Overview
Background
Dr Daniel Liang-Dar Hwang is a genetic epidemiologist and statistical geneticist by training. His research interests include sensory nutrition, causal modelling, and personalized nutrition. Dr Hwang applies statistical models to big data to understand genetic and environmental factors contributing to individual differences in taste and olfactory perception and their relationship with dietary behaviour and chronic conditions (See his research on taste perception in The Conversation). He develops methods for increasing statistical power for gene discovery, estimating intergenerational causal relationships, and personalized intervention. He also works with clinicians to investigate impaired chemosensory perception in cancer patients and COVID-19.
Daniel has a B.Sc from the National Taiwan University, majoring in Biochemical Science and Technology, and an M.Biotech from the University of Pennsylvania. Following graduation, he worked as a research technician in Danielle Reed's lab at the Monell Chemical Senses Center, where he first developed a keen interest in genetics and chemosensory perception. Later, he was awarded scholarships to complete an M.Sc in Nutrition at the University of Washington, under the supervision of Glen Duncan, and a PhD in Genetic Epidemiology at the QIMR Berghofer Medical Research Institute, under the supervision of Nicholas Martin and Margaret Wright. He then joined David Evans's group as a postdoc at the University of Queensland Diamantina Institute (now the Frazer Institute). Dr Hwang is an ARC DECRA Fellow at the Institute for Molecular Bioscience. He is also an Affiliated Scientist at the Monell Chemical Senses Center.
Dr Hwang has published more than 40 peer-reviewed publications. His work has been referred to in international health policy guidelines and a WHO report for the intervention of childhood obesity and in a global patent for personalized wine selection. He is on the editorial boards of BMC Medicine and Twin Research and Human Genetics. Dr Hwang is a Leadership Team member of the Global Consortium for Chemosensory Research, a global initiative to understand the relationship between smell loss and COVID-19 and foster the advancement of chemosensory science. He currently drives an international collaborative project to investigate the impact of COVID-19 vaccinations on long-COVID symptoms. Dr Hwang is a member of the National Committee for Nutrition of the Australian Academy of Science. He contributes to implementing the decadal plan for the science of nutrition in Australia.
Availability
- Dr Daniel Hwang is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Masters (Coursework) of Biotechnology, University of Pennsylvania
- Masters (Research) of Science, University of Washington
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Daniel Hwang’s works on UQ eSpace
2020
Journal Article
Author Correction: Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization
Ong, Jue-Sheng, Hwang, Liang-Dar, Zhong, Victor W., An, Jiyuan, Gharahkhani, Puya, Breslin, Paul A. S., Wright, Margaret J., Lawlor, Deborah A., Whitfield, John, MacGregor, Stuart, Martin, Nicholas G. and Corneli, Marilyn C. (2020). Author Correction: Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports, 10 (1) 4778, 4778. doi: 10.1038/s41598-020-60488-3
2020
Journal Article
Integrating family-based and Mendelian randomization designs
Hwang, Liang-Dar, Davies, Neil M., Warrington, Nicole M. and Evans, David M. (2020). Integrating family-based and Mendelian randomization designs. Cold Spring Harbor Perspectives in Medicine, 11 (3) a039503, 1-15. doi: 10.1101/cshperspect.a039503
2020
Journal Article
Do people with lower IQ have weaker taste perception? A hidden supplementary table in 'Is the Association between Sweet and Bitter Perception Due to Genetic Variation?'
Hwang, Liang-Dar (2020). Do people with lower IQ have weaker taste perception? A hidden supplementary table in 'Is the Association between Sweet and Bitter Perception Due to Genetic Variation?'. Twin Research and Human Genetics, 23 (2), 1-2. doi: 10.1017/thg.2020.19
2019
Journal Article
Chemosensory changes from cancer treatment and their effects on patients’ food behavior: a scoping review
Nolden, Alissa A., Hwang, Liang-Dar, Boltong, Anna and Reed, Danielle R. (2019). Chemosensory changes from cancer treatment and their effects on patients’ food behavior: a scoping review. Nutrients, 11 (10) 2285, 2285. doi: 10.3390/nu11102285
2019
Journal Article
Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight
Hwang, Liang-Dar, Lawlor, Deborah A., Freathy, Rachel M., Evans, David M. and Warrington, Nicole M. (2019). Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight. International Journal of Epidemiology, 48 (5), 1457-1467. doi: 10.1093/ije/dyz160
2019
Journal Article
New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances
Hwang, Liang-Dar, Lin, Cailu, Gharahkhani, Puya, Cuellar-Partida, Gabriel, Ong, Jue-Sheng, An, Jiyuan, Gordon, Scott D., Zhu, Gu, MacGregor, Stuart, Lawlor, Deborah A., Breslin, Paul A. S., Wright, Margaret J., Martin, Nicholas G. and Reed, Danielle R. (2019). New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. The American Journal of Clinical Nutrition, 109 (6), 1724-1737. doi: 10.1093/ajcn/nqz043
2019
Journal Article
Associations between brain structure and perceived intensity of sweet and bitter tastes
Hwang, Liang-Dar, Strike, Lachlan T, Couvy-Duchesne, Baptiste, de Zubicaray, Greig I, McMahon, Katie, Breslin, Paul A. S., Reed, Danielle R., Martin, Nicholas G. and Wright, Margaret J. (2019). Associations between brain structure and perceived intensity of sweet and bitter tastes. Behavioural Brain Research, 363, 103-108. doi: 10.1016/j.bbr.2019.01.046
2019
Journal Article
Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization
Evans, David M., Moen, Gunn-Helen, Hwang, Liang-Dar, Lawlor, Debbie A. and Warrington, Nicole M. (2019). Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. International Journal of Epidemiology, 48 (3), 861-875. doi: 10.1093/ije/dyz019
2019
Conference Publication
Complex-Traits Genetics Virtual Lab: A community-driven web platform for post-GWAS analyses
Cuéllar-Partida, Gabriel, Lundberg, Mischa, Campos-González, Adrian I., Kho, Pik Fang, D’Urso, Shannon, Hwang, Liang-Dar, Ngo, Trung Thanh and Rentería, Miguel E. (2019). Complex-Traits Genetics Virtual Lab: A community-driven web platform for post-GWAS analyses. American Society of Human Genetics (ASHG) 69th Annual Meeting, Houston, TX United States, 15–19 October 2019.
2019
Conference Publication
Genetic epidemiology of back pain: Examining causality with Complex Traits Virtual Lab
Ngo, Trung Thanh, Lundberg, Mischa, Campos-González, Adrian, Kho, Pik Fang, D’Urso, Shannon, Hwang, Liang-Dar, Rentería, Miguel and Cuéllar-Partida, Gabriel (2019). Genetic epidemiology of back pain: Examining causality with Complex Traits Virtual Lab. Australasian Epidemiological Association 2019 Annual Scientific Meeting — 'Epidemiology in the real world', South Brisbane, QLD Australia, 23–25 October 2019.
2019
Conference Publication
Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes
Evans, David, Warrington, Nicole, Partida, Gabriel Cuellar and Hwang, Daniel (2019). Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes. 49th Annual Meeting of the Behavior Genetics Association (BGA), Stockholm, Sweden, 26-29 June, 2019. New York, NY, United States: Springer New York LLC. doi: 10.1007/s10519-019-09973-8
2018
Journal Article
Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization
Ong, Jue-Sheng, Hwang, Liang-Dar, Zhong, Victor W., An, Jiyuan, Gharahkhani, Puya, Breslin, Paul A. S., Wright, Margaret J., Lawlor, Deborah A., Whitfield, John, MacGregor, Stuart, Martin, Nicholas G. and Cornelis, Marilyn C. (2018). Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports, 8 (1) 16414, 16414. doi: 10.1038/s41598-018-34713-z
2018
Journal Article
Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste
Hwang, Liang-Dar, Gharahkhani, Puya, Breslin, Paul A. S., Gordon, Scott D., Zhu, Gu, Martin, Nicholas G., Reed, Danielle R. and Wright, Margaret J. (2018). Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste. BMC Genomics, 19 (678) 678, 678. doi: 10.1186/s12864-018-5058-2
2018
Other Outputs
Individual differences in taste and their association with genes, dietary behaviour, and brain structure
Hwang, Liang-Dar (Daniel) (2018). Individual differences in taste and their association with genes, dietary behaviour, and brain structure. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2018.573
2018
Conference Publication
F271. The Moderating Roles of Parental Monitoring and Peer Group Deviance on Polygenic Risk for Alcohol Use Across Adolescence
Long, Elizabeth, Ong, Jue-Sheng, Hwang, Liang-Dar, Savage, Jeanne E., Edwards, Alexis, Prom-Wormley, Elizabeth, Salvatore, Jessica E., Kendler, Kenneth S., Vassileva, Jasmin and Gillespie, Nathan A. (2018). F271. The Moderating Roles of Parental Monitoring and Peer Group Deviance on Polygenic Risk for Alcohol Use Across Adolescence. 2018 Annual Meeting of the Society of Biological Psychiatry, New York, United States, 10-12 May 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.biopsych.2018.02.885
2018
Conference Publication
Replication and discovery of genetic variants influencing human bitter taste perception
Hwang, Liang-Dar, Gharahkhani, Puya, Zhu, Gu, Gordon, Scott D., Breslin, Paul A. S., Martin, Nicholas G., Reed, Danielle R. and Wright, Margaret J. (2018). Replication and discovery of genetic variants influencing human bitter taste perception. 39th Annual Meeting of the Association for Chemoreception Sciences, Bonita Springs, FL, United States, 26 - 29 April 2017. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjy003
2017
Journal Article
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study
Ong, Jue-Sheng, Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Martin, Nicholas G., Chenevix-Trench, Georgia, Quinn, Michael C. J., Cornelis, Marilyn C., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart and Ovarian Cancer Association Consortium (2017). Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. International Journal of Epidemiology, 47 (2), 450-459. doi: 10.1093/ije/dyx236
2017
Journal Article
Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue
Lipchock, Sarah V., Spielman, Andrew I., Mennella, Julie A., Mansfield, Corrine J., Hwang, Liang-Dar, Douglas, Jennifer E. and Reed, Danielle R. (2017). Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue. Perception, 46 (3-4), 245-256. doi: 10.1177/0301006616686098
2017
Journal Article
Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing
Guo, Yiran, Hwang, Liang-Dar, Li, Jiankang, Eades, Jason, Yu, Chung Wen, Mansfield, Corrine, Burdick-Will, Alexis, Chang, Xiao, Chen, Yulan, Duke, Fujiko F, Zhang, Jianguo, Fakharzadeh, Steven, Fennessey, Paul, Keating, Brendan J, Jiang, Hui, Hakonarson, Hakon, Reed, Danielle R and Preti, George (2017). Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC Medical Genetics, 18 (1) 11. doi: 10.1186/s12881-017-0369-8
2016
Journal Article
Is the association between sweet and bitter perception due to genetic variation?
Hwang, Liang-Dar, Breslin, Paul A. S., Reed, Danielle R., Zhu, Gu, Martin, Nicholas G. and Wright, Margaret J. (2016). Is the association between sweet and bitter perception due to genetic variation?. Chemical Senses, 41 (9), 737-744. doi: 10.1093/chemse/bjw083
Funding
Current funding
Supervision
Availability
- Dr Daniel Hwang is:
- Available for supervision
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Available projects
-
Develop novel approaches for personalised nutrition using large-scale genetically informative data
Polygenic risk scores have provided informative predictions for highly heritable traits and has been intergrated into risk prediction models along with traditional clinicial measurements to improvde risk prediction of cardiometabolic disease and other inherited health conditions. This project aims to develop novel polygenic scores specifically for priotising interventions or "personalised intervention" rather than risk prediction.
Supervision history
Current supervision
-
Doctor Philosophy
Genetics of sensory nutrition - using genetics to understand how taste and olfactory perception influences eating behaviour and health
Principal Advisor
Other advisors: Dr Brooke Devlin
-
Doctor Philosophy
Multi-omic Approaches to Understanding Septic Shock
Associate Advisor
Other advisors: Professor David Evans
-
Doctor Philosophy
Dietary patterns and molecular mechanisms associated with the pathogenicity of appendicitis in humans
Associate Advisor
Other advisors: Dr Olivia Wright, Professor Eugeni Roura
-
Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Associate Advisor
Other advisors: Professor David Evans, Dr Gunn-Helen Moen
-
Doctor Philosophy
Dietary patterns and molecular mechanisms associated with the pathogenicity of appendicitis in humans
Associate Advisor
Other advisors: Dr Olivia Wright, Professor Eugeni Roura
Completed supervision
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2024
Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Associate Advisor
Other advisors: Dr Gunn-Helen Moen, Professor David Evans
-
2023
Doctor Philosophy
Investigating a possible causal relationship between bone mineral density, osteoarthritis, and chronic pain
Associate Advisor
Other advisors: Associate Professor Adam Ewing, Dr John Kemp
Media
Enquiries
Contact Dr Daniel Hwang directly for media enquiries about:
- bitter
- genetics
- smell
- sweet
- taste
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