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2024 Journal Article TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cellsBong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421, 1-12. doi: 10.1038/s41420-024-02183-0 |
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2024 Journal Article Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cellsSo, Choon Leng, Robitaille, Mélanie, Sadras, Francisco, McCullough, Michael H., Milevskiy, Michael J. G., Goodhill, Geoffrey J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells. Communications Biology, 7 (1) 467, 1-14. doi: 10.1038/s42003-024-06163-z |
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2023 Journal Article The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosisHua, Trinh, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2023). The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research, 1870 (7) 119532, 1-13. doi: 10.1016/j.bbamcr.2023.119532 |
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2023 Journal Article TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluidsSo, Choon Leng, Robitaille, Mélanie and Monteith, Gregory R. (2023). TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids. Cell Calcium, 109 102685, 1-3. doi: 10.1016/j.ceca.2022.102685 |
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2022 Journal Article AKT regulation of ORAI1-mediated calcium influx in breast cancer cellsBong, Alice Hui Li, Hua, Trinh, So, Choon Leng, Peters, Amelia A., Robitaille, Mélanie, Tan, Yin Yi, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). AKT regulation of ORAI1-mediated calcium influx in breast cancer cells. Cancers, 14 (19) 4794, 1-14. doi: 10.3390/cancers14194794 |
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2022 Journal Article Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cellsSo, Choon Leng, Meinert, Christoph, Xia, Qing, Robitaille, Mélanie, Roberts-Thomson, Sarah J and Monteith, Gregory R (2022). Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells. Cell Calcium, 104 102569, 1-10. doi: 10.1016/j.ceca.2022.102569 |
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2022 Journal Article ORAI1-regulated gene expression in breast cancer cells: Roles for STIM1 binding, calcium influx and transcription factor translocationRobitaille, Mélanie, Chan, Shao Ming, Peters, Amelia A., Dai, Limin, So, Choon Leng, Bong, Alice H. L., Sadras, Francisco, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1-regulated gene expression in breast cancer cells: Roles for STIM1 binding, calcium influx and transcription factor translocation. International Journal of Molecular Sciences, 23 (11) 5867, 1-14. doi: 10.3390/ijms23115867 |
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2022 Journal Article Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cellsMonteith, Prof. Gregory R, Robitaille, Mélanie and Roberts-Thomson, Sarah J. (2022). Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cells. Cell Calcium, 103 102563, 102563. doi: 10.1016/j.ceca.2022.102563 |
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2022 Journal Article ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathwayBassett, John J., Robitaille, Mélanie, Peters, Amelia A., Bong, Alice H. L., Taing, Meng‐Wong, Wood, Ian A., Sadras, Francisco, Roberts‐Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. The FASEB Journal, 36 (1) e22108, e22108. doi: 10.1096/fj.202002031rr |
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2021 Journal Article Altered calcium influx pathways in cancer-associated fibroblastsSadras, Francisco, Stewart, Teneale A., Robitaille, Mélanie, Peters, Amelia A., Croft, Priyakshi Kalita-de, Soon, Patsy S., Saunus, Jodi M., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). Altered calcium influx pathways in cancer-associated fibroblasts. Biomedicines, 9 (6) 680, 1-13. doi: 10.3390/biomedicines9060680 |
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2020 Journal Article Activation of the ion channel TRPV4 induces epithelial to mesenchymal transition in breast cancer cellsAzimi, Iman, Robitaille, Mélanie, Armitage, Kaela, So, Choon Leng, Milevskiy, Michael J. G., Northwood, Korinne, Lim, Huai Fang, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2020). Activation of the ion channel TRPV4 induces epithelial to mesenchymal transition in breast cancer cells. International Journal of Molecular Sciences, 21 (24) 9417, 1-14. doi: 10.3390/ijms21249417 |
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2019 Journal Article NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicinBong, Alice H. L., Robitaille, Mélanie, Milevskiy, Michael J. G., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2019). NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin. Molecular Oncology, 14 (1) 1878-0261.12589, 87-104. doi: 10.1002/1878-0261.12589 |
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2019 Journal Article ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and developmentMagomedova, Lilia, Tiefenbach, Jens, Zilberman, Emma, Le Billan, Florian, Voisin, Veronique, Saikali, Michael, Boivin, Vincent, Robitaille, Melanie, Gueroussov, Serge, Irimia, Manuel, Ray, Debashish, Patel, Rucha, Xu, ChangJiang, Jeyasuria, Pancharatnam, Bader, Gary D, Hughes, Timothy R, Morris, Quaid D, Scott, Michelle S, Krause, Henry, Angers, Stephane, Blencowe, Benjamin J and Cummins, Carolyn L (2019). ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Nucleic Acids Research, 47 (6), 2856-2870. doi: 10.1093/nar/gkz010 |
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2019 Journal Article ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responsesAzimi, Iman, Milevskiy, Michael J. G., Chalmers, Silke B., Yapa, Kunsala T. D. S., Robitaille, Mélanie, Henry, Christopher, Baillie, Gregory J., Thompson, Erik W., Roberts-Thomson, Sarah J and Monteith, Gregory R (2019). ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses. Cancers, 11 (2) 208, 208. doi: 10.3390/cancers11020208 |
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2018 Journal Article A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor propertiesPavlovic, Zvezdan, Adams, Jarrett J., Blazer, Levi L., Gakhal, Amandeep K., Jarvik, Nick, Steinhart, Zachary, Robitaille, Melanie, Mascall, Keith, Pan, James, Angers, Stephane, Moffat, Jason and Sidhu, Sachdev S. (2018). A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties. mAbs, 10 (8), 1157-1167. doi: 10.1080/19420862.2018.1515565 |
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2018 Journal Article Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6mBassett, John J., Bong, Alice H.L., Janke, Ellen K., Robitaille, Mélanie, Roberts-Thomson, Sarah J., Peters, Amelia A. and Monteith, Gregory R. (2018). Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m. Cell Calcium, 72, 39-50. doi: 10.1016/j.ceca.2018.02.003 |
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2017 Journal Article Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumorsSteinhart, Zachary, Pavlovic, Zvezdan, Chandrashekhar, Megha, Hart, Traver, Wang, Xiaowei, Zhang, Xiaoyu, Robitaille, Melanie, Browne, Kevin R., Jaksani, Sridevi, Overmeer, Rene, Boj, Sylvia F., Adams, Jarrett, Pan, James, Clevers, Hans, Sidhu, Sachdev, Moffat, Jason and Angers, Stephane (2017). Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine, 23 (1), 60-68. doi: 10.1038/nm.4219 |
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2016 Journal Article YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cellsDey, A., Robitaille, M., Remke, M., Maier, C., Malhotra, A., Gregorieff, A., Wrana, J. L., Taylor, M. D., Angers, S. and Kenney, A. M. (2016). YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. Oncogene, 35 (32), 4256-4268. doi: 10.1038/onc.2015.491 |
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2016 Journal Article SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the G alpha i-LGN-NuMA Ternary ComplexChiu, Catherine W. N., Monat, Carine, Robitaille, Melanie, Lacomme, Marine, Daulat, Avais M., Macleod, Graham, McNeill, Helen, Cayouette, Michel and Angers, Stephane (2016). SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the G alpha i-LGN-NuMA Ternary Complex. Developmental Cell, 36 (1), 50-62. doi: 10.1016/j.devcel.2015.12.016 |
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2015 Journal Article Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signallingKhan, Shahriar M., Min, Adam, Gora, Sarah, Houranieh, Geeda M., Campden, Rhiannon, Robitaille, Melanie, Trieu, Phan, Petrin, Darlaine, Jacobi, Ashley M., Behlke, Mark A., Angers, Stephane and Hebert, Terence E. (2015). Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling. Cellular Signalling, 27 (8), 1597-1608. doi: 10.1016/j.cellsig.2015.04.007 |
