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Associate Professor Jane Nikles
Associate Professor

Jane Nikles

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Overview

Background

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Availability

Associate Professor Jane Nikles is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments

  • Single Case Experimental Designs

  • Whiplash, minor musculoskeletal injury, opioid prescribing

  • ADHD, children, sleep

  • Melatonin

  • Parkinson's Disease

  • Skin cancer prevention, improving children's sun protection practices

Works

Search Professor Jane Nikles’s works on UQ eSpace

188 works between 1983 and 2026

61 - 80 of 188 works

2019

Journal Article

Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies

Blackston, J. Walker, Chapple, Andrew G., McGree, James M., McDonald, Suzanne and Nikles, Jane (2019). Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies. Healthcare, 7 (4) 137, 137-13. doi: 10.3390/healthcare7040137

Comparison of aggregated N-of-1 trials with parallel and crossover randomized controlled trials using simulation studies

2019

Journal Article

Acceptability and barriers to implementation of N-of-1 tests in Ethiopia-a qualitative study

Alemayehu, Chalachew, Mitchell, Geoff, Nikles, Jane, Aseffa, Abraham and Clavarino, Alexandra (2019). Acceptability and barriers to implementation of N-of-1 tests in Ethiopia-a qualitative study. BMC Medical Research Methodology, 19 (1) 192, 192. doi: 10.1186/s12874-019-0832-7

Acceptability and barriers to implementation of N-of-1 tests in Ethiopia-a qualitative study

2019

Conference Publication

N-of-1 Trials in Clinical Research: Opportunities and Challenges

McDonald, S. and Nikles, J. (2019). N-of-1 Trials in Clinical Research: Opportunities and Challenges. ACTA International Clinical Trials Conference, Sydney, Australia, October 2019.

N-of-1 Trials in Clinical Research: Opportunities and Challenges

2019

Conference Publication

An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial

Neville, C., Beatty, E., Field, E., Pavey, T., Dawson, R., Nikles, J., Neville, E., Lindgren, A. and Banu, S. (2019). An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial. UQ Medical Student research conference, Brisbane, Australia, October 2019.

An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial

2019

Conference Publication

Interim findings of the n-of-1 trials of melatonin for Insomnia in stimulant-treated children with ADHD

Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2019). Interim findings of the n-of-1 trials of melatonin for Insomnia in stimulant-treated children with ADHD. UQ Medical Student research conference and showcase, Brisbane, QLD Australia, October 2019.

Interim findings of the n-of-1 trials of melatonin for Insomnia in stimulant-treated children with ADHD

2019

Journal Article

Protocol: using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease

Nikles, J., O'Sullivan, J. D., Mitchell, G. K., Smith, S. S., McGree, J. M., Senior, H., Dissanyaka, N. and Ritchie, A. (2019). Protocol: using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease. Contemporary Clinical Trials Communications, 15 100397, 100397. doi: 10.1016/j.conctc.2019.100397

Protocol: using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease

2019

Conference Publication

Understanding Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using Scientific Insights from N-of-1 Studies

McDonald, S., Tan, S., Banu, S., McGree, J., Mitchell, G. and Nikles, J. (2019). Understanding Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using Scientific Insights from N-of-1 Studies. Division of Health Psychology Annual conference, Manchester, United Kingdom, July 2019.

Understanding Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using Scientific Insights from N-of-1 Studies

2019

Journal Article

Normes de présentation de recherche utilisant les protocoles à cas unique en interventions comportementales (SCRIBE-2016)

Tate, R. L., Perdices, M., Rosenkoetter, U., Shadish, W., Vohra, S., Barlow, D. H., Horner, R., Kazdin, A., Kratochwill, T., McDonald, S., Sampson, M., Shamseer, L., Togher, L., Albin, R., Backman, C., Douglas, J., Evans, J. J., Gast, D., Manolov, R., Mitchell, G., Nickels, L., Nikles, J., Ownsworth, T., Rose, M., Schmid, C. H. and Wilson, B. (2019). Normes de présentation de recherche utilisant les protocoles à cas unique en interventions comportementales (SCRIBE-2016). Pratiques Psychologiques, 25 (2), 103-117. doi: 10.1016/j.prps.2018.11.001

Normes de présentation de recherche utilisant les protocoles à cas unique en interventions comportementales (SCRIBE-2016)

2019

Conference Publication

A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury.

Nikles, J., Khan, S., Leou, J., Keizjers, G., Ng, J., Bond, C., Nakamura, G., Le, J., Le, R. and Sterling, M. (2019). A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. . Australian Pain Society multidisciplinary conference, Gold Coast, QLD, Australia, April 2019.

A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury.

2019

Conference Publication

Using N-of-1 methods to identify patterns and predictors of ME/CFS symptom exacerbations

McDonald, S., Tan, S., Banu, S., McGree, J., Mitchell, G. and Nikles, J. (2019). Using N-of-1 methods to identify patterns and predictors of ME/CFS symptom exacerbations. ME/CFS International Research Symposium., Geelong, VIC, Australia, March 2019.

Using N-of-1 methods to identify patterns and predictors of ME/CFS symptom exacerbations

2019

Journal Article

A retrospective descriptive observational study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury

Nikles, Jane, Khan, Subaat, Leou, John, Keijzers, Gerben, Ng, Joanna, Bond, Catherine, Nakamura, Gota, Le, Rhonda and Sterling, Michele (2019). A retrospective descriptive observational study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. Emergency Medicine Australiasia, 31 (5) 1742-6723.13253, 805-812. doi: 10.1111/1742-6723.13253

A retrospective descriptive observational study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury

2018

Journal Article

Use of and attitudes to the role of medication for acute whiplash injury: a preliminary survey of emergency department doctors: emergency department Whiplash Medication Survey

Nikles, Jane, Keijzers, Gerben, De Silva, Muthuwahandi Ishan Diluka, Khan, Subaat and Sterling, Michele (2018). Use of and attitudes to the role of medication for acute whiplash injury: a preliminary survey of emergency department doctors: emergency department Whiplash Medication Survey. Emergency Medicine Australasia, 31 (3), 471-474. doi: 10.1111/1742-6723.13190

Use of and attitudes to the role of medication for acute whiplash injury: a preliminary survey of emergency department doctors: emergency department Whiplash Medication Survey

2018

Journal Article

Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities

Alemayehu, Chalachew, Mitchell, Geoff, Nikles, Jane, Aseffa, Abraham and Clavarino, Alexandra (2018). Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities. BMC Health Services Research, 18 (1) 624, 624. doi: 10.1186/s12913-018-3410-5

Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities

2018

Journal Article

N-of-1 trials in the clinical care of patients in developing countries: a systematic review

Alemayehu, Chalachew, Nikles, Jane and Mitchell, Geoffrey (2018). N-of-1 trials in the clinical care of patients in developing countries: a systematic review. Trials, 19 (1) 246, 246. doi: 10.1186/s13063-018-2596-5

N-of-1 trials in the clinical care of patients in developing countries: a systematic review

2018

Journal Article

Herbal medicines used in the treatment of chronic insomnia and how they influence sleep patterns: a review

Harris, Thomas and Nikles, Jane (2018). Herbal medicines used in the treatment of chronic insomnia and how they influence sleep patterns: a review. Journal of Complementary Medicine and Alternative Healthcare, 6 (1). doi: 10.19080/JCMAH.2018.06.555680

Herbal medicines used in the treatment of chronic insomnia and how they influence sleep patterns: a review

2018

Journal Article

Barriers for conducting clinical trials in developing countries- A systematic review

Alemayehu, Chalachew, Mitchell, Geoffrey and Nikles, Jane (2018). Barriers for conducting clinical trials in developing countries- A systematic review. International Journal for Equity in Health, 17 (1) 37, 37. doi: 10.1186/s12939-018-0748-6

Barriers for conducting clinical trials in developing countries- A systematic review

2018

Journal Article

Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial

Nikles, J., Keijzers, G., Mitchell, G., Schug, S., Ware, R., McLean, S. A., Connelly, L., Gibson, S., Farrell, S. F. and Sterling, M. (2018). Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. Trials, 19 (1) 44, 1-11. doi: 10.1186/s13063-018-2450-9

Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial

2018

Conference Publication

Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials

Nikles, J., Heussler, H., McGree, J., Senior, H., Melaku, M. and Mitchell, G. (2018). Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials. UQCCR 10th Birthday, Brisbane, QLD Australia, 2018.

Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials

2018

Conference Publication

Protocol for cost effectiveness analysis and longitudinal study of melatonin therapy in children with ADHD and sleep problems: an N-of-1 trial

Edelson, Jaclyn, Nikles, Jane, Byrnes, Josh, Heussler, Helen, Mitchell,Geoff and Melaku, Megdi (2018). Protocol for cost effectiveness analysis and longitudinal study of melatonin therapy in children with ADHD and sleep problems: an N-of-1 trial. Louisiana Chapter of the American College of Physicians meeting, Louisiana, United States, 2018.

Protocol for cost effectiveness analysis and longitudinal study of melatonin therapy in children with ADHD and sleep problems: an N-of-1 trial

2018

Conference Publication

Acceptability and barriers to implementation of N-of-1 trials in a developing country: Ethiopia as a case study

Alemayehu, C., Mitchell, G., Aseffa, A., Nikles, J. and Clavarino, A. (2018). Acceptability and barriers to implementation of N-of-1 trials in a developing country: Ethiopia as a case study. 7th International Conference on Clinical Trials , Chicago, IL United States, 2018.

Acceptability and barriers to implementation of N-of-1 trials in a developing country: Ethiopia as a case study

Supervision

Availability

Associate Professor Jane Nikles is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Available projects

  • Opioid use and misuse following road traffic musculoskeletal injury

    Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

Media

Enquiries

Contact Associate Professor Jane Nikles directly for media enquiries about:

  • ADHD
  • children
  • Clinical trials
  • General practice research
  • individualised treatments
  • melatonin
  • N-of-1 trials
  • Parkinson's Disease
  • Personalised medicine
  • Single Case Experimental Designs
  • sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au