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2024 Conference Publication Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastomaAhmad, Shiekh Tanveer, Garcia-Lopez, Jesus, Li, Yiran, Gudenas, Brian, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Soliman, Taha, Kojic, Marija, Pitre, Aaron, Manz, Frederik, Zindy, Frederique, Jones, Alun, Mayasundari, Anand, Bianski, Brandon, Tinkle, Christopher, Shirinifard, Abbas, Janke, Laura, Lu, Meifen, Pfister, Stefan M., Gajjar, Amar, Baker, Suzanne J., Roussel, Martine F., Rankovic, Zoran, Waszak, Sebastian M., Robinson, Giles W., Orr, Brent A., Wainwright, Brandon, Kutscher, Lena M. ... Northcott, Paul A. (2024). Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma. International Symposium on Pediatric Neuro-Oncology (ISPNO), Philadelphia, PA, United States, 29 June - 2 July 2024. Cary, NC, United States: Oxford University Press. doi: 10.1093/neuonc/noae064.462 |
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2024 Journal Article The Virtual ChildGilbertson, Richard J., Behjati, Sam, Böttcher, Anna-Lisa, Bronner, Marianne E., Burridge, Matthew, Clausing, Henrick, Clifford, Harry, Danaher, Tracey, Donovan, Laura K., Drost, Jarno, Eggermont, Alexander M.M., Emerson, Chris, Flores, Mona G., Hamerlik, Petra, Jabado, Nada, Jones, Andrew, Kaessmann, Henrick, Kleinman, Claudia L., Kool, Marcel, Kutscher, Lena M., Lindberg, Gavin, Linnane, Emily, Marioni, John C., Maris, John M., Monje, Michelle, Macaskill, Alexandra, Niederer, Steven, Northcott, Paul A., Peeters, Elizabeth ... Pfister, Stefan M. (2024). The Virtual Child. Cancer Discovery, 14 (4), 663-668. doi: 10.1158/2159-8290.cd-23-1500 |
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2023 Journal Article Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumorsEndersby, Raelene, Wainwright, Brandon J. and Gottardo, Nicholas G. (2023). Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumors. Frontiers in Oncology, 13 1274465. doi: 10.3389/fonc.2023.1274465 |
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2023 Journal Article Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screeningKojic, Marija, Maybury, Mellissa K., Waddell, Nicola, Koufariotis, Lambros T., Addala, Venkateswar, Millar, Amanda, Wood, Scott, Pearson, John V., Hansford, Jordan R., Hassall, Tim and Wainwright, Brandon J. (2023). Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening. Neuro-Oncology, 25 (8), 1507-1517. doi: 10.1093/neuonc/noad032 |
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2023 Conference Publication Uncovering Dynamic Changes In Medulloblastoma Associated Vasculature In ZebrafishMorris, Elysse, Daignault-Mill, Sheena, Ju, Robert J., da Silva, Jason, Gordon, Emma, Wainwright, Brandon, Stehbens, Samantha, Genovesi, Laura and Lagendijk, Anne (2023). Uncovering Dynamic Changes In Medulloblastoma Associated Vasculature In Zebrafish. 2023 Pediatric Neuro-Oncology Research Conference, Washington, DC United States, 22-24 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noad073.274 |
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2023 Conference Publication ELP1 Germline Deficiency Sensitizes The Granule Neuron Lineage To SHH Medulloblastoma And Exposes Novel Therapeutic VulnerabilitiesGarcia-Lopez, Jesus, Ahmad, Shiekh Tanveer, Li, Yiran, Gudenas, Brian, Kojic, Marija, Manz, Friedrik, Jonchere, Barbara, Mayasundari, Anand, Pitre, Aaron, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Pfister, Stefan, Waszak, Sebastian, Bianski, Brandon, Tinkle, Christopher, Orr, Brent, Rankovic, Zoran, Robinson, Giles, Wainwright, Brandon, Kutscher, Lena, Lin, Hong and Northcott, Paul (2023). ELP1 Germline Deficiency Sensitizes The Granule Neuron Lineage To SHH Medulloblastoma And Exposes Novel Therapeutic Vulnerabilities. 2023 Pediatric Neuro-Oncology Research Conference, Washington, DC United States, 22-24 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noad073.255 |
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2023 Journal Article Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibitionVo, Tuan, Balderson, Brad, Jones, Kahli, Ni, Guiyan, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Kojic, Marija, Robertson, Thomas, Walters, Shaun, Mulay, Onkar, Bhuva, Dharmesh D., Davis, Melissa J., Wainwright, Brandon J., Nguyen, Quan and Genovesi, Laura A. (2023). Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition. Genome Medicine, 15 (1) 29, 29. doi: 10.1186/s13073-023-01185-4 |
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2023 Journal Article A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotypeKojic, Marija, Abbassi, Nour E. H., Lin, Ting-Yu, Jones, Alun, Wakeling, Emma L., Clement, Emma, Nakou, Vasiliki, Singleton, Matthew, Dobosz, Dominika, Kaliakatsos, Marios, Glatt, Sebastian and Wainwright, Brandon J. (2023). A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype. Journal of Human Genetics, 68 (7), 445-453. doi: 10.1038/s10038-023-01135-3 |
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2023 Journal Article Elongator and the role of its subcomplexes in human diseasesGaik, Monika, Kojic, Marija, Wainwright, Brandon J and Glatt, Sebastian (2023). Elongator and the role of its subcomplexes in human diseases. EMBO Molecular Medicine, 15 (2) e16418, e16418. doi: 10.15252/emmm.202216418 |
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2022 Journal Article Functional divergence of the two Elongator subcomplexes during neurodevelopmentGaik, Monika, Kojic, Marija, Stegeman, Megan R., Öncü‐Öner, Tülay, Kościelniak, Anna, Jones, Alun, Mohamed, Ahmed, Chau, Pak Yan Stefanie, Sharmin, Sazia, Chramiec‐Głąbik, Andrzej, Indyka, Paulina, Rawski, Michał, Biela, Anna, Dobosz, Dominika, Millar, Amanda, Chau, Vann, Ünalp, Aycan, Piper, Michael, Bellingham, Mark C., Eichler, Evan E., Nickerson, Deborah A., Güleryüz, Handan, Abbassi, Nour El Hana, Jazgar, Konrad, Davis, Melissa J., Mercimek‐Andrews, Saadet, Cingöz, Sultan, Wainwright, Brandon J. and Glatt, Sebastian (2022). Functional divergence of the two Elongator subcomplexes during neurodevelopment. EMBO Molecular Medicine, 14 (7) e15608, e15608. doi: 10.15252/emmm.202115608 |
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2022 Conference Publication MEDB-06. Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that loss of heterogeneity and induced differentiation underlies the response to CDK4/6 inhibitionVo, Tuan, Balderson, Brad, Jones, Kahli, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Ruitenberg, Marc, Robertson, Thomas, Bhuva, Dharmesh, Davis, Melissa, Wainwright, Brandon, Nguyen, Quan and Genovesi, Laura (2022). MEDB-06. Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that loss of heterogeneity and induced differentiation underlies the response to CDK4/6 inhibition. International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, 12–15 June 2022. Cary, NC, United States: Oxford University Press. doi: 10.1093/neuonc/noac079.381 |
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2021 Journal Article SOX9 defines distinct populations of cells in SHH medulloblastoma but is not required for Math1-driven tumour formationAdolphe, Christelle, Millar, Amanda, Kojic, Marija, Barkauskas, Deborah S., Sundstrom, Anders, Swartling, Fredrik J., Hediyeh-zadeh, Soroor, Tan, Chin Wee, Davis, Melissa J., Genovesi, Laura A. and Wainwright, Brandon J. (2021). SOX9 defines distinct populations of cells in SHH medulloblastoma but is not required for Math1-driven tumour formation. Molecular Cancer Research, 19 (11), 1831-1839. doi: 10.1158/1541-7786.mcr-21-0117 |
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2021 Journal Article Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapseGuo, Duancheng, Wang, Yuan, Cheng, Yan, Liao, Shengyou, Hu, Jian, Du, Fang, Xu, Gang, Liu, Yongqiang, Cai, Kathy Q., Cheung, Martin, Wainwright, Brandon J., Lu, Q. Richard, Zhao, Yi and Yang, Zeng-jie (2021). Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. Journal of Experimental Medicine, 218 (9) e20202350, 1-18. doi: 10.1084/jem.20202350 |
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2021 Journal Article Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastomaGenovesi, Laura A., Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Hassall, Emily, Kojic, Marija, Brighi, Caterina, Girard, Emily, Andradas, Clara, Kuchibhotla, Mani, Bhuva, Dharmesh D., Endersby, Raelene, Gottardo, Nicholas G., Bernard, Anne, Adolphe, Christelle, Olson, James M., Taylor, Michael D., Davis, Melissa J. and Wainwright, Brandon J. (2021). Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Genome Medicine, 13 (1) 103, 103. doi: 10.1186/s13073-021-00920-z |
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2021 Journal Article Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotypeKojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen ... Wainwright, Brandon J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature Communications, 12 (1) 2678, 2678. doi: 10.1038/s41467-021-22888-5 |
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2021 Journal Article Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β releaseStarobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452 |
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2021 Journal Article Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibilityAdolphe, Christelle, Xue, Angli, Fard, Atefeh Taherian, Genovesi, Laura A., Yang, Jian and Wainwright, Brandon J. (2021). Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility. Genome Medicine, 13 (1) 19, 19. doi: 10.1186/s13073-021-00827-9 |
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2020 Journal Article Patient derived orthotopic xenograft models of Medulloblastoma lack a functional blood brain barrierGenovesi, Laura A., Puttick, Simon, Millar, Amanda, Kojic, Marija, Ji, Pengxiang, Lagendijk, Anne K., Brighi, Caterina, Bonder, Claudine S, Adolphe, Christelle and Wainwright, Brandon J. (2020). Patient derived orthotopic xenograft models of Medulloblastoma lack a functional blood brain barrier. Neuro-Oncology, 23 (5), 732-742. doi: 10.1093/neuonc/noaa266 |
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2020 Journal Article Germline elongator mutations in Sonic Hedgehog medulloblastomaWaszak, Sebastian M., Robinson, Giles W,, Gudenas, Brian L., Smith, Kyle S., Forget, Antoine, Kojic, Marija, Garcia-Lopez, Jesus, Hadley, Jennifer, Hamilton, Kayla V., Indersie, Emilie, Buchhalter, Ivo, Kerssemakers, Jules, Jäger, Natalie, Sharma, Tanvi, Rausch, Tobias, Kool, Marcel, Sturm, Dominik, Jones, David T. W., Vasilyeva, Aksana, Tatevossian, Ruth G., Neale, Geoffrey, Lombard, Bérangère, Loew, Damarys, Nakitandwe, Joy, Rusch, Michael, Bowers, Daniel C., Bendel, Anne, Partap, Sonia, Chintagumpala, Murali ... Pfister, Stefan M. (2020). Germline elongator mutations in Sonic Hedgehog medulloblastoma. Nature, 580 (7803), 396-401. doi: 10.1038/s41586-020-2164-5 |
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2020 Journal Article Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progressionVillani, Rehan, Sim, Seen Ling, Roy, Edwige, Wainwright, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98 (3), 179-185. doi: 10.1016/j.jdermsci.2020.04.006 |
