Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons (2008-2012)

This project aims to develop a novel class of hybrid inorganic nanoparticles for effective delivery of therapeutic siRNAs, either locally or systemically, into the mouse central nervous system to slow the progression of Huntington's disease, one typical neurodegenerative disease. To this end, a more efficient and reliable delivery system will be devised by combining advantages of both layered double hydroxide and silica materials, with suitable surface functionalisation. Such a system will promote passage across the blood brain barrier and improve efficient neuronal uptake of novel drugs (e.g. siRNAs) leading to the effective treatment of genetic and other neuronal diseases.