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Associate Professor Jane Nikles
Associate Professor

Jane Nikles

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Overview

Background

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Availability

Associate Professor Jane Nikles is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments

  • Single Case Experimental Designs

  • Whiplash, minor musculoskeletal injury, opioid prescribing

  • ADHD, children, sleep

  • Melatonin

  • Parkinson's Disease

  • Skin cancer prevention, improving children's sun protection practices

Works

Search Professor Jane Nikles’s works on UQ eSpace

188 works between 1983 and 2026

101 - 120 of 188 works

2016

Journal Article

Sun protection policies of Australian primary schools in a region of high sun exposure

Harrison, S. L., Garzon-Chavez, D. R. and Nikles, C. J. (2016). Sun protection policies of Australian primary schools in a region of high sun exposure. Health Education Research, 31 (3), 416-428. doi: 10.1093/her/cyw020

Sun protection policies of Australian primary schools in a region of high sun exposure

2016

Journal Article

The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. Journal of School Psychology, 56, 133-142. doi: 10.1016/j.jsp.2016.04.001

The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

2016

Journal Article

The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement

Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement. Journal of Clinical Epidemiology, 73, 142-152. doi: 10.1016/j.jclinepi.2016.04.006

The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement

2016

Journal Article

N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis

Punja, Salima, Xu, Dongying, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis. Journal of Clinical Epidemiology, 76, 65-75. doi: 10.1016/j.jclinepi.2016.03.026

N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis

2016

Journal Article

Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.

Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Senior, Hugh, Carmont, Sue-Ann, Schluter, Philip J., Vora, Rohan, Currow, David and Yelland, Michael (2016). Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.. Palliative Medicine: a multiprofessional journal, 30 (8), 1-3. doi: 10.1177/0269216316635012

Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.

2016

Journal Article

Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review)

Punja, Salima, Shamseer, Larissa, Hartling, Lisa, Urichuk, Liana, Vandermeer, Ben, Nikles, Jane and Vohra, Sunita (2016). Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review). Cochrane Database of Systematic Reviews, 2016 (2) CD009996. doi: 10.1002/14651858.CD009996.pub2

Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review)

2016

Journal Article

To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD

Punja, Salima, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD. Journal of Clinical Epidemiology, 76, 76-81. doi: 10.1016/j.jclinepi.2016.03.021

To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD

2016

Conference Publication

The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. AOTA 96th Annual Conference and Expo, Chicag, Il, United States, 7-10 April 2016. Bethesda, MD, United States: American Occupational Therapy Associatio. doi: 10.5014/ajot.2016.704002

The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement

2016

Conference Publication

Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer

Bates, N., Emeto, T., Turner, D., Nikles, J. and Harrison, S. (2016). Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer. Townsville Health Research Week 2016: Spotlight on Preventative Health, Townsville, QLD, Australia, 12-15 September 2016.

Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer

2015

Journal Article

The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial

Mitchell, Geoffrey K., Hardy, Janet R., Nikles, Catherine J., Carmont, Sue-Ann S., Senior, Hugh E., Schluter, Philip J., Good, Philip and Currow, David C. (2015). The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial. Journal of Pain and Symptom Management, 50 (3), 289-296. doi: 10.1016/j.jpainsymman.2015.03.009

The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. Journal of Clinical Epidemiology, 76, 18-46. doi: 10.1016/j.jclinepi.2015.05.018

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. Journal of Clinical Epidemiology, 76, 9-17. doi: 10.1016/j.jclinepi.2015.05.004

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

2015

Journal Article

Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study

Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Agar, Meera, Senior, Hugh Edgar John, Carmont, Sue-Ann, Schluter, Philip J., Good, Phillip, Vora, Rohan and Currow, David (2015). Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study. Palliative Medicine, 29 (10), 967-974. doi: 10.1177/0269216315585473

Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 350 (may14 17) h1738, h1738-h1738. doi: 10.1136/bmj.h1738

CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement

2015

Journal Article

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. BMJ, 350 (may14 15) h1793, h1793-h1793. doi: 10.1136/bmj.h1793

CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration

2015

Conference Publication

Using individualized randomized trials to improve health outcomes and reduce costs

Mitchell, G., Nikles, J., Senior, H., Whitty, J., McGree, James, Carmont, S., Kravitz, R., Bazzano, L. and Schmid, C. (2015). Using individualized randomized trials to improve health outcomes and reduce costs. US-Australia Biomedical Research Partnership Conference, Canberra, ACT, Australia, 13 July 2015.

Using individualized randomized trials to improve health outcomes and reduce costs

2015

Book

The essential guide to N-of-1 trials in health

Jane Nikles and Geoffrey Mitchell eds. (2015). The essential guide to N-of-1 trials in health. Amsterdam, Netherlands: Springer.

The essential guide to N-of-1 trials in health

2015

Book Chapter

Where Are N-of-1 Trials Headed?

Nikles, Jane (2015). Where Are N-of-1 Trials Headed?. The essential guide to N-of-1 trials in health. (pp. 233-241) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_17

Where Are N-of-1 Trials Headed?

2015

Book Chapter

What are N-of-1 Trials?

Nikles, Jane (2015). What are N-of-1 Trials?. The essential guide to N-of-1 trials in health. (pp. 9-17) edited by Jane Nikles and Geoffrey Mitchell. Dordecht, Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_2

What are N-of-1 Trials?

2015

Conference Publication

Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer

Agar, M., Lawlor, P., Caplan, G., Ely, E. W., Lam, L., de Souza, P. and Nikles, J. (2015). Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer. Australian Palliative Care Conference, Melbourne, VIC, Australia, 1-4 September 2015.

Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer

Supervision

Availability

Associate Professor Jane Nikles is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Available projects

  • Opioid use and misuse following road traffic musculoskeletal injury

    Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

Media

Enquiries

Contact Associate Professor Jane Nikles directly for media enquiries about:

  • ADHD
  • children
  • Clinical trials
  • General practice research
  • individualised treatments
  • melatonin
  • N-of-1 trials
  • Parkinson's Disease
  • Personalised medicine
  • Single Case Experimental Designs
  • sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au