Overview
Background
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
-
Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
-
Single Case Experimental Designs
-
Whiplash, minor musculoskeletal injury, opioid prescribing
-
ADHD, children, sleep
-
Melatonin
-
Parkinson's Disease
-
Skin cancer prevention, improving children's sun protection practices
Works
Search Professor Jane Nikles’s works on UQ eSpace
2019
Journal Article
Acceptability and barriers to implementation of N-of-1 tests in Ethiopia-a qualitative study
Alemayehu, Chalachew, Mitchell, Geoff, Nikles, Jane, Aseffa, Abraham and Clavarino, Alexandra (2019). Acceptability and barriers to implementation of N-of-1 tests in Ethiopia-a qualitative study. BMC Medical Research Methodology, 19 (1) 192, 192. doi: 10.1186/s12874-019-0832-7
2019
Conference Publication
An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial
Neville, C., Beatty, E., Field, E., Pavey, T., Dawson, R., Nikles, J., Neville, E., Lindgren, A. and Banu, S. (2019). An aquatic exercise program to reduce behavioural and psychological symptoms in people with dementia: pilot study for a multi-centre, cluster-randomised, controlled trial. UQ Medical Student research conference, Brisbane, Australia, October 2019.
2019
Conference Publication
Interim findings of the n-of-1 trials of melatonin for Insomnia in stimulant-treated children with ADHD
Ong, J., Nikles, J., Senior, H., Mitchell, G., Heussler, H. and McGree, J. (2019). Interim findings of the n-of-1 trials of melatonin for Insomnia in stimulant-treated children with ADHD. UQ Medical Student research conference and showcase, Brisbane, QLD Australia, October 2019.
2019
Conference Publication
N-of-1 Trials in Clinical Research: Opportunities and Challenges
McDonald, S. and Nikles, J. (2019). N-of-1 Trials in Clinical Research: Opportunities and Challenges. ACTA International Clinical Trials Conference, Sydney, Australia, October 2019.
2019
Journal Article
Protocol: using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease
Nikles, J., O'Sullivan, J. D., Mitchell, G. K., Smith, S. S., McGree, J. M., Senior, H., Dissanyaka, N. and Ritchie, A. (2019). Protocol: using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease. Contemporary Clinical Trials Communications, 15 100397, 100397. doi: 10.1016/j.conctc.2019.100397
2019
Conference Publication
Understanding Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using Scientific Insights from N-of-1 Studies
McDonald, S., Tan, S., Banu, S., McGree, J., Mitchell, G. and Nikles, J. (2019). Understanding Symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome using Scientific Insights from N-of-1 Studies. Division of Health Psychology Annual conference, Manchester, United Kingdom, July 2019.
2019
Journal Article
Normes de présentation de recherche utilisant les protocoles à cas unique en interventions comportementales (SCRIBE-2016)
Tate, R. L., Perdices, M., Rosenkoetter, U., Shadish, W., Vohra, S., Barlow, D. H., Horner, R., Kazdin, A., Kratochwill, T., McDonald, S., Sampson, M., Shamseer, L., Togher, L., Albin, R., Backman, C., Douglas, J., Evans, J. J., Gast, D., Manolov, R., Mitchell, G., Nickels, L., Nikles, J., Ownsworth, T., Rose, M., Schmid, C. H. and Wilson, B. (2019). Normes de présentation de recherche utilisant les protocoles à cas unique en interventions comportementales (SCRIBE-2016). Pratiques Psychologiques, 25 (2), 103-117. doi: 10.1016/j.prps.2018.11.001
2019
Conference Publication
A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury.
Nikles, J., Khan, S., Leou, J., Keizjers, G., Ng, J., Bond, C., Nakamura, G., Le, J., Le, R. and Sterling, M. (2019). A retrospective descriptive study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. . Australian Pain Society multidisciplinary conference, Gold Coast, QLD, Australia, April 2019.
2019
Conference Publication
Using N-of-1 methods to identify patterns and predictors of ME/CFS symptom exacerbations
McDonald, S., Tan, S., Banu, S., McGree, J., Mitchell, G. and Nikles, J. (2019). Using N-of-1 methods to identify patterns and predictors of ME/CFS symptom exacerbations. ME/CFS International Research Symposium., Geelong, VIC, Australia, March 2019.
2019
Journal Article
A retrospective descriptive observational study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury
Nikles, Jane, Khan, Subaat, Leou, John, Keijzers, Gerben, Ng, Joanna, Bond, Catherine, Nakamura, Gota, Le, Rhonda and Sterling, Michele (2019). A retrospective descriptive observational study of patients who presented to an Australian hospital Emergency Department with neck soft tissue injury. Emergency Medicine Australiasia, 31 (5) 1742-6723.13253, 805-812. doi: 10.1111/1742-6723.13253
2018
Journal Article
Use of and attitudes to the role of medication for acute whiplash injury: a preliminary survey of emergency department doctors: emergency department Whiplash Medication Survey
Nikles, Jane, Keijzers, Gerben, De Silva, Muthuwahandi Ishan Diluka, Khan, Subaat and Sterling, Michele (2018). Use of and attitudes to the role of medication for acute whiplash injury: a preliminary survey of emergency department doctors: emergency department Whiplash Medication Survey. Emergency Medicine Australasia, 31 (3), 471-474. doi: 10.1111/1742-6723.13190
2018
Journal Article
Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities
Alemayehu, Chalachew, Mitchell, Geoff, Nikles, Jane, Aseffa, Abraham and Clavarino, Alexandra (2018). Views and perceptions about locally manufactured medicines in Ethiopia: a qualitative study of physicians, patients and regulatory authorities. BMC Health Services Research, 18 (1) 624, 624. doi: 10.1186/s12913-018-3410-5
2018
Journal Article
N-of-1 trials in the clinical care of patients in developing countries: a systematic review
Alemayehu, Chalachew, Nikles, Jane and Mitchell, Geoffrey (2018). N-of-1 trials in the clinical care of patients in developing countries: a systematic review. Trials, 19 (1) 246, 246. doi: 10.1186/s13063-018-2596-5
2018
Journal Article
Herbal medicines used in the treatment of chronic insomnia and how they influence sleep patterns: a review
Harris, Thomas and Nikles, Jane (2018). Herbal medicines used in the treatment of chronic insomnia and how they influence sleep patterns: a review. Journal of Complementary Medicine and Alternative Healthcare, 6 (1). doi: 10.19080/JCMAH.2018.06.555680
2018
Journal Article
Barriers for conducting clinical trials in developing countries- A systematic review
Alemayehu, Chalachew, Mitchell, Geoffrey and Nikles, Jane (2018). Barriers for conducting clinical trials in developing countries- A systematic review. International Journal for Equity in Health, 17 (1) 37, 37. doi: 10.1186/s12939-018-0748-6
2018
Journal Article
Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial
Nikles, J., Keijzers, G., Mitchell, G., Schug, S., Ware, R., McLean, S. A., Connelly, L., Gibson, S., Farrell, S. F. and Sterling, M. (2018). Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. Trials, 19 (1) 44, 1-11. doi: 10.1186/s13063-018-2450-9
2018
Conference Publication
A pilot aquatic exercise program to improve the health and wellbeing of people with dementia and their family carers
Neville, C., Zamora, A., Neville, E., Nikles, J., Lindgren, A. and Ansari, S. (2018). A pilot aquatic exercise program to improve the health and wellbeing of people with dementia and their family carers. UQ medical student research conference , Brisbane, QLD, Australia, 2018.
2018
Conference Publication
Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials
Nikles, J., Heussler, H. and McGree, J. (2018). Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials. NHMRC Symposium on Research Translation, Sydney, NSW Australia, 2018.
2018
Conference Publication
A retrospective descriptive study of patients who presented to an Australian hospital emergency department with neck soft tissue injury
Nikles, J., Khan, S., Leou, J., Keijzers, G., Ng, J., Bond, C., Nakamura, G., Le, R. and Sterling, M. (2018). A retrospective descriptive study of patients who presented to an Australian hospital emergency department with neck soft tissue injury. BrisPain Multidisciplinary conference, Brisbane, QLD, Australia, 6 December 2018.
2018
Conference Publication
Managing symptoms of ME/CFS using scientific insights from N-of-1 studies
Tan, S., McDonald, S., McGree, J., Mitchell, G. and Nikles, J. (2018). Managing symptoms of ME/CFS using scientific insights from N-of-1 studies. CFS/ME International Conference , Gold Coast, QLD, Australia, 2018.
Funding
Current funding
Supervision
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Opioid use and misuse following road traffic musculoskeletal injury
Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.
-
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.
Please contact me on uqjnikle@uq.edu.au to discuss several available projects.
Supervision history
Completed supervision
-
2019
Doctor Philosophy
N-of-1 Trials as a Bioequivalence Method to assess local medicines in resources limited countries: the case of Anti-hypertensive Medicines in Ethiopia
Associate Advisor
Media
Enquiries
Contact Associate Professor Jane Nikles directly for media enquiries about:
- ADHD
- children
- Clinical trials
- General practice research
- individualised treatments
- melatonin
- N-of-1 trials
- Parkinson's Disease
- Personalised medicine
- Single Case Experimental Designs
- sleep
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: