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2014 Conference Publication Mouse Functional Genomics to Predict Novel Drug Targets for All Subgroups of MedulloblastomaGenovesi, Laura, Ji, Pengxiang, Davis, Melissa, Ching Ging Ng, Remke, Marc, Taylor, Michael, Cho, Yoon-Jae, Jenkins, Nancy, Copeland, Neil and Wainwright, Brandon (2014). Mouse Functional Genomics to Predict Novel Drug Targets for All Subgroups of Medulloblastoma. 16th International Symposium on Pediatric Neuro-Oncology (ISPNO), Singapore, Singapore, 28 June - 02 July 2014. Cary, NC United States: Oxford University Press. doi: 10.1093/neuonc/nou074 |
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2014 Journal Article Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progressionMilla, Luis A., Arros, Andrea, Espinoza, Natalie, Remke. Marc, Kool, Marcel, Taylor, Michael D., Pfister, Stefan M., Wainwright, Brandon J. and Palma, Verónica (2014). Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. International Journal of Cancer, 134 (1), 21-31. doi: 10.1002/ijc.28330 |
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2013 Conference Publication Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working GroupGottardo, Nicholas G., Hansford, Jordan R., McGlade, Jacqueline P., Alvaro, Frank, Ashley, David M., Bailey, Simon, Baker, David L., Bourdeaut, Franck, Cho, Yoon‑Jae, Clay, Moira, Clifford, Steven C., Cohn, Richard J., Cole, Catherine H., Dallas, Peter B., Downie, Peter, Doz, François, Ellison, David W., Endersby, Raelene, Fisher, Paul G., Hassall, Timothy, Heath, John A., Hii, Hilary L., Jones, David T. W., Junckerstorff, Reimar, Kellie, Stewart, Kool, Marcel, Kotecha, Rishi S., Lichter, Peter, Laughton, Stephen J. ... Gajjar, Amar (2013). Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Heidelberg, Germany: Springer. doi: 10.1007/s00401-013-1213-7 |
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2013 Journal Article Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroupsGenovesi, Laura A., Ng, Ching Ging, Davis, Melissa J., Remke, Marc, Taylor, Michael D., Adams, David J., Rust, Alistair G., Ward, Jerrold M., Ban, Kenneth H., Jenkins, Nancy A., Copeland, Neal G. and Wainwright, Brandon J. (2013). Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proceedings of the National Academy of Sciences of the United States of America, 110 (46), E4325-E4334. doi: 10.1073/pnas.1318639110 |
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2013 Journal Article Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiationCalao, M., Sekyere, E. O., Cui, H. J., Cheung, B. B., Thomas, W. D., Keating, J., Chen, J. B., Raif, A., Jankowski, K., Davies, N. P., Bekkum, M. V., Chen, B., Tan, O., Ellis, T., Norris, M. D., Haber, M., Kim. E. S., Shohet, J. M., Trahair, T. N., Lui, T., Wainwright, B. J., Ding, H. F. and Marshall, G. M. (2013). Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation. Oncogene, 32 (31), 3616-3626. doi: 10.1038/onc.2012.368 |
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2013 Journal Article Patched1 is required in neural crest cells for the prevention of orofacial cleftsMetzis, Vicki, Courtney, Andrew D., Kerr, Markus C., Ferguson, Charles, Rondón Galeano, Maria C., Parton, Robert G., Wainwright, Brandon J. and Wicking, Carol (2013). Patched1 is required in neural crest cells for the prevention of orofacial clefts. Human Molecular Genetics, Advance Access (24) ddt353, 1-10. doi: 10.1093/hmg/ddt353 |
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2013 Journal Article Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) SourceMartinez, Constanza, Hugo Cornejo, Victor, Lois, Pablo, Ellis, Tammy, Solis, Natalia P., Wainwright, Brandon J. and Palma, Veronica (2013). Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source. PLoS One, 8 (6) e65818, e65818.1-e65818.10. doi: 10.1371/journal.pone.0065818 |
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2013 Journal Article Murine basal cell carcinoma leads to tumor mediated alterations in endocrine lgf1 signalingVillani, Rehan M., Waters, Michael J. and Wainwright, Brandon J. (2013). Murine basal cell carcinoma leads to tumor mediated alterations in endocrine lgf1 signaling. Endocrine - Related Cancer, 20 (3), 273-281. doi: 10.1530/ERC-12-0307 |
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2012 Journal Article Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesisLi, Zhu Juan, Nieuwenhuis, Erica, Nien, Weilun, Zhang, Xiaoyun, Zhang, Jennifer, Puviindran, Vijitha, Wainwright, Brandon J., Kim, Peter C. W. and Hui, Chi-chung (2012). Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development, 139 (22), 4152-4161. doi: 10.1242/dev.081190 |
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2012 Journal Article Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma modelLee, Michelle J., Hatton, Beryl A., Villavicencio, Elisabeth H., Khanna, Paritosh C., Friedman, Seth D., Ditzler, Sally, Pullar, Barbara, Robison, Keith, White, Kerry F., Tunkey, Chris, LeBlanc, Michael, Randolph-Habecker, Julie, Knoblaugh, Sue E., Hansen, Stacey, Richards, Andrew, Wainwright, Brandon J., McGovern, Karen and Olson, James M. (2012). Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proceedings of the National Academy of Sciences of the United States of America, 109 (20), 7859-7864. doi: 10.1073/pnas.1114718109 |
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2012 Journal Article Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathiesAshe, Alyson, Butterfield, Natalie C., Town, Liam, Courtney, Andrew D., Cooper, Ashley N., Ferguson, Charles, Barry, Rachael, Olsson, Fredrik, Liem, Karel F., Parton, Robert G., Wainwright, Brandon J., Anderson, Kathryn V., Whitelaw, Emma and Wicking, Carol (2012). Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Human Molecular Genetics, 21 (8) ddr613, 1808-1823. doi: 10.1093/hmg/ddr613 |
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2012 Conference Publication Hedgehog pathway regulation of basal cell carcinoma and epidermal differentiationAdolphe, C., Villani, R., Niewenhuis, E., Li, S., Kaur, P., Hui, C. and Wainwright, B. (2012). Hedgehog pathway regulation of basal cell carcinoma and epidermal differentiation. Conjoint 3rd Australasian Wound & Tissue Repair Society and 9th Australasian Society for Dermatology Research Conference, Sydney, NSW, Australia, 22-24 May 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1524-475X.2012.00835.x |
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2011 Journal Article Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humansNgan, Elly Sau-Wai, Garcia-Barcelo, Maria-Merce, Yip, Benjamin Hon-Kei, Poon, Hiu-Cheng, Lau, Sin-Ting, Kwok, Carmen Ka-Man, Sat, Eric, Sham, Mai-Har, Wong, Kenneth Kak-Yuen, Wainwright, Brandon J., Cherny, Stacey S, Hui, Chi-Chung, Sham, Pak Chung, Lui, Vincent Chi-Hang and Tam, Paul Kwong-Ham (2011). Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. Journal of Clinical Investigation, 121 (9), 3467-3478. doi: 10.1172/JCI43737 |
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2011 Journal Article Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signalingFan, Qipeng, Gu, Dongsheng, He, Miao, Liu, Hailan, Sheng. Tao, Xie, Guorui, Li, Ching-xin, Zhang, Xaoili, Wainwright, Brandon J., Garrossian, Arash, Garrossian, Massoud, Gardner, Dale and Xie, Jingwu (2011). Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chinese Journal of Cancer, 30 (7), 472-481. doi: 10.5732/cjc.011.10157 |
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2011 Journal Article Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitorsDave, Richa K., Ellis, Tammy, Toumpas, Melissa C., Robson, Jonathan P., Julian, Elaine, Adolphe, Christelle, Bartlett, Perry F., Cooper, Helen M., Reynolds, Brent A. and Wainwright, Brandon J. (2011). Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One, 6 (2) e14680, e14680-1-e14680-13. doi: 10.1371/journal.pone.0014680 |
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2011 Journal Article Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stagesShikata, Yayoi, Okada, Toshiaki, Hashimoto, Mitsuhiro, Ellis, Tammy L., Matsumaru, Daisuke, Shiroishi, Toshihiko, Ogawa, Masaharu, Wainwright, Brandon J. and Motoyama, Jun (2011). Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Developmental Biology, 349 (2), 147-159. doi: 10.1016/j.ydbio.2010.10.014 |
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2011 Conference Publication Patched1 is essential for nasal pit invagination in mouseMetzis, Vicki, Courtney, Andrew, Ferguson, Charles, Cooper, Ashley, Wainwright, Brandon and Wicking, Carol (2011). Patched1 is essential for nasal pit invagination in mouse. Society for Developmental Biology 70th Annual Meeting, Chicago IL, United States, 21-25 July 2011. Maryland Heights MO, United States: Academic Press. doi: 10.1016/j.ydbio.2011.05.164 |
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2010 Journal Article An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammationMacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296 |
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2010 Journal Article RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layerJulian, Elaine, Hallahan, Andrew R. and Wainwright, Brandon J. (2010). RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer. Neural Development, 5 (1) 27, 27. doi: 10.1186/1749-8104-5-27 |
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2010 Journal Article Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activityVillani, Rehan M., Adolphe, Christelle, Palmer, James, Waters, Michael J. and Wainwright, Brandon J. (2010). Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prevention Research, 3 (10), 1222-1234. doi: 10.1158/1940-6207.CAPR-10-0082 |
