Overview
Background
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
-
Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
-
Single Case Experimental Designs
-
Whiplash, minor musculoskeletal injury, opioid prescribing
-
ADHD, children, sleep
-
Melatonin
-
Parkinson's Disease
-
Skin cancer prevention, improving children's sun protection practices
Works
Search Professor Jane Nikles’s works on UQ eSpace
2021
Journal Article
Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study
Ritchie, Carrie, Clanchy, Kelly, Sterling, Michele, Tate, Robyn, Smits, Esther J., Day, Melissa, Nikles, Jane, Liimatainen, Jenna and Tweedy, Sean M. (2021). Evaluation of a physical activity promotion intervention for adults with whiplash associated disorders: a single-case experimental design study. Disability and Rehabilitation, 44 (23), 1-14. doi: 10.1080/09638288.2021.1989062
2021
Conference Publication
A systematic review of N-of-1 studies in musculoskeletal physiotherapy
Hams, A., Evans, K., Sterling, M. and Nikles, J. (2021). A systematic review of N-of-1 studies in musculoskeletal physiotherapy. Australian Physiotherapy Association conference , Brisbane, Australia, October 2021.
2021
Conference Publication
N-of-1 Trials of Melatonin For Insomnia In Stimulant-Treated Children With ADHD (Poster and Abstract)
Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2021). N-of-1 Trials of Melatonin For Insomnia In Stimulant-Treated Children With ADHD (Poster and Abstract). UQ Medical Student research conference & showcase, Brisbane, QLD Australia, October 2021.
2021
Journal Article
Correction to: Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: A protocol for a feasibility and acceptability study
McDonald, Suzanne, Tan, Samuel X., Banu, Shamima, van Driel, Mieke, McGree, James M., Mitchell, Geoffrey and Nikles, Jane (2021). Correction to: Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: A protocol for a feasibility and acceptability study. The Patient - Patient-Centered Outcomes Research, 15 (2), 267-267. doi: 10.1007/s40271-021-00549-5
2021
Journal Article
Establishment of an international collaborative network for N-of-1 trials and single-case designs
Nikles, Jane, Onghena, Patrick, Vlaeyen, Johan W.S., Wicksell, Rikard K., Simons, Laura E., McGree, James M. and McDonald, Suzanne (2021). Establishment of an international collaborative network for N-of-1 trials and single-case designs. Contemporary Clinical Trials Communications, 23 100826, 1-8. doi: 10.1016/j.conctc.2021.100826
2021
Journal Article
Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: a protocol for a feasibility and acceptability study
McDonald, Suzanne, Tan, Samuel X., Banu, Shamima, van Driel, Mieke, McGree, James M., Mitchell, Geoffrey and Nikles, Jane (2021). Exploring symptom fluctuations and triggers in myalgic encephalomyelitis/chronic fatigue syndrome using novel patient-centred N-of-1 observational designs: a protocol for a feasibility and acceptability study. The Patient - Patient-Centered Outcomes Research, 15 (2), 197-206. doi: 10.1007/s40271-021-00540-0
2021
Journal Article
N-of-1 trials in healthcare
McDonald, Suzanne and Nikles, Jane (2021). N-of-1 trials in healthcare. Healthcare, 9 (3) 330, 330. doi: 10.3390/healthcare9030330
2021
Journal Article
Editorial: creating evidence from real world patient digital data
Nikles, Jane, Daza, Eric J., McDonald, Suzanne, Hekler, Eric and Schork, Nicholas J. (2021). Editorial: creating evidence from real world patient digital data. Frontiers in Computer Science, 2 636996. doi: 10.3389/fcomp.2020.636996
2021
Book
Creating Evidence from Real World Patient Digital Data
Nikles, Jane, Daza, Eric J., McDonald, Suzanne, Hekler, Eric and Schork, Nicholas eds. (2021). Creating Evidence from Real World Patient Digital Data. Frontiers Research Topics, Lausanne, Switzerland: Frontiers Research Foundation. doi: 10.3389/978-2-88966-671-3
2020
Conference Publication
The Value of N-of-1 Clinical Trials and Single-Case Designs in Clinical Research
McDonald, S. and Nikles, J. (2020). The Value of N-of-1 Clinical Trials and Single-Case Designs in Clinical Research. Herston Health Precinct Symposium, Brisbane, Australia, December 2020.
2020
Conference Publication
Melatonin for insomnia in children with attention deficit hyperactivity disorder (ADHD) on stimulants
Nikles, J., Mitchell, G., Heussler, H., Price, A., McGree, J. and Ong, J. (2020). Melatonin for insomnia in children with attention deficit hyperactivity disorder (ADHD) on stimulants. Herston Health Precinct Symposium, Brisbane, QLD Australia, December 2020.
2020
Conference Publication
Comparison of parental expectations and clinical cut-off for improvement in sleep onset latency in children with ADHD on stimulants
Heussler, H., Ong, J., Price, A., McGree, J., Mitchell, G., Senior, H. and Nikles, J. (2020). Comparison of parental expectations and clinical cut-off for improvement in sleep onset latency in children with ADHD on stimulants. Herston Health Precinct Symposium, Brisbane, QLD Australia, December 2020.
2020
Conference Publication
N-Of-1 trials of melatonin for insomnia in stimulant-treated children with ADHD
Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2020). N-Of-1 trials of melatonin for insomnia in stimulant-treated children with ADHD. UQ Medical Student research conference and showcase, Brisbane, QLD, Australia, October 2020.
2020
Journal Article
Exercise improves the health and well‐being of people with dementia
Neville, Christine C., Nikles, Catherine J., Neville, Emily K., Zamora, Angelique and Banu, Shamima (2020). Exercise improves the health and well‐being of people with dementia. Australasian Journal on Ageing, 39 (3), 311-312. doi: 10.1111/ajag.12837
2020
Journal Article
A systematic review of the effectiveness of sleep hygiene in children with ADHD
Nikles, Jane, Mitchell, Geoffrey Keith, de Miranda Araújo, Rossiniê, Harris, Thomas, Heussler, Helen S., Punja, Salima, Vohra, Sunita and Senior, Hugh Edgar John (2020). A systematic review of the effectiveness of sleep hygiene in children with ADHD. Psychology, Health and Medicine, 25 (4), 497-518. doi: 10.1080/13548506.2020.1732431
2020
Journal Article
Protocol for a longitudinal study of melatonin therapy and cost effectiveness analysis in stimulant-treated children with ADHD and insomnia: an N-of-1 trial
Edelson, Jaclyn, Byrnes, Josh, Mitchell, Geoffrey, Heussler, Helen, Melaku, Megdelawit and Nikles, Jane (2020). Protocol for a longitudinal study of melatonin therapy and cost effectiveness analysis in stimulant-treated children with ADHD and insomnia: an N-of-1 trial. Contemporary Clinical Trials Communications, 17 100530, 100530. doi: 10.1016/j.conctc.2020.100530
2019
Journal Article
Evaluation of a novel intervention to improve physical activity for adults with whiplash associated disorders: Protocol for a multiple-baseline, single case experimental study
Clanchy, Kelly M., Tweedy, Sean M., Tate, Robyn L., Sterling, Michele, Day, Melissa A., Nikles, Jane and Ritchie, Carrie (2019). Evaluation of a novel intervention to improve physical activity for adults with whiplash associated disorders: Protocol for a multiple-baseline, single case experimental study. Contemporary Clinical Trials Communications, 16 100455, 100455. doi: 10.1016/j.conctc.2019.100455
2019
Conference Publication
A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury
Nikles, J., Khan, S., Leou, J., Ng, J., Bond, C., Nakamura, G., Le, R. and Sterling, M. (2019). A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. Brispain, Brisbane, Australia, December 2019.
2019
Journal Article
Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design
Nikles, J., Tate, R. L., Mitchell, G., Perdices, M., McGree, J. M., Freeman, C., Jacob, S., Taing, M. W. and Sterling, M. (2019). Personalised treatments for acute whiplash injuries: A pilot study of nested N-of-1 trials in a multiple baseline single-case experimental design. Contemporary Clinical Trials Communications, 16 100480, 100480. doi: 10.1016/j.conctc.2019.100480
2019
Journal Article
Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies
Blackston, J. Walker, Chapple, Andrew G., McGree, James M., McDonald, Suzanne and Nikles, Jane (2019). Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies. Healthcare, 7 (4), 137-13. doi: 10.3390/healthcare7040137
Funding
Current funding
Supervision
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Opioid use and misuse following road traffic musculoskeletal injury
Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.
-
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.
Please contact me on uqjnikle@uq.edu.au to discuss several available projects.
Supervision history
Completed supervision
-
2019
Doctor Philosophy
N-of-1 Trials as a Bioequivalence Method to assess local medicines in resources limited countries: the case of Anti-hypertensive Medicines in Ethiopia
Associate Advisor
Media
Enquiries
Contact Associate Professor Jane Nikles directly for media enquiries about:
- ADHD
- children
- Clinical trials
- General practice research
- individualised treatments
- melatonin
- N-of-1 trials
- Parkinson's Disease
- Personalised medicine
- Single Case Experimental Designs
- sleep
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: