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2012 Journal Article Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma modelLee, Michelle J., Hatton, Beryl A., Villavicencio, Elisabeth H., Khanna, Paritosh C., Friedman, Seth D., Ditzler, Sally, Pullar, Barbara, Robison, Keith, White, Kerry F., Tunkey, Chris, LeBlanc, Michael, Randolph-Habecker, Julie, Knoblaugh, Sue E., Hansen, Stacey, Richards, Andrew, Wainwright, Brandon J., McGovern, Karen and Olson, James M. (2012). Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proceedings of the National Academy of Sciences of the United States of America, 109 (20), 7859-7864. doi: 10.1073/pnas.1114718109 |
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2012 Journal Article Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathiesAshe, Alyson, Butterfield, Natalie C., Town, Liam, Courtney, Andrew D., Cooper, Ashley N., Ferguson, Charles, Barry, Rachael, Olsson, Fredrik, Liem, Karel F., Parton, Robert G., Wainwright, Brandon J., Anderson, Kathryn V., Whitelaw, Emma and Wicking, Carol (2012). Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Human Molecular Genetics, 21 (8) ddr613, 1808-1823. doi: 10.1093/hmg/ddr613 |
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2011 Journal Article Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humansNgan, Elly Sau-Wai, Garcia-Barcelo, Maria-Merce, Yip, Benjamin Hon-Kei, Poon, Hiu-Cheng, Lau, Sin-Ting, Kwok, Carmen Ka-Man, Sat, Eric, Sham, Mai-Har, Wong, Kenneth Kak-Yuen, Wainwright, Brandon J., Cherny, Stacey S, Hui, Chi-Chung, Sham, Pak Chung, Lui, Vincent Chi-Hang and Tam, Paul Kwong-Ham (2011). Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. Journal of Clinical Investigation, 121 (9), 3467-3478. doi: 10.1172/JCI43737 |
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2011 Journal Article Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signalingFan, Qipeng, Gu, Dongsheng, He, Miao, Liu, Hailan, Sheng. Tao, Xie, Guorui, Li, Ching-xin, Zhang, Xaoili, Wainwright, Brandon J., Garrossian, Arash, Garrossian, Massoud, Gardner, Dale and Xie, Jingwu (2011). Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chinese Journal of Cancer, 30 (7), 472-481. doi: 10.5732/cjc.011.10157 |
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2011 Journal Article Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitorsDave, Richa K., Ellis, Tammy, Toumpas, Melissa C., Robson, Jonathan P., Julian, Elaine, Adolphe, Christelle, Bartlett, Perry F., Cooper, Helen M., Reynolds, Brent A. and Wainwright, Brandon J. (2011). Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One, 6 (2) e14680, e14680-1-e14680-13. doi: 10.1371/journal.pone.0014680 |
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2011 Journal Article Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stagesShikata, Yayoi, Okada, Toshiaki, Hashimoto, Mitsuhiro, Ellis, Tammy L., Matsumaru, Daisuke, Shiroishi, Toshihiko, Ogawa, Masaharu, Wainwright, Brandon J. and Motoyama, Jun (2011). Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Developmental Biology, 349 (2), 147-159. doi: 10.1016/j.ydbio.2010.10.014 |
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2010 Journal Article An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammationMacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296 |
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2010 Journal Article RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layerJulian, Elaine, Hallahan, Andrew R. and Wainwright, Brandon J. (2010). RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer. Neural Development, 5 (1) 27, 27. doi: 10.1186/1749-8104-5-27 |
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2010 Journal Article Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activityVillani, Rehan M., Adolphe, Christelle, Palmer, James, Waters, Michael J. and Wainwright, Brandon J. (2010). Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prevention Research, 3 (10), 1222-1234. doi: 10.1158/1940-6207.CAPR-10-0082 |
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2010 Journal Article Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastomaJulian, E., Dave, R. K., Robson, J. P., Hallahan, A. R. and Wainwright, B. J. (2010). Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma. Oncogene, 29 (24), 3465-3476. doi: 10.1038/onc.2010.101 |
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2010 Journal Article International network of cancer genome projectsHudson, T. J., Anderson, W., Aretz, A., Barker, A. D., Grimmond, S. M., Pearson, J. V., Cloonan, N., Gardiner, B. A., Waddell, N. J., Wilson, P. J., Wainwright, B. J. and The International Cancer Genome Consortium (2010). International network of cancer genome projects. Nature, 464 (7291), 993-998. doi: 10.1038/nature08987 |
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2010 Journal Article Wnt2 regulates progenitor proliferation in the developing ventral midbrainSousa, Kyle M., Villaescusa, J. Carlos, Cajanek, Lukas, Ondr, Jennifer K., Castelo-Branco, Goncalo, Hofstra, Wytske, Bryja, Vitezslav, Palmberg, Carina, Bergman, Tomas, Wainwright, Brandon, Lang, Richard A. and Arenas, Ernest (2010). Wnt2 regulates progenitor proliferation in the developing ventral midbrain. Journal of Biological Chemistry, 285 (10), 7246-7253. doi: 10.1074/jbc.M109.079822 |
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2009 Journal Article Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limbButterfield, N. C., Metzis, V, McGlinn, E, Bruce, S. J., Wainwright, B. J. and Wicking, C (2009). Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. DEVELOPMENT, 136 (20), 3515-3524. doi: 10.1242/dev.037507 |
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2009 Journal Article The hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanismsSiggins, S. L., Nguyen, N. Y. N., McCormack, M. P., Vasudevan, S, Villani, R, Jane, S. M., Wainwright, B. J. and Curtis, D. J. (2009). The hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. BLOOD, 114 (5), 995-1004. doi: 10.1182/blood-2009-03-208330 |
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2009 Journal Article Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongationMoraes, R. C., Chang, H, Harrington, N, Landua, J. D., Prigge, J. T., Lane, T. F., Wainwright, B. J., Hamel, P. A. and Lewis, M. T. (2009). Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation. DEVELOPMENT, 136 (9), 1423-1432. doi: 10.1242/dev.023994 |
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2009 Journal Article Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progressionThomas, W. D., Chen, J, Gao, Y. R., Cheung, B, Koach, J, Sekyere, E, Norris, M. D., Haber, M, Ellis, T, Wainwright, B and Marshall, G. M. (2009). Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression. ONCOGENE, 28 (13), 1605-1615. doi: 10.1038/onc.2009.3 |
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2008 Journal Article Targeted disruption of Brca1 in restricted compartments of the mouse mammary epitheliaSmart, Chanel E., Clarke, Catherine, Brooks, Kelly M., Raghavendra, Ashwini, Brewster, Brooke L., French, Juliet D., Hetherington, Rehan, Fleming, Jean S., Rothnagel, Joseph A., Wainwright, Brandon, Lakhani, Sunil R. and Brown, Melissa A. (2008). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Breast Cancer Research and Treatment, 112 (2), 237-241. doi: 10.1007/s10549-007-9859-2 |
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2008 Journal Article Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cellsYang, Zeng-Jie, Ellis, Tammy L., Markant, Shirley L., Read, Tracy-Ann, Kessler, Jessica D, Melissa Bourboulas, Schuller, Ulrich, Machold, Robert, Fishell, Gord, Rowitch, David H., Wainwright, Brandon J. and Wechsler-Reya, Robert J. (2008). Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell, 14 (2), 135-145. doi: 10.1016/j.ccr.2008.07.003 |
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2008 Journal Article Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limbMcGlinn, Edwina, Richman, Joy M., Metzis, Vicki, Town, Liam, Butterfield, Natalie C., Wainwright, Brandon J. and Wicking, Carol (2008). Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb. Developmental Dynamics, 237 (4), 1172-1182. doi: 10.1002/dvdy.21508 |
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2008 Journal Article Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signallingIngram, W. J., McCue, K. I., Tran, T. H., Hallahan, A. R. and Wainwright, B. J. (2008). Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene, 27 (10), 1489-1500. doi: 10.1038/sj.onc.1210767 |
