Overview
Background
I am a clinician scientist and academic leader with research in melanoma cell biology and experimental melanoma therapy. I received my degree in medicine from the University of Heidelberg, Germany (1990-1998). I graduated summa cum laude with a PhD in Cell Biology from the University of Heidelberg (1993-1999) and trained in clinical dermatology at the University of Hamburg, Germany (1999-2003). In 2003 I moved to Philadelphia, PA, to work as a post-doctoral fellow in Meenhard Herlyn’s lab at The Wistar Institute (2003-2007). From there I was recruited as an associate faculty member to the Centenary Institute/University of Sydney (2007-2013). In 2013 I commenced a position as Associate Professor for Cutaneous Oncology at University of Queensland Diamantina Institute (now Frazer Institute) and was promoted to full Professor in April 2016.
Availability
- Professor Nikolas Haass is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma, Ruprecht Karls Universität Heidelberg
Research impacts
Using cutting-edge technology, including real-time cell cycle imaging in 3D culture and in vivo, my team studies the role of dynamic melanoma heterogeneity in melanomagenesis with the goal to develop novel therapeutic approaches by simultaneously targeting different tumor cell subpopulations. My laboratory and our team are in the unique position to combine sophisticated imaging and biosensor approaches with biochemical methods to provide unprecedented insight to the mechanisms of tumor heterogeneity, tumor-stroma interactions and cancer immunology.
My contribution to the field is best evidenced by 97 original papers and invited reviews in leading biomedical journals. Many of our papers have a large impact in the field (>7500 citations in total, and 19 papers cited >100 times each). The papers in Mol Cancer Ther (2006, cited >500x), Cancer Res (2007, cited 265x) and PNAS (2008, cited 1500x) were evaluated by Faculty 1000 Biology as recommended or exceptional, respectively.
Works
Search Professor Nikolas Haass’s works on UQ eSpace
2022
Journal Article
Rapid Optical Clearing for Semi-High-Throughput Analysis of Tumor Spheroids
Gunasingh, Gency, Browning, Alexander P. and Haass, Nikolas K. (2022). Rapid Optical Clearing for Semi-High-Throughput Analysis of Tumor Spheroids. Journal of Visualized Experiments, 2022 (186) e64103. doi: 10.3791/64103
2022
Journal Article
Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion
Fane, Mitchell E., Chhabra, Yash, Spoerri, Loredana, Simmons, Jacinta L., Ludwig, Raquelle, Bonvin, Elise, Goding, Colin R., Sturm, Richard A., Boyle, Glen M., Haass, Nikolas K., Piper, Michael and Smith, Aaron G. (2022). Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion. Journal of Investigative Dermatology, 142 (7), 1845-1857. doi: 10.1016/j.jid.2020.12.039
2022
Journal Article
Persister state-directed transitioning and vulnerability in melanoma
Chauvistré, Heike, Shannan, Batool, Daignault-Mill, Sheena M., Ju, Robert J., Picard, Daniel, Egetemaier, Stefanie, Váraljai, Renáta, Gibhardt, Christine S., Sechi, Antonio, Kaschani, Farnusch, Keminer, Oliver, Stehbens, Samantha J., Liu, Qin, Yin, Xiangfan, Jeyakumar, Kirujan, Vogel, Felix C. E., Krepler, Clemens, Rebecca, Vito W., Kubat, Linda, Lueong, Smiths S., Forster, Jan, Horn, Susanne, Remke, Marc, Ehrmann, Michael, Paschen, Annette, Becker, Jürgen C., Helfrich, Iris, Rauh, Daniel, Kaiser, Markus ... Roesch, Alexander (2022). Persister state-directed transitioning and vulnerability in melanoma. Nature Communications, 13 (1) 3055, 3055. doi: 10.1038/s41467-022-30641-9
2022
Journal Article
PTEN: a novel target for vitamin D in melanoma
Shariev, Artur, Painter, Nicole, Reeve, Vivienne E., Haass, Nikolas K., Rybchyn, Mark S., Ince, Furkan A., Mason, Rebecca S. and Dixon, Katie M. (2022). PTEN: a novel target for vitamin D in melanoma. The Journal of Steroid Biochemistry and Molecular Biology, 218 106059, 1-10. doi: 10.1016/j.jsbmb.2022.106059
2022
Journal Article
A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling
Klowss, Jonah J., Browning, Alexander P., Murphy, Ryan J., Carr, Elliot J., Plank, Michael J., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2022). A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling. Journal of the Royal Society. Interface, 19 (189) 20210903, 20210903. doi: 10.1098/rsif.2021.0903
2022
Journal Article
Designing and interpreting 4D tumour spheroid experiments
Murphy, Ryan J., Browning, Alexander P., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2022). Designing and interpreting 4D tumour spheroid experiments. Communications Biology, 5 (1) 91, 91. doi: 10.1038/s42003-022-03018-3
2021
Journal Article
Quantitative analysis of tumour spheroid structure
Browning, Alexander P., Sharp, Jesse A., Murphy, Ryan J., Gunasingh, Gency, Lawson, Brodie, Burrage, Kevin, Haass, Nikolas K. and Simpson, Matthew (2021). Quantitative analysis of tumour spheroid structure. eLife, 10 e73020. doi: 10.7554/elife.73020
2021
Journal Article
Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression
Proctor, Martina, Gonzalez Cruz, Jazmina L., Daignault-Mill, Sheena M., Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K., Wells, James W. and Gabrielli, Brian (2021). Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers, 13 (15) 3733, 1-19. doi: 10.3390/cancers13153733
2021
Journal Article
GGCX mutations in a patient with PXE/CL-like overlapping phenotype
Li, D., Ryu, E., Saeidian, A. H., Youssefian, L., Oliphant, E., Terry, S. F., Tong, P. L., Uitto, J., Haass, N. K. and Li, Q. (2021). GGCX mutations in a patient with PXE/CL-like overlapping phenotype. British Journal of Dermatology, 184 (6) , 1170-1174. doi: 10.1111/bjd.19576
2021
Journal Article
Fluorescence-based quantitative and spatial analysis of tumour spheroids: a proposed tool to predict patient-specific therapy response
Spoerri, Loredana, Gunasingh, Gency and Haass, Nikolas K. (2021). Fluorescence-based quantitative and spatial analysis of tumour spheroids: a proposed tool to predict patient-specific therapy response. Frontiers in Digital Health, 3 668390, 1-19. doi: 10.3389/fdgth.2021.668390
2021
Journal Article
Synchronised oscillations in growing cell populations are explained by demographic noise
Gavagnin, Enrico, Vittadello, Sean T., Gunasingh, Gency, Haass, Nikolas K., Simpson, Matthew J., Rogers, Tim and Yates, Christian A. (2021). Synchronised oscillations in growing cell populations are explained by demographic noise. Biophysical Journal, 120 (8), 1314-1322. doi: 10.1016/j.bpj.2021.02.017
2021
Journal Article
Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity
Ippati, Stefania, Deng, Yuanyuan, van der Hoven, Julia, Heu, Celine, van Hummel, Annika, Chua, Sook Wern, Paric, Esmeralda, Chan, Gabriella, Feiten, Astrid, Fath, Thomas, Ke, Yazi D., Haass, Nikolas K. and Ittner, Lars M. (2021). Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity. Proceedings of the National Academy of Sciences, 118 (12) e2011876118, e2011876118. doi: 10.1073/pnas.2011876118
2021
Journal Article
Mathematical model of tumour spheroid experiments with real-time cell cycle imaging
Jin, Wang, Spoerri, Loredana, Haass, Nikolas K. and Simpson, Matthew J. (2021). Mathematical model of tumour spheroid experiments with real-time cell cycle imaging. Bulletin of Mathematical Biology, 83 (5) 44, 1-23. doi: 10.1007/s11538-021-00878-4
2021
Journal Article
A novel mathematical model of heterogeneous cell proliferation
Vittadello, Sean T., McCue, Scott W., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2021). A novel mathematical model of heterogeneous cell proliferation. Journal of Mathematical Biology, 82 (5) 34, 34. doi: 10.1007/s00285-021-01580-8
2020
Journal Article
Editorial: recent developments in therapies and diagnostic tools for melanoma and non-melanoma skin cancer
Fujimura, Taku, Fujisawa, Yasuhiro, Otsuka, Atsushi and Haass, Nikolas K. (2020). Editorial: recent developments in therapies and diagnostic tools for melanoma and non-melanoma skin cancer. Frontiers in Medicine, 7 613152, 613152. doi: 10.3389/fmed.2020.613152
2020
Journal Article
Abrogation of RAB27A expression transiently affects melanoma cell proliferation
Guo, Dajiang, Beaumont, Kimberley A., Sharp, Danae M., Lui, Goldie Y. L., Weninger, Wolfgang, Haass, Nikolas K. and Tikoo, Shweta (2020). Abrogation of RAB27A expression transiently affects melanoma cell proliferation. Pigment Cell and Melanoma Research, 33 (6), 889-894. doi: 10.1111/pcmr.12903
2020
Journal Article
Examining go-or-grow using fluorescent cell-cycle indicators and cell-cycle-inhibiting drugs
Vittadello, Sean T., McCue, Scott W., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2020). Examining go-or-grow using fluorescent cell-cycle indicators and cell-cycle-inhibiting drugs. Biophysical journal, 118 (6), 1243-1247. doi: 10.1016/j.bpj.2020.01.036
2020
Conference Publication
MITF-mediated changes of tumor architecture, tensile stress and extracellular matrix control intratumor heterogeneity in melanoma
Spoerri, L., Tonnessen-Murray, Ca, Beaumont, K. A., Hill, D., Jurek, R., Gunasingh, G., Weninger, W. and Haass, N. K. (2020). MITF-mediated changes of tumor architecture, tensile stress and extracellular matrix control intratumor heterogeneity in melanoma. Virtual Conference of the Society for Investigative Dermatology (SID ), Online, 13-16 May 2020. New York, NY, United States: Elsevier.
2020
Conference Publication
Estimation of cell cycle states of human melanoma cells with quantitative phase imaging and deep learning
Henser-Brownhill, Tristan, Ju, Robert J., Haass, Nikolas K., Stehbens, Samantha J., Ballestrem, Christoph and Cootes, Timothy F. (2020). Estimation of cell cycle states of human melanoma cells with quantitative phase imaging and deep learning. 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), Iowa City, IA United States, 3-7 April 2020. Piscataway, NJ United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/isbi45749.2020.9098458
2019
Journal Article
Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronization in cell proliferation
Vittadello, Sean T., McCue, Scott W., Gunasingh, Gency, Haass, Nikolas K. and Simpson, Matthew J. (2019). Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronization in cell proliferation. Journal of The Royal Society Interface, 16 (157) 20190382, 20190382. doi: 10.1098/rsif.2019.0382
Funding
Current funding
Supervision
Availability
- Professor Nikolas Haass is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Understanding the interplay of MITF, TFEB and CDK4/6 on lysosome activity in melanoma
Principal Advisor
Other advisors: Associate Professor Jason Lee
-
Doctor Philosophy
Proteomics and transcriptomics analysis of phenotypic heterogeneity in 3D melanoma spheroids
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Helmut Schaider
-
Doctor Philosophy
Assessment of cell cycle phase-dependent immunogenicity of melanoma treated with the proteasome inhibitor bortezomib
Principal Advisor
Other advisors: Professor Brian Gabrielli
-
Doctor Philosophy
Modulating phenotypic melanoma heterogeneity and lymphocyte infiltration to improve both targeted and immune therapy
Principal Advisor
Other advisors: Professor Brian Gabrielli, Dr Janin Chandra
-
Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani, Dr Abbas Shafiee, Associate Professor Jason Lee
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Doctor Philosophy
Strategies to improve immunotherapy for patients with glioblastoma or breast cancer brain metastases
Associate Advisor
Other advisors: Dr Jodi Saunus, Associate Professor Fiona Simpson
Completed supervision
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2023
Doctor Philosophy
Enhancing ER stress induced apoptosis and immunogenic cell death in melanoma
Principal Advisor
-
2019
Doctor Philosophy
Investigation of Microphthalmia-Associated Transcription Factor (MITF)-driven tumour heterogeneity in a 3D melanoma spheroid model in vitro.
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
-
2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Associate Advisor
Other advisors: Professor Paul Clarke
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2022
Doctor Philosophy
Regulation of Microtubules in 3D by CLASPs
Associate Advisor
Other advisors: Dr Samantha Stehbens
-
2017
Doctor Philosophy
Mechanisms and markers of CHK1 inhibitors sensitivity in melanoma
Associate Advisor
Other advisors: Professor Brian Gabrielli
Media
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