Overview
Background
Dr Daniel Liang-Dar Hwang is a genetic epidemiologist and statistical geneticist by training. His research interests include sensory nutrition, causal modelling, and personalized nutrition. Dr Hwang applies statistical models to big data to understand genetic and environmental factors contributing to individual differences in taste and olfactory perception and their relationship with dietary behaviour and chronic conditions (See his research on taste perception in The Conversation). He develops methods for increasing statistical power for gene discovery, estimating intergenerational causal relationships, and personalized intervention. He also works with clinicians to investigate impaired chemosensory perception in cancer patients and COVID-19.
Daniel has a B.Sc from the National Taiwan University, majoring in Biochemical Science and Technology, and an M.Biotech from the University of Pennsylvania. Following graduation, he worked as a research technician in Danielle Reed's lab at the Monell Chemical Senses Center, where he first developed a keen interest in genetics and chemosensory perception. Later, he was awarded scholarships to complete an M.Sc in Nutrition at the University of Washington, under the supervision of Glen Duncan, and a PhD in Genetic Epidemiology at the QIMR Berghofer Medical Research Institute, under the supervision of Nicholas Martin and Margaret Wright. He then joined David Evans's group as a postdoc at the University of Queensland Diamantina Institute (now the Frazer Institute). Dr Hwang is an ARC DECRA Fellow at the Institute for Molecular Bioscience. He is also an Affiliated Scientist at the Monell Chemical Senses Center.
Dr Hwang has published more than 50 peer-reviewed publications. His work has been referred to in international health policy guidelines and a WHO report for the intervention of childhood obesity and in a global patent for personalized wine selection. He is on the editorial boards of BMC Medicine and Twin Research and Human Genetics. Dr Hwang is a Leadership Team member of the Global Consortium for Chemosensory Research, a global initiative to understand the relationship between smell loss and COVID-19 and foster the advancement of chemosensory science. He currently drives an international collaborative project to investigate the impact of COVID-19 vaccinations on long-COVID symptoms. Dr Hwang is a member of the National Committee for Nutrition of the Australian Academy of Science. He contributes to implementing the decadal plan for the science of nutrition in Australia.
Availability
- Dr Daniel Hwang is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Masters (Coursework) of Biotechnology, University of Pennsylvania
- Masters (Research) of Science, University of Washington
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Daniel Hwang’s works on UQ eSpace
2019
Conference Publication
Genetic epidemiology of back pain: Examining causality with Complex Traits Virtual Lab
Ngo, Trung Thanh, Lundberg, Mischa, Campos-González, Adrian, Kho, Pik Fang, D’Urso, Shannon, Hwang, Liang-Dar, Rentería, Miguel and Cuéllar-Partida, Gabriel (2019). Genetic epidemiology of back pain: Examining causality with Complex Traits Virtual Lab. Australasian Epidemiological Association 2019 Annual Scientific Meeting — 'Epidemiology in the real world', South Brisbane, QLD Australia, 23–25 October 2019.
2019
Conference Publication
Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes
Evans, David, Warrington, Nicole, Partida, Gabriel Cuellar and Hwang, Daniel (2019). Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes. 49th Annual Meeting of the Behavior Genetics Association (BGA), Stockholm, Sweden, 26-29 June, 2019. New York, NY, United States: Springer New York LLC. doi: 10.1007/s10519-019-09973-8
2018
Journal Article
Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization
Ong, Jue-Sheng, Hwang, Liang-Dar, Zhong, Victor W., An, Jiyuan, Gharahkhani, Puya, Breslin, Paul A. S., Wright, Margaret J., Lawlor, Deborah A., Whitfield, John, MacGregor, Stuart, Martin, Nicholas G. and Cornelis, Marilyn C. (2018). Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports, 8 (1) 16414, 16414. doi: 10.1038/s41598-018-34713-z
2018
Journal Article
Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste
Hwang, Liang-Dar, Gharahkhani, Puya, Breslin, Paul A. S., Gordon, Scott D., Zhu, Gu, Martin, Nicholas G., Reed, Danielle R. and Wright, Margaret J. (2018). Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste. BMC Genomics, 19 (678) 678, 678. doi: 10.1186/s12864-018-5058-2
2018
Other Outputs
Individual differences in taste and their association with genes, dietary behaviour, and brain structure
Hwang, Liang-Dar (Daniel) (2018). Individual differences in taste and their association with genes, dietary behaviour, and brain structure. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2018.573
2018
Conference Publication
F271. The Moderating Roles of Parental Monitoring and Peer Group Deviance on Polygenic Risk for Alcohol Use Across Adolescence
Long, Elizabeth, Ong, Jue-Sheng, Hwang, Liang-Dar, Savage, Jeanne E., Edwards, Alexis, Prom-Wormley, Elizabeth, Salvatore, Jessica E., Kendler, Kenneth S., Vassileva, Jasmin and Gillespie, Nathan A. (2018). F271. The Moderating Roles of Parental Monitoring and Peer Group Deviance on Polygenic Risk for Alcohol Use Across Adolescence. 2018 Annual Meeting of the Society of Biological Psychiatry, New York, United States, 10-12 May 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.biopsych.2018.02.885
2018
Conference Publication
Replication and discovery of genetic variants influencing human bitter taste perception
Hwang, Liang-Dar, Gharahkhani, Puya, Zhu, Gu, Gordon, Scott D., Breslin, Paul A. S., Martin, Nicholas G., Reed, Danielle R. and Wright, Margaret J. (2018). Replication and discovery of genetic variants influencing human bitter taste perception. 39th Annual Meeting of the Association for Chemoreception Sciences, Bonita Springs, FL, United States, 26 - 29 April 2017. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjy003
2017
Journal Article
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study
Ong, Jue-Sheng, Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Martin, Nicholas G., Chenevix-Trench, Georgia, Quinn, Michael C. J., Cornelis, Marilyn C., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart and Ovarian Cancer Association Consortium (2017). Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. International Journal of Epidemiology, 47 (2), 450-459. doi: 10.1093/ije/dyx236
2017
Journal Article
Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue
Lipchock, Sarah V., Spielman, Andrew I., Mennella, Julie A., Mansfield, Corrine J., Hwang, Liang-Dar, Douglas, Jennifer E. and Reed, Danielle R. (2017). Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue. Perception, 46 (3-4), 245-256. doi: 10.1177/0301006616686098
2017
Journal Article
Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing
Guo, Yiran, Hwang, Liang-Dar, Li, Jiankang, Eades, Jason, Yu, Chung Wen, Mansfield, Corrine, Burdick-Will, Alexis, Chang, Xiao, Chen, Yulan, Duke, Fujiko F, Zhang, Jianguo, Fakharzadeh, Steven, Fennessey, Paul, Keating, Brendan J, Jiang, Hui, Hakonarson, Hakon, Reed, Danielle R and Preti, George (2017). Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC Medical Genetics, 18 (1) 11. doi: 10.1186/s12881-017-0369-8
2016
Journal Article
Is the association between sweet and bitter perception due to genetic variation?
Hwang, Liang-Dar, Breslin, Paul A. S., Reed, Danielle R., Zhu, Gu, Martin, Nicholas G. and Wright, Margaret J. (2016). Is the association between sweet and bitter perception due to genetic variation?. Chemical Senses, 41 (9), 737-744. doi: 10.1093/chemse/bjw083
2016
Journal Article
Sweet taste perception is associated with body mass index at the phenotypic and genotypic level
Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Ong, Jue-Sheng, Breslin, Paul A. S., Reed, Danielle R., Macgregor, Stuart, Gharahkhani, Puya, Martin, Nicholas G. and Renteria, Miguel E. (2016). Sweet taste perception is associated with body mass index at the phenotypic and genotypic level. Twin Research and Human Genetics, 19 (5), 465-471. doi: 10.1017/thg.2016.60
2016
Conference Publication
Is the Association between Sweet and Bitter Perception due to Genetics?
Hwang, Liang-Dar, Breslin, Paul A., Reed, Danielle R., Zhu, Gu, Martin, Nicholas G. and Wright, Margaret J. (2016). Is the Association between Sweet and Bitter Perception due to Genetics?. 38th Annual Meeting of the Association-for-Chemoreception-Sciences (AChemS), Bonita Springs Fl, Apr 20-23, 2016. OXFORD: OXFORD UNIV PRESS.
2016
Journal Article
Cross sectional association between spatially measured walking bouts and neighborhood walkability
Hwang, Liang-Dar, Hurvitz, Philip M. and Duncan, Glen E. (2016). Cross sectional association between spatially measured walking bouts and neighborhood walkability. International Journal of Environmental Research and Public Health, 13 (4) 412, 1-11. doi: 10.3390/ijerph13040412
2016
Journal Article
Sugar cravings
Hwang, Daniel (2016). Sugar cravings. Australasian Science, 37 (2), 14-16.
2016
Conference Publication
The Molecular Basis of Individual Differences in the Taste of an HIV Treatment Drug
Mennella, Julie A., Lowenthal, Elizabeth D., Mathew, Phoebe, Roberts, Kristi, Mansfield, Corrine, Hwang, Liang-Dar, Lin, Cailu and Reed, Danielle R. (2016). The Molecular Basis of Individual Differences in the Taste of an HIV Treatment Drug. 38th Annual Meeting of the Association-for-Chemoreception-Sciences (AChemS), Bonita Springs, Fl United States, 20-23 April 2016. Oxford, United Kingdom: Oxford University Press.
2016
Conference Publication
GWAS of bitter taste perception in Australian adolescents
Hwang, Liang-Dar, Reed, Danielle, Breslin, Paul, Zhu, Gu, Martin, Nicholas and Wright, Margaret (2016). GWAS of bitter taste perception in Australian adolescents. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane Australia, 20-23 June 2016. New York, NY, United States: Springer.
2015
Journal Article
A common genetic influence on human intensity ratings of sugars and high-potency sweeteners
Hwang, Liang-Dar, Zhu, Gu, Breslin, Paul A. S., Reed, Danielle R., Martin, Nicholas G. and Wright, Margaret J. (2015). A common genetic influence on human intensity ratings of sugars and high-potency sweeteners. Twin Research and Human Genetics, 18 (4), 361-367. doi: 10.1017/thg.2015.42
2015
Conference Publication
Epigenetics of the human TAS2R38 gene
Reed, Danielle R., Lipchock, Sarah V., Evans, Emily, Mansfield, Corrine, Hwang, Liang-Dar, Spielman, Andrew and Mennella, Julie A. (2015). Epigenetics of the human TAS2R38 gene. 37th Annual Meeting of the Association-for-Chemoreception-Sciences (AChemS), Bonita Spring, FL, United States, 22-25 April 2015. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv029
2015
Conference Publication
Genetic Modeling of Human Intensity Ratings of Four Sweeteners
Hwang, Liang-Dar, Zhu, Gu, Wright, Margaret J., Martin, Nicholas G., Reed, Danielle R. and Breslin, Paul A. S. (2015). Genetic Modeling of Human Intensity Ratings of Four Sweeteners. 15th Scientific Meeting of the Australasian Association for ChemoSensory Science (AACSS), Brisbane, QLD Australia, 03-05 December 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv008
Funding
Current funding
Supervision
Availability
- Dr Daniel Hwang is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
-
Develop novel approaches for personalised nutrition using large-scale genetically informative data
Polygenic risk scores have provided informative predictions for highly heritable traits and has been intergrated into risk prediction models along with traditional clinicial measurements to improvde risk prediction of cardiometabolic disease and other inherited health conditions. This project aims to develop novel polygenic scores specifically for priotising interventions or "personalised intervention" rather than risk prediction.
Supervision history
Current supervision
-
Doctor Philosophy
Genetics of sensory nutrition - using genetics to understand how taste and olfactory perception influences eating behaviour and health
Principal Advisor
Other advisors: Dr Brooke Devlin, Professor David Evans
-
Doctor Philosophy
Investigating the relationship between adverse perinatal environments and the development of childhood depression and anxiety using statistical genetics methods
Principal Advisor
Other advisors: Professor David Evans
-
Doctor Philosophy
Dietary patterns and molecular mechanisms associated with the pathogenicity of appendicitis in humans
Associate Advisor
Other advisors: Dr Olivia Wright, Professor Eugeni Roura
-
Doctor Philosophy
Improved understanding of complex traits through intermediate phenotypes and robust methodologies
Associate Advisor
Other advisors: Professor David Evans
Completed supervision
-
2024
Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Associate Advisor
Other advisors: Dr Gunn-Helen Moen, Professor David Evans
-
2023
Doctor Philosophy
Investigating a possible causal relationship between bone mineral density, osteoarthritis, and chronic pain
Associate Advisor
Other advisors: Associate Professor Adam Ewing, Dr John Kemp
Media
Enquiries
Contact Dr Daniel Hwang directly for media enquiries about:
- bitter
- genetics
- smell
- sweet
- taste
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