Associate Professor Jane Nikles
Associate Professor

Jane Nikles

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Background

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Availability

Associate Professor Jane Nikles is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments

  • Single Case Experimental Designs

  • Whiplash, minor musculoskeletal injury, opioid prescribing

  • ADHD, children, sleep

  • Melatonin

  • Parkinson's Disease

  • Skin cancer prevention, improving children's sun protection practices

Search Professor Jane Nikles’s works on UQ eSpace

188 works between 1983 and 2026
All (188) Book (3) Journal Article (86) Other Outputs (4) Conference Publication (89) Book Chapter (6)

1 - 20 of 188 works

Featured

2014

Journal Article

Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury: a pilot study

Nikles, Catherine J., McKinlay, Lynne, Mitchell, Geoffrey K., Carmont, Sue-Ann S., Senior, Hugh E., Waugh, Mary-Clare A., Epps, Adrienne, Schluter, Philip J. and Lloyd, Owen T. (2014). Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury: a pilot study. Trials, 15 (54) 54, 1-11. doi: 10.1186/1745-6215-15-54

Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury: a pilot study

Featured

2013

Journal Article

Do pilocarpine drops help dry mouth in palliative care patients: a protocol for an aggregated series of n-of-1 trials

Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Agar, Meera, Senior, Hugh, Carmont, Sue-Ann, Schluter, Philip J., Good, Phillip, Vora, Rohan and Currow, David (2013). Do pilocarpine drops help dry mouth in palliative care patients: a protocol for an aggregated series of n-of-1 trials. BMC Palliative Care, 12 (39) 39, 1-15. doi: 10.1186/1472-684X-12-39

Do pilocarpine drops help dry mouth in palliative care patients: a protocol for an aggregated series of n-of-1 trials

Featured

2013

Journal Article

Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials

Senior, Hugh E. J., McKinlay, Lynne, Nikles, Jane, Schluter, Philip J., Carmont, Sue-Ann, Waugh, Mary-Clare, Epps, Adrienne, Lloyd, Owen and Mitchell, Geoffrey K. (2013). Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials. BMC Pediatrics, 13 (1) 89, 89.1-89.7. doi: 10.1186/1471-2431-13-89

Central nervous system stimulants for secondary attention deficit-hyperactivity disorder after paediatric traumatic brain injury: a rationale and protocol for single patient (n-of-1) multiple cross-over trials

Featured

2013

Journal Article

Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol

Senior, Hugh E. J., Mitchell, Geoffrey K., Nikles, Jane, Carmont, Sue-Ann, Schluter, Philip J., Currow, David C., Vora, Rohan, Yelland, Michael J., Agar, Meera, Good, Phillip D. and Hardy, Janet R. (2013). Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol. BMC Palliative Care, 12 (1) 17, 17.1-17.6. doi: 10.1186/1472-684X-12-17

Using aggregated single patient (N-of-1) trials to determine the effectiveness of psychostimulants to reduce fatigue in advanced cancer patients: a rationale and protocol

Featured

2012

Journal Article

Amphetamines for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents (Protocol)

Punja, Salima, Shamseer, Larissa, Hartling, Lisa, Urichuk, Liana, Vandermeer, Ben, Nikles, Catherine J. and Vohra, Sunita (2012). Amphetamines for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents (Protocol). Cochrane Database of Systematic Reviews (7). doi: 10.1002/14651858.CD009996

Amphetamines for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents (Protocol)

Featured

2012

Conference Publication

Impact of the SunSmart Early Childhood Program in Queensland

Harrison, Simone, Saunders, Vicki and Nikles, Jane (2012). Impact of the SunSmart Early Childhood Program in Queensland. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.

Impact of the SunSmart Early Childhood Program in Queensland

Featured

2011

Journal Article

Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: The case of palliative care

Nikles, Jane, Mitchell, Geoffrey K., Schluter, Philip, Good, Phillip, Hardy, Janet, Rowett, Debra, Shelby-James, Tania, Vohra, Sunita and Currow, David (2011). Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: The case of palliative care. Journal of Clinical Epidemiology, 64 (5), 471-480. doi: 10.1016/j.jclinepi.2010.05.009

Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: The case of palliative care

Featured

2010

Journal Article

Pilot study to determine the optimal dose of methylphenidate for an n-of-1 trial for fatigue in patients with cancer

Hardy, Janet Rea, Carmont, Sue-Ann S., O'Shea, Angela, Vora, Rohan, Schluter, Philip, Nikles, Catherine Jane and Mitchell, Geoffrey Keith (2010). Pilot study to determine the optimal dose of methylphenidate for an n-of-1 trial for fatigue in patients with cancer. Journal of Palliative Medicine, 13 (10), 1193-1197. doi: 10.1089/jpm.2010.0185

Pilot study to determine the optimal dose of methylphenidate for an n-of-1 trial for fatigue in patients with cancer

Featured

2010

Journal Article

Using N-of-1 Trials to improve patient management and save costs

Scuffham, Paul A., Nikles, Jane, Mitchell, Geoffrey K., Yelland, Michael J., Vine, Norma, Poulos, Christopher J., Pillans, Peter I., Bashford, Guy, del Mar, Chris, Schluter, Philip J. and Glasziou, Paul (2010). Using N-of-1 Trials to improve patient management and save costs. Journal of General Internal Medicine, 25 (9), 906-913. doi: 10.1007/s11606-010-1352-7

Using N-of-1 Trials to improve patient management and save costs

Featured

2010

Journal Article

Stakeholders' views on the routine use of n-of-1 trials to improve clinical care and to make resource allocation decisions for drug use

Nikles, Jane, Mitchell, Geoffrey K., Clavarino, Alexandra, Yelland, Michael J. and Del Mar, Christopher B. (2010). Stakeholders' views on the routine use of n-of-1 trials to improve clinical care and to make resource allocation decisions for drug use. Australian Health Review, 34 (1), 131-136. doi: 10.1071/AH09654

Stakeholders' views on the routine use of n-of-1 trials to improve clinical care and to make resource allocation decisions for drug use

Featured

2009

Journal Article

Prioritising drugs for single patient (n-of-1) trials in palliative care

Nikles, J., Mitchell, G., Walters, J., Hardy, J., Good, P., Rowett, D., Shelby-James, T. and Currow, D. (2009). Prioritising drugs for single patient (n-of-1) trials in palliative care. Palliative Medicine, 23 (7), 623-634. doi: 10.1177/0269216309106461

Prioritising drugs for single patient (n-of-1) trials in palliative care

Featured

2009

Journal Article

N-of-1 Randomized Trials to Assess the Efficacy of Gabapentin for Chronic Neuropathic Pain

Yelland, Michael J., Poulos, Christopher J., Pillans, Peter I., Bashford, Guy M., Nikles, Catherine Jane, Sturtevant, Joanna M., Vine, Norma, Del Mar, Christopher, Schluter, Philip J., Tan, Meng, Chan, Jonathon, Mackenzie, Fraser and Brown, Robyn (2009). N-of-1 Randomized Trials to Assess the Efficacy of Gabapentin for Chronic Neuropathic Pain. Pain Medicine, 10 (4), 754-761. doi: 10.1111/j.1526-4637.2009.00615.x

N-of-1 Randomized Trials to Assess the Efficacy of Gabapentin for Chronic Neuropathic Pain

Featured

2008

Journal Article

Are N-of-1 trials an economically viable option to improve access to selected high cost medications? The Australian experience

Scuffham, P. A., Yelland, M. J., Nikles, C. J., Pietrzak, E. and Wilkinson, D. (2008). Are N-of-1 trials an economically viable option to improve access to selected high cost medications? The Australian experience. Value in Health, 11 (1), 97-109. doi: 10.1111/j.1524-4733.2007.00218.x

Are N-of-1 trials an economically viable option to improve access to selected high cost medications? The Australian experience

Featured

2007

Journal Article

Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorder

Nikles, C. Jane, Mitchell, Geoffrey K., Del Mar, Chris B., McNairn, Norma and Clavarino, Alexandra (2007). Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorder. European Journal of Clinical Pharmacology, 63 (11), 985-989. doi: 10.1007/s00228-007-0361-x

Long-term changes in management following n-of-1 trials of stimulants in attention-deficit/hyperactivity disorder

Featured

2007

Journal Article

Celecoxib compared with sustained release paracetamol for osteoarthritis: a series of n-of-1 trials

Yelland, M. J., Nikles, C. J., McNairn, N., Del Mar, C. B., Schluter, P. J. and Brown, R. M. (2007). Celecoxib compared with sustained release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatology, 46 (1), 135-140. doi: 10.1093/rheumatology/kel195

Celecoxib compared with sustained release paracetamol for osteoarthritis: a series of n-of-1 trials

Featured

2006

Other Outputs

Using n-of-1 trials as a diagnostic clinical tool

Nikles, Jane (2006). Using n-of-1 trials as a diagnostic clinical tool. PhD Thesis, Population Health, The University of Queensland.

Using n-of-1 trials as a diagnostic clinical tool

Featured

2006

Journal Article

An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder

Nikles, C. J., Mitchell, G. K., Del Mar, C. B., Clavarino, A. and McNairn, N. (2006). An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder. Pediatrics, 117 (6), 2040-2046. doi: 10.1542/peds.2005-1328

An n-of-1 trial service in clinical practice: Testing the effectiveness of stimulants for attention-deficit/hyperactivity disorder

Featured

2005

Journal Article

Using n-of-1 trials as a clinical tool to improve prescribing

Nikles, C. J., Clavarino, A. M. and Del Mar, C. B. (2005). Using n-of-1 trials as a clinical tool to improve prescribing. British Journal Of General Practice, 55 (512), 175-180.

Using n-of-1 trials as a clinical tool to improve prescribing

Featured

2005

Journal Article

The role of paracetamol in chronic pain: An evidence-based approach

Nikles, C. J., Yelland, M., Del Mar, C. and Wilkinson, D. (2005). The role of paracetamol in chronic pain: An evidence-based approach. American Journal of Therapeutics, 12 (1), 80-91. doi: 10.1097/00045391-200501000-00011

The role of paracetamol in chronic pain: An evidence-based approach

Featured

2003

Journal Article

Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-I trials

Coxeter, P. D., Schluter, P. J., Eastwood, H. L., Nikles, C. J. and Glasziou, P. P. (2003). Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-I trials. Complementary Therapies In Medicine, 11 (4), 215-222. doi: 10.1016/S0965-2299(03)00122-5

Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-I trials

Availability

Associate Professor Jane Nikles is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Available projects

  • Opioid use and misuse following road traffic musculoskeletal injury

    Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

Supervision history

Completed supervision

Enquiries

Contact Associate Professor Jane Nikles directly for media enquiries about:

  • ADHD
  • children
  • Clinical trials
  • General practice research
  • individualised treatments
  • melatonin
  • N-of-1 trials
  • Parkinson's Disease
  • Personalised medicine
  • Single Case Experimental Designs
  • sleep

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