
Overview
Background
Professor Geoff Hill MBChB MD BHB FRCPA FRACP geoffH@qimr.edu.au
NHMRC Australia and QLD Health Senior Clinical Research Fellow
Coordinator, Cancer Programme, QIMR Berghofer
Head, Bone Marrow Transplantation Laboratory, QIMR Berghofer
Director of Research, Cancer Care Services, Royal Brisbane & Womens’ Hospital
Bone Marrow Transplant Physician and Haematologist, Royal Brisbane & Womens’ Hospital
Geoff Hill is a medical graduate of the University of Auckland and Haematologist, training in New Zealand, The Dana Farber Cancer Institute in Boston. He is a NHMRC Australia Fellow and his immunology laboratory focuses on the interactions between cytokines, antigen presenting cells and regulatory T cells during transplantation.
Professor Hill was the 2005 Queenslander of the Year and recipient of the Transplantation Society of Australia and New Zealand 2009 Ian McKenzie Award and the 2014 Translational Research Institute National Prize for excellence within basic and clinical research in the transplant field. He was also awarded a Queensland Health Senior Clinical Research Fellowship in 2010 to translate new cytokine and cell based therapies into clinic practice.
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, The University of Auckland
- Masters (Coursework) of Medicine Surgery, The University of Auckland
- Doctoral Diploma of Medicine, The University of Auckland
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
Works
Search Professor Geoffrey Hill’s works on UQ eSpace
2010
Journal Article
CD4+ natural regulatory T Cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo
Haque, Ashraful, Best, Shannon E., Amante, Fiona H., Mustafah, Seri, Desbarrieres, Laure, de Labastida, Fabian, Sparwasser, Tim, Hill, Geoffrey R. and Engwerda, Christian R. (2010). CD4+ natural regulatory T Cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathogens, 6 (12) e1001221, 1 - e1001221-14 - e1001221. doi: 10.1371/journal.ppat.1001221
2010
Journal Article
An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation
MacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296
2010
Journal Article
Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria
Amante, FH, Haque, A, Stanley, AC, Rivera, FD, Randall, LM, Wilson, YA, Yeo, G, Pieper, C, Crabb, BS, de Koning-Ward, TF, Lundie, RJ, Good, MF, Pinzon-Charry, A, Pearson, MS, Duke, MG, McManus, DP, Loukas, A, Hill, GR and Engwerda, CR (2010). Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. Journal of Immunology, 185 (6), 3632-3642. doi: 10.4049/jimmunol.1000944
2010
Journal Article
Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
Hill, Geoffrey R., Olver, Stuart D., Kuns, Rachel D., Varelias, Antiopi, Raffelt, Neil C., Don, Alistair L., Markey, Kate A., Wilson, Yana A., Smyth, Mark J., Iwakura, Yoichiro, Tocker, Joel, Clouston, Andrew D. and MacDonald, Kelli P. A. (2010). Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood, 116 (5), 819-828. doi: 10.1182/blood-2009-11-256495
2010
Journal Article
SOCS3 regulates graft-versus-host disease
Hill, Geoffrey R., Kuns, Rachel D., Raffelt, Neil C., Don, Alistair L. J., Olver, Stuart D., Markey, Kate A., Wilson, Yana A., Tocker, Joel, Alexander, Warren S., Clouston, Andrew D., Roberts, Andrew W. and MacDonald, Kelli P. A. (2010). SOCS3 regulates graft-versus-host disease. Blood, 116 (2), 287-296. doi: 10.1182/blood-2009-12-259598
2010
Journal Article
Innate immunity defines the capacity of antiviral T cells to limit persistent infection
Andrews, Daniel M., Estcourt, Marie J., Andoniou, Christopher E, Wikstrom, Matthew E., Khong, Andrea, Voigt, Valentina, Fleming, Peter, Tabarias, Hyacinth, Hill, Geoffrey R., van der Most, Robbert G., Scalzo, Anthony A., Smyth, Mark J. and Degli-Esposti, Mariapia A. (2010). Innate immunity defines the capacity of antiviral T cells to limit persistent infection. Journal of Experimental Medicine, 207 (6), 1333-1343. doi: 10.1084/jem.20091193
2010
Journal Article
IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis
Teng, Michele W. L., Andrews, Daniel M., McLaughlin, Nicole, von Scheidt, Bianca, Ngiow, Shin Foong, Moeller, Andreas, Hill, Geoffrey R., Iwakura, Yoichiro, Oft, Martin and Smyth, Mark J. (2010). IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proceedings of the National Academy of Sciences of USA, 107 (18), 8328-8333. doi: 10.1073/pnas.1003251107
2010
Journal Article
Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity
Haque, Ashraful, Stanley, Amanda C., Amante, Fiona H., de Labastida Rivera, Fabian, Zhou, YongHong, Kuns, Rachel D., Yardley, Vanessa, Sakaguchi, Shimon, Hill, Geoffrey R. and Engwerda, Christian R. (2010). Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity. Journal of Immunology, 184 (5), 2583-2592. doi: 10.4049/jimmunol.0903080
2010
Journal Article
Soluble lymphotoxin is an important effector molecule in GVHD and GVL
Markey, KA, Burman, AC, Banovic, T, Kuns, RD, Raffelt, NC, Rowe, V, Olver, SD, Don, ALJ, Morris, ES, Pettit, AR, Wilson, YA, Robb, RJ, Randall, LM, Korner, H, Engwerda, CR, Clouston, AD, MacDonald, KPA and Hill, GR (2010). Soluble lymphotoxin is an important effector molecule in GVHD and GVL. Blood, 115 (1), 122-132. doi: 10.1182/blood-2009-01-199927
2010
Journal Article
Successful immunotherapy of HCMV disease using virus-specific T cells expanded from an allogeneic stem cell transplant recipient
Hill, G. R., Tey, S-K., Beagley, L., Crough, T., Morton, J.A., Clouston, A.D., Whiting, P. and Khanna, R. (2010). Successful immunotherapy of HCMV disease using virus-specific T cells expanded from an allogeneic stem cell transplant recipient. American Journal of Transplantation, 10 (1), 173-179. doi: 10.1111/j.1600-6143.2009.02872.x
2009
Journal Article
Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration
Kuns, Rachel D., Morris, Edward S., MacDonald, Kelli P.A., Markey, Kate A., Morris, Helen M., Raffelt, Neil C., Banovic, Tatjana, Don, Alistair L.J., Rowe, Vanessa, Burman, Angela C., Clouston, Andrew D., Farah, Camile, Besra, Gurdyal S., Illarionov, Petr A., Smyth, Mark J., Porcelli, Steven A. and Hill, Geoffrey R. (2009). Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration. Blood, 113 (23), 5999-6010. doi: 10.1182/blood-2008-10-183335
2009
Journal Article
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation
Markey, KA, Banovic, T, Kuns, RD, Olver, SD, Don, ALJ, Raffelt, NC, Wilson, YA, Raggatt, LJ, Pettit, AR, Bromberg, JS, Hill, GR and MacDonald, KPA (2009). Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation. BLOOD, 113 (22), 5644-5649. doi: 10.1182/blood-2008-12-191833
2009
Journal Article
Induction of natural killer T cell–dependent alloreactivity by administration of granulocyte colony–stimulating factor after bone marrow transplantation
Edward S Morris, Kelli P A MacDonald, Rachel D Kuns, Helen M Morris, Tatjana Banovic, Alistair L J Don, Vanessa Rowe, Yana A Wilson, Neil C Raffelt, Christian R Engwerda, Angela C Burman, Kate A Markey, Dale I Godfrey, Mark J Smyth and Geoffrey R Hill (2009). Induction of natural killer T cell–dependent alloreactivity by administration of granulocyte colony–stimulating factor after bone marrow transplantation. Nature Medicine, 15 (4), 436-441. doi: 10.1038/nm.1948
2009
Journal Article
Erratum
Markey, K. A., MacDonald, K. P. and Hill, G. R. (2009). Erratum. Tissue Antigens, 73 (2), 192-192. doi: 10.1111/j.1399-0039.2008.01203.x
2009
Journal Article
Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells
Tatjana Banovic, Kate A. Markey, Rachel D. Kuns, Stuart D. Olver, Neil C. Raffelt, Alistair L. Don, Mariapia A. Degli-Esposti, Christian R. Engwerda, Kelli P. A. MacDonald and Geoffrey R. Hill (2009). Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells. Journal of Immunology, 182 (2), 912-920. doi: 10.4049/jimmunol.182.2.912
2009
Journal Article
Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT
Markey, Kate A., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2009). Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT. Blood, 113 (23), 6038-6039. doi: 10.1182/blood-2009-03-212944
2009
Journal Article
Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects
Banovic, Tatjana, MacDonald , Kelli P. A., Markey, Kate A., Morris, Edward S., Kuns, Rachel D., Varelias, Antiopi and Hill, Geofffrey R. (2009). Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects. Biology of Blood and Marrow Transplantation, 15 (1), 126-130. doi: 10.1016/j.bbmt.2008.11.019
2009
Journal Article
Inflammation and bone marrow transplantation
Hill, Geoffrey R. (2009). Inflammation and bone marrow transplantation. Biology of Blood and Marrow Transplantation, 15 (1 SUPPL.), 139-141. doi: 10.1016/j.bbmt.2008.11.008
2008
Journal Article
Cutting edge: Selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA
Randall, Louise M., Amante, Fiona H., Zhou, Yonghong, Stanley, Amanda C., Haque, Ashraful, Rivera, Fabian, Pfeffer, Klaus, Scheu, Stefanie, Hill, Geoff R., Tamada, Koji and Engwerda, Christian R. (2008). Cutting edge: Selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. Journal of Immunology, 181 (11), 7458-7460. doi: 10.4049/jimmunol.181.11.7458
2008
Journal Article
Impact of cytokine gene polymorphisms on graft-vs-host disease
Markey, K. A., MacDonald, K. P. A. and Hill, G. R. (2008). Impact of cytokine gene polymorphisms on graft-vs-host disease. Tissue Antigens, 72 (6), 507-516. doi: 10.1111/j.1399-0039.2008.01139.x
Supervision
Availability
- Honorary Professor Geoffrey Hill is:
- Available for supervision
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Supervision history
Completed supervision
-
2019
Doctor Philosophy
Restoring myeloma-immune equilibrium by stem cell transplantation
Principal Advisor
-
2019
Doctor Philosophy
Understanding the role of IL-6 signalling in Graft-Versus-Host Disease (GVHD)
Principal Advisor
-
2019
Doctor Philosophy
Anti-leukaemia effect of Interferons
Principal Advisor
Other advisors: Professor Steven Lane
-
2012
Doctor Philosophy
Mechanisms of Immune Modulation after Stem Cell Transplantation
Principal Advisor
-
2021
Doctor Philosophy
Interplay between cytomegalovirus infection and graft-versus-leukaemia effect
Associate Advisor
-
2019
Doctor Philosophy
The contribution of cytokine signals, autophagy and antigen presentation to complications associated with allogeneic stem cell transplantation
Associate Advisor
-
2019
Doctor Philosophy
The Psychosocial Impact of Haematopoietic Stem Cell Donation on Adult Related Donors
Associate Advisor
-
2017
Doctor Philosophy
Maintenance of blood stem cells and the development of haematological malignancies
Associate Advisor
Other advisors: Professor Steven Lane
-
2016
Doctor Philosophy
Stem Cell Therapies and Radiological Imaging in Ataxia Telangiectasia
Associate Advisor
Other advisors: Professor Ernst Wolvetang
-
2014
Doctor Philosophy
Immune mediators of alloreactive responses in allogeneic stem cell transplantation and in pregnancy-induced microchimerism
Associate Advisor
Other advisors: Professor Kiarash Khosrotehrani
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2012
Doctor Philosophy
Self-renewal pathways in leukaemia stem cells and haematopoietic stem cells
Associate Advisor
-
2012
Doctor Philosophy
T cell immune response to human cytomegalovirus in latency and reactivation
Associate Advisor
-
2011
Doctor Philosophy
Antigen Presentation and Inflammation in Allogeneic Bone Marrow Transplantation
Associate Advisor
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Associate Advisor
Other advisors: Professor Ian Frazer
Media
Enquiries
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