Overview
Background
I am a clinician scientist and academic leader with research in melanoma cell biology and experimental melanoma therapy. I received my degree in medicine from the University of Heidelberg, Germany (1990-1998). I graduated summa cum laude with a PhD in Cell Biology from the University of Heidelberg (1993-1999) and trained in clinical dermatology at the University of Hamburg, Germany (1999-2003). In 2003 I moved to Philadelphia, PA, to work as a post-doctoral fellow in Meenhard Herlyn’s lab at The Wistar Institute (2003-2007). From there I was recruited as an associate faculty member to the Centenary Institute/University of Sydney (2007-2013). In 2013 I commenced a position as Associate Professor for Cutaneous Oncology at University of Queensland Diamantina Institute (now Frazer Institute) and was promoted to full Professor in April 2016.
Availability
- Professor Nikolas Haass is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma, Ruprecht Karls Universität Heidelberg
Research impacts
Using cutting-edge technology, including real-time cell cycle imaging in 3D culture and in vivo, my team studies the role of dynamic melanoma heterogeneity in melanomagenesis with the goal to develop novel therapeutic approaches by simultaneously targeting different tumor cell subpopulations. My laboratory and our team are in the unique position to combine sophisticated imaging and biosensor approaches with biochemical methods to provide unprecedented insight to the mechanisms of tumor heterogeneity, tumor-stroma interactions and cancer immunology.
My contribution to the field is best evidenced by 97 original papers and invited reviews in leading biomedical journals. Many of our papers have a large impact in the field (>7500 citations in total, and 19 papers cited >100 times each). The papers in Mol Cancer Ther (2006, cited >500x), Cancer Res (2007, cited 265x) and PNAS (2008, cited 1500x) were evaluated by Faculty 1000 Biology as recommended or exceptional, respectively.
Works
Search Professor Nikolas Haass’s works on UQ eSpace
2019
Journal Article
Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronization in cell proliferation
Vittadello, Sean T., McCue, Scott W., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2019). Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronization in cell proliferation. Journal of The Royal Society Interface, 16 (157) 20190382, 20190382. doi: 10.1098/rsif.2019.0382
2019
Journal Article
Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine
Oo, Zay Yar, Proctor, Martina, Stevenson, Alexander J., Nazareth, Deborah, Fernando, Madushan, Daignault, Sheena M., Lanagan, Catherine, Walpole, Sebastian, Bonazzi, Vanessa, Škalamera, Dubravka, Snell, Cameron, Haass, Nikolas K., Larsen, Jill E. and Gabrielli, Brian (2019). Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine. Molecular Oncology, 13 (7) 1878-0261.12497, 1503-1518. doi: 10.1002/1878-0261.12497
2019
Journal Article
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes
Guo, Dajiang, Lui, Goldie Y. L., Lai, Siew Li, Wilmott, James S., Tikoo, Shweta, Jackett, Louise A., Quek, Camelia, Brown, Darren L., Sharp, Danae M., Kwan, Rain Y. Q., Chacon, Diego, Wong, Jason H., Beck, Dominik, van Geldermalsen, Michelle, Holst, Jeff, Thompson, John F., Mann, Graham J., Scolyer, Richard A., Stow, Jennifer L., Weninger, Wolfgang, Haass, Nikolas K. and Beaumont, Kimberley A. (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. International Journal of Cancer, 144 (12), 3070-3085. doi: 10.1002/ijc.32064
2019
Journal Article
RAB27A-mediated melanoma exosomes: promoters of invasion and metastasis
Guo, Dajiang, Tikoo, Shweta and Haass, Nikolas K. (2019). RAB27A-mediated melanoma exosomes: promoters of invasion and metastasis. Translational Cancer Research, 8 (3), 732-735. doi: 10.21037/tcr.2019.04.25
2019
Journal Article
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
Lee, Erinna F., Harris, Tiffany J., Tran, Sharon, Evangelista, Marco, Arulananda, Surein, John, Thomas, Ramnac, Celeste, Hobbs, Chloe, Zhu, Haoran, Gunasingh, Gency, Segal, David, Behren, Andreas, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., Strasser, Andreas, Rohrbeck, Leona, Haass, Nikolas K., Herold, Marco J. and Fairlie, W. Douglas (2019). BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival. Cell Death & Disease, 10 (5) 342, 342. doi: 10.1038/s41419-019-1568-3
2019
Journal Article
Cover image
Emran, Abdullah Al, Chinna Chowdary, Brinda Reddy, Ahmed, Farzana, Hammerlindl, Heinz, Huefner, Antje, Haass, Nikolas K., Schuehly, Wolfgang and Schaider, Helmut (2019). Cover image. Cancer Medicine, 8 (3), i-i. doi: 10.1002/cam4.2129
2019
Journal Article
Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma
Emran, Abdullah Al, Chinna Chowdary, Brinda Reddy, Ahmed, Farzana, Hammerlindl, Heinz, Huefner, Antje, Haass, Nikolas K., Schuehly, Wolfgang and Schaider, Helmut (2019). Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma. Cancer Medicine, 8 (3), 1186-1196. doi: 10.1002/cam4.1978
2019
Conference Publication
GGCX mutations in a patient with co-existent overlapping PXE/CL phenotype and thalassemia minor
Li, D., Ryu, E., Saeidian, A. H., Youssefian, L., Duvall, E., Oliphant, E., Terry, S., Haass, N. K., Uitto, J. and Li, Q. (2019). GGCX mutations in a patient with co-existent overlapping PXE/CL phenotype and thalassemia minor. Society for Investigative Dermatology (SID) Meeting, Chicago, IL United States, 8-11 May 2019. New York, NY United States: Elsevier.
2019
Conference Publication
Enforcing cellular stress promotes apoptotic and immunogenic responses in melanoma
Daignault, S. M., Spoerri, L., Ju, R. J., Stehbens, S. J., Hill, D. S., Dolcetti, R. and Haass, N. (2019). Enforcing cellular stress promotes apoptotic and immunogenic responses in melanoma. 46th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Munich, Germany, 13-16 March 2019. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/exd.13859
2019
Conference Publication
Bortezomib induces immunogenic cell death in melanoma and enhances immune responses in vivo
Daignault, S. M., Ju, R. J., Spoerri, L., Stehbens, S. J., Dolcetti, R. and Haass, N. K. (2019). Bortezomib induces immunogenic cell death in melanoma and enhances immune responses in vivo. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.506
2019
Conference Publication
Uncovering microtubule-driven mechanisms of melanoma invasion
Ju, R. J., Chhabra, Y., Haass, N. and Stehbens, S. J. (2019). Uncovering microtubule-driven mechanisms of melanoma invasion. 46th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Munich Germany, Mar 13-16, 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
2019
Conference Publication
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes
Guo, D., Lui, G. Y., Wilmott, J. S., Tikoo, S., Brown, D. L., Mann, G. J., Scolyer, R. A., Stow, J. L., Weninger, W., Beaumont, K. A. and Haass, N. (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. 46th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Munich, GERMANY, MAR 13-16, 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
2019
Conference Publication
Bortezomib-induced immunogenic cell death enhances immune response in melanoma
Daignault, S. M., Ju, R., Spoerri, L., Stehbens, S. J., Hill, D. S., Gabrielli, B., Dolcetti, R. and Haass, N. K. (2019). Bortezomib-induced immunogenic cell death enhances immune response in melanoma. Society for Investigative Dermatology (SID) Meeting, Chicago, IL United States, 8-11 May 2019. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2019.03.907
2019
Conference Publication
Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo
Oo, Zay Yar, Proctor, Martina, Stevenson, Alex, Nazareth, Deborah, Larsen, Jill, Haass, Nikolas and Gabrielli, Brian G. (2019). Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo. AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, Atlanta Ga, Mar 29-Apr 03, 2019. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2019-1236
2019
Conference Publication
Microphthalmia-associated transcription factor regulates dynamic heterogeneity and structural integrity in melanoma
Spoerri, L., Tonnessen, C. A., Beaumont, K. A., Hill, D. S., Jurek, R. J., Smith, A., Scott, E., Schaider, H., Gabrielli, B., Weninger, W. and Haass, N. (2019). Microphthalmia-associated transcription factor regulates dynamic heterogeneity and structural integrity in melanoma. 46th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Munich, Germany, 13-16 March, 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/exd.13859
2019
Conference Publication
MITF-mediated extracellular matrix changes control intratumour heterogeneity in melanoma
Spoerri, L., Tonnessen, C., Beaumont, K., Hill, D., Jurek, R., Gunasingh, G., Daignault, S. M., Vanwalleghem, G., Weninger, W., Scott, E. and Haass, N. K. (2019). MITF-mediated extracellular matrix changes control intratumour heterogeneity in melanoma. 49th Annual ESDR Meeting, Bordeaux, France, 18-21 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.709
2018
Journal Article
Stochastic models of cell invasion with fluorescent cell cycle indicators
Simpson, Matthew J., Jin, Wang, Vittadello, Sean T., Tambyah, Tamara A., Ryan, Jacob M., Gunasingh, Gency, Haass, Nikolas K. and McCue, Scott W. (2018). Stochastic models of cell invasion with fluorescent cell cycle indicators. Physica A: Statistical Mechanics and its Applications, 510, 375-386. doi: 10.1016/j.physa.2018.06.128
2018
Journal Article
The role of melanoma cell-stroma interaction in cell motility, invasion, and metastasis
Ju, Robert J., Stehbens, Samantha J. and Haass, Nikolas K. (2018). The role of melanoma cell-stroma interaction in cell motility, invasion, and metastasis. Frontiers in Medicine, 5 (NOV) 307, 1-9. doi: 10.3389/fmed.2018.00307
2018
Conference Publication
Less is more: subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors in vitro and in vivo
Oo, Z. U., Proctor, M., Stevenson, A., Nazareth, D., Haass, N., Larsen, J. and Gabrielli, B. (2018). Less is more: subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors in vitro and in vivo. 30th EORTC-NCI-AACR Symposium, Dublin Ireland, Nov 13-16, 2018. OXFORD: ELSEVIER SCI LTD.
2018
Journal Article
FGFR2b activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer
Stehbens, Samantha J., Ju, Robert J., Adams, Mark N., Perry, Samuel, Haass, Nikolas K., Bryant, David M. and Pollock, Pamela M. (2018). FGFR2b activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer. Journal of Cell Science, 131 (15) jcs.213678, 1-16. doi: 10.1242/jcs.213678
Funding
Supervision
Availability
- Professor Nikolas Haass is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Proteomics and transcriptomics analysis of phenotypic heterogeneity in 3D melanoma spheroids
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Helmut Schaider
-
Doctor Philosophy
Assessment of cell cycle phase-dependent immunogenicity of melanoma treated with the proteasome inhibitor bortezomib
Principal Advisor
Other advisors: Professor Brian Gabrielli
-
Doctor Philosophy
Proteomics and transcriptomics analysis of phenotypic heterogeneity in 3D melanoma spheroids
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Helmut Schaider
-
Doctor Philosophy
Modulating phenotypic melanoma heterogeneity and lymphocyte infiltration to improve both targeted and immune therapy
Principal Advisor
Other advisors: Professor Brian Gabrielli, Dr Janin Chandra
-
Doctor Philosophy
Understanding the interplay of MITF, TFEB and CDK4/6 on lysosome activity in melanoma
Principal Advisor
Other advisors: Associate Professor Jason Lee
-
Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani, Dr Abbas Shafiee, Associate Professor Jason Lee
-
Doctor Philosophy
Strategies to improve immunotherapy for patients with glioblastoma or breast cancer brain metastases
Associate Advisor
Other advisors: Dr Jodi Saunus, Professor Fiona Simpson
Completed supervision
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2023
Doctor Philosophy
Enhancing ER stress induced apoptosis and immunogenic cell death in melanoma
Principal Advisor
-
2019
Doctor Philosophy
Investigation of Microphthalmia-Associated Transcription Factor (MITF)-driven tumour heterogeneity in a 3D melanoma spheroid model in vitro.
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
-
2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Associate Advisor
Other advisors: Professor Paul Clarke
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2022
Doctor Philosophy
Regulation of Microtubules in 3D by CLASPs
Associate Advisor
Other advisors: Dr Samantha Stehbens
-
2017
Doctor Philosophy
Mechanisms and markers of CHK1 inhibitors sensitivity in melanoma
Associate Advisor
Other advisors: Professor Brian Gabrielli
Media
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