Professor Paul Bernhardt
Professor

Paul Bernhardt

Email: 
Phone: 
+61 7 336 54266

Background

After completing my undergraduate and postgraduate studies at the University of Newcastle, I held a Postdoctoral Fellowship at the University of Basel (Switzerland) from 1990-2. I returned to Australia in 1993 to take up an Australian Research Council Postdoctoral Fellowship at the Australian National University (Canberra) from 1993-4. I joined The University of Queensland in 1994.

Availability

Professor Paul Bernhardt is:
Available for supervision
Media expert

Fields of research

Inorganic chemistry Medicinal and biomolecular chemistry

Qualifications

  • Doctor of Philosophy, University of Newcastle

Research interests

  • Protein Electrochemistry

    This research involves incorporating redox active enzymes with electrochemical systems such that the enzyme functions natively whilst in communication with an electrode (rather than with a natural electron transfer partner). We are currently investigating a number of systems, most from the molybdenum enzyme family that catalyse oxygen transfer reactions of both organic and inorganic substrates.

  • Copper Complexes as Atom Transfer Radical Catalysts

    Atom transfer radical polymerisation (ATRP) is one of the most widely used 'controlled' radical polymerisation techniques and has resulted in polymers with well defined molecular weights and architectures. Our work is focused on complexes that catalyse this process by generating organic radicals from the simple reaction between a Cu(I) complex and an alkyl halide initiator. We can probe this atom transfer reaction with cyclic voltammetry and we have gained new insight to this interesting and fundamentally important reaction. This has now progressed to developing electrocatalytic synthetic methods for C-C bond formation reactions in collaboration with Prof. Craig Williams (SCMB).

Research impacts

My research interests include all aspects of coordination chemistry; particularly its relevance to the areas of electrochemistry, bioinorganic chemistry, spectroscopy and catalysis.

In recent years some of the areas in which we have been, and continue to be, actively involved include:

  • Enzyme electrochemistry (collaborations with several UQ and international groups).
  • Invesitigation of copper complexes that are active in atom transfer radical polymerisation catalysis
  • Transition metal-mediated organic oxidation and reduction reactions

Search Professor Paul Bernhardt’s works on UQ eSpace

545 works between 1987 and 2025
All (545) Journal Article (513) Book Chapter (3) Conference Publication (28) Other Outputs (1)

261 - 280 of 545 works

2010

Journal Article

The Fe-catalyzed oxidation of aroyl hydrazones to aroyl hydrazines: mechanistic insight to a remarkable reaction

Bernhardt, Paul V. and Martinez, Manuel (2010). The Fe-catalyzed oxidation of aroyl hydrazones to aroyl hydrazines: mechanistic insight to a remarkable reaction. Journal of Coordination Chemistry, 63 (14-16), 2619-2628. doi: 10.1080/00958972.2010.491912

The Fe-catalyzed oxidation of aroyl hydrazones to aroyl hydrazines: mechanistic insight to a remarkable reaction

2010

Journal Article

Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner

Hawkes, David B., Slessor, Kate E., Bernhardt, Paul V. and De Voss, James J. (2010). Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner. ChemBioChem, 11 (8), 1107-1114. doi: 10.1002/cbic.201000119

Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner

2010

Journal Article

Pulsed EPR investigations of the Mo(V) centers of the R55Q and R55M variants of sulfite dehydrogenase from Starkeya novella

Rapson, Trevor D., Astashkin, Andrei V., Johnson-Winters, Kayunta, Bernhardt, Paul V., Kappler, Ulrike, Raitsimring, Arnold M. and Enemark, John H. (2010). Pulsed EPR investigations of the Mo(V) centers of the R55Q and R55M variants of sulfite dehydrogenase from Starkeya novella. Journal of Biological Inorganic Chemistry, 15 (4), 505-514. doi: 10.1007/s00775-009-0619-0

Pulsed EPR investigations of the Mo(V) centers of the R55Q and R55M variants of sulfite dehydrogenase from Starkeya novella

2010

Journal Article

The absolute structure of (+)-aplysulfurin

Graham, SK, Garson, MJ and Bernhardt, PV (2010). The absolute structure of (+)-aplysulfurin. Journal of Chemical Crystallography, 40 (5), 468-471. doi: 10.1007/s10870-009-9679-9

The absolute structure of (+)-aplysulfurin

2010

Journal Article

The single-domain globin from the pathogenic bacterium Campylobacter jejuni: Novel D-helix conformation, proximal hydrogen bonding that influences ligand binding, and peroxidase-like redox properties

Shepherd, M, Barynin, V, Lu, CY, Bernhardt, PV, Wu, GH, Yeh, SR, Egawa, T, Sedelnikova, SE, Rice, DW, Wilson, JL and Poole, RK (2010). The single-domain globin from the pathogenic bacterium Campylobacter jejuni: Novel D-helix conformation, proximal hydrogen bonding that influences ligand binding, and peroxidase-like redox properties. Journal of Biological Chemistry, 285 (17), 12747-12754. doi: 10.1074/jbc.M109.084509

The single-domain globin from the pathogenic bacterium Campylobacter jejuni: Novel D-helix conformation, proximal hydrogen bonding that influences ligand binding, and peroxidase-like redox properties

2010

Journal Article

Synthesis and characterization of pentagonal bipyramidal organotin(IV) complexes of 2,6-diacetylpyridine Schiff bases of S-alkyl- and aryldithiocarbazates

Ali, Mohammad Akbar, Mirza, Aminul Huq, Wei, Lim Kok, Bernhardt, Paul V., Atchade, Olaniran, Song, Xueqing, Eng, George and May, Leopold (2010). Synthesis and characterization of pentagonal bipyramidal organotin(IV) complexes of 2,6-diacetylpyridine Schiff bases of S-alkyl- and aryldithiocarbazates. Journal of Coordination Chemistry, 63 (7), 1194-1206. doi: 10.1080/00958971003739798

Synthesis and characterization of pentagonal bipyramidal organotin(IV) complexes of 2,6-diacetylpyridine Schiff bases of S-alkyl- and aryldithiocarbazates

2010

Journal Article

Structure and absolute configuration of 3-alkylpiperidine alkaloids from an Indonesian sponge of the genus Halichondria

Mudianta, IW, Katavic, PL, Lambert, LK, Hayes, PY, Banwell, MG, Munro, MHG, Bernhardt, PV and Garson, MJ (2010). Structure and absolute configuration of 3-alkylpiperidine alkaloids from an Indonesian sponge of the genus Halichondria. Tetrahedron, 66 (14), 2752-2760. doi: 10.1016/j.tet.2010.01.068

Structure and absolute configuration of 3-alkylpiperidine alkaloids from an Indonesian sponge of the genus Halichondria

2010

Journal Article

9-azidoacridine and 9-acridinylnitrene

Taherpour, Avat Arman, Kvaskoff, David, Bernhardt, Paul V. and Wentrup, Curt (2010). 9-azidoacridine and 9-acridinylnitrene. Journal of Physical Organic Chemistry, 23 (4), 382-389. doi: 10.1002/poc.1657

9-azidoacridine and 9-acridinylnitrene

2010

Journal Article

The 293 K structure of tetradehydrohaliclonacyclamine A

Mudianta, I. W., Garson, M. J. and Bernhardt, P. V. (2010). The 293 K structure of tetradehydrohaliclonacyclamine A. Acta Crystallographica Section C: Crystal Structure Communications, 66 (4), O176-O178. doi: 10.1107/S0108270110004634

The 293 K structure of tetradehydrohaliclonacyclamine A

2010

Journal Article

Methyl acrylate polymerizations in the presence of a copper/N3S3 macrobicyclic cage in DMSO at 25 °C

Bell, Craig A., Sun, Qiao, Zhang, Hong, Smith, Sean C., Bernhardt, Paul V. and Monteiro, Michael J. (2010). Methyl acrylate polymerizations in the presence of a copper/N3S3 macrobicyclic cage in DMSO at 25 °C. Polymer Chemistry, 1 (2), 207-212. doi: 10.1039/b9py00315k

Methyl acrylate polymerizations in the presence of a copper/N3S3 macrobicyclic cage in DMSO at 25 °C

2010

Journal Article

Copper(II) complexes of a hexadentate mixed-donor N3S3 macrobicyclic cage: Facile rearrangements and interconversions

Bell, CA, Bernhardt, PV, Gahan, LR, Martinez, M, Monteiro, MJ, Rodriguez, C and Sharrad, CA (2010). Copper(II) complexes of a hexadentate mixed-donor N3S3 macrobicyclic cage: Facile rearrangements and interconversions. Chemistry: A European Journal, 16 (10), 3166-3175. doi: 10.1002/chem.200902611

Copper(II) complexes of a hexadentate mixed-donor N3S3 macrobicyclic cage: Facile rearrangements and interconversions

2010

Journal Article

On the solid-state isomerization of terpinolene tetrabromide

Bernhardt, Paul V., Carman, Raymond M. and Le, Tri T. (2010). On the solid-state isomerization of terpinolene tetrabromide. Australian Journal of Chemistry, 63 (3), 458-462. doi: 10.1071/CH09606

On the solid-state isomerization of terpinolene tetrabromide

2010

Journal Article

Outer-sphere redox reactions leading to the formation of discrete Co III/FeII pyrazine-bridged mixed-valence compounds

Bernhardt, Paul V., Martínez, Manuel and Rodríguez, Carlos (2010). Outer-sphere redox reactions leading to the formation of discrete Co III/FeII pyrazine-bridged mixed-valence compounds. European Journal of Inorganic Chemistry, 2010 (4), 562-569. doi: 10.1002/ejic.200900832

Outer-sphere redox reactions leading to the formation of discrete Co III/FeII pyrazine-bridged mixed-valence compounds

2010

Journal Article

Helical metallomacrocyclic nickel(II) complexes of a tetradentate N 2S2 ligand derived from N-methyldithiocarbazic acid

Akbar Ali, Mohammad, Mirza, Aminul Huq, Hamid, Malai Haniti S. A., Siew, Ik Chin, Sia, Lo Pei and Bernhardt, Paul V. (2010). Helical metallomacrocyclic nickel(II) complexes of a tetradentate N 2S2 ligand derived from N-methyldithiocarbazic acid. Inorganic Chemistry Communications, 13 (12), 1445-1447. doi: 10.1016/j.inoche.2010.08.012

Helical metallomacrocyclic nickel(II) complexes of a tetradentate N 2S2 ligand derived from N-methyldithiocarbazic acid

2010

Conference Publication

Structure and absolute configuration of tetradehydrohaliclonacyclamine A, a new alkaloid from an Indonesian sponge of the genus Halichondria

Mudianta, I. Wayan, Katavic, Peter L., Lambert, Lynette K., Hayes, Patricia T., Banwell, Martin G., Bernhardt, Paul V. and Garson, Mary J. (2010). Structure and absolute configuration of tetradehydrohaliclonacyclamine A, a new alkaloid from an Indonesian sponge of the genus Halichondria. 13th International Symposium on Marine Natural Products, Phuket, Thailand, 17-22 October 2010.

Structure and absolute configuration of tetradehydrohaliclonacyclamine A, a new alkaloid from an Indonesian sponge of the genus Halichondria

2010

Conference Publication

Metalloproteins and their role in sulfur oxidation processes

Bernhardt, P. V., Hanson, G. R., Kappler, Ulrike, Kilmartin, J. R., Low, L., Maher, M.M, Rapson, T.D. and Riley, M.J. (2010). Metalloproteins and their role in sulfur oxidation processes. Boden Research Conference 2010, Canberra, Australia, 28 November – 1 December 2010. ACT, Australia: Australian Academy of Science.

Metalloproteins and their role in sulfur oxidation processes

2009

Journal Article

Microwave-induced molecular rearrangements. Flash thermolysis in the gas-phase and in solution: Synthesis of quinolones and naphthyridones

Lecoq, Delphine, Chalmers, Benjamin A., Veedu, Rakesh N., Kvaskoff, David, Bernhardt, Paul V. and Wentrup, Curt (2009). Microwave-induced molecular rearrangements. Flash thermolysis in the gas-phase and in solution: Synthesis of quinolones and naphthyridones. Australian Journal of Chemistry, 62 (12), 1631-1638. doi: 10.1071/CH09447

Microwave-induced molecular rearrangements. Flash thermolysis in the gas-phase and in solution: Synthesis of quinolones and naphthyridones

2009

Journal Article

Foreword to Professor Alan M. Sargeson special issue

Bernhardt, Paul V. (2009). Foreword to Professor Alan M. Sargeson special issue. Australian Journal of Chemistry, 62 (10), 1195-1195. doi: 10.1071/CH09508

Foreword to Professor Alan M. Sargeson special issue

2009

Journal Article

Macrocyclic thiophene-appended cyanido-bridged Co-III/Fe-II complexes: Precursors to mixed-valent poly-thiophene hybrid materials

Hasan. Sharizal, Kilah, Nathan L., Martinez, Manuel and Bernhardt, Paul V. (2009). Macrocyclic thiophene-appended cyanido-bridged Co-III/Fe-II complexes: Precursors to mixed-valent poly-thiophene hybrid materials. Australian Journal of Chemistry, 62 (10), 1214-1220. doi: 10.1071/CH09245

Macrocyclic thiophene-appended cyanido-bridged Co-III/Fe-II complexes: Precursors to mixed-valent poly-thiophene hybrid materials

2009

Journal Article

Mechanistic aspects of the chemistry of mononuclear Cr-III complexes with pendant-arm macrocyclic ligands and formation of discrete Cr-III/Fe-II and Cr-III/Fe-II/Co-III cyano-bridged mixed valence compounds

Basallote, Manuel G., Bernhardt, Paul V., Calvet, Teresa, Castillo, Carmen E., Font-Bardia, Merce, Martinez, Manuel and Rodriguez, Carlos (2009). Mechanistic aspects of the chemistry of mononuclear Cr-III complexes with pendant-arm macrocyclic ligands and formation of discrete Cr-III/Fe-II and Cr-III/Fe-II/Co-III cyano-bridged mixed valence compounds. Dalton Transactions, 2009 (43), 9567-9577. doi: 10.1039/b909151c

Mechanistic aspects of the chemistry of mononuclear Cr-III complexes with pendant-arm macrocyclic ligands and formation of discrete Cr-III/Fe-II and Cr-III/Fe-II/Co-III cyano-bridged mixed valence compounds

Current funding

  • 2024 - 2027
    Emergent organocopper complexes as robust catalysts for electrosynthesis
    ARC Discovery Projects
    Open grant
  • 2023 - 2026
    An Innovative, Non-Hormonal, Pharmacological Strategy that Down-Regulates the Oestrogen, Androgen, Progesterone, and Prolactin Receptors and Inhibits the Triad-of-Death in Breast Cancer (Griffith led)
    Griffith University
    Open grant
  • 2023 - 2025
    Pharmaceutical Development of Innovative "Trojan Horse" Anti-Cancer Agents that Inhibit Desmoplasia by Reprogramming Signalling (NHMRC Ideas Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2022 - 2025
    Bioelectrochemical interconversion of the building blocks of life
    ARC Discovery Projects
    Open grant

Past funding

  • 2023 - 2024
    High-Resolution Electron Paramagnetic Resonance Imaging and Spectroscopy
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2021 - 2024
    Pioneering stable copper carbanions for new C-C bond forming paradigms
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    Molybdenum enzyme electrochemical communication
    ARC Discovery Projects
    Open grant
  • 2018 - 2021
    To Biochemically Trick P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp (NHMRC Project Grant led by Griffith University)
    Griffith University
    Open grant
  • 2017
    Advanced X-ray Facility for Structural Elucidation and Photocrystallography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2015 - 2017
    Enzyme Electrochemical Communication
    ARC Discovery Projects
    Open grant
  • 2015 - 2019
    The fate of copper in atom transfer radical reactions
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    A facility for ex-vivo molecular imaging
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    Facilities for Integrated Bioinorganic and Materials Chemistry Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Short circuiting redox enzymes
    ARC Discovery Projects
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Spotlighting Biologically Active Fe Chelators within Cells
    ARC Discovery Projects
    Open grant
  • 2009 - 2011
    Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class (NHMRC project grant administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2008 - 2010
    Electrochemically Driven Molybdoenzyme Catalysis
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007 - 2009
    Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential
    ARC Discovery Projects
    Open grant
  • 2007 - 2009
    Examination of the molecular pharmacology of anthracyclines induced via their interaction with iron
    University of Sydney
    Open grant
  • 2007 - 2008
    Mechanistic Studies on Biologically Active Iron Chelators
    ARC Linkage International
    Open grant
  • 2005
    New synthetic routes to the immobilisation of mixed valence transition metal complexes on conducting metal oxides
    ARC Linkage International
    Open grant
  • 2004
    Australian Bio-Metals Research Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Research expenses for visiting Research Fellow (Dr A. Meacham)
    The Royal Society
    Open grant
  • 2003 - 2005
    Mechanistic Studies of Dimethylsulfide Dehydrogenase: A Novel Bacterial Molybdoenzyme
    ARC Discovery Projects
    Open grant
  • 2003
    Novel Molecular Electrochronic Devices
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002
    Single electron reactions of multi-redox centred systems (CREDITS ONLY AWARDED)
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2001
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2000
    Excited state dynamics of light induced molecular processes.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    Mixed-Valence Transition Metal Assemblies
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Single electron transfer reactions of multi redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1999
    Self-assembling transition metal arrays
    UQ External Support Enabling Grant
    Open grant
  • 1999
    Single electron transfer reactions of multi redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1999
    Toward discrete dinuclear cyano-bridged coordination compounds
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Macrocyclic receptors for ionic guests
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Toward supramolecular charge separated molecules
    ARC Australian Research Council (Small grants)
    Open grant
  • 1997 - 1998
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1997
    Toward Proactive Supramolecular Coordination Compounds
    UQ External Support Enabling Grant
    Open grant
  • 1996
    Single electron transfer reactions of multi-redox centre complexes
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 1996
    Structurally organised oligonuclear coordination compounds
    University of Queensland New Staff Research Grant
    Open grant

Availability

Professor Paul Bernhardt is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Developing novel copper catalysts for carbon-carbon bond forming reactions using electrosynthesis.

    Principal Advisor

    Other advisors: Professor Craig Williams, Dr Masnun Naher

  • Doctor Philosophy

    Quantum Chemistry as a tool for Spectroscopic Analysis

    Principal Advisor

  • Doctor Philosophy

    Quantum Chemistry as a tool for Spectroscopic Analysis

    Principal Advisor

  • Doctor Philosophy

    New Applications for Photoactive Lanthanoid and Earth Abundant Metal Complexes

    Associate Advisor

    Other advisors: Associate Professor Evan Moore

  • Doctor Philosophy

    Pioneering stable copper carbanions for new C-C bond forming paradigms

    Associate Advisor

    Other advisors: Professor Craig Williams

  • Doctor Philosophy

    Electrochemical investigations of bacterial molybdenum enzymes

    Associate Advisor

    Other advisors: Professor Ulrike Kappler

  • Doctor Philosophy

    Development of innovative synthetic methodologies: electrochemical Atom Transfer Radical Addition (eATRA) and strained nitrogen ring synthesis paradigms

    Associate Advisor

    Other advisors: Professor Craig Williams

  • Doctor Philosophy

    New Applications for Photoactive Lanthanoid and Earth Abundant Metal Complexes

    Associate Advisor

    Other advisors: Associate Professor Evan Moore

Completed supervision

Enquiries

Contact Professor Paul Bernhardt directly for media enquiries about:

  • Crystallography
  • Electrochemistry
  • Transition metal chemistry

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