
Overview
Background
Professor Geoff Hill MBChB MD BHB FRCPA FRACP geoffH@qimr.edu.au
NHMRC Australia and QLD Health Senior Clinical Research Fellow
Coordinator, Cancer Programme, QIMR Berghofer
Head, Bone Marrow Transplantation Laboratory, QIMR Berghofer
Director of Research, Cancer Care Services, Royal Brisbane & Womens’ Hospital
Bone Marrow Transplant Physician and Haematologist, Royal Brisbane & Womens’ Hospital
Geoff Hill is a medical graduate of the University of Auckland and Haematologist, training in New Zealand, The Dana Farber Cancer Institute in Boston. He is a NHMRC Australia Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory T cells during transplantation.
Professor Hill was the 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award and the 2014 Translational Research Institute National Prize for excellence within basic and clinical research in the transplant field. He was also awarded a Queensland Health Senior Clinical Research Fellowship in 2010 to translate new cytokine and cell based therapies into clinic practice.
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, The University of Auckland
- Masters (Coursework) of Medicine Surgery, The University of Auckland
- Doctoral Diploma of Medicine, The University of Auckland
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
Works
Search Professor Geoffrey Hill’s works on UQ eSpace
2005
Journal Article
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production
Johnson, BJ, Le, TTT, Dobbin, CA, Banovic, T, Howard, CB, Flores, FDL, Vanags, D, Naylor, DJ, Hill, GR and Suhrbier, A (2005). Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. Journal of Biological Chemistry, 280 (6), 4037-4047. doi: 10.1074/jbc.M411569200
2005
Journal Article
Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells
MacDonald, Kelli P. A., Rowe, Vanessa, Clouston, Andrew D., Welply, Joseph K., Kuns, Rachel D., Ferrara, James L. M., Thomas, Ranjeny and Hill, Geoffrey R. (2005). Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. Journal of Immunology, 174 (4), 1841-1850. doi: 10.4049/jimmunol.174.4.1841
2005
Journal Article
Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation
Kennedy, GA, Butler, J, Western, R, Morton, J, Hill, G and Durrant, S (2005). Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation. Leukemia, 19 (2), 317-318. doi: 10.1038/sj.leu.2403549
2005
Conference Publication
Nuclear translocation of ROB within host and donor antigen presenting cells is critical for the initiation and maintenance of acute graft-versus-host disease
MacDonald, Kelli, Kuns, Rachel, Rowe, Vanessa, Don, Alistair, Morris, Edward, Thomas, Ranjeny and Hill, Geoffrey (2005). Nuclear translocation of ROB within host and donor antigen presenting cells is critical for the initiation and maintenance of acute graft-versus-host disease. 47th Annual Meeting of the American Society of Hematology, Atlanta, GA, United States, 10 -13 December 2005. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V106.11.455.455
2005
Conference Publication
The mechanism of inflammation in RelB deficient mice
Pai, S., O'Sullivan, B. J., MacDonald, K. P., Duggan, E., Gerondakis, S., Hill, G. and Thomas, R. (2005). The mechanism of inflammation in RelB deficient mice. 35th Annual Scentific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, 29 November - 2 December 2005. OXFORD: Australasian Society of Immunology.
2004
Journal Article
Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: The role of donor T-cell dose and differentiation
MacDonald, Kelli P. A., Rowe, Vanessa, Filippich, Cheryl, Johnson, Diana, Morris, Edward S., Clouston, Andrew D., Ferrara, James L. M. and Hill, Geoffrey R. (2004). Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: The role of donor T-cell dose and differentiation. Biology of Blood And Marrow Transplantation, 10 (6), 373-385. doi: 10.1016/j.bbmt.2004.02.002
2004
Journal Article
Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance
Morris, ES, MacDonald, KPA, Rowe, V, Johnson, DH, Banovic, T, Clouston, AD and Hill, GR (2004). Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. Blood, 103 (9), 3573-3581. doi: 10.1182/blood-2003-08-2864
2004
Conference Publication
Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells
MacDonald, K. P. A., Rowe, V., Thomas, R., Ferrera, J. L. M. and Hill, G. R. (2004). Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells. 22nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Canberra, Australia, 31st March - 2nd April, 2004. Basingstoke, U.K.: Nature Publishing Group. doi: 10.1111/j.1440-1711.2004.1259_2.x
2003
Journal Article
Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression
Vuckovic, S., Kim, M., Turtle, C. J., Khalil, D., Crosbie, G.V., Williams, K., Williams, N., Brown, L., Kelly, C., Stravos, P., Rodwell, R., Hill, G., Wright, S. J., Taylor, K., Gill, D., Marlton, P., Bradstock, K. and Hart, D. N. J. (2003). Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression. Blood, 101 (6), 2314-2317. doi: 10.1182/blood-2002-03-0973
2003
Journal Article
Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation
MacDonald, Kelli P. A., Rowe, Vanessa, Filippich, Cheryl, Thomas, Ranjeny, Clouston, Andrew D., Welply, Joseph K., Hart, Derek N. J., Ferrara, James L. M. and Hill, Geoffrey R. (2003). Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation. Blood, 101 (5), 2033-2042. doi: 10.1182/blood-2002-05-1529
2003
Conference Publication
Progenipoietin-1 and G-CSF expand a novel CD40(neg) APC that induces transplant tolerance through IL-10 producing regulatory T cells
MacDonald, K. P. A., Rowe, V., Thomas, R., Welply, J. K., Woulfe, S., Ferrara, J. L. M. and Hill, G. R. (2003). Progenipoietin-1 and G-CSF expand a novel CD40(neg) APC that induces transplant tolerance through IL-10 producing regulatory T cells. 45th Annual Meeting of the American Society of Hematology, San Diego, CA, United States, 6 - 9 December 2003. Washington, DC, United States: American Society of Hematology.
2002
Journal Article
Relapsed plasma cell leukaemia presenting with aggressive extramedullary plasmacytomas in the meninges and testis - A missed opportunity for induction CNS prophylaxis
Wellwood, J, Taylor, K, Wright, S, Bentley, M, Hill, G, Phan, H, Norris, D and Livsey, R (2002). Relapsed plasma cell leukaemia presenting with aggressive extramedullary plasmacytomas in the meninges and testis - A missed opportunity for induction CNS prophylaxis. Leukemia & Lymphoma, 43 (4), 893-896. doi: 10.1080/10428190290017060
2002
Journal Article
Keratinocyte Growth factor (KGF) in hematology and oncology
MacDonald, KPA and Hill, GR (2002). Keratinocyte Growth factor (KGF) in hematology and oncology. Current Pharmaceutical Design, 8 (5), 395-403. doi: 10.2174/1381612023396104
2001
Journal Article
LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation
Cooke, KR, Gerbitz, A, Crawford, JM, Teshima, T, Hill, GR, Tesolin, A, Rossignol, DP and Ferrara, JLM (2001). LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. Journal of Clinical Investigation, 107 (12), 1581-1589. doi: 10.1172/JCI12156
2001
Journal Article
Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation
Teshima, T, Mach, N, Hill, GR, Pan, LY, Gillessen, S, Dranoff, G and Ferrara, JLM (2001). Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation. Cancer Research, 61 (1), 162-171.
2000
Journal Article
Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation
Cooke, KR, Hill, GR, Gerbitz, A, Kobzik, L, Martin, TR, Crawford, JM, Brewer, JP and Ferrara, JLM (2000). Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation. Journal of Immunology, 165 (11), 6612-6619. doi: 10.4049/jimmunol.165.11.6612
2000
Journal Article
Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation
Cooke, KR, Hill, GR, Gerbitz, A, Kobzik, L, Martin, TR, Crawford, JM, Brewer, JP and Ferrara, JLM (2000). Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation, 70 (2), 272-279. doi: 10.1097/00007890-200007270-00006
2000
Journal Article
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
Hill, GR and Ferrara, JLM (2000). The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood, 95 (9), 2754-2759.
2000
Journal Article
G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient
Reddy, , Hill, GR, Pan, LY, Gerbitz, A, Teshima, T, Brinson, Y and Ferrara, JLM (2000). G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient. Transplantation, 69 (4), 691-693. doi: 10.1097/00007890-200002270-00041
2000
Journal Article
The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity
Hill, GR, Teshima, T, Rebel, , Krijanovski, OI, Cooke, KR, Brinson, YS and Ferrara, JLM (2000). The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. Journal of Immunology, 164 (2), 656-663. doi: 10.4049/jimmunol.164.2.656
Supervision
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
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Supervision history
Completed supervision
-
2019
Doctor Philosophy
Restoring myeloma-immune equilibrium by stem cell transplantation
Principal Advisor
-
2019
Doctor Philosophy
Understanding the role of IL-6 signalling in Graft-Versus-Host Disease (GVHD)
Principal Advisor
-
2019
Doctor Philosophy
Anti-leukaemia effect of Interferons
Principal Advisor
Other advisors: Professor Steven Lane
-
2012
Doctor Philosophy
Mechanisms of Immune Modulation after Stem Cell Transplantation
Principal Advisor
-
2021
Doctor Philosophy
Interplay between cytomegalovirus infection and graft-versus-leukaemia effect
Associate Advisor
-
2019
Doctor Philosophy
The contribution of cytokine signals, autophagy and antigen presentation to complications associated with allogeneic stem cell transplantation
Associate Advisor
-
2019
Doctor Philosophy
The Psychosocial Impact of Haematopoietic Stem Cell Donation on Adult Related Donors
Associate Advisor
-
2017
Doctor Philosophy
Maintenance of blood stem cells and the development of haematological malignancies
Associate Advisor
Other advisors: Professor Steven Lane
-
2016
Doctor Philosophy
Stem Cell Therapies and Radiological Imaging in Ataxia Telangiectasia
Associate Advisor
Other advisors: Professor Ernst Wolvetang
-
2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2012
Doctor Philosophy
T cell immune response to human cytomegalovirus in latency and reactivation
Associate Advisor
-
2012
Doctor Philosophy
Self-renewal pathways in leukaemia stem cells and haematopoietic stem cells
Associate Advisor
-
2011
Doctor Philosophy
Antigen Presentation and Inflammation in Allogeneic Bone Marrow Transplantation
Associate Advisor
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Associate Advisor
Other advisors: Professor Ian Frazer
Media
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