Overview
Availability
- Dr Natalie Saez is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Natalie Saez’s works on UQ eSpace
2024
Conference Publication
Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractility
Rojas-Azofeifa, Daniela, Passioura, Toby, McMillen, Timothy, Cheesman, Elisabeth, Saez, Natalie, Chow, Jonathan, Eagles, David, Norman, Alexander, Perry, Matthew, Molenar, Peter, Regnier, Michael, King, Glenn and Palpant, Nathan (2024). Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractility. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.
2024
Conference Publication
In-silico application of structure prediction to peptide mechanism of action
Tucker, Isaac, King, Glenn, Saez, Natalie, Deplazes, Evelyne, Rash, Lachlan, Cristofori-Armstrong, Ben and Budusan, Elena (2024). In-silico application of structure prediction to peptide mechanism of action. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.
2024
Journal Article
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793
2024
Journal Article
Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice
Knezic, Adriana, Budusan, Elena, Saez, Natalie J., Broughton, Brad R. S., Rash, Lachlan D., King, Glenn F., Widdop, Robert E. and McCarthy, Claudia A. (2024). Hi1a improves sensorimotor deficit following endothelin-1-induced stroke in rats but does not improve functional outcomes following filament-induced stroke in mice. ACS Pharmacology and Translational Science, 7 (4), 1043-1054. doi: 10.1021/acsptsci.3c00328
2023
Journal Article
Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons
Foster, Victoria S., Saez, Natalie, King, Glenn F. and Rank, Michelle M. (2023). Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons. PLoS One, 18 (11 November) e0289053, 1-23. doi: 10.1371/journal.pone.0289053
2023
Journal Article
Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a
Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346
2023
Journal Article
Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injury
Foster, Victoria, Saez, Natalie, Gillespie, Ellen, Jogia, Trisha, Reid, Chantelle, Maljevic, Snezana, Jung, Woncheol, Lao, Hong W., Ruitenberg, Marc Jan and King, Glen (2023). Genetic or pharmacological ablation of acid-sensing ion channel 1a (ASIC1a) is not neuroprotective in a mouse model of spinal cord injury. Journal of Neurotrauma, 41 (9-10), 1007-1019. doi: 10.1089/neu.2022.0295
2022
Journal Article
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals
Eagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119
2022
Journal Article
Strategies for heterologous expression, synthesis, and purification of animal venom toxins
Rivera-de-Torre, Esperanza, Rimbault, Charlotte, Jenkins, Timothy P., Sørensen, Christoffer V., Damsbo, Anna, Saez, Natalie J., Duhoo, Yoan, Hackney, Celeste Menuet, Ellgaard, Lars and Laustsen, Andreas H. (2022). Strategies for heterologous expression, synthesis, and purification of animal venom toxins. Frontiers in Bioengineering and Biotechnology, 9 811905, 811905. doi: 10.3389/fbioe.2021.811905
2021
Journal Article
Total synthesis of the spider-venom peptide Hi1a
Duggan, Nisharnthi M., Saez, Natalie J., Clayton, Daniel, Budusan, Elena, Watson, Emma E., Tucker, Isaac J., Rash, Lachlan D., King, Glenn F. and Payne, Richard J. (2021). Total synthesis of the spider-venom peptide Hi1a. Organic Letters, 23 (21) acs.orglett.1c03112, 8375-8379. doi: 10.1021/acs.orglett.1c03112
2021
Journal Article
Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury
Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360
2020
Journal Article
A venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists
Reynaud, Steve, Ciolek, Justyna, Degueldre, Michel, Saez, Natalie J., Sequeira, Ana Filipa, Duhoo, Yoan, Brás, Joana L A, Meudal, Hervé, Cabo Díez, Miguel, Fernández Pedrosa, Victoria, Verdenaud, Marion, Boeri, Julia, Pereira Ramos, Oscar, Ducancel, Frédéric, Vanden Driessche, Margot, Fourmy, Rudy, Violette, Aude, Upert, Grégory, Mourier, Gilles, Beck-Sickinger, Annette G., Mörl, Karin, Landon, Céline, Fontes, Carlos M. G. A., Miñambres Herráiz, Rebeca, Rodríguez de la Vega, Ricardo C., Peigneur, Steve, Tytgat, Jan, Quinton, Loïc, De Pauw, Edwin ... Gilles, Nicolas (2020). A venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists. Journal of Medicinal Chemistry, 63 (15), 8250-8264. doi: 10.1021/acs.jmedchem.0c00485
2020
Conference Publication
A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction
Redd, M. A., Scheuer, S. E., Saez, N. J., Macdonald, P. S., Palpant, N. J. and King, G. F. (2020). A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction. Venom Week, Gainesville, FL, United States, 4-7 March, 2020. Oxford, United Kingdom : Elsevier.
2019
Journal Article
The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro
Nixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019). The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270, 40-46. doi: 10.1016/j.vetpar.2019.05.008
2019
Journal Article
The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues
Cristofori-Armstrong, Ben, Saez, Natalie J., Chassagnon, Irène R., King, Glenn F. and Rash, Lachlan D. (2019). The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochemical Pharmacology, 163, 381-390. doi: 10.1016/j.bcp.2019.03.004
2019
Journal Article
Versatile spider venom peptides and their medical and agricultural applications
Saez, Natalie J. and Herzig, Volker (2019). Versatile spider venom peptides and their medical and agricultural applications. Toxicon, 158, 109-126. doi: 10.1016/j.toxicon.2018.11.298
2019
Book Chapter
High-throughput production of oxidized animal toxins in Escherichia coli
Duhoo, Yoan, Sequeira, Ana Filipa, Saez, Natalie J, Turchetto, Jeremy, Ramond, Laurie, Peysson, Fanny, Brás, Joana L A, Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M G A and Vincentelli, Renaud (2019). High-throughput production of oxidized animal toxins in Escherichia coli. High-Throughput Protein Production and Purification. (pp. 165-190) edited by Renaud Vincentelli. New York, NY, United States: Humana. doi: 10.1007/978-1-4939-9624-7_7
2018
Journal Article
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain
Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089
2017
Journal Article
ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins
Pineda, Sandy S., Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W. C., Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique and King, Glenn F. (2017). ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins. Bioinformatics, 34 (6), 1074-1076. doi: 10.1093/bioinformatics/btx661
2017
Journal Article
Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli
Sequeira, Ana Filipa, Turchetto, Jeremy, Saez, Natalie J., Peysson, Fanny, Ramond, Laurie, Duhoo, Yoan, Blemont, Marilyne, Fernandes, Vânia O., Gama, Luís T., Ferreira, Luís M. A., Guerreiro, Catarina I. P. I., Gilles, Nicolas, Darbon, Hervé, Fontes, Carlos M. G. A. and Vincentelli, Renaud (2017). Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli. Microbial Cell Factories, 16 (1) 4, 4. doi: 10.1186/s12934-016-0618-0
Funding
Past funding
Supervision
Availability
- Dr Natalie Saez is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of a first-in-class biologic drug for stroke
Associate Advisor
Other advisors: Professor Glenn King
Completed supervision
-
2024
Doctor Philosophy
Enhancing the efficacy of venom-derived peptide therapeutics for the treatment of ion channel diseases
Associate Advisor
Other advisors: Professor Glenn King
Media
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