P. J., Pretorius, C., Hammett, C. J., Lamanna, A., Chu, K., Brown, A. F. T. and Parsonage, W. A. (2014). Performance of Risk Stratification for Acute Coronary Syndrome with Two-hour Sensitive Troponin Assay Results. Heart Lung and Circulation, 23 (5), 428-434. doi: 10.1016/j.hlc.2013.11.003
2014
Journal Article
Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain
Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., Hammett, C. J., Richards, A. M., Ungerer, J. P. J., Troughton, R. W., Brown, A. F. T., Flaws, D. F., Lamanna, A., Pemberton, C. J., Florkowski, C., Pretorius, C. J., Chu, K. and Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47 (6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019
2014
Journal Article
A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial
Than, Martin, Aldous, Sally, Lord, Sarah Jane, Goodacre, Stephen, Frampton, Christopher M. A., Troughton, Richard, George, Peter, Florkowski, Christopher Michael, Ardagh, Michael, Smyth, David, Jardine, David Lewis, Peacock, William Frank, Young, Joanna, Hamilton, Gregory, Deely, Joanne M., Cullen, Louise and Richards, A. Mark (2014). A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial. JAMA Internal Medicine, 174 (1), 51-58. doi: 10.1001/jamainternmed.2013.11362
2013
Journal Article
Acute assessment of possible cardiac chest pain
Cullen, L. and Parsonage, W. (2013). Acute assessment of possible cardiac chest pain. Medicine Today, 14 (12), 41-44.
2013
Journal Article
Troponin testing: End of an era?
Peacock, W. Frank, Cullen, Louise, Mueller, Christian and Than, Martin (2013). Troponin testing: End of an era?. Clinical Biochemistry, 46 (16-17), 1627-1628. doi: 10.1016/j.clinbiochem.2013.10.008
2013
Journal Article
Delta troponin for the early diagnosis of AMI in emergency patients with chest pain
Cullen, L., Parsonage, W. A., Greenslade, J., Lamanna, A., Hammett, C. J., Than, M., Tate, J., Kalinowski, L., Ungerer, J. P. J., Chu, K. and Brown, A. (2013). Delta troponin for the early diagnosis of AMI in emergency patients with chest pain. International Journal of Cardiology, 168 (3), 2602-2608. doi: 10.1016/j.ijcard.2013.03.044
2013
Journal Article
Validation of High-Sensitivity Troponin I in a 2-Hour Diagnostic Strategy to Assess 30-Day Outcomes in Emergency Department Patients With Possible Acute Coronary Syndrome
Cullen, Louise, Mueller, Christian, Parsonage, William A., Wildi, Karin, Greenslade, Jaimi H., Twerenbold, Raphael, Aldous, Sally, Meller, Bernadette, Tate, Jillian R., Reichlin, Tobias, Hammett, Christopher J., Zellweger, Christa, Ungerer, Jacobus P. J., Gimenez, Maria Rubini, Troughton, Richard, Murray, Karsten, Brown, Anthony F. T., Mueller, Mira, George, Peter, Mosimann, Tamina, Flaws, Dylan F., Reiter, Miriam, Lamanna, Arvin, Haaf, Philip, Pemberton, Christopher J., Richards, A. Mark, Chu, Kevin, Reid, Christopher M., Peacock, William Frank ... Than, Martin (2013). Validation of High-Sensitivity Troponin I in a 2-Hour Diagnostic Strategy to Assess 30-Day Outcomes in Emergency Department Patients With Possible Acute Coronary Syndrome. Journal of the American College of Cardiology, 62 (14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078
2013
Journal Article
The HEART score for the assessment of patients with chest pain in the emergency department: A multinational validation study
Six, A.J., Cullen, L., Backus, B.E., Greenslade, J., Parsonage, W., Aldous, S., Doevendans, P.A. and Than, M. (2013). The HEART score for the assessment of patients with chest pain in the emergency department: A multinational validation study. Critical Pathways in Cardiology, 12 (3), 121-126. doi: 10.1097/HPC.0b013e31828b327e
2013
Conference Publication
Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation
Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., Ungerer, J., Richards, M., Pemberton, C. J. and Than, M. (2013). Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation. Congress of the European-Society-of-Cardiology (ESC), Amsterdam Netherlands, Aug 31-Sep 04, 2013. OXFORD: OXFORD UNIV PRESS.
2013
Journal Article
Introduction of an accelerated diagnostic protocol in the assessment of emergency department patients with possible acute coronary syndrome: The Nambour Short Low-Intermediate Chest pain project
George, Terry, Ashover, Sarah, Cullen, Louise, Larsen, Peter, Gibson, Jason, Bilesky, Jennifer, Coverdale, Steven and Parsonage, William (2013). Introduction of an accelerated diagnostic protocol in the assessment of emergency department patients with possible acute coronary syndrome: The Nambour Short Low-Intermediate Chest pain project. Emergency Medicine Australasia, 25 (4), 340-344. doi: 10.1111/1742-6723.12091
2013
Conference Publication
Use of sex-specific cut-offs with highly sensitive troponin I assay values for the diagnosis of acute myocardial infarction in emergency patients with chest pain
Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., Ungerer, J., Richards, M., Pemberton, C. J. and Than, M. (2013). Use of sex-specific cut-offs with highly sensitive troponin I assay values for the diagnosis of acute myocardial infarction in emergency patients with chest pain. Congress of the European-Society-of-Cardiology (ESC), Amsterdam Netherlands, Aug 31-Sep 04, 2013. OXFORD: OXFORD UNIV PRESS.
2013
Journal Article
The approach to patients with possible cardiac chest pain
Parsonage, W.A., Cullen, L. and Younger, J.F. (2013). The approach to patients with possible cardiac chest pain. Medical Journal of Australia, 199 (1), 30-34. doi: 10.5694/mja12.11171
2013
Journal Article
Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study
Greenslade, Jaimi H., Cullen, Louise, Than, Martin, Aldous, Sally, Chu, Kevin, Brown, Anthony F. T., Richards, A. Mark, Pemberton, Christopher J., George, Peter and Parsonage, William A. (2013). Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study. American Journal of Emergency Medicine, 31 (7), 1103-1107. doi: 10.1016/j.ajem.2013.04.016
Funding
Current funding
Supervision
Availability
- Professor Louise Cullen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Automated data extraction of electronic health records using natural language processing for a statewide chest pain clinical data registry: The HER DECoDeR study
Principal Advisor
-
Doctor Philosophy
Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study
Principal Advisor
Completed supervision
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2017
Doctor Philosophy
Decision Aid Derivation Methods for the Acute Coronary Syndrome Pathway
Principal Advisor
-
2024
Doctor Philosophy
Atrial Fibrillation in Critical Care
Associate Advisor
Other advisors: Associate Professor Robert Boots
Media
Enquiries
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