
Overview
Background
Associate Professor Jakob Begun is the IBD Group leader in the Immunity, Infection, and Inflammation Program at Mater Research University of Queensalnd, and has a basic and translational laboratory at the Translational Research Institute in Brisbane. He is an Associate Professor in the University of Queensland Faculty of Medicine. After completing his Bachelor of Science at Cornell University Jakob attended Cambridge University where he completed an MPhil in Biochemistry. He then moved on to Harvard Medical School where he completed his MD and PhD in genetics studying the host pathogen interaction using C. elegans as a model system. He completed his clinical training in internal medicine at Brigham and Women’s hospital and went on to complete general gastroenterology training at Massachusetts General Hospital (MGH) as well as advanced training in the treatment of Inflammatory Bowel Disease (IBD).
Dr Begun first joined Mater Research - University of Queensland in 2014, and at the same time received a clinical staff appointment in Gastroenterology at the Mater Hospital Brisbane. His clinical activities are focussed on the treatment and mangement of patients with IBD. He is the director of the IBD unit at the Mater Hospital Brisbane and at the Mater Young Adult Health Centre Brisbane .In January 2015 he was awarded the University of Queensland Reginald Ferguson Fellowship in Gastroenterology to support his research activity. He leads a basic and translational laboratory at the Translational Research Institute investigating the interaction between the innate immune system and the gut microbiome, as well as genetic contributions to disease. He also performs clinical research examining predictors of response to therapy, minimising barriers of care for adolescents and young adults with IBD, improving outcomes in pregnancy and IBD, and the use of intestinal ultrasound in IBD. He is the chair of the Gastroenterology Society of Australia-IBD Faculty and of the president of the Gastroenterology Network of Intestinal Ultrasound (GENIUS).
Availability
- Associate Professor Jakob Begun is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Biology, Cornell University
- Doctoral Diploma of Medicine, Harvard University
- Doctor of Philosophy of Genetics, Harvard University
- Member, Gastroenterological Society of Australia, Gastroenterological Society of Australia
- Fellow, Royal Australasian College of Physicians, Royal Australasian College of Physicians
Research impacts
Inflammatory bowel disease(IBD) is a complex disease with genetic and environmental triggers. The microbiota is one of the biggest environmental contributors and interest in its impact on human health and disease is a growing. Studies in IBD have led the way in identifying disease associated microbial signals, but has not yet led to any new therapies.
As a clinician-scientist I am driven by my patients’ needs to address all aspects of their disease: including genetic and environmental risk factors, disease monitoring, and developing novel therapeutics. My tranlsational research program contributes to KNOWLEDGE IMPACT by discovering the function of IBD-susceptibility genes and anti-inflammatory bio-actives produced by the gut microbiota. My clinical research program advances HEALTH IMPACT by optimizing patient monitoring through evidence-based use of biochemical tests and imaging technology.
-Knowledge Impact. My research into the interaction between IBD susceptibility genes and bacterial handling has been highly cited, and led to an NHMRC collaborative project grant.
-Health Impact. My research program into advances in patient monitoring has led to the application for faecal calprotectin testing to be covered by the Medicare Benefit Scheme – which will have a direct impact on patient monitoring in the clinic. Additionally my monitoring research into the use of intestinal ultrasound has led to the formation of the Gastroenterology Network of Intestinal Ultrasound and the increase in ultrasound use in IBD patients in Australia.
Works
Search Professor Jakob Begun’s works on UQ eSpace
2016
Conference Publication
Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis
Oancea, I., Das, I., de Carcer, D. Aguirre, Movva, R., Schreiber, V., Yang, Y., Proctor, M., Wang, R., Sheng, Y., Lobb, M., Cuiv, P. O., Duley, J. A., Begun, J. and Florin, T. H. J. (2016). Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis. 11th Congress of ECCO - European Crohn’s and Colitis Organisation, Amsterdam, Netherlands, 16-19 March 2016. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjw019.177
2016
Journal Article
Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease
O Cuiv, Paraic, Begun, Jake, Keely, Simon, Lewindon, Peter and Morrison, Mark (2016). Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease. Food and Function, 7 (4), 1741-1751. doi: 10.1039/C5FO01196E
2016
Conference Publication
Clinical presentation of IBD diagnosed after age 60
Shukla, D., Begun, J. and Florin, T. (2016). Clinical presentation of IBD diagnosed after age 60. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522
2016
Conference Publication
Severe bacterial infections with vedolizumab therapy: 3 illustrative cases
Szetoo, S. W., Hume, G., De Cruz, P. and Begun, J. (2016). Severe bacterial infections with vedolizumab therapy: 3 illustrative cases. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522
2016
Conference Publication
An inhibitor of Wnt protein production improves host control of Listeria monocytogenes
Tran, T. T., Andrades, M. G., Nguyen, T. T. K., Wyer, O., Kling, J. C., Begun, J. and Blumenthal, A. (2016). An inhibitor of Wnt protein production improves host control of Listeria monocytogenes. ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200
2016
Conference Publication
The burden of illness among adolescents and young adults with inflammatory bowel disease
Duffy, K. and Begun, J. (2016). The burden of illness among adolescents and young adults with inflammatory bowel disease. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522
2016
Conference Publication
High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22
Gulhane, M., Lourie, R., Tong, H., Kang, A., Schreiber, V., Magor, G., Denman, S., Begun, J., Florin, T., Perkins, A., O Cuiv, P., Mcguckin, M. and Hasnain, S. Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
2016
Conference Publication
Alleviation of Acute Drug-Induced Liver Injury Following Acetaminophen Overdose by Therapeutic Blockade of E-Selectin in Preclinical Mouse Model
Oancea, Iulia, Barbier, Valerie, Chee, David, Lourie, Rohan, Movva, Ramya, Proctor, Martina A., Begun, Jakob, Magnani, John L., Florin, Timothy H. and Winkler, Ingrid (2016). Alleviation of Acute Drug-Induced Liver Injury Following Acetaminophen Overdose by Therapeutic Blockade of E-Selectin in Preclinical Mouse Model. 57th Annual Meeting and Residents Fellow Conference of the Society for Surgery of the Alimentary Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), San Diego, CA United States, 21-24 May 2016. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(16)33483-7
2016
Conference Publication
The incidence of 30-day adverse events after colonoscopy in an IBD population
An, Y. K., Wong, J., You, I. S., Mortimore, M., Hewett, D. G., Appleyard, M. N. and Begun, J. (2016). The incidence of 30-day adverse events after colonoscopy in an IBD population. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.13522
2016
Conference Publication
Thiopurine Mediated Chemoprevention of Colitis-Associated Colorectal Dysplasia
Jose, Beulah, Lourie, Rohan, Schreiber, Veronika, Florin, Timothy H., Oancea, Iulia and Begun, Jakob (2016). Thiopurine Mediated Chemoprevention of Colitis-Associated Colorectal Dysplasia. 57th Annual Meeting and Residents Fellow Conference of the Society for Surgery of the Alimentary Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American Gastroenterological Association (AGA57th Annual Meeting and Residents Fellow Conference of the Society for Surgery of the Alimentary Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), San Diego, CA United States, 21-24 May 2016. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(16)33291-7
2015
Conference Publication
Malnutrition and quality of life among inflammatory bowel disease outpatients
Pulley, J., Todd, A., Flatley, C. and Begun, J. (2015). Malnutrition and quality of life among inflammatory bowel disease outpatients. Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015, Brisbane, QLD Australia, 28 September‐2 October 2015. Richmond, VIC Australia: John Wiley and Sons. doi: 10.1111/jgh.13096
2015
Journal Article
Integrated genomics of crohn's disease risk variant identifies a role for CLEC12A in antibacterial autophagy
Begun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A. B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca and Xavier, Ramnik J. (2015). Integrated genomics of crohn's disease risk variant identifies a role for CLEC12A in antibacterial autophagy. Cell Reports, 11 (12), 1905-1918. doi: 10.1016/j.celrep.2015.05.045
2015
Journal Article
Enteroliths in a Kock continent ileostomy: case report and review of the literature
Moattar, Hadi, Begun, Jakob and Florin, Timothy (2015). Enteroliths in a Kock continent ileostomy: case report and review of the literature. Endoscopy, 47 (S 01), E200-E201. doi: 10.1055/s-0034-1391302
2014
Journal Article
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
de Luca, Antonella, Smeekens, Sanne P., Casagrande, Andrea, Iannitti, Rossana, Conway, Kara L., Gresnigt, Mark. S., Begun, Jakob, Plantinga, Theo S., Joosten, Leo A. B., van der Meer, Jos W. M., Chamilos, Georgios, Netea, Mihai G., Xavier, Ramnik J., Dinarello, Charles A., Romani, Luigina and van de Veerdonk, Frank L. (2014). IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proceedings of the National Academy of Sciences of the United States of America, 111 (9), 3526-3531. doi: 10.1073/pnas.1322831111
2013
Journal Article
Autophagy at the crossroads of metabolism and cellular defense
Begun, Jakob and Xavier, Ramnik J. (2013). Autophagy at the crossroads of metabolism and cellular defense. Current Opinion in Gastroenterology, 29 (6), 588-596. doi: 10.1097/MOG.0b013e328365d34d
2013
Journal Article
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
Beaudoin, Melissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A., Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Torkvist, Leif, Goel, Gautam, Lagace, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R., Bresso, Francesca, Cho, Judy H., Duerr, Richard H., Halfvarson, Jonas, McGovern, Dermot P. B., Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L., Sharma, Yashoda, Silverberg, Mark S., Weersma, Rinse K., D'Amato, Mauro, Vermeire, Severine ... Rioux, John D. (2013). Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genetics, 9 (9) e1003723, e1003723.1-e1003723.11. doi: 10.1371/journal.pgen.1003723
2012
Journal Article
The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium
Huett, Alan, Heath, Robert J., Begun, Jakob, Sassi, Slim O., Baxt, Leigh A., Vyas, Jatin M., Goldberg, Marcia B. and Xavier, Ramnik J. (2012). The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium. Cell Host and Microbe, 12 (6), 778-790. doi: 10.1016/j.chom.2012.10.019
2012
Journal Article
ATG16L1 T300A dependent differential gene expression identifies genes required for anti-bacterial autophagy : P-227 YI
Begun, Jakob, Ng, Aylwin and Xavier, Ramnik (2012). ATG16L1 T300A dependent differential gene expression identifies genes required for anti-bacterial autophagy : P-227 YI. Inflammatory Bowel Diseases, 18, S103. doi: 10.1097/00054725-201212001-00260
2008
Journal Article
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans
Miyata, Sachiko, Begun, Jakob, Troemel, Emily R. and Ausubel, Frederick M. (2008). DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics, 178 (2), 903-918. doi: 10.1534/genetics.107.083923
2007
Journal Article
Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses
Begun, Jakob, Gaiani, Jessica M., Rohde, Holger, Mack, Dietrich, Calderwood, Stephen B., Ausubel, Frederick M. and Sifri, Costi D. (2007). Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses. PLoS Pathogens, 3 (4), 526-540. doi: 10.1371/journal.ppat.0030057
Funding
Current funding
Supervision
Availability
- Associate Professor Jakob Begun is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Novel and real-world use of Janus Kinase inhibitors for the management of Inflammatory Bowel Disease
Principal Advisor
-
Doctor Philosophy
Microbial Regulation of Host Inflammatory Pathways in Inflammatory Bowel Disease
Principal Advisor
Other advisors: Professor Mark Morrison
-
Doctor Philosophy
Study of TOfacitinib for the treatment of chronic Pouchitis
Principal Advisor
Other advisors: Professor Gerald Holtmann
-
Doctor Philosophy
Study of TOfacitinib for the treatment of chronic Pouchitis
Principal Advisor
Other advisors: Professor Gerald Holtmann
-
Doctor Philosophy
Reducing post-operative Crohn's disease recurrence
Principal Advisor
Other advisors: Professor David Clark, Dr Rabina Giri
-
Doctor Philosophy
Defining the Role of the Mucosa-Associated Microbiota in Digestive Health and Disease Using Novel ex-vivo Combinations of Microbe Culture with Metagenomics
Associate Advisor
Other advisors: Professor Mark Morrison
-
Doctor Philosophy
Investigating immunomodulatory function of gut microbiome and FXR pathway in IBD
Associate Advisor
Other advisors: Dr Rabina Giri
-
Doctor Philosophy
Bacteria x Archaea Interactions in Crohn's disease
Associate Advisor
Other advisors: Professor Mark Morrison
-
Doctor Philosophy
Medicinal chemistry of new Nature-inspired treatments for Inflammatory Bowel Disease (IBD)
Associate Advisor
Other advisors: Dr Angela Salim, Dr Zeinab Khalil, Professor Rob Capon
-
Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Dr Md Moniruzzaman, Professor Amirali Popat
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Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Dr Md Moniruzzaman, Professor Amirali Popat, Dr Rabina Giri
Completed supervision
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2024
Doctor Philosophy
Australia Ustekinumab Real-world Observational Research (AURORA)
Principal Advisor
-
2024
Doctor Philosophy
Drugs from Bugs: Harnessing the host-microbe interactions that modulate the immune responses in Inflammatory Bowel Disease
Principal Advisor
Other advisors: Dr Angela Salim, Professor Mark Morrison
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2017
Master Philosophy
Delivery of Interleukin-22 using Mesoporous Silica Nanoparticles for the Treatment of Murine Colitis
Principal Advisor
Other advisors: Professor Amirali Popat
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2024
Doctor Philosophy
Defining the Role of the Mucosa-Associated Microbiota in Digestive Health and Disease Using Novel ex-vivo Combinations of Microbe Culture with Metagenomics
Associate Advisor
Other advisors: Professor Mark Morrison
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2023
Doctor Philosophy
Structure-function relationships of the mucosa-associated microbiota in Crohn's disease
Associate Advisor
Other advisors: Professor Gerald Holtmann, Professor Mark Morrison
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2023
Doctor Philosophy
Mindfulness Based Cognitive Therapy for Youth with Inflammatory Bowel Disease and Depression: Understanding Mindfulness in the Context of Depression and Inflammation
Associate Advisor
Other advisors: Professor Steve Kisely
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2022
Master Philosophy
Targeting Intestinal Epithelial Cell-Derived Interleukin-23 (p19) To Improve Intestinal Barrier Integrity in Inflammatory Bowel Disease
Associate Advisor
Other advisors: Dr Ran Wang
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2021
Doctor Philosophy
Exploring the gut-liver axis and immunity in paracetamol-induced toxicity
Associate Advisor
Other advisors: Dr Ran Wang
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2019
Doctor Philosophy
Investigation of Wnt pathway inhibition on host cell control of Listeria monocytogenes infection
Associate Advisor
Other advisors: Professor Antje Blumenthal
Media
Enquiries
Contact Associate Professor Jakob Begun directly for media enquiries about:
- adolescent
- autophagy
- Crohn's disease
- Inflammatory Bowel Disease
- ulcerative colitis
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