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2021 Journal Article Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibilityvan Blokland, Irene V., Lanting, Pauline, Ori, Anil P.S., Vonk, Judith M., Warmerdam, Robert C.A., Herkert, Johanna C., Boulogne, Floranne, Claringbould, Annique, Lopera-Maya, Esteban A., Bartels, Meike, Hottenga, Jouke-Jan, Ganna, Andrea, Karjalainen, Juha, Hayward, Caroline, Fawns-Ritchie, Chloe, Campbell, Archie, Porteous, David, Cirulli, Elizabeth T., Barrett, Kelly M. Schiabor, Riffle, Stephen, Bolze, Alexandre, White, Simon, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Lim, Yan Wei, Lu, James T., Washington, Nicole L., de Geus, Eco J. C. ... Yengo, Loic (2021). Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility. PLoS One, 16 (8) e0255402, 1-18. doi: 10.1371/journal.pone.0255402 |
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2021 Journal Article Genetic association study of childhood aggression across raters, instruments, and ageIp, Hill F., van der Laan, Camiel M., Krapohl, Eva M. L., Brikell, Isabell, Sánchez-Mora, Cristina, Nolte, Ilja M., St Pourcain, Beate, Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi, Colodro-Conde, Lucía, Gordon, Scott, Zayats, Tetyana, Aliev, Fazil, Jiang, Chang, Wang, Carol A., Saunders, Gretchen, Karhunen, Ville, Hammerschlag, Anke R., Adkins, Daniel E., Border, Richard, Peterson, Roseann E., Prinz, Joseph A., Thiering, Elisabeth, Seppälä, Ilkka, Vilor-Tejedor, Natàlia, Ahluwalia, Tarunveer S., Day, Felix R., Hottenga, Jouke-Jan ... Boomsma, Dorret I. (2021). Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry, 11 (1) 413, 413. doi: 10.1038/s41398-021-01480-x |
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2021 Journal Article Genetic risk for chronic pain is associated with lower antidepressant effectiveness: converging evidence for a depression subtypeCampos, Adrián I., Ngo, Trung Thanh, Medland, Sarah E., Wray, Naomi R., Hickie, Ian B., Byrne, Enda M., Martin, Nicholas G. and Rentería, Miguel E. (2021). Genetic risk for chronic pain is associated with lower antidepressant effectiveness: converging evidence for a depression subtype. Australian and New Zealand Journal of Psychiatry, 56 (9) 00048674211031491, 1-10. doi: 10.1177/00048674211031491 |
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2021 Journal Article Genomic partitioning of inbreeding depression in humansYengo, Loic, Yang, Jian, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2021). Genomic partitioning of inbreeding depression in humans. American Journal of Human Genetics, 108 (8), 1488-1501. doi: 10.1016/j.ajhg.2021.06.005 |
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2021 Journal Article Neurobiology Youth Follow-up Study: Protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention serviceNichles, Alissa, Zmicerevska, Natalia, Song, Yun Ju Christine, Wilson, Chloe, McHugh, Catherine, Hamilton, Blake, Crouse, Jacob, Rohleder, Cathrin, Carpenter, Joanne Sarah, Ho, Nicholas, Hermens, Daniel F., Wray, Naomi, Scott, Jan, Merikangas, Kathleen R., Leweke, F. Markus, Koethe, Dagmar, Iorfino, Frank, Naismith, Sharon L., Guastella, Adam J., Scott, Elizabeth M. and Hickie, Ian B (2021). Neurobiology Youth Follow-up Study: Protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service. BMJ Open, 11 (6) e044731, 1-8. doi: 10.1136/bmjopen-2020-044731 |
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2021 Journal Article Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traitsMartin, Joanna, Khramtsova, Ekaterina A., Goleva, Slavina B., Blokland, Gabriëlla A.M., Traglia, Michela, Walters, Raymond K., Hübel, Christopher, Coleman, Jonathan R.I., Breen, Gerome, Børglum, Anders D., Demontis, Ditte, Grove, Jakob, Werge, Thomas, Bralten, Janita, Bulik, Cynthia M., Lee, Phil H., Mathews, Carol A., Peterson, Roseann E., Winham, Stacey J., Wray, Naomi, Edenberg, Howard J., Guo, Wei, Yao, Yin, Neale, Benjamin M., Faraone, Stephen V., Petryshen, Tracey L., Weiss, Lauren A., Duncan, Laramie E., Goldstein, Jill M. ... Stahl, Eli (2021). Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Biological Psychiatry, 89 (12), 1127-1137. doi: 10.1016/j.biopsych.2020.12.024 |
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2021 Journal Article Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic predictionAlbiñana, Clara, Grove, Jakob, McGrath, John J., Agerbo, Esben, Wray, Naomi R., Bulik, Cynthia M, Nordentoft, Merete, Hougaard, David M, Werge, Thomas, Børglum, Anders D, Mortensen, Preben Bo, Privé, Florian and Vilhjálmsson, Bjarni J (2021). Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction. American Journal of Human Genetics, 108 (6), 1-11. doi: 10.1016/j.ajhg.2021.04.014 |
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2021 Journal Article Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biologyMullins, Niamh, Forstner, Andreas J., O'Connell, Kevin S., Coombes, Brandon, Coleman, Jonathan R I, Qiao, Zhen, Als, Thomas D., Bigdeli, Tim B., Børte, Sigrid, Bryois, Julien, Charney, Alexander W., Drange, Ole Kristian, Gandal, Michael J., Hagenaars, Saskia P., Ikeda, Masashi, Kamitaki, Nolan, Kim, Minsoo, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Steinberg, Stacy, Trubetskoy, Vassily, Winsvold, Bendik S., Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Agerbo, Esben, Al Eissa, Mariam ... Andreassen, Ole A. (2021). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature genetics, 53 (6), 817-829. doi: 10.1038/s41588-021-00857-4 |
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2021 Journal Article Gene action, genetic variation, and GWAS: A user-friendly web toolHivert, Valentin, Wray, Naomi R. and Visscher, Peter M. (2021). Gene action, genetic variation, and GWAS: A user-friendly web tool. PLoS Genetics, 17 (5) e1009548, 1-9. doi: 10.1371/journal.pgen.1009548 |
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2021 Journal Article Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021)Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021). American Journal of Human Genetics, 108 (5), 962-962. doi: 10.1016/j.ajhg.2021.04.012 |
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2021 Journal Article Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophreniaRestuadi, Restuadi, Garton, Fleur C., Benyamin, Beben, Lin, Tian, Williams, Kelly L., Vinkhuyzen, Anna, van Rheenen, Wouter, Zhu, Zhihong, Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Visscher, Peter M., Needham, Merrilee, Mathers, Susan, Nicholson, Garth, Rowe, Dominic B., Henderson, Robert D., McCombe, Pamela A., Pamphlett, Roger, Blair, Ian P., Wray, Naomi R. and McRae, Allan F. (2021). Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia. European Journal of Human Genetics, 30 (5), 1-8. doi: 10.1038/s41431-021-00885-y |
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2021 Journal Article Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectivenessRoughan, William H., Campos, Adrián I., García-Marín, Luis M., Cuéllar-Partida, Gabriel, Lupton, Michelle K., Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Byrne, Enda M., Ngo, Trung Thanh, Martin, Nicholas G. and Rentería, Miguel E. (2021). Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness. Frontiers in Psychiatry, 12 643609, 1-13. doi: 10.3389/fpsyt.2021.643609 |
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2021 Journal Article Risk of early-onset depression associated with polygenic liability, parental psychiatric history, and socioeconomic statusAgerbo, Esben, Trabjerg, Betina B., Børglum, Anders D., Schork, Andrew J., Vilhjálmsson, Bjarni J., Pedersen, Carsten B., Hakulinen, Christian, Albiñana, Clara, Hougaard, David M., Grove, Jakob, McGrath, John J., Bybjerg-Grauholm, Jonas, Mors, Ole, Plana-Ripoll, Oleguer, Werge, Thomas, Wray, Naomi R., Mortensen, Preben Bo and Musliner, Katherine L. (2021). Risk of early-onset depression associated with polygenic liability, parental psychiatric history, and socioeconomic status. JAMA Psychiatry, 78 (4), 387-397. doi: 10.1001/jamapsychiatry.2020.4172 |
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2021 Journal Article Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individualsHivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals. The American Journal of Human Genetics, 108 (5), 786-798. doi: 10.1016/j.ajhg.2021.02.014 |
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2021 Journal Article Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disordersNabais, Marta F., Laws, Simon M., Lin, Tian, Vallerga, Costanza L., Armstrong, Nicola J., Blair, Ian P., Kwok, John B., Mather, Karen A., Mellick, George D., Sachdev, Perminder S., Wallace, Leanne, Henders, Anjali K., Zwamborn, Ramona A. J., Hop, Paul J., Lunnon, Katie, Pishva, Ehsan, Roubroeks, Janou A. Y., Soininen, Hilkka, Tsolaki, Magda, Mecocci, Patrizia, Lovestone, Simon, Kloszewska, Iwona, Vellas, Bruno, Furlong, Sarah, Garton, Fleur C., Henderson, Robert D., Mathers, Susan, McCombe, Pamela A., Needham, Merrilee ... McRae, Allan F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22 (1) 90, 1-30. doi: 10.1186/s13059-021-02275-5 |
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2021 Journal Article Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization studyChauquet, Solal, Zhu, Zhihong, O'Donovan, Michael C., Walters, James T. R., Wray, Naomi R. and Shah, Sonia (2021). Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study. JAMA Psychiatry, 78 (6), 623-631. doi: 10.1001/jamapsychiatry.2021.0005 |
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2021 Journal Article Genome-wide gene expression changes in postpartum depression point towards an altered immune landscapeMehta, Divya, Grewen, Karen, Pearson, Brenda, Wani, Shivangi, Wallace, Leanne, Henders, Anjali K., Binder, Elisabeth B., Frokjaer, Vibe G., Meltzer-Brody, Samantha, Wray, Naomi R. and Stuebe, Alison M. (2021). Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape. Translational Psychiatry, 11 (1) 155, 155. doi: 10.1038/s41398-021-01270-5 |
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2021 Journal Article Widespread signatures of natural selection across human complex traits and functional genomic categoriesZeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3 |
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2021 Journal Article GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depressionWu, Yeda, Murray, Graham K., Byrne, Enda M., Sidorenko, Julia, Visscher, Peter M. and Wray, Naomi R. (2021). GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression. Nature Communications, 12 (1) 1146, 1-17. doi: 10.1038/s41467-021-21280-7 |
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2021 Journal Article Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individualsKemper, Kathryn E., Yengo, Loic, Zheng, Zhili, Abdellaoui, Abdel, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2021). Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals. Nature Communications, 12 (1) 1050, 1050. doi: 10.1038/s41467-021-21283-4 |
