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Associate Professor Jane Nikles
Associate Professor

Jane Nikles

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Overview

Background

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Availability

Associate Professor Jane Nikles is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments

  • Single Case Experimental Designs

  • Whiplash, minor musculoskeletal injury, opioid prescribing

  • ADHD, children, sleep

  • Melatonin

  • Parkinson's Disease

  • Skin cancer prevention, improving children's sun protection practices

Works

Search Professor Jane Nikles’s works on UQ eSpace

188 works between 1983 and 2026

41 - 60 of 188 works

2021

Journal Article

N-of-1 trials in neurology: a systematic review

Stunnenberg, Bas C, Berends, Joost, Griggs, Robert C, Statland, Jeffrey, Drost, Gea, Nikles, Jane, Groenewoud, Hans, van Engelen, Baziel G.M., Jan van der Wilt, Gert and Raaphorst, Joost (2021). N-of-1 trials in neurology: a systematic review. Neurology, 98 (2), e174-e185. doi: 10.1212/wnl.0000000000012998

N-of-1 trials in neurology: a systematic review

2021

Journal Article

Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study

Ritchie, Carrie, Clanchy, Kelly, Sterling, Michele, Tate, Robyn, Smits, Esther J., Day, Melissa, Nikles, Jane, Liimatainen, Jenna and Tweedy, Sean M. (2021). Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study. Disability and Rehabilitation, 44 (23), 1-14. doi: 10.1080/09638288.2021.1989062

Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study

2021

Conference Publication

A systematic review of N-of-1 studies in musculoskeletal physiotherapy

Hams, A., Evans, K., Sterling, M. and Nikles, J. (2021). A systematic review of N-of-1 studies in musculoskeletal physiotherapy. Australian Physiotherapy Association conference , Brisbane, Australia, October 2021.

A systematic review of N-of-1 studies in musculoskeletal physiotherapy

2021

Conference Publication

N-of-1 Trials of Melatonin For Insomnia In Stimulant-Treated Children With ADHD (Poster and Abstract)

Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2021). N-of-1 Trials of Melatonin For Insomnia In Stimulant-Treated Children With ADHD (Poster and Abstract). UQ Medical Student research conference & showcase, Brisbane, QLD Australia, October 2021.

N-of-1 Trials of Melatonin For Insomnia In Stimulant-Treated Children With ADHD (Poster and Abstract)

2021

Journal Article

Correction to: Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: A protocol for a feasibility and acceptability study

McDonald, Suzanne, Tan, Samuel X., Banu, Shamima, van Driel, Mieke, McGree, James M., Mitchell, Geoffrey and Nikles, Jane (2021). Correction to: Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: A protocol for a feasibility and acceptability study. The Patient - Patient-Centered Outcomes Research, 15 (2), 267-267. doi: 10.1007/s40271-021-00549-5

Correction to: Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: A protocol for a feasibility and acceptability study

2021

Journal Article

Establishment of an international collaborative network for N-of-1 trials and single-case designs

Nikles, Jane, Onghena, Patrick, Vlaeyen, Johan W.S., Wicksell, Rikard K., Simons, Laura E., McGree, James M. and McDonald, Suzanne (2021). Establishment of an international collaborative network for N-of-1 trials and single-case designs. Contemporary Clinical Trials Communications, 23 100826, 1-8. doi: 10.1016/j.conctc.2021.100826

Establishment of an international collaborative network for N-of-1 trials and single-case designs

2021

Journal Article

Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: a protocol for a feasibility and acceptability study

McDonald, Suzanne, Tan, Samuel X., Banu, Shamima, van Driel, Mieke, McGree, James M., Mitchell, Geoffrey and Nikles, Jane (2021). Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: a protocol for a feasibility and acceptability study. The Patient - Patient-Centered Outcomes Research, 15 (2), 197-206. doi: 10.1007/s40271-021-00540-0

Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: a protocol for a feasibility and acceptability study

2021

Journal Article

N-of-1 trials in healthcare

McDonald, Suzanne and Nikles, Jane (2021). N-of-1 trials in healthcare. Healthcare, 9 (3) 330, 330. doi: 10.3390/healthcare9030330

N-of-1 trials in healthcare

2021

Journal Article

Editorial: creating evidence from real world patient digital data

Nikles, Jane, Daza, Eric J., McDonald, Suzanne, Hekler, Eric and Schork, Nicholas J. (2021). Editorial: creating evidence from real world patient digital data. Frontiers in Computer Science, 2 636996. doi: 10.3389/fcomp.2020.636996

Editorial: creating evidence from real world patient digital data

2021

Book

Creating Evidence from Real World Patient Digital Data

Nikles, Jane, Daza, Eric J., McDonald, Suzanne, Hekler, Eric and Schork, Nicholas eds. (2021). Creating Evidence from Real World Patient Digital Data. Frontiers Research Topics, Lausanne, Switzerland: Frontiers Research Foundation. doi: 10.3389/978-2-88966-671-3

Creating Evidence from Real World Patient Digital Data

2020

Conference Publication

Comparison of parental expectations and clinical cut-off for improvement in sleep onset latency in children with ADHD on stimulants

Heussler, H., Ong, J., Price, A., McGree, J., Mitchell, G., Senior, H. and Nikles, J. (2020). Comparison of parental expectations and clinical cut-off for improvement in sleep onset latency in children with ADHD on stimulants. Herston Health Precinct Symposium, Brisbane, QLD Australia, December 2020.

Comparison of parental expectations and clinical cut-off for improvement in sleep onset latency in children with ADHD on stimulants

2020

Conference Publication

The Value of N-of-1 Clinical Trials and Single-Case Designs in Clinical Research

McDonald, S. and Nikles, J. (2020). The Value of N-of-1 Clinical Trials and Single-Case Designs in Clinical Research. Herston Health Precinct Symposium, Brisbane, Australia, December 2020.

The Value of N-of-1 Clinical Trials and Single-Case Designs in Clinical Research

2020

Conference Publication

Melatonin for insomnia in children with attention deficit hyperactivity disorder (ADHD) on stimulants

Nikles, J., Mitchell, G., Heussler, H., Price, A., McGree, J. and Ong, J. (2020). Melatonin for insomnia in children with attention deficit hyperactivity disorder (ADHD) on stimulants. Herston Health Precinct Symposium, Brisbane, QLD Australia, December 2020.

Melatonin for insomnia in children with attention deficit hyperactivity disorder (ADHD) on stimulants

2020

Conference Publication

N-Of-1 trials of melatonin for insomnia in stimulant-treated children with ADHD

Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2020). N-Of-1 trials of melatonin for insomnia in stimulant-treated children with ADHD. UQ Medical Student research conference and showcase, Brisbane, QLD, Australia, October 2020.

N-Of-1 trials of melatonin for insomnia in stimulant-treated children with ADHD

2020

Journal Article

Exercise improves the health and well‐being of people with dementia

Neville, Christine C., Nikles, Catherine J., Neville, Emily K., Zamora, Angelique and Banu, Shamima (2020). Exercise improves the health and well‐being of people with dementia. Australasian Journal on Ageing, 39 (3), 311-312. doi: 10.1111/ajag.12837

Exercise improves the health and well‐being of people with dementia

2020

Journal Article

A systematic review of the effectiveness of sleep hygiene in children with ADHD

Nikles, Jane, Mitchell, Geoffrey Keith, de Miranda Araújo, Rossiniê, Harris, Thomas, Heussler, Helen S., Punja, Salima, Vohra, Sunita and Senior, Hugh Edgar John (2020). A systematic review of the effectiveness of sleep hygiene in children with ADHD. Psychology, Health and Medicine, 25 (4), 497-518. doi: 10.1080/13548506.2020.1732431

A systematic review of the effectiveness of sleep hygiene in children with ADHD

2020

Journal Article

Protocol for a longitudinal study of melatonin therapy and cost effectiveness analysis in stimulant-treated children with ADHD and insomnia: an N-of-1 trial

Edelson, Jaclyn, Byrnes, Josh, Mitchell, Geoffrey, Heussler, Helen, Melaku, Megdelawit and Nikles, Jane (2020). Protocol for a longitudinal study of melatonin therapy and cost effectiveness analysis in stimulant-treated children with ADHD and insomnia: an N-of-1 trial. Contemporary Clinical Trials Communications, 17 100530, 100530. doi: 10.1016/j.conctc.2020.100530

Protocol for a longitudinal study of melatonin therapy and cost effectiveness analysis in stimulant-treated children with ADHD and insomnia: an N-of-1 trial

2019

Conference Publication

A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury

Nikles, J., Khan, S., Leou, J., Ng, J., Bond, C., Nakamura, G., Le, R. and Sterling, M. (2019). A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. Brispain, Brisbane, Australia, December 2019.

A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury

2019

Journal Article

Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design

Nikles, J., Tate, R. L., Mitchell, G., Perdices, M., McGree, J. M., Freeman, C., Jacob, S., Taing, M. W. and Sterling, M. (2019). Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design. Contemporary Clinical Trials Communications, 16 100480, 100480. doi: 10.1016/j.conctc.2019.100480

Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design

2019

Journal Article

Evaluation of a novel intervention to improve physical activity for adults with whiplash associated disorders: Protocol for a multiple-baseline, single case experimental study

Clanchy, Kelly M., Tweedy, Sean M., Tate, Robyn L., Sterling, Michele, Day, Melissa A., Nikles, Jane and Ritchie, Carrie (2019). Evaluation of a novel intervention to improve physical activity for adults with whiplash associated disorders: Protocol for a multiple-baseline, single case experimental study. Contemporary Clinical Trials Communications, 16 100455, 100455. doi: 10.1016/j.conctc.2019.100455

Evaluation of a novel intervention to improve physical activity for adults with whiplash associated disorders: Protocol for a multiple-baseline, single case experimental study

Supervision

Availability

Associate Professor Jane Nikles is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Available projects

  • Opioid use and misuse following road traffic musculoskeletal injury

    Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

Media

Enquiries

Contact Associate Professor Jane Nikles directly for media enquiries about:

  • ADHD
  • children
  • Clinical trials
  • General practice research
  • individualised treatments
  • melatonin
  • N-of-1 trials
  • Parkinson's Disease
  • Personalised medicine
  • Single Case Experimental Designs
  • sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au