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2020

Journal Article

Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system

Lunke, Sebastian, Eggers, Stefanie, Wilson, Meredith, Patel, Chirag, Barnett, Christopher P., Pinner, Jason, Sandaradura, Sarah A., Buckley, Michael F., Krzesinski, Emma I., De Silva, Michelle G., Brett, Gemma R., Boggs, Kirsten, Mowat, David, Kirk, Edwin P., Adès, Lesley C., Akesson, Lauren S., Amor, David J., Ayres, Samantha, Baxendale, Anne, Borrie, Sarah, Bray, Alessandra, Brown, Natasha J., Chan, Cheng Yee, Chong, Belinda, Cliffe, Corrina, Delatycki, Martin B., Edwards, Matthew, Elakis, George, Fahey, Michael C. ... Stark, Zornitza (2020). Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system. JAMA - Journal of the American Medical Association, 323 (24), 2503-2511. doi: 10.1001/jama.2020.7671

Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system

2020

Journal Article

Editorial: The immunology of sepsis—understanding host susceptibility, pathogenesis of disease, and avenues for future treatment

Schlapbach, Luregn J., Trück, Johannes and Roger, Thierry (2020). Editorial: The immunology of sepsis—understanding host susceptibility, pathogenesis of disease, and avenues for future treatment. Frontiers in Immunology, 11 1263, 1263. doi: 10.3389/fimmu.2020.01263

Editorial: The immunology of sepsis—understanding host susceptibility, pathogenesis of disease, and avenues for future treatment

2020

Journal Article

Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Menon, Kusum, Schlapbach, Luregn J., Akech, Samuel, Argent, Andrew, Chiotos, Kathleen, Chisti, Mohammod Jobayer, Hamid, Jemila, Ishimine, Paul, Kissoon, Niranjan, Lodha, Rakesh, Oliveira, Cláudio Flauzino, Peters, Mark, Tissieres, Pierre, Watson, R. Scott, Wiens, Matthew O., Wynn, James L., Sorce, Lauren R. and for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine (2020). Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce. Critical Care Explorations, 2 (6), e0123. doi: 10.1097/CCE.0000000000000123

Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

2020

Journal Article

Enteral hydration in high-flow therapy for infants with bronchiolitis: secondary analysis of a randomised trial

Babl, Franz E., Franklin, Donna, Schlapbach, Luregn J., Oakley, Ed, Dalziel, Stuart, Whitty, Jennifer A., Neutze, Jocelyn, Furyk, Jeremy, Craig, Simon, Fraser, John F., Jones, Mark and Schibler, Andreas (2020). Enteral hydration in high-flow therapy for infants with bronchiolitis: secondary analysis of a randomised trial. Journal of Paediatrics and Child Health, 56 (6) jpc.14799, 950-955. doi: 10.1111/jpc.14799

Enteral hydration in high-flow therapy for infants with bronchiolitis: secondary analysis of a randomised trial

2020

Journal Article

A rare mutation in SPLUNC1 affects bacterial adherence and invasion in meningococcal disease

Mashbat, Bayarchimeg, Bellos, Evangelos, Hodeib, Stephanie, Bidmos, Fadil, Thwaites, Ryan S., Lu, Yaxuan, Wright, Victoria J., Herberg, Jethro A., Klobassa, Daniela S., Zenz, Werner, Hansel, Trevor T., Nadel, Simon, Langford, Paul R., Schlapbach, Luregn J., Li, Ming-Shi, Redinbo, Matthew R., Di, Y Peter, Levin, Michael and Sancho-Shimizu, Vanessa (2020). A rare mutation in SPLUNC1 affects bacterial adherence and invasion in meningococcal disease. Clinical Infectious Diseases, 70 (10), 2045-2053. doi: 10.1093/cid/ciz600

A rare mutation in SPLUNC1 affects bacterial adherence and invasion in meningococcal disease

2020

Journal Article

Neonatal sepsis: need for consensus definition, collaboration and core outcomes

Molloy, Eleanor J., Wynn, James L., Bliss, Joseph, Koenig, Joyce M., Keij, Fleur M., McGovern, Matt, Kuester, Helmut, Turner, Mark A., Giannoni, Eric, Mazela, Jan, Degtyaeva, Marina, Strunk, Tobias, Simons, Sinno H. P., Janota, Jan, Plotz, Franz B., van den Hoogen, Ages, de Boode, Willem, Schlapbach, Luregn J. and Reiss, Irwin K. M. (2020). Neonatal sepsis: need for consensus definition, collaboration and core outcomes. Pediatric Research, 88 (1), 2-4. doi: 10.1038/s41390-020-0850-5

Neonatal sepsis: need for consensus definition, collaboration and core outcomes

2020

Journal Article

Whole-exome sequencing for the identification of rare variants in primary immunodeficiency genes in children with sepsis - a prospective population-based cohort study

Borghesi, Alessandro, Trück, Johannes, Asgari, Samira, Sancho-Shimizu, Vanessa, Agyeman, Philipp K. A., Bellos, Evangelos, Giannoni, Eric, Stocker, Martin, Posfay-Barbe, Klara M., Heininger, Ulrich, Bernhard-Stirnemann, Sara, Niederer-Loher, Anita, Kahlert, Christian R., Natalucci, Giancardlo, Relly, Christa, Riedel, Thomas, Kuehni, Claudia E., Thorball, Christian W., Chaturvedi, Nimisha, Martinon-Torres, Federico, Kuijpers, Taco W., Coin, Lachlan, Wright, Victoria, Herberg, Jethro, Levin, Michael, Aebi, Christoph, Berger, Christoph, Fellay, Jacques, Schlapbach, Luregn J. and EUCLIDS consortium and the Swiss Paediatric Sepsis Study (2020). Whole-exome sequencing for the identification of rare variants in primary immunodeficiency genes in children with sepsis - a prospective population-based cohort study. Clinical Infectious Diseases, 71 (10), E614-E623. doi: 10.1093/cid/ciaa290

Whole-exome sequencing for the identification of rare variants in primary immunodeficiency genes in children with sepsis - a prospective population-based cohort study

2020

Journal Article

Testing for Common Respiratory Viruses in Children Admitted to Pediatric Intensive Care: Epidemiology and Outcomes

Moynihan, Katie M., McGarvey, Tambra, Barlow, Andrew, Heney, Claire, Gibbons, Kristen, Clark, Julia E., Schlebusch, Sanmarié and Schlapbach, Luregn J. (2020). Testing for Common Respiratory Viruses in Children Admitted to Pediatric Intensive Care: Epidemiology and Outcomes. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 21 (6), 1-e341. doi: 10.1097/PCC.0000000000002302

Testing for Common Respiratory Viruses in Children Admitted to Pediatric Intensive Care: Epidemiology and Outcomes

2020

Journal Article

Nosocomial infections during extracorporeal membrane oxygenation in neonatal, pediatric, and adult patients: a comprehensive narrative review

MacLaren, Graeme, Schlapbach, Luregn J. and Aiken, Alexander M. (2020). Nosocomial infections during extracorporeal membrane oxygenation in neonatal, pediatric, and adult patients: a comprehensive narrative review. Pediatric Critical Care Medicine, 21 (3), 283-290. doi: 10.1097/PCC.0000000000002190

Nosocomial infections during extracorporeal membrane oxygenation in neonatal, pediatric, and adult patients: a comprehensive narrative review

2020

Other Outputs

Severe infections in critically ill children – from epidemiology to outcome prediction

Schlapbach Tribolet, Luregn (2020). Severe infections in critically ill children – from epidemiology to outcome prediction. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.190

Severe infections in critically ill children – from epidemiology to outcome prediction

2020

Journal Article

Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Weiss, Scott L., Peters, Mark J., Alhazzani, Waleed, Agus, Michael S D, Flori, Heidi R., Inwald, David P., Nadel, Simon, Schlapbach, Luregn J., Tasker, Robert C., Argent, Andrew C., Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D., Carroll, Christopher L., Cheifetz, Ira M., Choong, Karen, Cies, Jeffry J., Cruz, Andrea T., De Luca, Daniele, Deep, Akash, Faust, Saul N., De Oliveira, Claudio Flauzino, Hall, Mark W., Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F M, Joshi, Poonam, Karam, Oliver, Kneyber, Martin C J ... Tissieres, Pierre (2020). Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine, 46 (S1), 1-9. doi: 10.1007/s00134-019-05877-7

Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

2020

Journal Article

Executive summary: Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Weiss, Scott L., Peters, Mark J., Alhazzani, Waleed, Agus, Michael S D, Flori, Heidi R., Inwald, David P., Nadel, Simon, Schlapbach, Luregn J., Tasker, Robert C., Argent, Andrew C., Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D., Carroll, Christopher L., Cheifetz, Ira M., Choong, Karen, Cies, Jeffry J., Cruz, Andrea T., De Luca, Daniele, Deep, Akash, Faust, Saul N., De Oliveira, Claudio Flauzino, Hall, Mark W., Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F M, Joshi, Poonam, Karam, Oliver, Kneyber, Martin C J ... Tissieres, Pierre (2020). Executive summary: Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatric Critical Care Medicine, 21 (2), 186-195. doi: 10.1097/PCC.0000000000002197

Executive summary: Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

2020

Journal Article

Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Weiss, Scott L., Peters, Mark J., Alhazzani, Waleed, Agus, Michael S D, Flori, Heidi R., Inwald, David P., Nadel, Simon, Schlapbach, Luregn J., Tasker, Robert C., Argent, Andrew C., Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D., Carroll, Christopher L., Cheifetz, Ira M., Choong, Karen, Cies, Jeffry J., Cruz, Andrea T., De Luca, Daniele, Deep, Akash, Faust, Saul N., De Oliveira, Claudio Flauzino, Hall, Mark W., Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F. M., Joshi, Poonam, Karam, Oliver, Kneyber, Martin C. J. ... Tissieres, Pierre (2020). Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatric Critical Care Medicine, 21 (2), e52-e106. doi: 10.1097/PCC.0000000000002198

Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

2020

Journal Article

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

Weiss, Scott L., Peters, Mark J., Alhazzani, Waleed, Agus, Michael S. D., Flori, Heidi R., Inwald, David P., Nadel, Simon, Schlapbach, Luregn J., Tasker, Robert C., Argent, Andrew C., Brierley, Joe, Carcillo, Joseph, Carrol, Enitan D., Carroll, Christopher L., Cheifetz, Ira M., Choong, Karen, Cies, Jeffry J., Cruz, Andrea T., De Luca, Daniele, Deep, Akash, Faust, Saul N., De Oliveira, Claudio Flauzino, Hall, Mark W., Ishimine, Paul, Javouhey, Etienne, Joosten, Koen F. M., Joshi, Poonam, Karam, Oliver, Kneyber, Martin C. J. ... Tissieres, Pierre (2020). Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine, 46 (S1), 10-67. doi: 10.1007/s00134-019-05878-6

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

2020

Journal Article

Corrigendum: Sepsis: changing definitions, unchanging treatment (vol 6, 425, 2019)

Obonyo, Nchafatso Gikenyi, Schlapbach, Luregn Jan and Fraser, John Francis (2020). Corrigendum: Sepsis: changing definitions, unchanging treatment (vol 6, 425, 2019). Frontiers in Pediatrics, 7 538, 538. doi: 10.3389/fped.2019.00538

Corrigendum: Sepsis: changing definitions, unchanging treatment (vol 6, 425, 2019)

2019

Journal Article

Multicentre, randomised trial to investigate early nasal high—flow therapy in paediatric acute hypoxaemic respiratory failure: a protocol for a randomised controlled trial—a Paediatric Acute respiratory Intervention Study (PARIS 2)

Franklin, Donna, Shellshear, Deborah, Babl, Franz E., Schlapbach, Luregn J., Oakley, Ed, Borland, Meredith L., Hoeppner, Tobias, George, Shane, Craig, Simon, Neutze, Jocelyn, Williams, Amanda, Acworth, Jason, McCay, Hamish, Wallace, Alex, Mattes, Joerg, Gangathimn, Vinay, Wildman, Mark, Fraser, John F, Moloney, Susan, Gavranich, John, Waugh, John, Hobbins, Sue, Fahy, Rose, Grew, Simon, Gannon, Brenda, Gibbons, Kristen, Dalziel, Stuart and Schibler, Andreas (2019). Multicentre, randomised trial to investigate early nasal high—flow therapy in paediatric acute hypoxaemic respiratory failure: a protocol for a randomised controlled trial—a Paediatric Acute respiratory Intervention Study (PARIS 2). BMJ Open, 9 (12) e030516, e030516. doi: 10.1136/bmjopen-2019-030516

Multicentre, randomised trial to investigate early nasal high—flow therapy in paediatric acute hypoxaemic respiratory failure: a protocol for a randomised controlled trial—a Paediatric Acute respiratory Intervention Study (PARIS 2)

2019

Journal Article

Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis—a binational multicenter cohort study

Schlapbach, Luregn J., Chiletti, Roberto, Straney, Lahn, Festa, Marino, Alexander, Daniel, Butt, Warwick and MacLaren, Graeme (2019). Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis—a binational multicenter cohort study. Critical Care, 23 (1) 429, 429. doi: 10.1186/s13054-019-2685-1

Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis—a binational multicenter cohort study

2019

Journal Article

Translational gap in pediatric septic shock management: an ESPNIC perspective

Morin, Luc, Kneyber, Martin, Jansen, Nicolaas J. G., Peters, Mark J., Javouhey, Etienne, Nadel, Simon, Maclaren, Graeme, Schlapbach, Luregn Jan and Tissieres, Pierre (2019). Translational gap in pediatric septic shock management: an ESPNIC perspective. Annals of Intensive Care, 9 (1) 73, 73. doi: 10.1186/s13613-019-0545-4

Translational gap in pediatric septic shock management: an ESPNIC perspective

2019

Journal Article

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Wang, Xinzhu, Nijman, Ruud, Camuzeaux, Stephane, Sands, Caroline, Jackson, Heather, Kaforou, Myrsini, Emonts, Marieke, Herberg, Jethro A., Maconochie, Ian, Carrol, Enitan D., Paulus, Stephane C., Zenz, Werner, Van der Flier, Michiel, de Groot, Ronald, Martinon-Torres, Federico, Schlapbach, Luregn J., Pollard, Andrew J., Fink, Colin, Kuijpers, Taco T., Anderson, Suzanne, Lewis, Matthew R., Levin, Michael, McClure, Myra and & EUCLIDS consortium (2019). Plasma lipid profiles discriminate bacterial from viral infection in febrile children. Scientific Reports, 9 (1) 17714, 17714. doi: 10.1038/s41598-019-53721-1

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

2019

Journal Article

Burden of Streptococcus pneumoniae sepsis in children after introduction of pneumococcal conjugate vaccines: a prospective population-based cohort study

Asner, Sandra A., Agyeman, Philipp K. A., Gradoux, Eugénie, Posfay-Barbe, Klara M., Heininger, Ulrich, Giannoni, Eric, Crisinel, Pierre A., Stocker, Martin, Bernhard-Stirnemann, Sara, Niederer-Loher, Anita, Kahlert, Christian R., Hasters, Paul, Relly, Christa, Baer, Walter, Aebi, Christoph, Schlapbach, Luregn J. and Berger, Christoph (2019). Burden of Streptococcus pneumoniae sepsis in children after introduction of pneumococcal conjugate vaccines: a prospective population-based cohort study. Clinical Infectious Diseases, 69 (9), 1574-1580. doi: 10.1093/cid/ciy1139

Burden of Streptococcus pneumoniae sepsis in children after introduction of pneumococcal conjugate vaccines: a prospective population-based cohort study