Professor

Helen Cooper

Email: 
Phone: 
+61 7 334 66354

Availability

Professor Helen Cooper is:
Available for supervision

Fields of research

Biological Sciences Neurosciences Organic chemistry

Research interests

  • Neural Migration

    The adult human brain contains approximately 1011 neurons which make an estimated 1014 synaptic connections. How is such a astonishing structure generated? Cell and axon migration are fundamental processes essential for establishing the architectural plan of the central nervous system during vertebrate embryogenesis. Newly born neurons migrate along predefined pathways to establish the variety of distinct structures present in the adult brain. In addition, young neurons must also extend axons to their appropriate targets in order to establish the extensive network of connections found between neurons in the adult brain. Research in the Neural Migration Laboratory focuses on the molecular signalling systems governing neural differentiation, migration and axon pathfinding in the embryonic brain. This team has now identified several important cell surface receptors essential for these developmental processes. Current research is aimed at discovering how these receptors function during key phases of nervous system development. To address these questions we use both the mouse and zebrafish as our developmental models.

Search Professor Helen Cooper’s works on UQ eSpace

98 works between 1984 and 2024
All (98) Journal Article (95) Book Chapter (1) Other Outputs (2)

61 - 80 of 98 works

2008

Other Outputs

Production of polyclonal antisera

Cooper, Helen M. and Paterson, Yvonne (2008). Production of polyclonal antisera.

Production of polyclonal antisera

2008

Book Chapter

Production of polyclonal antisera

Cooper, Helen M. and Paterson, Yvonne (2008). Production of polyclonal antisera. Current protocols in molecular biology. (pp. 11.12.1-11.12.10) edited by Frederick M. Ausubel, Roger Brent, Robert E. Kingston, David D. Moore, J. G. Seidman and Kevin Struhl. New York, U.S.: John Wiley. doi: 10.1002/0471142727.mb1112s81

Production of polyclonal antisera

2008

Other Outputs

Production of polyclonal antisera

Cooper, Helen M. and Paterson, Yvonne (2008). Production of polyclonal antisera.

Production of polyclonal antisera

2007

Journal Article

Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system

Fitzgerald, D. P., Bradford, D. and Cooper, H. M. (2007). Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system. Gene Expression Patterns, 7 (7), 784-792. doi: 10.1016/j.modgep.2007.05.004

Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system

2007

Journal Article

Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA

Xu, Zhi Ping, Walker, Tara L., Liu, Kerh-lin, Cooper, Helen M., Lu, G. Q. Max and Bartlett, Perry F. (2007). Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA. International Journal of Nanomedicine, 2 (2), 163-174. doi: 10.2147/IJN.S

Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA

2007

Journal Article

Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA

Xu, Zhi Ping, Walker, Tara L., Liu, Kerh-lin, Cooper, Helen M., Lu, G. Q. Max and Bartlett, Perry F. (2007). Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA. International Journal of Nanomedicine, 2 (2), 163-74.

Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA

2007

Journal Article

Neogenin: A multi-functional receptor regulating diverse developmental processes

Cole, S. J., Bradford, D. and Cooper, H. M. (2007). Neogenin: A multi-functional receptor regulating diverse developmental processes. The International Journal of Biochemistry & Cell Biology, 39 (9), 1569-1575. doi: 10.1016/j.biocel.2006.11.009

Neogenin: A multi-functional receptor regulating diverse developmental processes

2006

Journal Article

Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain

Fitzgerald, D. P., Cole, S. J., Hammond, A., Seaman, C. and Cooper, H. M. (2006). Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain. Neuroscience, 142 (3), 703-716. doi: 10.1016/j.neuroscience.2006.06.041

Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain

2006

Journal Article

Localization of neogenin protein during morphogenesis in the mouse embryo

Fitzgerald, D. P., Seaman, C. and Cooper, H. M. (2006). Localization of neogenin protein during morphogenesis in the mouse embryo. Developmental Dynamics, 235 (6), 1720-1725. doi: 10.1002/dvdy.20744

Localization of neogenin protein during morphogenesis in the mouse embryo

2006

Journal Article

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

Keeble, T. R., Halford, M., Seaman, C., Kee, N., Macheda, M., Andersen, R. B., Stacker, S. A. and Cooper, H. M. (2006). The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. Journal of Neuroscience, 26 (21), 5840-5848. doi: 10.1523/JNEUROSCI.1175-06.2006

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

2006

Journal Article

Ryk: A novel Wnt receptor regulating axon pathfinding

Keeble, T. R. and Cooper, H. M. (2006). Ryk: A novel Wnt receptor regulating axon pathfinding. International Journal of Biochemistry & Cell Biology, 38 (12), 2011-2017. doi: 10.1016/j.biocel.2006.07.005

Ryk: A novel Wnt receptor regulating axon pathfinding

2006

Journal Article

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

Emery, B., Cate, H. S., Marriottt, M., Merson, T., Binder, M. D., Snell, C., Soo, P. Y., Murray, S., Croker, B., Zhang, J. G., Alexander, W. S., Cooper, H., Butzkueven, H. and Kilpatrick, T. J. (2006). Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Proceedings of The National Academy of Sciences of The United States of America, 103 (20), 7859-7864. doi: 10.1073/pnas.0602574103

Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination

2005

Journal Article

Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents

Osborne, P. B., Halliday, G. M., Cooper, H. M. and Keast, J. R. (2005). Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience, 131 (3), 671-681. doi: 10.1016/j.neuroscience.2004.11.043

Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents

2004

Journal Article

The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish

Mawdsley, David J., Cooper, Helen M., Hogan, Benjamin M., Cody, Stephen H., Lieschke, Graham J. and Heath, Joan K. (2004). The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. Developmental Biology, 269 (1), 302-315. doi: 10.1016/j.ydbio.2004.02.001

The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish

2003

Journal Article

Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor

Petratos, S., Butzkueven, H., Shipham, K., Cooper, H., Bucci, T., Reid, K., Lopes, E., Emery, B., Cheema, S. S. and Kilpatrick, T. J. (2003). Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor. Journal of Neuropathology And Experimental Neurology, 62 (4), 398-411.

Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor

2002

Journal Article

Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge

Cooper, H. M. (2002). Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge. International Journal of Developmental Biology, 46 (4), 621-631.

Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge

2001

Journal Article

Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems

Seaman, Clare, Anderson, Richard, Emery, Ben and Cooper, Helen M. (2001). Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems. Mechanisms of Development, 103 (1-2), 173-175. doi: 10.1016/S0925-4773(01)00350-1

Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems

2001

Journal Article

Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons

Seaman, Clare and Cooper, Helen M. (2001). Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons. Mechanisms of Development, 101 (1-2), 245-248. doi: 10.1016/S0925-4773(00)00563-3

Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons

2001

Journal Article

A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain

Hjorth, J. T., Gad, J., Cooper, H. and Key, B. (2001). A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain. Mechanisms of Development, 109 (1), 105-109. doi: 10.1016/S0925-4773(01)00513-5

A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain

2000

Journal Article

The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina

Gad, Jacqueline M. , Keeling, Sharon L. , Shu, Tianzhi , Richards, Linda J. and Cooper, Helen M. (2000). The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. Experimental Eye Research, 70 (6), 711-722. doi: 10.1006/exer.2000.0823

The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina

Current funding

  • 2023 - 2028
    Neuroscience research at the Queensland Brain Institute
    Alison and Jamie Nicol
    Open grant
  • 2023 - 2030
    QBI circRNA Research
    The McCusker Charitable Foundation
    Open grant
  • 2023 - 2030
    QBI Dementia Research
    The McCusker Charitable Foundation
    Open grant
  • 2023 - 2025
    Identifying novel factors that control ependymal cell production: a potential approach for the repair of the hydrocephalic brain
    The Donald & Joan Wilson Foundation Ltd
    Open grant

Past funding

  • 2021 - 2024
    Identifying an autism gene network governing stem cell division, neurogenesis and cortical malformation
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    Identifying a molecular signalling network governing spine morphogenesis
    NHMRC IDEAS Grants
    Open grant
  • 2019
    Advanced Nanoparticle, Colloid and Microparticle Characterisation and Precision Engineering Nanosystems Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2020
    Aberrant ependymal development and the formation of hydrocephalus
    NHMRC Project Grant
    Open grant
  • 2016
    Light-sheet microscope for high-speed 3D imaging of live organisms and fixed tissue
    NHMRC Equipment Grant
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015
    Spectral Applied Research spinning disc confocal microscope for high speed 3D imaging of tissue and live organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Dissecting the role of RYK in cortical neuron specification and schizophrenia
    NHMRC Project Grant
    Open grant
  • 2014
    Two-photon microscopy for live and fixed imaging in model organisms and thick tissue
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Understanding the embryonic origins of cortical malformations
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Neogenin: a molecular determinant of neural progenitor polarity and function
    NHMRC Project Grant
    Open grant
  • 2012
    Zebrafish Aquarium-Genetic Screening, Nursery and Importation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Neogenin: a regulator of neuronal differentiation and migration in the adult brain
    NHMRC Project Grant
    Open grant
  • 2010
    Zebrafish Aquarium - expand capacity of existing Zebrafish facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Smart Futures Fellowship: Development of LDH nanoparticles as an effective drug delivery system for the treatment of neurodegenerative diseses
    Queensland Government Smart Futures Fellowships
    Open grant
  • 2009
    AKTA Explorer Fast Protein Liquid Chromatography Equipment
    UQ Institute Co-Funding
    Open grant
  • 2009 - 2011
    Neogenin regulates progenitor division and interneuron migration in the developing forebrain
    NHMRC Project Grant
    Open grant
  • 2008 - 2012
    Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons
    ARC Discovery Projects
    Open grant
  • 2007 - 2009
    The role of Netrin-DCC in the development of the corpus callosum
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Wnt-Ryk signaling in the establishment of major axon tracts in the embryonic mouse brain
    NHMRC Project Grant
    Open grant
  • 2005
    Developmental Imaging Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005
    NHMRC_Equipment Grant = Zeiss Cryo-Star cryostat
    NHMRC Equipment Grant
    Open grant
  • 2005 - 2007
    Tailoring of layered double hydroxide nanoparticles for effective delivery of biologically active peptides and cDNAs
    ARC Discovery Projects
    Open grant
  • 2004
    ARC Research Network in Microarray Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Dissecting the molecular mechanism driving neuronal migration triggered by the Netrin Receptor, Neogenin
    NHMRC Project Grant
    Open grant
  • 2004
    The Role Of Netrin-3 In Motor Axon Innervation And The Establishment Of Synapses
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004
    Understanding the pathophysiological role of the orphan nuclear receptor, Nurr1 in neurological disease: pharmacogenomic identification of Nurr1 genes
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2003
    Protein targeting and signal transduction (NHMRC Project Grant -- transfer from BFI Grant)
    NHMRC Project Grant - Standard
    Open grant

Availability

Professor Helen Cooper is:
Available for supervision

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Supervision history

Completed supervision

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