Overview
Background
I am a clinician scientist and academic leader with research in melanoma cell biology and experimental melanoma therapy. I received my degree in medicine from the University of Heidelberg, Germany (1990-1998). I graduated summa cum laude with a PhD in Cell Biology from the University of Heidelberg (1993-1999) and trained in clinical dermatology at the University of Hamburg, Germany (1999-2003). In 2003 I moved to Philadelphia, PA, to work as a post-doctoral fellow in Meenhard Herlyn’s lab at The Wistar Institute (2003-2007). From there I was recruited as an associate faculty member to the Centenary Institute/University of Sydney (2007-2013). In 2013 I commenced a position as Associate Professor for Cutaneous Oncology at University of Queensland Diamantina Institute (now Frazer Institute) and was promoted to full Professor in April 2016.
Availability
- Professor Nikolas Haass is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma, Ruprecht Karls Universität Heidelberg
Research impacts
Using cutting-edge technology, including real-time cell cycle imaging in 3D culture and in vivo, my team studies the role of dynamic melanoma heterogeneity in melanomagenesis with the goal to develop novel therapeutic approaches by simultaneously targeting different tumor cell subpopulations. My laboratory and our team are in the unique position to combine sophisticated imaging and biosensor approaches with biochemical methods to provide unprecedented insight to the mechanisms of tumor heterogeneity, tumor-stroma interactions and cancer immunology.
My contribution to the field is best evidenced by 97 original papers and invited reviews in leading biomedical journals. Many of our papers have a large impact in the field (>7500 citations in total, and 19 papers cited >100 times each). The papers in Mol Cancer Ther (2006, cited >500x), Cancer Res (2007, cited 265x) and PNAS (2008, cited 1500x) were evaluated by Faculty 1000 Biology as recommended or exceptional, respectively.
Works
Search Professor Nikolas Haass’s works on UQ eSpace
2016
Journal Article
Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer
Maadi, Hamid, Moshtaghian, Abdolvahab, Taha, Masoumeh Fakhr, Mowla, Seyed Javad, Kazeroonian, Asiye, Haass, Nikolas K. and Javeri, Arash (2016). Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer. International Journal of Biochemistry and Cell Biology, 81 (A), 121-132. doi: 10.1016/j.biocel.2016.11.004
2016
Journal Article
JNK-ERK signalling in melanoma: rewired or entangled?
Haass, N. K. (2016). JNK-ERK signalling in melanoma: rewired or entangled?. British Journal of Dermatology, 175 (6), 1139-1140. doi: 10.1111/bjd.14903
2016
Journal Article
Zielgerichtete Melanomtherapie – Die Rolle der dynamischen Tumorheterogenität
Haass, Nikolas K. (2016). Zielgerichtete Melanomtherapie – Die Rolle der dynamischen Tumorheterogenität. Spectrum Dermatologie, 2016 (3), 14-17.
2016
Journal Article
Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer
Skalamera, Dubravka, Dahmer-Heath, Mareike, Stevenson, Alexander J., Pinto, Cletus, Shah, Esha T., Daignault, Sheena M., Said, Nur Akmarina B. M., Davis, Melissa, Haass, Nikolas K., Williams, Elizabeth D., Hollier, Brett G., Thompson, Erik W., Gabrielli, Brian and Gonda, Thomas J. (2016). Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer. Oncotarget, 7 (38), 61000-61020. doi: 10.18632/oncotarget.11314
2016
Journal Article
Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells
Beaumont, Kimberley A., Hill, David S., Daignault, Sheena M., Lui, Goldie Y. L., Sharp, Danae M., Gabrielli, Brian, Weninger, Wolfgang and Haass, Nikolas K. (2016). Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. Journal of Investigative Dermatology, 136 (7), 1479-1489. doi: 10.1016/j.jid.2016.02.805
2016
Journal Article
microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB
Giles, Keith M., Brown, Rikki A. M., Ganda, Clarissa, Podgorny, Melissa J., Candy, Patrick A., Wintle, Larissa C., Richardson, Kirsty L., Kalinowski, Felicity C., Stuart, Lisa M., Epis, Michael R., Haass, Nikolas K., Herlyn, Meenhard and Leedman, Peter J. (2016). microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB. Oncotarget, 7 (22), 31663-31680. doi: 10.18632/oncotarget.9421
2016
Conference Publication
Developing a new melanoma drug
Stehn, J. R., Stevenson, A., Spoerri, L., Daignault, S. M., Gabrielli, B., Eiffe, E., Gunning, P. W. and Haass, N. (2016). Developing a new melanoma drug. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells
Beaumont, K., Hill, D., Daignault, S., Sharp, D., Gabrielli, B., Weninger, W. and Haass, N. (2016). Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. Annual Meeting of the Society-for-Investigative-Dermatology (SID), Scottsdale, AZ, United States, 11-14 May 2016. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2016.02.695
2016
Journal Article
In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis
Vaidyanathan, Srividya, Cato, Kathleen, Tang, Lu, Pavey, Sandra, Haass, Nikolas K., Gabrielli, Brian G. and Duijf, Pascal H. G. (2016). In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. Oncogene, 35 (41), 5446-5455. doi: 10.1038/onc.2016.94
2016
Conference Publication
Real-time cell cycle and cell death imaging of the effect of sphingosine kinase inhibition on 3D melanoma spheroids
Kienzle, A., McGowan, E., Douglas, G., Kaczorowski, D., Weninger, W. and Haass, N. K. (2016). Real-time cell cycle and cell death imaging of the effect of sphingosine kinase inhibition on 3D melanoma spheroids. 43rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung-e-V (ADF), Vienna Austria, Mar 10-12, 2016. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
MITF regulates cell adhesion and subcompartment-specific distribution of differentially cycling melanoma cells
Tonnessen, C. A., Beaumont, K. A., Spoerri, L., Hill, D. S., Jurek, R. J., Daignault, S. M., Ahmed, F., Fane, M., Smith, A., Weninger, W. and Haass, N. K. (2016). MITF regulates cell adhesion and subcompartment-specific distribution of differentially cycling melanoma cells. 43rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung-e-V (ADF), Vienna Austria, Mar 10-12, 2016. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
Cell cycle phase determines efficacy of bortezomib, temozolomide and MAPK inhibitor-induced apoptosis in melanoma
Hill, D. S., Beaumont, K. A., Daignault, S. M., Sharp, D. M., Gabrielli, B., Weninger, W. and Haass, N. K. (2016). Cell cycle phase determines efficacy of bortezomib, temozolomide and MAPK inhibitor-induced apoptosis in melanoma. 43rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung-e-V (ADF), Vienna Austria, Mar 10-12, 2016. HOBOKEN: WILEY-BLACKWELL.
2016
Conference Publication
MITF modifies invasion and characteristics of the epithelial to mesenchymal transition in melanoma
Daignault, S. M., Tonnessen, C. A., Ahmed, F., Spoerri, L. and Haass, N. K. (2016). MITF modifies invasion and characteristics of the epithelial to mesenchymal transition in melanoma. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
2016
Conference Publication
Overexpression of Early Mitotic Inhibitor 1 (Emi1) promotes genomic instability and cancer
Vaidyanathan, S., Cato, K., Tang, L., Pavey, S., Haass, N. K., Gabrielli, B. G. and Duijf, P. H. G. (2016). Overexpression of Early Mitotic Inhibitor 1 (Emi1) promotes genomic instability and cancer. Annual Meeting of the American Society for Cell Biology (ASCB), San Francisco Ca, Dec 03-07, 2016. BETHESDA: American Society for Cell Biology.
2016
Conference Publication
Stress induced multi-drug tolerance precedes acquired drug resistance in melanoma
Schaider, H., Menon, D. R., Emran, A., Gabrielli, B., Haass, N., Somasundaram, R. and Herlyn, M. (2016). Stress induced multi-drug tolerance precedes acquired drug resistance in melanoma. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, 18-21 November 2014. Richmond, VIC Australia: Wiley-Blackwell .
2016
Conference Publication
Identification of unique molecular signatures of differentially cycling tumour cell subpopulations in a 3D melanoma model
Ahmed, F., Tonnessen, C., Spoerri, L., Daignault, S., Stark, M., Schaider, H., Hill, M. and Haass, N. (2016). Identification of unique molecular signatures of differentially cycling tumour cell subpopulations in a 3D melanoma model. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
2016
Conference Publication
Rose Bengal melanoma therapy - phototoxicity versus intrinsic cytotoxicity
Nierfeld, M., Nascimento, P. R., Baesler, K., Knuever, J., Spoerri, L., Schaider, H., Weninger, W. and Haass, N. K. (2016). Rose Bengal melanoma therapy - phototoxicity versus intrinsic cytotoxicity. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
2016
Conference Publication
Rab27a regulates invadopodia activity and invasion in melanoma
Haass, N. K., Lui, G. Y., Sharp, D. M., Tan, S. -Y., Weninger, W. and Beaumont, K. A. (2016). Rab27a regulates invadopodia activity and invasion in melanoma. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
2015
Journal Article
Imaging- and flow cytometry-based analysis of cell position and the cell cycle in 3d melanoma spheroids
Beaumont, Kimberley A., Anfosso, Andrea, Ahmed, Farzana, Weninger, Wolfgang and Haass, Nikolas K. (2015). Imaging- and flow cytometry-based analysis of cell position and the cell cycle in 3d melanoma spheroids. Journal of Visualized Experiments, 106 (e53486) e53486, e53486. doi: 10.3791/53486
2015
Journal Article
Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS
Ke, Yazi D., van Hummel, Annika, Stevens, Claire H., Gladbach, Amadeus, Ippati, Stefania, Bi, Mian, Lee, Wei S., Kruger, Sarah, van der Hoven, Julia, Volkerling, Alexander, Bongers, Andre, Halliday, Glenda, Haass, Nikolas K., Kiernan, Matthew, Delerue, Fabien and Ittner, Lars M. (2015). Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathologica, 130 (5), 661-678. doi: 10.1007/s00401-015-1486-0
Funding
Current funding
Supervision
Availability
- Professor Nikolas Haass is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Proteomics and transcriptomics analysis of phenotypic heterogeneity in 3D melanoma spheroids
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Helmut Schaider
-
Doctor Philosophy
Assessment of cell cycle phase-dependent immunogenicity of melanoma treated with the proteasome inhibitor bortezomib
Principal Advisor
Other advisors: Professor Brian Gabrielli
-
Doctor Philosophy
Modulating phenotypic melanoma heterogeneity and lymphocyte infiltration to improve both targeted and immune therapy
Principal Advisor
Other advisors: Professor Brian Gabrielli, Dr Janin Chandra
-
Doctor Philosophy
Understanding the interplay of MITF, TFEB and CDK4/6 on lysosome activity in melanoma
Principal Advisor
Other advisors: Associate Professor Jason Lee
-
Doctor Philosophy
Targeting epigenetic regulation to overcome immunotherapy resistance in cutaneous melanoma
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani, Dr Abbas Shafiee, Associate Professor Jason Lee
-
Doctor Philosophy
Strategies to improve immunotherapy for patients with glioblastoma or breast cancer brain metastases
Associate Advisor
Other advisors: Dr Jodi Saunus, Associate Professor Fiona Simpson
Completed supervision
-
2023
Doctor Philosophy
Enhancing ER stress induced apoptosis and immunogenic cell death in melanoma
Principal Advisor
-
2019
Doctor Philosophy
Investigation of Microphthalmia-Associated Transcription Factor (MITF)-driven tumour heterogeneity in a 3D melanoma spheroid model in vitro.
Principal Advisor
Other advisors: Associate Professor Helmut Schaider
-
2023
Doctor Philosophy
The regulation of cGAS during cell cycle
Associate Advisor
Other advisors: Professor Paul Clarke
-
2022
Doctor Philosophy
Regulation of Microtubules in 3D by CLASPs
Associate Advisor
Other advisors: Dr Samantha Stehbens
-
2017
Doctor Philosophy
Mechanisms and markers of CHK1 inhibitors sensitivity in melanoma
Associate Advisor
Other advisors: Professor Brian Gabrielli
Media
Enquiries
For media enquiries about Professor Nikolas Haass's areas of expertise, story ideas and help finding experts, contact our Media team: