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Professor Louise Cullen
Professor

Louise Cullen

Email: 

Overview

Background

Louise Cullen is a Pre-Eminent Staff Specialist in Emergency Medicine, a clinical trialist and outcomes researcher in acute diseases. She is enthusiastically involved in the translation of research by clinical redesign and innovation.

As an accomplished acute disease researcher, Prof Cullen has focused on the diagnosis and management of patients presenting with possible Acute Coronary Syndromes (ACS) in the Emergency Department (ED). She has been engaged in many international collaborations (including ASPECT and ADAPT studies) She has authored over 100 publications in peer-reviewed journals including The Lancet, focussed on strategies to improve efficiency, whilst maintaining safety for patients with possible ACS, syncope, heart failure, shortness of breath and atrial fibrillation.

More recently Prof Cullen has focussed on Health Services research and investigating methods to use medications and other resources in the ED wisely. She led the CREDIT trail, aimed at reducing unnecessary peripheral intravenous cannulation in the ED.

Professor Cullen’s mantra is that “you do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.

Pre-Eminent Staff Specialist, Department of Emergency Medicine

Prof, Queensland University of Technology

A/Prof, University of Queensland

Royal Brisbane and Women’s Hospital

Brisbane, Queensland 4029, AUSTRALIA.

Tel: (+ 61 7) 3636 7901. Fax: (+ 61 7) 3636 1643.

Email: louise.cullen@health.qld.gov.au

Twitter: @louiseacullen

Qualifications: MBBS (Hon) FACEM PhD

Availability

Professor Louise Cullen is:
Available for supervision

Research impacts

Prof Cullen has been extensively involved translation of research findings into changed clinical practice. She is currently the Clinical Lead in the Accelerated Chest pain Risk Evaluation project (ACRE 2012-8), implementing changed practice models of care across Queensland Health for ED patients based on her research. This change has translated into significant improvements in ED efficiency while maintaining patient safety. She was awarded the Metro North Chief Executive Award for Research in 2018, QH Metro North Research Excellence Award: Integrated Care and Health Services Research in 2016, the Australian Society for Medical Research: Clinical Research winner in 2016 and Most Outstanding Redesign Practitioner in 2013.

Works

Search Professor Louise Cullen’s works on UQ eSpace

268 works between 2004 and 2025

221 - 240 of 268 works

2014

Journal Article

Limited utility of exercise stress testing in the evaluation of suspected acute coronary syndrome in patients aged less than 40 years with intermediate risk features

Scott, Adam C., Bilesky, Jennifer, Lamanna, Arvin, Cullen, Louise, Brown, Anthony F. T., Denaro, Charles and Parsonage, William (2014). Limited utility of exercise stress testing in the evaluation of suspected acute coronary syndrome in patients aged less than 40 years with intermediate risk features. EMA - Emergency Medicine Australasia, 26 (2), 170-176. doi: 10.1111/1742-6723.12222

Limited utility of exercise stress testing in the evaluation of suspected acute coronary syndrome in patients aged less than 40 years with intermediate risk features

2014

Journal Article

In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days

Cullen, L. and Carpenter, Christopher R. (2014). In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days. Annals of Internal Medicine, 160 (6), JC13. doi: 10.7326/0003-4819-160-6-201403180-02013

In suspected ACS, a diagnostic protocol using hs-TnI identified patients at low cardiac risk at 30 days

2014

Journal Article

Implementation of a chest pain management service improves patient care and reduces length of stay

Scott, Adam C., O'Dwyer, Kristina M., Cullen, Louise, Brown, Anthony, Denaro, Charles and Parsonage, William (2014). Implementation of a chest pain management service improves patient care and reduces length of stay. Critical Pathways in Cardiology, 13 (1), 9-13. doi: 10.1097/01.hpc.0000441082.64971.54

Implementation of a chest pain management service improves patient care and reduces length of stay

2014

Journal Article

Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol

Than, Martin, Flaws, Dylan, Sanders, Sharon, Doust, Jenny, Glasziou, Paul, Kline, Jeffery, Aldous, Sally, Troughton, Richard, Reid, Christopher, Parsonage, William A., Frampton, Christopher, Greenslade, Jaimi H., Deely, Joanne M., Hess, Erik, Sadiq, Amr Bin, Singleton, Rose, Shopland, Rosie, Vercoe, Laura, Woolhouse-Williams, Morgana, Ardagh, Michael, Bossuyt, Patrick, Bannister, Laura and Cullen, Louise (2014). Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol. EMA - Emergency Medicine Australasia, 26 (1), 34-44. doi: 10.1111/1742-6723.12164

Development and validation of the Emergency Department assessment of chest pain score and 2h accelerated diagnostic protocol

2014

Journal Article

Effect of recalibration of the hs-TnT assay on diagnostic performance

Parsonage, William A., Tate, Jillian R., Greenslade, Jaimi H., Hammett, Christopher J., Ungerer, Jacobus P. J., Pretorius, Carel J., Brown, Anthony F. T. and Cullen, Louise (2014). Effect of recalibration of the hs-TnT assay on diagnostic performance. Clinical Chemistry and Laboratory Medicine, 52 (2), E25-E27. doi: 10.1515/cclm-2013-0490

Effect of recalibration of the hs-TnT assay on diagnostic performance

2014

Journal Article

Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain

Parsonage, William A, Greenslade, Jaimi H, Hammett, Christopher J, Lamanna, Arvin, Tate, Jillian R, Ungerer, Jacobus P, Chu, Kevin, Than, Martin, Brown, Anthony F T and Cullen, Louise (2014). Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain. Medical Journal of Australia, 200 (3), 161-165. doi: 10.5694/mja13.10466

Validation of an accelerated high‐sensitivity troponin T assay protocol in an Australian cohort with chest pain

2014

Journal Article

The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study

Cullen, L., Greenslade, J.H., Than, M., Brown, A.F.T., Hammett, C.J., Lamanna, A., Flaws, D.F., Chu, K., Fowles, L.F. and Parsonage, W.A. (2014). The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study. American Journal of Emergency Medicine, 32 (2), 129-134. doi: 10.1016/j.ajem.2013.10.021

The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study

2014

Journal Article

Performance of Risk Stratification for Acute Coronary Syndrome with Two-hour Sensitive Troponin Assay Results

Cullen, L., Greenslade, J., Than, M., Tate, J., Ungerer, J. P. J., Pretorius, C., Hammett, C. J., Lamanna, A., Chu, K., Brown, A. F. T. and Parsonage, W. A. (2014). Performance of Risk Stratification for Acute Coronary Syndrome with Two-hour Sensitive Troponin Assay Results. Heart Lung and Circulation, 23 (5), 428-434. doi: 10.1016/j.hlc.2013.11.003

Performance of Risk Stratification for Acute Coronary Syndrome with Two-hour Sensitive Troponin Assay Results

2014

Journal Article

Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain

Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., Hammett, C. J., Richards, A. M., Ungerer, J. P. J., Troughton, R. W., Brown, A. F. T., Flaws, D. F., Lamanna, A., Pemberton, C. J., Florkowski, C., Pretorius, C. J., Chu, K. and Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47 (6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019

Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain

2014

Journal Article

A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial

Than, Martin, Aldous, Sally, Lord, Sarah Jane, Goodacre, Stephen, Frampton, Christopher M. A., Troughton, Richard, George, Peter, Florkowski, Christopher Michael, Ardagh, Michael, Smyth, David, Jardine, David Lewis, Peacock, William Frank, Young, Joanna, Hamilton, Gregory, Deely, Joanne M., Cullen, Louise and Richards, A. Mark (2014). A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial. JAMA Internal Medicine, 174 (1), 51-58. doi: 10.1001/jamainternmed.2013.11362

A 2-Hour Diagnostic Protocol for Possible Cardiac Chest Pain in the Emergency Department : A Randomized Clinical Trial

2013

Journal Article

Acute assessment of possible cardiac chest pain

Cullen, L. and Parsonage, W. (2013). Acute assessment of possible cardiac chest pain. Medicine Today, 14 (12), 41-44.

Acute assessment of possible cardiac chest pain

2013

Journal Article

Troponin testing: End of an era?

Peacock, W. Frank, Cullen, Louise, Mueller, Christian and Than, Martin (2013). Troponin testing: End of an era?. Clinical Biochemistry, 46 (16-17), 1627-1628. doi: 10.1016/j.clinbiochem.2013.10.008

Troponin testing: End of an era?

2013

Journal Article

Delta troponin for the early diagnosis of AMI in emergency patients with chest pain

Cullen, L., Parsonage, W. A., Greenslade, J., Lamanna, A., Hammett, C. J., Than, M., Tate, J., Kalinowski, L., Ungerer, J. P. J., Chu, K. and Brown, A. (2013). Delta troponin for the early diagnosis of AMI in emergency patients with chest pain. International Journal of Cardiology, 168 (3), 2602-2608. doi: 10.1016/j.ijcard.2013.03.044

Delta troponin for the early diagnosis of AMI in emergency patients with chest pain

2013

Journal Article

Validation of High-Sensitivity Troponin I in a 2-Hour Diagnostic Strategy to Assess 30-Day Outcomes in Emergency Department Patients With Possible Acute Coronary Syndrome

Cullen, Louise, Mueller, Christian, Parsonage, William A., Wildi, Karin, Greenslade, Jaimi H., Twerenbold, Raphael, Aldous, Sally, Meller, Bernadette, Tate, Jillian R., Reichlin, Tobias, Hammett, Christopher J., Zellweger, Christa, Ungerer, Jacobus P. J., Gimenez, Maria Rubini, Troughton, Richard, Murray, Karsten, Brown, Anthony F. T., Mueller, Mira, George, Peter, Mosimann, Tamina, Flaws, Dylan F., Reiter, Miriam, Lamanna, Arvin, Haaf, Philip, Pemberton, Christopher J., Richards, A. Mark, Chu, Kevin, Reid, Christopher M., Peacock, William Frank ... Than, Martin (2013). Validation of High-Sensitivity Troponin I in a 2-Hour Diagnostic Strategy to Assess 30-Day Outcomes in Emergency Department Patients With Possible Acute Coronary Syndrome. Journal of the American College of Cardiology, 62 (14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078

Validation of High-Sensitivity Troponin I in a 2-Hour Diagnostic Strategy to Assess 30-Day Outcomes in Emergency Department Patients With Possible Acute Coronary Syndrome

2013

Journal Article

The HEART score for the assessment of patients with chest pain in the emergency department: A multinational validation study

Six, A.J., Cullen, L., Backus, B.E., Greenslade, J., Parsonage, W., Aldous, S., Doevendans, P.A. and Than, M. (2013). The HEART score for the assessment of patients with chest pain in the emergency department: A multinational validation study. Critical Pathways in Cardiology, 12 (3), 121-126. doi: 10.1097/HPC.0b013e31828b327e

The HEART score for the assessment of patients with chest pain in the emergency department: A multinational validation study

2013

Conference Publication

Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation

Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., Ungerer, J., Richards, M., Pemberton, C. J. and Than, M. (2013). Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation. Congress of the European-Society-of-Cardiology (ESC), Amsterdam Netherlands, Aug 31-Sep 04, 2013. OXFORD: OXFORD UNIV PRESS.

Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation

2013

Journal Article

Introduction of an accelerated diagnostic protocol in the assessment of emergency department patients with possible acute coronary syndrome: The Nambour Short Low-Intermediate Chest pain project

George, Terry, Ashover, Sarah, Cullen, Louise, Larsen, Peter, Gibson, Jason, Bilesky, Jennifer, Coverdale, Steven and Parsonage, William (2013). Introduction of an accelerated diagnostic protocol in the assessment of emergency department patients with possible acute coronary syndrome: The Nambour Short Low-Intermediate Chest pain project. Emergency Medicine Australasia, 25 (4), 340-344. doi: 10.1111/1742-6723.12091

Introduction of an accelerated diagnostic protocol in the assessment of emergency department patients with possible acute coronary syndrome: The Nambour Short Low-Intermediate Chest pain project

2013

Conference Publication

Use of sex-specific cut-offs with highly sensitive troponin I assay values for the diagnosis of acute myocardial infarction in emergency patients with chest pain

Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., Ungerer, J., Richards, M., Pemberton, C. J. and Than, M. (2013). Use of sex-specific cut-offs with highly sensitive troponin I assay values for the diagnosis of acute myocardial infarction in emergency patients with chest pain. Congress of the European-Society-of-Cardiology (ESC), Amsterdam Netherlands, Aug 31-Sep 04, 2013. OXFORD: OXFORD UNIV PRESS.

Use of sex-specific cut-offs with highly sensitive troponin I assay values for the diagnosis of acute myocardial infarction in emergency patients with chest pain

2013

Journal Article

The approach to patients with possible cardiac chest pain

Parsonage, W.A., Cullen, L. and Younger, J.F. (2013). The approach to patients with possible cardiac chest pain. Medical Journal of Australia, 199 (1), 30-34. doi: 10.5694/mja12.11171

The approach to patients with possible cardiac chest pain

2013

Journal Article

Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study

Greenslade, Jaimi H., Cullen, Louise, Than, Martin, Aldous, Sally, Chu, Kevin, Brown, Anthony F. T., Richards, A. Mark, Pemberton, Christopher J., George, Peter and Parsonage, William A. (2013). Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study. American Journal of Emergency Medicine, 31 (7), 1103-1107. doi: 10.1016/j.ajem.2013.04.016

Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study

Funding

Current funding

  • 2022 - 2025
    NUDG-ED: Trial of behavioural 'nudging' interventions to reduce unnecessary care for low back pain in the Emergency Department (NHMRC CTCS Externally administered by USyd)
    University of Sydney
    Open grant
  • 2021 - 2025
    Difficult peripheral intravenous catheter insertion: Australian considerations for sustainable implementation of ultrasound guided procedures
    NHMRC Partnership Projects
    Open grant

Past funding

  • 2021 - 2024
    Development of a first-in-class therapeutic for protecting the ischemic heart
    NHMRC Development Grant
    Open grant
  • 2017 - 2020
    Improving Rapid Decision-Making in the Face of Uncertainty: A randomised trial of a 1-hour troponin protocol in suspected acute coronary syndromes (NHMRC Project Grant led by Flinders University)
    Flinders University
    Open grant
  • 2017 - 2020
    Is highly-sensitive troponin testing advancing clinical practice, improving outcomes and cost-effective in the investigation and manageme..(NHMRC Project Grant led by University of Western Australia)
    University of Western Australia
    Open grant
  • 2015 - 2020
    Centre of Research Excellence in Cardiovascular Outcomes Improvement (NHMRC CRE administered by Curtin University)
    Curtin University of Technology
    Open grant
  • 2011 - 2016
    Study 3: A decision analytic cost-effectiveness model for chest pain pathways
    QEMRF Project Grants Scheme
    Open grant
  • 2011 - 2016
    Rapid assessment of cardiac chest pain: the Australian and New Zealand Assessment of chest Pain Rule (ANZAP rule): A prospective validation study
    QEMRF Program Grants Scheme
    Open grant
  • 2010 - 2012
    Controlling Laboratory Test Ordering in Emergency Departments
    QEMRF Emergency Medicine Staff Specialist Research Grants Scheme
    Open grant
  • 2010 - 2011
    Factors influencing triage allocation for patients with acute myocardial infarction
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2009 - 2010
    Accelerated pathway in the assessment of suspected acute coronary syndrome in the Emergency Department
    QEMRF Emergency Medicine Staff Specialist Research Grants Scheme
    Open grant

Supervision

Availability

Professor Louise Cullen is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Automated data extraction of electronic health records using natural language processing for a statewide chest pain clinical data registry: The HER DECoDeR study

    Principal Advisor

  • Doctor Philosophy

    Data Extraction, Cohort Selection and Risk Stratification from Electronic Health Records of Emergency Department Suspected Acute Coronary Syndrome Patients: The Chest Pain DECoDeR Study

    Principal Advisor

Completed supervision

Media

Enquiries

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