Professor

Helen Cooper

Email: 
Phone: 
+61 7 334 66354

Availability

Professor Helen Cooper is:
Available for supervision

Fields of research

Biological Sciences Neurosciences Organic chemistry

Research interests

  • Neural Migration

    The adult human brain contains approximately 1011 neurons which make an estimated 1014 synaptic connections. How is such a astonishing structure generated? Cell and axon migration are fundamental processes essential for establishing the architectural plan of the central nervous system during vertebrate embryogenesis. Newly born neurons migrate along predefined pathways to establish the variety of distinct structures present in the adult brain. In addition, young neurons must also extend axons to their appropriate targets in order to establish the extensive network of connections found between neurons in the adult brain. Research in the Neural Migration Laboratory focuses on the molecular signalling systems governing neural differentiation, migration and axon pathfinding in the embryonic brain. This team has now identified several important cell surface receptors essential for these developmental processes. Current research is aimed at discovering how these receptors function during key phases of nervous system development. To address these questions we use both the mouse and zebrafish as our developmental models.

Search Professor Helen Cooper’s works on UQ eSpace

98 works between 1984 and 2024
All (98) Journal Article (95) Book Chapter (1) Other Outputs (2)

81 - 98 of 98 works

2000

Journal Article

Expression of the netrin-1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain

Shu, Tianzhi, Valentino, Kimberly M., Seaman, Clare, Cooper, Helen M. and Richards, Linda J. (2000). Expression of the netrin-1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain. Journal of Comparative Neurology, 416 (2), 201-212. doi: 10.1002/(SICI)1096-9861(20000110)416:23.0.CO;2-Z

Expression of the netrin-1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain

2000

Journal Article

DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic Xenopus

Anderson, R. B., Cooper, H. M., Jackson, S. C., Seaman, C. and Key, B. (2000). DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic Xenopus. Developmental Biology, 217 (2), 244-253. doi: 10.1006/dbio.1999.9549

DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic Xenopus

1999

Journal Article

The deleted in colorectal cancer netrin guidance system: a molecular strategy for neuronal navigation

Cooper, Helen M. (1999). The deleted in colorectal cancer netrin guidance system: a molecular strategy for neuronal navigation. Clinical and Experimental Pharmacology and Physiology, 26 (9), 749-751. doi: 10.1046/j.1440-1681.1999.03106.x

The deleted in colorectal cancer netrin guidance system: a molecular strategy for neuronal navigation

1997

Journal Article

The expression patterns of guidance receptors, DCC and neogenin, are spatially and temporally distinct throughout mouse embryogenesis

Gad, J. M., Keeling, S. L., Wilks, A. F., Tan, S. S. and Cooper, H. M. (1997). The expression patterns of guidance receptors, DCC and neogenin, are spatially and temporally distinct throughout mouse embryogenesis. Developmental Biology, 192 (2), 258-273. doi: 10.1006/dbio.1997.8756

The expression patterns of guidance receptors, DCC and neogenin, are spatially and temporally distinct throughout mouse embryogenesis

1997

Journal Article

Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis

Keeling, S. L., Gad, J. M. and Cooper, H. M. (1997). Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene, 15 (6), 691-700. doi: 10.1038/sj.onc.1201225

Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis

1995

Journal Article

Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo

Cooper, H. M., Armes, P., Britto, J., Gad, J. and Wilks, A. F. (1995). Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene, 11 (11), 2243-2254.

Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo

1991

Journal Article

Cell type-specific integrin variants with alternative α chain cytoplasmic domains

Tamura, R. N., Cooper, H. M., Collo, G. and Quaranta, V. (1991). Cell type-specific integrin variants with alternative α chain cytoplasmic domains. Proceedings of the National Academy of Sciences, 88 (22), 10183-10187. doi: 10.1073/pnas.88.22.10183

Cell type-specific integrin variants with alternative α chain cytoplasmic domains

1991

Journal Article

The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin

Cooper, H. M., Tamura, R. N. and Quaranta, V. (1991). The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. Journal of Cell Biology, 115 (3), 843-850. doi: 10.1083/jcb.115.3.843

The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin

1991

Journal Article

Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta

Korhonen, M., Ylänne, J., Laitinen, L., Cooper, H. M., Quaranta, V. and Virtanen, I. (1991). Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta. Laboratory Investigation, 65 (3), 347-356.

Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta

1991

Journal Article

A function for the integrin α6β4 in the hemidesmosome

Jones, Jonathan, C. R., Kurpakus, Michelle A., Cooper, Helen M. and Quaranta, Vito (1991). A function for the integrin α6β4 in the hemidesmosome. Cell Regulation, 2 (6), 427-438. doi: 10.1091/mbc.2.6.427

A function for the integrin α6β4 in the hemidesmosome

1990

Journal Article

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4

Tamura, R. N., Rozzo, C., Starr, L., Chambers, J., Reichardt, L. F., Cooper, H. M. and Quaranta, V. (1990). Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. Journal of Cell Biology, 111 (4), 1593-1604. doi: 10.1083/jcb.111.4.1593

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4

1989

Journal Article

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

Cheresh, David A., Smith, Jeffrey W., Cooper, Helen M. and Quaranta, Vito (1989). A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells. Cell, 57 (1), 59-69. doi: 10.1016/0092-8674(89)90172-4

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

1989

Journal Article

The autoantigenic response to rabbit cytochrome C

Cooper, Helen M., Klinman, Norman R. and Paterson, Yvonne (1989). The autoantigenic response to rabbit cytochrome C. European Journal of Immunology, 19 (2), 315-322. doi: 10.1002/eji.1830190215

The autoantigenic response to rabbit cytochrome C

1988

Journal Article

The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope

Cooper, H. M., Corradin, G. and Paterson, Y. (1988). The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope. Journal of Experimental Medicine, 168 (3), 1127-1143. doi: 10.1084/jem.168.3.1127

The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope

1987

Journal Article

Site-directed Chemical Modification of Horse Cytochrome c Results in Changes in Antigenicity Due to Local and Long-range Conformational Perturbation

Cooper, Helen M., Jemmerson, Ronald, Hunt, Donald F., Griffin, Patrick R., Yates, John R. , Shabanowitz, Jeffrey, Zhu, Nian-Zhou and Paterson, Yvonne (1987). Site-directed Chemical Modification of Horse Cytochrome c Results in Changes in Antigenicity Due to Local and Long-range Conformational Perturbation. Journal of Biological Chemistry, 262 (24), 11591-11597.

Site-directed Chemical Modification of Horse Cytochrome c Results in Changes in Antigenicity Due to Local and Long-range Conformational Perturbation

1986

Journal Article

Antibody response to the C-terminal peptide sequence in beef myoglobin

Cooper, H.M., Todd, P.E.E. and Leach, S.J. (1986). Antibody response to the C-terminal peptide sequence in beef myoglobin. Molecular Immunology, 23 (12), 1289-1299. doi: 10.1016/0161-5890(86)90014-3

Antibody response to the C-terminal peptide sequence in beef myoglobin

1985

Journal Article

Original antigenic sin and the production of autoantibodies

Cooper, H.M., Todd, P.E.E. and Leach, S.J. (1985). Original antigenic sin and the production of autoantibodies. Molecular Immunology, 22 (8), 921-927. doi: 10.1016/0161-5890(85)90078-1

Original antigenic sin and the production of autoantibodies

1984

Journal Article

Antibody response to myoglobins: effect of host species

Cooper, H.M., East, I.J., Todd, P.E.E. and Leach, S.J. (1984). Antibody response to myoglobins: effect of host species. Molecular Immunology, 21 (6), 479-487. doi: 10.1016/0161-5890(84)90063-4

Antibody response to myoglobins: effect of host species

Current funding

  • 2023 - 2028
    Neuroscience research at the Queensland Brain Institute
    Alison and Jamie Nicol
    Open grant
  • 2023 - 2030
    QBI circRNA Research
    The McCusker Charitable Foundation
    Open grant
  • 2023 - 2030
    QBI Dementia Research
    The McCusker Charitable Foundation
    Open grant
  • 2023 - 2025
    Identifying novel factors that control ependymal cell production: a potential approach for the repair of the hydrocephalic brain
    The Donald & Joan Wilson Foundation Ltd
    Open grant

Past funding

  • 2021 - 2024
    Identifying an autism gene network governing stem cell division, neurogenesis and cortical malformation
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2024
    Identifying a molecular signalling network governing spine morphogenesis
    NHMRC IDEAS Grants
    Open grant
  • 2019
    Advanced Nanoparticle, Colloid and Microparticle Characterisation and Precision Engineering Nanosystems Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Histology and Advanced Microscopy Research Facility upgrade
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2020
    Aberrant ependymal development and the formation of hydrocephalus
    NHMRC Project Grant
    Open grant
  • 2016
    Light-sheet microscope for high-speed 3D imaging of live organisms and fixed tissue
    NHMRC Equipment Grant
    Open grant
  • 2015
    Computerised stereotaxic stages and rapid tissue processor for enhanced fixation and immunolabelling
    NHMRC Equipment Grant
    Open grant
  • 2015
    Spectral Applied Research spinning disc confocal microscope for high speed 3D imaging of tissue and live organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Dissecting the role of RYK in cortical neuron specification and schizophrenia
    NHMRC Project Grant
    Open grant
  • 2014
    Two-photon microscopy for live and fixed imaging in model organisms and thick tissue
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Understanding the embryonic origins of cortical malformations
    NHMRC Project Grant
    Open grant
  • 2013
    Spinning disk confocal for advanced high-speed histocytometry and neuromorphology analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Neogenin: a molecular determinant of neural progenitor polarity and function
    NHMRC Project Grant
    Open grant
  • 2012
    Zebrafish Aquarium-Genetic Screening, Nursery and Importation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Neogenin: a regulator of neuronal differentiation and migration in the adult brain
    NHMRC Project Grant
    Open grant
  • 2010
    Zebrafish Aquarium - expand capacity of existing Zebrafish facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Smart Futures Fellowship: Development of LDH nanoparticles as an effective drug delivery system for the treatment of neurodegenerative diseses
    Queensland Government Smart Futures Fellowships
    Open grant
  • 2009
    AKTA Explorer Fast Protein Liquid Chromatography Equipment
    UQ Institute Co-Funding
    Open grant
  • 2009 - 2011
    Neogenin regulates progenitor division and interneuron migration in the developing forebrain
    NHMRC Project Grant
    Open grant
  • 2008 - 2012
    Novel Hybrid Inorganic Nanoparticles for Effective siRNA Delivery to Neurons
    ARC Discovery Projects
    Open grant
  • 2007 - 2009
    The role of Netrin-DCC in the development of the corpus callosum
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Wnt-Ryk signaling in the establishment of major axon tracts in the embryonic mouse brain
    NHMRC Project Grant
    Open grant
  • 2005
    Developmental Imaging Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005
    NHMRC_Equipment Grant = Zeiss Cryo-Star cryostat
    NHMRC Equipment Grant
    Open grant
  • 2005 - 2007
    Tailoring of layered double hydroxide nanoparticles for effective delivery of biologically active peptides and cDNAs
    ARC Discovery Projects
    Open grant
  • 2004
    ARC Research Network in Microarray Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Dissecting the molecular mechanism driving neuronal migration triggered by the Netrin Receptor, Neogenin
    NHMRC Project Grant
    Open grant
  • 2004
    The Role Of Netrin-3 In Motor Axon Innervation And The Establishment Of Synapses
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004
    Understanding the pathophysiological role of the orphan nuclear receptor, Nurr1 in neurological disease: pharmacogenomic identification of Nurr1 genes
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2003
    Protein targeting and signal transduction (NHMRC Project Grant -- transfer from BFI Grant)
    NHMRC Project Grant - Standard
    Open grant

Availability

Professor Helen Cooper is:
Available for supervision

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Supervision history

Completed supervision

Enquiries

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