Overview
Background
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
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Single Case Experimental Designs
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Whiplash, minor musculoskeletal injury, opioid prescribing
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ADHD, children, sleep
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Melatonin
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Parkinson's Disease
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Skin cancer prevention, improving children's sun protection practices
Works
Search Professor Jane Nikles’s works on UQ eSpace
2015
Book Chapter
Introduction
Nikles, Jane and Mitchell, Geoffrey (2015). Introduction. The essential guide to N-of-1 trials in health. (pp. 1-8) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_1
2013
Journal Article
An observational study of sun-protective behaviour at an outdoor spectator sporting event in a region of high sun exposure
Nikles, Jane and Harrison, Simone Lee (2013). An observational study of sun-protective behaviour at an outdoor spectator sporting event in a region of high sun exposure. Journal of Carcinogenesis and Mutagenesis. doi: 10.4172/2157-2518.S4-003
2013
Journal Article
Don’t burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy
Harrison, Simone Lee, Nikles, Jane and Nowak, Madeleine (2013). Don’t burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy. Open Journal of Preventive Medicine, 3 (2), 212-218. doi: 10.4236/ojpm.2013.32029
2013
Conference Publication
Overview of N-of-1 study suite – lessons learned from three aggregated N-of-1 trials
Mitchell, Geoff, Nikles, Jane, Carmont, Sue-Ann, Hardy, Janet, Good, Phillip, Agar, Meera, Clark, Katherine, Douglas, Carol, Vora, Rohan, Currow, David and Senior, H. (2013). Overview of N-of-1 study suite – lessons learned from three aggregated N-of-1 trials. PaCCSC 4th Annual Scientific Meeting and Research Forum 2013, Sydney, NSW, Australia, 20-21 Mar, 2013.
2012
Journal Article
Exploring melatonin prescribing among customers of compounding pharmacies in Australia
Nikles, Jane, Lo, Victor, Giam, Jennifer A . and Saini, Bandana (2012). Exploring melatonin prescribing among customers of compounding pharmacies in Australia. Medical Journal of Australia, 196 (6), 384-385. doi: 10.5694/mja12.10145
2012
Conference Publication
Don't burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy
Harrison, Simone and Nikles, Jane (2012). Don't burn the baby: advice from Australian nurses recommending therapeutic sun exposure during infancy. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.
2012
Conference Publication
The effectiveness of methylphenidate in fatigue in advanced cancer: aggregated N-of-1 trails
Mitchell, Geoffrey, Hardy, Janet, Carmont, Sue-Ann, Nikles, Jane, Senior, Hugh, Schluter, Philip, Good, Philip, Agar, Meera, Clark, Katherine, Vora,Rohan, Douglas, Carol and Currow, David (2012). The effectiveness of methylphenidate in fatigue in advanced cancer: aggregated N-of-1 trails. Ipswich Hospital Research Day, Ipswich, Qld, Australia, 1 September 2012.
2012
Conference Publication
The effectiveness of methylphenidate in fatigue in advanced cancer: Aggregated n-of-1 trial results
Mitchell, G., Hardy, J., Carmont, S., Nikles, J., Senior, H., Schluter, P., Good, P., Agar, M., Clark, K., Vora, R. and Currow, D. (2012). The effectiveness of methylphenidate in fatigue in advanced cancer: Aggregated n-of-1 trial results. Australian and New Zealand Society of Palliative Medicine conference, Queenstown, New Zealand, 4 - 7 September 2012.
2012
Conference Publication
Preliminary observations of hat wearing in Brisbane schools
Harrison, Simone and Nikles, Jane (2012). Preliminary observations of hat wearing in Brisbane schools. Townsville Health Research Week, Townsville, QLD, Australia, 8 - 12 October 2012. Brisbane, QLD, Australia: Australasian College of Tropical Medicine.
2011
Conference Publication
The use of stimulant medication in children with brain injury
McKinlay, L., Lloyd, O., Nikles, J. and Mitchell, G. (2011). The use of stimulant medication in children with brain injury. Changed Lives, New pathways: A Conference on Children's Rehabilitation, Royal Children's Hospital, Herston QLD, Australia, 14 - 15 July 2011.
2011
Conference Publication
Exploring melatonin use among customers of compounding pharmacies in Australia
Saini, B., Lo, V., Giam, J. and Nikles, J. (2011). Exploring melatonin use among customers of compounding pharmacies in Australia. 23rd Annual Scientific Meeting of the Australasian Sleep Association and Australasian Sleep Technologists Association, Sydney, N.S.W., Australia, 27-29 October 2011. Oxford, England, U. K.: Wiley-Blackwell Publishing. doi: 10.1111/j.1365-2869.2011.00953.x
2010
Other Outputs
N-of-1 trials of stimulants versus placebo for paediatric traumatic brain injury: Pilot Final Report
McKinlay, L., Mitchell, G., Nikles, J., Lloyd, O., Waugh, M. and Epps, A. (2010). N-of-1 trials of stimulants versus placebo for paediatric traumatic brain injury: Pilot Final Report. Unknown:
2008
Conference Publication
Investigating n-of-1 trials as a means of gathering palliative care evidence
Carmont, S., Currow, D., Hardy, J., Mitchell, G. K., Nikles, J., Schluter, P., Vora, R. and Yelland, M. (2008). Investigating n-of-1 trials as a means of gathering palliative care evidence. 8th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine (ANZSPM), Darwin, NT, Australia, 23-26 September 2008.
2008
Book
Using single patient trials to determine the effectiveness of psychostimulants in fatigue in advanced cancer patients
Mitchell, Geoffrey, Hardy, Janet, Vora, Rohan, Currow, David, Schluter, Philip, Nikles, Jane and Yelland, Michael (2008). Using single patient trials to determine the effectiveness of psychostimulants in fatigue in advanced cancer patients. Herston, QLD Brisbane:
2007
Conference Publication
Investigating the role of single patient trial as a means of gathering population level evidence in palliative care
Mitchell, G., Nikles, J., Hardy, J., Currow, D., Good, P., Rowett, D. and Walters, J. (2007). Investigating the role of single patient trial as a means of gathering population level evidence in palliative care. Clinical Oncological Society of Australia 34th Annual Scientific Meeting, Adelaide, Australia, 14-16 November, 2007. Carlton, Australia: Blackwell Publishing. doi: 10.1111/j.1743-7563.2007.00127.x
2006
Conference Publication
Do n-of-1 trials of celeocxib compared to sustained release paracetamol change patient use of drugs for osteoarthritis?
Yelland, Michael, Nikles, Jane, McNairn, Norma, Brown, Robyn, Del Mar, Christopher and Schluter, Philip (2006). Do n-of-1 trials of celeocxib compared to sustained release paracetamol change patient use of drugs for osteoarthritis?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.
2006
Conference Publication
Could N-of-1 trials make prescribing more cost-effective?
Yelland, Michael, Pietrzak, Eva, Scuffham, Paul, Nikles, Jane and Wilkinson, David (2006). Could N-of-1 trials make prescribing more cost-effective?. 2006 GP & PHC Research Conference: Optimising Impact, Perth, WA, Australia, 5-7 July 2006.
2006
Conference Publication
Could N-of-1 trials make prescribing more cost-effective?
Yelland, Michael, Pietrzak, E,, Schluter, Philip, Nikles, Jane and Wilkinson, D. (2006). Could N-of-1 trials make prescribing more cost-effective?. RACGP 49th Annual Scientific Convention: Be the Future, Brisbane, QLD, Australia, 5-8 October 2006.
2006
Conference Publication
Single patient trials of gabapentin - the experience from a pain clinic
Christopher Poulos, Guy Bashford, Michael Yelland, Jane Nikles, Norma McNairn and Nancy Fish (2006). Single patient trials of gabapentin - the experience from a pain clinic. Australian Faculty of Rehabilitation Medicine 14th Annual Scientific Meeting, Cairns, Australia, 2006.
2006
Other Outputs
An economic evaluation of n-of-1 trials in clinical practice : Final report
Clark, R., Del Mar, C. B., Mitchell, G. K., Nikles, C. J., Scuffham, P. and Yelland, M. (2006). An economic evaluation of n-of-1 trials in clinical practice : Final report. Canberra, ACT, Australia: Australian Health Ministers Advisory Council.
Funding
Current funding
Supervision
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Opioid use and misuse following road traffic musculoskeletal injury
Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.
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N-of-1 trials in health care, melatonin, complementary and alternative medicines.
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.
Please contact me on uqjnikle@uq.edu.au to discuss several available projects.
Supervision history
Completed supervision
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2019
Doctor Philosophy
N-of-1 Trials as a Bioequivalence Method to assess local medicines in resources limited countries: the case of Anti-hypertensive Medicines in Ethiopia
Associate Advisor
Media
Enquiries
Contact Associate Professor Jane Nikles directly for media enquiries about:
- ADHD
- children
- Clinical trials
- General practice research
- individualised treatments
- melatonin
- N-of-1 trials
- Parkinson's Disease
- Personalised medicine
- Single Case Experimental Designs
- sleep
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