Overview
Background
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
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Single Case Experimental Designs
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Whiplash, minor musculoskeletal injury, opioid prescribing
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ADHD, children, sleep
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Melatonin
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Parkinson's Disease
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Skin cancer prevention, improving children's sun protection practices
Works
Search Professor Jane Nikles’s works on UQ eSpace
2018
Conference Publication
Acceptability and barriers to implementation of N-of-1 trials in a developing country: Ethiopia as a case study
Alemayehu, C., Mitchell, G., Aseffa, A., Nikles, J. and Clavarino, A. (2018). Acceptability and barriers to implementation of N-of-1 trials in a developing country: Ethiopia as a case study. 7th International Conference on Clinical Trials , Chicago, IL United States, 2018.
2018
Conference Publication
N-of-1 trials in the clinical care of patients in developing countries: a systematic review
Alemayehu, C., Mitchell, G. and Nikles, J. (2018). N-of-1 trials in the clinical care of patients in developing countries: a systematic review. 6th International Conference on Advanced Clinical Research and Clinical Trials, Zurich, Switzerland, 2018.
2018
Conference Publication
N-of-1 therapeutic equivalence trial of two formulations of Enalapril in the treatment of hypertension in Ethiopia - Pilot study
Alemayehu, C., Mitchell, G., Aseffa, A., Clavarino, A., McGree, J. and Nikles, J. (2018). N-of-1 therapeutic equivalence trial of two formulations of Enalapril in the treatment of hypertension in Ethiopia - Pilot study. Translational Research Institute, Brisbane, QLD, Australia, 2018.
2018
Conference Publication
A pilot aquatic exercise program to improve the health and wellbeing of people with dementia and their family carers
Neville, C., Zamora, A., Neville, E., Nikles, J., Lindgren, A. and Ansari, S. (2018). A pilot aquatic exercise program to improve the health and wellbeing of people with dementia and their family carers. UQ medical student research conference , Brisbane, QLD, Australia, 2018.
2018
Conference Publication
Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials
Nikles, J., Heussler, H. and McGree, J. (2018). Melatonin for insomnia in stimulant-treated ADHD – the value of N-of-1 trials. NHMRC Symposium on Research Translation, Sydney, NSW Australia, 2018.
2018
Conference Publication
A retrospective descriptive study of patients who presented to an Australian hospital emergency department with neck soft tissue injury
Nikles, J., Khan, S., Leou, J., Keijzers, G., Ng, J., Bond, C., Nakamura, G., Le, R. and Sterling, M. (2018). A retrospective descriptive study of patients who presented to an Australian hospital emergency department with neck soft tissue injury. BrisPain Multidisciplinary conference, Brisbane, QLD, Australia, 6 December 2018.
2017
Journal Article
Management of whiplash associated disorders in Australian general practice
Nikles, Jane, Yelland, Michael, Bayram, Clare, Miller, Graeme and Sterling, Michele (2017). Management of whiplash associated disorders in Australian general practice. BMC Musculoskeletal Disorders, 18 (1) 551, 551. doi: 10.1186/s12891-017-1899-0
2017
Journal Article
Sun protective behaviors at an outdoor entertainment event in Australia
Barrett, Fiona, Usher, Kim, Woods, Cindy, Harrison, Simone L, Nikles, Jane and Conway, Jane (2017). Sun protective behaviors at an outdoor entertainment event in Australia. Nursing and Health Sciences, 20 (1), 132-138. doi: 10.1111/nhs.12396
2017
Journal Article
A series of N-of-1 trials to assess therapeutic interchangeability of two Enalapril formulations in the treatment of hypertension, Addis Ababa, Ethiopia
Alemayu, Chalachew, Mitchell, Geoffrey, Aseffa, Abraham, Clavarino, Alexandra, McGree, James and Nikles, Jane (2017). A series of N-of-1 trials to assess therapeutic interchangeability of two Enalapril formulations in the treatment of hypertension, Addis Ababa, Ethiopia. Trials, 18 (1) 470, 470. doi: 10.1186/s13063-017-2212-0
2017
Journal Article
A series of n-of-1 trials of stimulants in brain injured children
Nikles, Jane, Mitchell, Geoffrey, McKinlay, Lynne, Waugh, Mary-Clare, Epps, Adrienne, Carmont, Sue-Ann, Schluter, Philip J., Lloyd, Owen and Senior, Hugh (2017). A series of n-of-1 trials of stimulants in brain injured children. NeuroRehabilitation, 40 (1), 11-21. doi: 10.3233/NRE-161386
2017
Conference Publication
N-of-1 therapeutic equivalence trial of two formulations of Enalapril in the treatment of hypertension, Ethiopia
Alemayhu, Chalachew , Mitchell, Geoffrey , Nikles, Jane , Aseffa, Abraham , Clavarino, Alexandra and McGree, James (2017). N-of-1 therapeutic equivalence trial of two formulations of Enalapril in the treatment of hypertension, Ethiopia. PCRIS, Brisbane, Australia, 7-9 August 2017.
2017
Journal Article
The single-case reporting guideline in behavioural interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2017). The single-case reporting guideline in behavioural interventions (SCRIBE) 2016 statement. Neuropsychological Rehabilitation, 27 (1), 1-15. doi: 10.1080/09602011.2016.1190533
2016
Journal Article
The single-case reporting guideline in BEhavioural Interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline in BEhavioural Interventions (SCRIBE) 2016 statement. Remedial and Special Education, 37 (6), 370-380. doi: 10.1177/0741932516652893
2016
Journal Article
Melatonin in youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol for a randomized controlled trial
Punja, Salima, Nikles, Catherine J., Senior, Hugh, Mitchell, Geoffrey, Schmid, Christopher H., Heussler, Helen, Witmans, Manisha and Vohra, Sunita (2016). Melatonin in youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol for a randomized controlled trial. Trials, 17 (1) 375, 375. doi: 10.1186/s13063-016-1499-6
2016
Journal Article
The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. Aphasiology, 30 (7), 862-876. doi: 10.1080/02687038.2016.1178022
2016
Journal Article
Do N-of-1 trials need IRB review?
Cen, Ruiqi, Hussain, Azad, Pak, Kirk J., Mitchell, Geoffrey, Nikles, Jane, Gaudreau, Stephanie, Bazzano, Lydia A. and Breault, Joseph L. (2016). Do N-of-1 trials need IRB review?. Journal of Empirical Research on Human Research Ethics, 11 (3), 250-255. doi: 10.1177/1556264616662560
2016
Journal Article
The single-case reporting guideline in BEhavioural interventions (SCRIBE) 2016 Statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline in BEhavioural interventions (SCRIBE) 2016 Statement. Physical Therapy, 96 (7), e1-e10. doi: 10.2522/ptj.2016.96.7.e1
2016
Journal Article
The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement. Evidence-Based Communication Assessment and Intervention, 10 (1), 44-58. doi: 10.1080/17489539.2016.1190525
2016
Journal Article
The Single-Case Reporting Guideline in BEhavioural Interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline in BEhavioural Interventions (SCRIBE) 2016 statement. Canadian Journal of Occupational Therapy, 83 (3), 184-195. doi: 10.1177/0008417416648124
2016
Journal Article
Sun protection policies of Australian primary schools in a region of high sun exposure
Harrison, S. L., Garzon-Chavez, D. R. and Nikles, C. J. (2016). Sun protection policies of Australian primary schools in a region of high sun exposure. Health Education Research, 31 (3), 416-428. doi: 10.1093/her/cyw020
Funding
Current funding
Supervision
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Opioid use and misuse following road traffic musculoskeletal injury
Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.
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N-of-1 trials in health care, melatonin, complementary and alternative medicines.
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.
Please contact me on uqjnikle@uq.edu.au to discuss several available projects.
Supervision history
Completed supervision
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2019
Doctor Philosophy
N-of-1 Trials as a Bioequivalence Method to assess local medicines in resources limited countries: the case of Anti-hypertensive Medicines in Ethiopia
Associate Advisor
Media
Enquiries
Contact Associate Professor Jane Nikles directly for media enquiries about:
- ADHD
- children
- Clinical trials
- General practice research
- individualised treatments
- melatonin
- N-of-1 trials
- Parkinson's Disease
- Personalised medicine
- Single Case Experimental Designs
- sleep
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