
Overview
Background
I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.
I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.
I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
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Single Case Experimental Designs
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Whiplash, minor musculoskeletal injury, opioid prescribing
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ADHD, children, sleep
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Melatonin
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Parkinson's Disease
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Skin cancer prevention, improving children's sun protection practices
Works
Search Professor Jane Nikles’s works on UQ eSpace
2016
Journal Article
The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. Journal of School Psychology, 56, 133-142. doi: 10.1016/j.jsp.2016.04.001
2016
Journal Article
The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The Single-Case Reporting Guideline in BEhavioural interventions (SCRIBE) 2016 statement. Journal of Clinical Epidemiology, 73, 142-152. doi: 10.1016/j.jclinepi.2016.04.006
2016
Journal Article
N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis
Punja, Salima, Xu, Dongying, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). N-of-1 trials can be aggregated to generate group mean treatment effects: a systematic review and meta-analysis. Journal of Clinical Epidemiology, 76, 65-75. doi: 10.1016/j.jclinepi.2016.03.026
2016
Journal Article
Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.
Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Senior, Hugh, Carmont, Sue-Ann, Schluter, Philip J., Vora, Rohan, Currow, David and Yelland, Michael (2016). Single patient multiple cross-over studies to determine the effectiveness of paracetamol in relieving pain suffered by patients with advanced cancer taking regular opioids: a pilot study.. Palliative Medicine: a multiprofessional journal, 30 (8), 1-3. doi: 10.1177/0269216316635012
2016
Journal Article
Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review)
Punja, Salima, Shamseer, Larissa, Hartling, Lisa, Urichuk, Liana, Vandermeer, Ben, Nikles, Jane and Vohra, Sunita (2016). Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents (Review). Cochrane Database of Systematic Reviews, 2016 (2) CD009996. doi: 10.1002/14651858.CD009996.pub2
2016
Conference Publication
Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer
Bates, N., Emeto, T., Turner, D., Nikles, J. and Harrison, S. (2016). Sun protection provided by regulation school uniforms worn by primary school students in Queensland during summer. Townsville Health Research Week 2016: Spotlight on Preventative Health, Townsville, QLD, Australia, 12-15 September 2016.
2016
Journal Article
To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD
Punja, Salima, Schmid, Christopher H., Hartling, Lisa, Urichuk, Liana, Nikles, Catherine Jane and Vohra, Sunita (2016). To meta-analyze or not to meta-analyze? A combined meta-analysis of N-of-1 trial data with RCT data on amphetamines and methylphenidate for pediatric ADHD. Journal of Clinical Epidemiology, 76, 76-81. doi: 10.1016/j.jclinepi.2016.03.021
2016
Conference Publication
The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement
Tate, Robyn L., Perdices, Michael, Rosenkoetter, Ulrike, Shadish, William, Vohra, Sunita, Barlow, David H., Horner, Robert, Kazdin, Alan, Kratochwill, Thomas, McDonald, Skye, Sampson, Margaret, Shamseer, Larissa, Togher, Leanne, Albin, Richard, Backman, Catherine, Douglas, Jacinta, Evans, Jonathan J., Gast, David, Manolov, Rumen, Mitchell, Geoffrey, Nickels, Lyndsey, Nikles, Jane, Ownsworth, Tamara, Rose, Miranda, Schmid, Christopher H. and Wilson, Barbara (2016). The single-case reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement. AOTA 96th Annual Conference and Expo, Chicag, Il, United States, 7-10 April 2016. Bethesda, MD, United States: American Occupational Therapy Associatio. doi: 10.5014/ajot.2016.704002
2015
Journal Article
The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial
Mitchell, Geoffrey K., Hardy, Janet R., Nikles, Catherine J., Carmont, Sue-Ann S., Senior, Hugh E., Schluter, Philip J., Good, Philip and Currow, David C. (2015). The effect of methylphenidate on fatigue in advanced cancer: an aggregated n-of-1 trial. Journal of Pain and Symptom Management, 50 (3), 289-296. doi: 10.1016/j.jpainsymman.2015.03.009
2015
Journal Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration
Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. Journal of Clinical Epidemiology, 76, 18-46. doi: 10.1016/j.jclinepi.2015.05.018
2015
Journal Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement
Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. Journal of Clinical Epidemiology, 76, 9-17. doi: 10.1016/j.jclinepi.2015.05.004
2015
Journal Article
Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study
Nikles, Jane, Mitchell, Geoffrey K., Hardy, Janet, Agar, Meera, Senior, Hugh Edgar John, Carmont, Sue-Ann, Schluter, Philip J., Good, Phillip, Vora, Rohan and Currow, David (2015). Testing pilocarpine drops for dry mouth in advanced cancer using n-of-1 trials: A feasibility study. Palliative Medicine, 29 (10), 967-974. doi: 10.1177/0269216315585473
2015
Journal Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration
Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David, Vohra, Sunita and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: explanation and elaboration. BMJ, 350 (may14 15) h1793, h1793-h1793. doi: 10.1136/bmj.h1793
2015
Journal Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement
Vohra, Sunita, Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Tate, Robyn, Nikles, Jane, Zucker, Deborah R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and the CENT group (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 350 (may14 17) h1738, h1738-h1738. doi: 10.1136/bmj.h1738
2015
Conference Publication
Using individualized randomized trials to improve health outcomes and reduce costs
Mitchell, G., Nikles, J., Senior, H., Whitty, J., McGree, James, Carmont, S., Kravitz, R., Bazzano, L. and Schmid, C. (2015). Using individualized randomized trials to improve health outcomes and reduce costs. US-Australia Biomedical Research Partnership Conference, Canberra, ACT, Australia, 13 July 2015.
2015
Book
The essential guide to N-of-1 trials in health
Jane Nikles and Geoffrey Mitchell eds. (2015). The essential guide to N-of-1 trials in health. Amsterdam, Netherlands: Springer.
2015
Book Chapter
Where Are N-of-1 Trials Headed?
Nikles, Jane (2015). Where Are N-of-1 Trials Headed?. The essential guide to N-of-1 trials in health. (pp. 233-241) edited by Jane Nikles and Geoffrey Mitchell. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_17
2015
Book Chapter
What are N-of-1 Trials?
Nikles, Jane (2015). What are N-of-1 Trials?. The essential guide to N-of-1 trials in health. (pp. 9-17) edited by Jane Nikles and Geoffrey Mitchell. Dordecht, Netherlands: Springer. doi: 10.1007/978-94-017-7200-6_2
2015
Conference Publication
Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer
Agar, M., Lawlor, P., Caplan, G., Ely, E. W., Lam, L., de Souza, P. and Nikles, J. (2015). Randomised double blind placebo controlled phase II trial of melatonin for prevention of delirium in inpatients with advanced cancer. Australian Palliative Care Conference, Melbourne, VIC, Australia, 1-4 September 2015.
2015
Journal Article
CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration
Shamseer, Larissa, Sampson, Margaret, Bukutu, Cecilia, Schmid, Christopher H., Nikles, Jane, Tate, Robyn, Johnston, Bradley C., Zucker, Deborah, Shadish, William R., Kravitz, Richard, Guyatt, Gordon, Altman, Douglas G., Moher, David and Vohra, Sunita (2015). CONSORT extension for reporting N-of-1 trials (CENT) 2015: Explanation and elaboration. The BMJ, 350 h1793. doi: 10.1016/j.jclinepi.2015.05.018
Funding
Current funding
Supervision
Availability
- Associate Professor Jane Nikles is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Opioid use and misuse following road traffic musculoskeletal injury
Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.
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N-of-1 trials in health care, melatonin, complementary and alternative medicines.
N-of-1 trials in health care, melatonin, complementary and alternative medicines.
Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.
Please contact me on uqjnikle@uq.edu.au to discuss several available projects.
Supervision history
Completed supervision
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2019
Doctor Philosophy
N-of-1 Trials as a Bioequivalence Method to assess local medicines in resources limited countries: the case of Anti-hypertensive Medicines in Ethiopia
Associate Advisor
Media
Enquiries
Contact Associate Professor Jane Nikles directly for media enquiries about:
- ADHD
- children
- Clinical trials
- General practice research
- individualised treatments
- melatonin
- N-of-1 trials
- Parkinson's Disease
- Personalised medicine
- Single Case Experimental Designs
- sleep
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