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Associate Professor Jane Nikles
Associate Professor

Jane Nikles

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Overview

Background

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Availability

Associate Professor Jane Nikles is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments

  • Single Case Experimental Designs

  • Whiplash, minor musculoskeletal injury, opioid prescribing

  • ADHD, children, sleep

  • Melatonin

  • Parkinson's Disease

  • Skin cancer prevention, improving children's sun protection practices

Works

Search Professor Jane Nikles’s works on UQ eSpace

188 works between 1983 and 2026

121 - 140 of 188 works

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and Vohra, Sunita (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration. The BMJ, 350 h1793. doi: 10.1016/j.jclinepi.2015.05.018

CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration

2015

Book Chapter

Introduction

Nikles, Jane and Mitchell, Geoffrey (2015). Introduction. The essential guide to N-of-1 trials in health. (pp. 1-8) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_1

Introduction

2013

Journal Article

An observational study of sun-protective behaviour at an outdoor spectator sporting event in a region of high sun exposure

Nikles, Jane and Harrison, Simone Lee (2013). An observational study of sun-protective behaviour at an outdoor spectator sporting event in a region of high sun exposure. Journal of Carcinogenesis and Mutagenesis. doi: 10.4172/2157-2518.S4-003

An observational study of sun-protective behaviour at an outdoor spectator sporting event in a region of high sun exposure

2013

Journal Article

Don’t burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy

Harrison, Simone Lee, Nikles, Jane and Nowak, Madeleine (2013). Don’t burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy. Open Journal of Preventive Medicine, 3 (2), 212-218. doi: 10.4236/ojpm.2013.32029

Don’t burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy

2013

Conference Publication

Overview of N-of-1 study suite – lessons learned from three aggregated N-of-1 trials

Mitchell, Geoff, Nikles, Jane, Carmont, Sue-Ann, Hardy, Janet, Good, Phillip, Agar, Meera, Clark, Katherine, Douglas, Carol, Vora, Rohan, Currow, David and Senior, H. (2013). Overview of N-of-1 study suite – lessons learned from three aggregated N-of-1 trials. PaCCSC 4th Annual Scientific Meeting and Research Forum 2013, Sydney, NSW, Australia, 20-21 Mar, 2013.

Overview of N-of-1 study suite – lessons learned from three aggregated N-of-1 trials

2012

Journal Article

Exploring melatonin prescribing among customers of compounding pharmacies in Australia

Nikles, Jane, Lo, Victor, Giam, Jennifer A . and Saini, Bandana (2012). Exploring melatonin prescribing among customers of compounding pharmacies in Australia. Medical Journal of Australia, 196 (6), 384-385. doi: 10.5694/mja12.10145

Exploring melatonin prescribing among customers of compounding pharmacies in Australia

2012

Conference Publication

The effectiveness of methylphenidate in fatigue in advanced cancer: aggregated N-of-1 trails

Mitchell, Geoffrey, Hardy, Janet, Carmont, Sue-Ann, Nikles, Jane, Senior, Hugh, Schluter, Philip, Good, Philip, Agar, Meera, Clark, Katherine, Vora,Rohan, Douglas, Carol and Currow, David (2012). The effectiveness of methylphenidate in fatigue in advanced cancer: aggregated N-of-1 trails. Ipswich Hospital Research Day, Ipswich, Qld, Australia, 1 September 2012.

The effectiveness of methylphenidate in fatigue in advanced cancer: aggregated N-of-1 trails

2012

Conference Publication

Don't burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy

Harrison, Simone and Nikles, Jane (2012). Don't burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.

Don't burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy

2012

Conference Publication

The effectiveness of methylphenidate in fatigue in advanced cancer: Aggregated n-of-1 trial results

Mitchell, G., Hardy, J., Carmont, S., Nikles, J., Senior, H., Schluter, P., Good, P., Agar, M., Clark, K., Vora, R. and Currow, D. (2012). The effectiveness of methylphenidate in fatigue in advanced cancer: Aggregated n-of-1 trial results. Australian and New Zealand Society of Palliative Medicine conference, Queenstown, New Zealand, 4 - 7 September 2012.

The effectiveness of methylphenidate in fatigue in advanced cancer: Aggregated n-of-1 trial results

2012

Conference Publication

Preliminary observations of hat wearing in Brisbane schools

Harrison, Simone and Nikles, Jane (2012). Preliminary observations of hat wearing in Brisbane schools. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.

Preliminary observations of hat wearing in Brisbane schools

2011

Conference Publication

The use of stimulant medication in children with brain injury

McKinlay, L., Lloyd, O., Nikles, J. and Mitchell, G. (2011). The use of stimulant medication in children with brain injury. Changed Lives, New pathways: A Conference on Children's Rehabilitation, Royal Children's Hospital, Herston QLD, Australia, 14 - 15 July 2011.

The use of stimulant medication in children with brain injury

2011

Conference Publication

Exploring melatonin use among customers of compounding pharmacies in Australia

Saini, B., Lo, V., Giam, J. and Nikles, J. (2011). Exploring melatonin use among customers of compounding pharmacies in Australia. 23rd Annual Scientific Meeting of the Australasian Sleep Association and Australasian Sleep Technologists Association, Sydney, N.S.W., Australia, 27-29 October 2011. Oxford, England, U. K.: Wiley-Blackwell Publishing. doi: 10.1111/j.1365-2869.2011.00953.x

Exploring melatonin use among customers of compounding pharmacies in Australia

2010

Other Outputs

N-of-1 trials of stimulants versus placebo for paediatric traumatic brain injury: Pilot Final Report

McKinlay, L., Mitchell, G., Nikles, J., Lloyd, O., Waugh, M. and Epps, A. (2010). N-of-1 trials of stimulants versus placebo for paediatric traumatic brain injury: Pilot Final Report. Unknown:

N-of-1 trials of stimulants versus placebo for paediatric traumatic brain injury: Pilot Final Report

2008

Conference Publication

Investigating n-of-1 trials as a means of gathering palliative care evidence

Carmont, S., Currow, D., Hardy, J., Mitchell, G. K., Nikles, J., Schluter, P., Vora, R. and Yelland, M. (2008). Investigating n-of-1 trials as a means of gathering palliative care evidence. 8th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine (ANZSPM), Darwin, NT, Australia, 23-26 September 2008.

Investigating n-of-1 trials as a means of gathering palliative care evidence

2008

Book

Using single patient trials to determine the effectiveness of psychostimulants in fatigue in advanced cancer patients

Mitchell, Geoffrey, Hardy, Janet, Vora, Rohan, Currow, David, Schluter, Philip, Nikles, Jane and Yelland, Michael (2008). Using single patient trials to determine the effectiveness of psychostimulants in fatigue in advanced cancer patients. Herston, QLD Brisbane:

Using single patient trials to determine the effectiveness of psychostimulants in fatigue in advanced cancer patients

2007

Conference Publication

Investigating the role of single patient trial as a means of gathering population level evidence in palliative care

Mitchell, G., Nikles, J., Hardy, J., Currow, D., Good, P., Rowett, D. and Walters, J. (2007). Investigating the role of single patient trial as a means of gathering population level evidence in palliative care. Clinical Oncological Society of Australia 34th Annual Scientific Meeting, Adelaide, Australia, 14-16 November, 2007. Carlton, Australia: Blackwell Publishing. doi: 10.1111/j.1743-7563.2007.00127.x

Investigating the role of single patient trial as a means of gathering population level evidence in palliative care

2006

Conference Publication

Do n-of-1 trials of celeocxib compared to sustained release paracetamol change patient use of drugs for osteoarthritis?

Yelland, Michael, Nikles, Jane, McNairn, Norma, Brown, Robyn, Del Mar, Christopher and Schluter, Philip (2006). Do n-of-1 trials of celeocxib compared to sustained release paracetamol change patient use of drugs for osteoarthritis?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.

Do n-of-1 trials of celeocxib compared to sustained release paracetamol change patient use of drugs for osteoarthritis?

2006

Conference Publication

Could N-of-1 trials make prescribing more cost-effective?

Yelland, Michael, Pietrzak, Eva, Scuffham, Paul, Nikles, Jane and Wilkinson, David (2006). Could N-of-1 trials make prescribing more cost-effective?. 2006 GP & PHC Research Conference: Optimising Impact, Perth, WA, Australia, 5-7 July 2006.

Could N-of-1 trials make prescribing more cost-effective?

2006

Conference Publication

Could N-of-1 trials make prescribing more cost-effective?

Yelland, Michael, Pietrzak, E,, Schluter, Philip, Nikles, Jane and Wilkinson, D. (2006). Could N-of-1 trials make prescribing more cost-effective?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.

Could N-of-1 trials make prescribing more cost-effective?

2006

Other Outputs

An economic evaluation of n-of-1 trials in clinical practice : Final report

Clark, R., Del Mar, C. B., Mitchell, G. K., Nikles, C. J., Scuffham, P. and Yelland, M. (2006). An economic evaluation of n-of-1 trials in clinical practice : Final report. Canberra, ACT, Australia: Australian Health Ministers Advisory Council.

An economic evaluation of n-of-1 trials in clinical practice : Final report

Supervision

Availability

Associate Professor Jane Nikles is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Available projects

  • Opioid use and misuse following road traffic musculoskeletal injury

    Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

Media

Enquiries

Contact Associate Professor Jane Nikles directly for media enquiries about:

  • ADHD
  • children
  • Clinical trials
  • General practice research
  • individualised treatments
  • melatonin
  • N-of-1 trials
  • Parkinson's Disease
  • Personalised medicine
  • Single Case Experimental Designs
  • sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au