Overview
Background
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
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Single Case Experimental Designs
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Whiplash, minor musculoskeletal injury, opioid prescribing
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ADHD, children, sleep
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Melatonin
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Parkinson's Disease
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Skin cancer prevention, improving children's sun protection practices
Works
Search Professor Jane Nikles’s works on UQ eSpace
2006
Conference Publication
Single patient trials of gabapentin - the experience from a pain clinic
Christopher Poulos, Guy Bashford, Michael Yelland, Jane Nikles, Norma McNairn and Nancy Fish (2006). Single patient trials of gabapentin - the experience from a pain clinic. Australian Faculty of Rehabilitation Medicine 14th Annual Scientific Meeting, Cairns, Australia, 2006.
2006
Other Outputs
An economic evaluation of n-of-1 trials in clinical practice : Final report
Clark, R., Del Mar, C. B., Mitchell, G. K., Nikles, C. J., Scuffham, P. and Yelland, M. (2006). An economic evaluation of n-of-1 trials in clinical practice : Final report. Canberra, ACT, Australia: Australian Health Ministers Advisory Council.
2005
Conference Publication
Single patient trials comparing NSAIDs with paracetamol for osteoarthritis and chronic pain
Yelland, M., Nikles, J., McNairn, N., Glasziou, P. and Glasziou, C. (2005). Single patient trials comparing NSAIDs with paracetamol for osteoarthritis and chronic pain. Australian Association of Musculoskeletal Medicine Conference, Singapore, 2005.
2005
Conference Publication
Single patient trials of gabapentin for chronic neuropathic pain
Yelland, M. J., Nikles, C. J. and McNairn, N. (2005). Single patient trials of gabapentin for chronic neuropathic pain. 11th IASP World Congress on Pain, Sydney, NSW, Australia, 21-26 August 2005. Seattle, WA, United States: IASP Press.
2005
Journal Article
Do individualized medication effectiveness tests (N-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?
Nikles, C. J., Yelland, M., Glasziou, P. P. and Del Mar, C (2005). Do individualized medication effectiveness tests (N-of-1 trials) change clinical decisions about which drugs to use for osteoarthritis and chronic pain?. American Journal of Therapeutics, 12 (1), 92-97. doi: 10.1097/00045391-200501000-00012
2005
Conference Publication
Single patient trials comparing NSAIDs with paracetamol for osteoarthritis and chronic pain
Yelland, M., Nikles, J., McNairn, N., Glasziou, P. and Del Mar, C. (2005). Single patient trials comparing NSAIDs with paracetamol for osteoarthritis and chronic pain. Australian Association of Musculoskeletal Medicine Conference - Pain Management in the Elderly, Noosa, Australia, 3-7 March 2005.
2005
Book Chapter
Individualised medication effectiveness tests as a means of targeting stimulants to responders in attention deficit hyperactivity disorder
Nikles, C. J., Mitchell, G. K., Del Mar, C. B. and Clavarino, A. (2005). Individualised medication effectiveness tests as a means of targeting stimulants to responders in attention deficit hyperactivity disorder. Attention Deficit Hyperactivity Disorder Research Developments. (pp. 169-187) edited by M. P. Larimer. New York, U.S.A.: Nova Science.
2004
Conference Publication
Do individualised medication effectiveness tests improve decisions about which drugs to use for osteoarthritis or chronic pain?
Nikles, C.J., Yelland, M., Glasziou, P., Del Mar, C., Pillans, P. and Sturtevant, J. (2004). Do individualised medication effectiveness tests improve decisions about which drugs to use for osteoarthritis or chronic pain?. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, Australia, 7-10 March 2004.
2004
Conference Publication
Individual Medication Effectiveness Tests (IMETs) to assess the efficacy of gabapentin in individual patients with chronic neuropathic pain
Yelland, M., Nikles, J., Glasziou, P., Del Mar, C., Pillans, P. and Sturtevant, J. (2004). Individual Medication Effectiveness Tests (IMETs) to assess the efficacy of gabapentin in individual patients with chronic neuropathic pain. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, Australia, 7-10 March 2004.
2003
Conference Publication
N of 1 trials: individualizing the evidence
Mitchell, G., Del Mar, C., Glasziou, P. and Nikles, J. (2003). N of 1 trials: individualizing the evidence. The Australasian Pharmaceutical Science Association Annual Conference, Sydney, 3-5 December 2003.
2003
Conference Publication
Do individualised medication effectiveness tests improve decisions about which drugs to use for osteoarthritis or chronic pain?
Nikles, J., Yelland, M., Glasziou, P. and Del Mar, C. (2003). Do individualised medication effectiveness tests improve decisions about which drugs to use for osteoarthritis or chronic pain?. Queensland Health Research Conference, Brisbane, QLD, Australia, 2003.
2003
Conference Publication
Individual medication effectiveness tests (IMETs) to assess the efficacy of gabapentin in individual patients with chronic neuropathic pain
Yelland, M., Nikles, J., Glasziou, P., Del Mar, C., Pillans, P. and Sturtevant, J. (2003). Individual medication effectiveness tests (IMETs) to assess the efficacy of gabapentin in individual patients with chronic neuropathic pain. Queensland Health Research Conference, Brisbane, QLD, Australia, 2003.
2002
Conference Publication
Individualised medication effectiveness tests may improve osteoarthritis management and decrease NSAID expenditure
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Yelland, M. and King, J. (2002). Individualised medication effectiveness tests may improve osteoarthritis management and decrease NSAID expenditure. Quality Use of Medicines Conference, Canberra ACT, Australia, 2002.
2002
Conference Publication
Individual medication effectiveness tests of stimulants in the treatment of attention deficit hyperactivity disorder
Mitchell, G. K., Nikles, C.J., Glasziou, P. P., Del Mar, C. B. and Schluter, P. J. (2002). Individual medication effectiveness tests of stimulants in the treatment of attention deficit hyperactivity disorder. General Practice and Primary Health Care Conference, Melbourne, VIC, Australia, 29-31 May 2002. Melbourne VIC, Australia: Primary Health Care Research Care & Information Services, DHAC.
2002
Conference Publication
Research as practice: using individualised medication effectiveness tests to improve prescribing
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Mitchell, G., O'Connor, V., Price, J., Yelland, M., Coxeter, P., Askew, D., Janamian, T., Spinks, A., Clavarino, A. and Schluter, P. (2002). Research as practice: using individualised medication effectiveness tests to improve prescribing. General Practice and Primary Health Care conference, Melbourne VIC, Australia, 29-31 May 2002.
2002
Conference Publication
Research as practice: using individualised medication effectiveness tests to improve prescribing
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Mitchell, G., O'Connor, V., Price, J., Yelland, M., Coxeter, P., Askew, D., Janamian, T., Spinks, A., Clavarino, A. and Schluter, P. (2002). Research as practice: using individualised medication effectiveness tests to improve prescribing. Quality Use of Medicines Conference, Canberra ACT, Australia, 2002.
2002
Other Outputs
Individualised Medical Effectivenss Tests comparing Dexamphetamine or Methylphenidate with placebo for the treatment of Attention- Deficit Hyperactivity Disorder in General Practice
Mitchell, G. K., Nikles, C.J., Duggan, C., Glasziou, P. P. and Del Mar, C. B. (2002). Individualised Medical Effectivenss Tests comparing Dexamphetamine or Methylphenidate with placebo for the treatment of Attention- Deficit Hyperactivity Disorder in General Practice. Australia: University of Queensland.
2002
Conference Publication
Targeting stimulants to responders: Individual Medication Effectiveness Tests for Attention Deficit Hyperactivity Disorder
Mitchell, G. K., Nikles, C. J., Glasziou, P. P., Steer, P. and Jenkins-Manning, S. (2002). Targeting stimulants to responders: Individual Medication Effectiveness Tests for Attention Deficit Hyperactivity Disorder. Queensland Health and Medical Scientific Meeting, Brisbane, Australia, 4-5 December, 2002. Brisbane: Centre for Palliative Care.
2002
Conference Publication
Individualised medication effectiveness tests may improve osteoarthritis management and decrease NSAID expenditure
Nikles, J., Glasziou, P., Del Mar, C., Duggan, C., Yelland, M. and King, J. (2002). Individualised medication effectiveness tests may improve osteoarthritis management and decrease NSAID expenditure. General Practice and Primary Health Care conference, Melbourme, VIC, Australia, 29-31 May 2002.
2002
Conference Publication
Achieving good compliance and followup in clinical trials
Yelland, M. J., Beller, E., Nikles, J. and Glasziou, P. (2002). Achieving good compliance and followup in clinical trials. Australian Association of Academic General Practice Research Meeting, Melbourne, VIC, Australia, 29-31 May 2002. Adelaide, South Australia: Primary Health Care Research and Information Service.
Funding
Current funding
Supervision
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
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Available projects
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Opioid use and misuse following road traffic musculoskeletal injury
Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.
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N-of-1 trials in health care, melatonin, complementary and alternative medicines.
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.
Please contact me on uqjnikle@uq.edu.au to discuss several available projects.
Supervision history
Completed supervision
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2019
Doctor Philosophy
N-of-1 Trials as a Bioequivalence Method to assess local medicines in resources limited countries: the case of Anti-hypertensive Medicines in Ethiopia
Associate Advisor
Media
Enquiries
Contact Associate Professor Jane Nikles directly for media enquiries about:
- ADHD
- children
- Clinical trials
- General practice research
- individualised treatments
- melatonin
- N-of-1 trials
- Parkinson's Disease
- Personalised medicine
- Single Case Experimental Designs
- sleep
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