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Associate Professor Jane Nikles
Associate Professor

Jane Nikles

Email: 

Overview

Background

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Availability

Associate Professor Jane Nikles is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments

  • Single Case Experimental Designs

  • Whiplash, minor musculoskeletal injury, opioid prescribing

  • ADHD, children, sleep

  • Melatonin

  • Parkinson's Disease

  • Skin cancer prevention, improving children's sun protection practices

Works

Search Professor Jane Nikles’s works on UQ eSpace

187 works between 1983 and 2024

101 - 120 of 187 works

2016

Journal Article

The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. Journal of School Psychology, 56, 133-142. doi: 10.1016/j.jsp.2016.04.001

The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

2016

Journal Article

The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement

Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement. Journal of Clinical Epidemiology, 73, 142-152. doi: 10.1016/j.jclinepi.2016.04.006

The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement

2016

Journal Article

N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis

Punja, Salima, Xu, Dongying, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis. Journal of Clinical Epidemiology, 76, 65-75. doi: 10.1016/j.jclinepi.2016.03.026

N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis

2016

Journal Article

Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.

Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Senior, Hugh, Carmont, Sue-Ann, Schluter, Philip J., Vora, Rohan, Currow, David and Yelland, Michael (2016). Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.. Palliative Medicine: a multiprofessional journal, 30 (8), 1-3. doi: 10.1177/0269216316635012

Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.

2016

Journal Article

Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review)

Punja, Salima, Shamseer, Larissa, Hartling, Lisa, Urichuk, Liana, Vandermeer, Ben, Nikles, Jane and Vohra, Sunita (2016). Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review). Cochrane Database of Systematic Reviews, 2016 (2) CD009996. doi: 10.1002/14651858.CD009996.pub2

Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review)

2016

Conference Publication

Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer

Bates, N., Emeto, T., Turner, D., Nikles, J. and Harrison, S. (2016). Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer. Townsville Health Research Week 2016: Spotlight on Preventative Health, Townsville, QLD, Australia, 12-15 September 2016.

Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer

2016

Journal Article

To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD

Punja, Salima, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD. Journal of Clinical Epidemiology, 76, 76-81. doi: 10.1016/j.jclinepi.2016.03.021

To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD

2016

Conference Publication

The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. AOTA 96th Annual Conference and Expo, Chicag, Il, United States, 7-10 April 2016. Bethesda, MD, United States: American Occupational Therapy Associatio. doi: 10.5014/ajot.2016.704002

The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

2015

Journal Article

The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial

Mitchell, Geoffrey K., Hardy, Janet R., Nikles, Catherine J., Carmont, Sue-Ann S., Senior, Hugh E., Schluter, Philip J., Good, Philip and Currow, David C. (2015). The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial. Journal of Pain and Symptom Management, 50 (3), 289-296. doi: 10.1016/j.jpainsymman.2015.03.009

The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. Journal of Clinical Epidemiology, 76, 18-46. doi: 10.1016/j.jclinepi.2015.05.018

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. Journal of Clinical Epidemiology, 76, 9-17. doi: 10.1016/j.jclinepi.2015.05.004

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

2015

Journal Article

Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study

Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Agar, Meera, Senior, Hugh Edgar John, Carmont, Sue-Ann, Schluter, Philip J., Good, Phillip, Vora, Rohan and Currow, David (2015). Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study. Palliative Medicine, 29 (10), 967-974. doi: 10.1177/0269216315585473

Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. BMJ, 350 (may14 15) h1793, h1793-h1793. doi: 10.1136/bmj.h1793

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 350 (may14 17) h1738, h1738-h1738. doi: 10.1136/bmj.h1738

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

2015

Conference Publication

Using individualized randomized trials to improve health outcomes and reduce costs

Mitchell, G., Nikles, J., Senior, H., Whitty, J., McGree, James, Carmont, S., Kravitz, R., Bazzano, L. and Schmid, C. (2015). Using individualized randomized trials to improve health outcomes and reduce costs. US-Australia Biomedical Research Partnership Conference, Canberra, ACT, Australia, 13 July 2015.

Using individualized randomized trials to improve health outcomes and reduce costs

2015

Book

The essential guide to N-of-1 trials in health

Jane Nikles and Geoffrey Mitchell eds. (2015). The essential guide to N-of-1 trials in health. Amsterdam, Netherlands: Springer.

The essential guide to N-of-1 trials in health

2015

Book Chapter

Where Are N-of-1 Trials Headed?

Nikles, Jane (2015). Where Are N-of-1 Trials Headed?. The essential guide to N-of-1 trials in health. (pp. 233-241) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_17

Where Are N-of-1 Trials Headed?

2015

Book Chapter

What are N-of-1 Trials?

Nikles, Jane (2015). What are N-of-1 Trials?. The essential guide to N-of-1 trials in health. (pp. 9-17) edited by Jane Nikles and Geoffrey Mitchell. Dordecht, Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_2

What are N-of-1 Trials?

2015

Conference Publication

Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer

Agar, M., Lawlor, P., Caplan, G., Ely, E. W., Lam, L., de Souza, P. and Nikles, J. (2015). Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer. Australian Palliative Care Conference, Melbourne, VIC, Australia, 1-4 September 2015.

Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and Vohra, Sunita (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration. The BMJ, 350 h1793. doi: 10.1016/j.jclinepi.2015.05.018

CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration

Funding

Current funding

  • 2024 - 2025
    StudyU: a personalised digital tool to improve self-management of chronic non-cancer pain and support shared decision-making in general practice
    Royal Australian College of General Practitioners
    Open grant
  • 2024 - 2025
    Personalising non-pharmacological management of chronic non-cancer pain
    Metro South Health Research Support Scheme Project Grant
    Open grant
  • 2023 - 2028
    PRioRTI: PReventing chronic pain after whiplash Road Traffic Injury
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant

Past funding

  • 2024
    Co-creation and evaluation of a culturally appropriate mHealth intervention to support management of chronic musculoskeletal pain among people from culturally and linguistically diverse background
    Health Translation Queensland
    Open grant
  • 2024
    Identifying effective self-management options for individual patients with persistent neck and/or back pain following road traffic crashes: a general practice-based feasibility study
    Royal Australian College of General Practitioners
    Open grant
  • 2023 - 2025
    Making it Personal: Feasibility and Acceptability of using N-of-1 Studies to Identify Personalised Fatigue Patterns and Triggers in Multiple Sclerosis
    Incubator Grant Scheme
    Open grant
  • 2022 - 2023
    Early prevention of chronic musculoskeletal pain after injury: a survey of GP attitudes and behaviours
    Health Developments Corporation
    Open grant
  • 2022 - 2023
    StudyU: A Unique Tool to Self-Manage Chronic Pain
    Health Developments Corporation
    Open grant
  • 2021
    MTP Connect REDI Bridge Industry Fellowship
    Queensland University of Technology
    Open grant
  • 2021 - 2024
    Opioids and other prescription medicines use in people presenting to Queensland emergency departments for acute minor (non-admitted) Road Traffic Crash injury: a one year community follow-up study usi
    Metro South Hospital and Health Service
    Open grant
  • 2018 - 2021
    Using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's disease
    Wesley Medical Research Ltd
    Open grant
  • 2018 - 2019
    Preventing chronic pain after whiplash injury
    Emergency Medicine Foundation Ltd
    Open grant
  • 2012 - 2018
    Melatonin for initial insomnia in stimulant-treated pediatric ADHD
    NHMRC Project Grant
    Open grant
  • 2010 - 2013
    N-of-1 trials of stimulants compared to placebo for traumatic brain injury in children
    Motor Accident Insurance Commission
    Open grant
  • 2010 - 2012
    n-of-1 trials of pilocarpine vs placebo for dry mouth in palliative care patients
    Cancer Council Queensland
    Open grant
  • 2010 - 2012
    Stimulants compared to placebo for paediatric traumatic brain inquiry
    Children's Health Foundation Queensland
    Open grant
  • 2009 - 2012
    Using n-of 1 trials to determine the effectiveness of paracetamol in advanced cancer patients on opioids
    NHMRC Palliative Care Research Program
    Open grant
  • 2008 - 2010
    N-OF-1 trials of stimulant vs. placebo for paediatric traumatic brain injury
    Royal Children's Hospital Foundation
    Open grant
  • 2008 - 2012
    Using single patient trials to determine the effectiveness of psychostimulants in end stage fatigue in cancer patients.
    NHMRC Palliative Care Research Program
    Open grant
  • 2007 - 2008
    N-OF-1 Trials comparing stimulants with placebo for traumatic brain injury in children
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2008
    Identifying priority drugs for n-of-1 trials in palliative care research
    UQ Early Career Researcher
    Open grant
  • 2006 - 2011
    NHMRC Training (Postdoctoral) Fellowship: What is the place of IMETs in difficult to research clinical conditions: palliative care as a case study
    NHMRC Training (Postdoctoral) Fellowship
    Open grant
  • 2002 - 2006
    Can routine N-of-1 studies improve net benefits and reduce costs by better targeting chronic therapy?
    NHMRC: State Commonwealth Research Issues Forum
    Open grant
  • 2002
    Do N-of-1trials improve concordance with management decsions? Piloting a randomised controlled trial
    University of Queensland Research Development Grants Scheme
    Open grant
  • 1999 - 2001
    Single Patient Trials: Phase I - The consumer's perspective
    Dpt Health & Aged Care Pharmaceutical Ed Program
    Open grant

Supervision

Availability

Associate Professor Jane Nikles is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Opioid use and misuse following road traffic musculoskeletal injury

    Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

Media

Enquiries

Contact Associate Professor Jane Nikles directly for media enquiries about:

  • ADHD
  • children
  • Clinical trials
  • General practice research
  • individualised treatments
  • melatonin
  • N-of-1 trials
  • Parkinson's Disease
  • Personalised medicine
  • Single Case Experimental Designs
  • sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au