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2025 Journal Article An Asynchronous, Concerted Mechanism for Cytochrome P450-Catalyzed Dehydrogenation: A Combined Deuterium Labeling and QM/MM StudyKirk, Alicia M., Stok, Jeanette E., Wong, Siew Hoon, Coleman, Tom, Challinor, Victoria L., Herring, Joel N., Bruning, John B., Bernhardt, Paul V., Bell, Stephen G., Krenske, Elizabeth H. and De Voss, James J. (2025). An Asynchronous, Concerted Mechanism for Cytochrome P450-Catalyzed Dehydrogenation: A Combined Deuterium Labeling and QM/MM Study. ACS Catalysis, 1274-1286. doi: 10.1021/acscatal.4c06278 |
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2024 Journal Article Goondolinones A and B: Terpenyl-quinolin-4(1H)-ones from an Australian volcanic crater soil-derived Actinomadura sp., with selective activity against Dirofilaria immitis (Heartworm)Han, Jianying, Bruhn, David F, Roberts, Dana C., Burkman, Erica J., Moreno, Yovany, Bernhardt, Paul V., Salim, Angela A. and Capon, Robert J. (2024). Goondolinones A and B: Terpenyl-quinolin-4(1H)-ones from an Australian volcanic crater soil-derived Actinomadura sp., with selective activity against Dirofilaria immitis (Heartworm). Journal of Natural Products, 87 (12), 2855-2862. doi: 10.1021/acs.jnatprod.4c01146 |
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2024 Journal Article Divalent organocopper complexes: masked radicals for effective electrochemically driven atom transfer radical additionNaher, Masnun, Su, Chuyi, Gonzálvez, Miguel A., Williams, Craig M. and Bernhardt, Paul V. (2024). Divalent organocopper complexes: masked radicals for effective electrochemically driven atom transfer radical addition. Organometallics, 43 (21), 2821-2830. doi: 10.1021/acs.organomet.4c00377 |
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2024 Journal Article Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer EfficacyKaya, Busra, Gholam Azad, Mahan, Suleymanoglu, Mediha, Harmer, Jeffrey R., Wijesinghe, Tharushi P., Richardson, Vera, Zhao, Xiao, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2024). Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy. Journal of Medicinal Chemistry, 67 (14), 12155-12183. doi: 10.1021/acs.jmedchem.4c00884 |
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2024 Journal Article Miniaturized Cultivation Profiling (MATRIX)-Facilitated Discovery of Noonazines A–C and Noonaphilone A from an Australian Marine-Derived Fungus, Aspergillus noonimiae CMB-M0339Kankanamge, Sarani, Bernhardt, Paul V., Khalil, Zeinab G. and Capon, Robert J. (2024). Miniaturized Cultivation Profiling (MATRIX)-Facilitated Discovery of Noonazines A–C and Noonaphilone A from an Australian Marine-Derived Fungus, Aspergillus noonimiae CMB-M0339. Marine Drugs, 22 (6) 243, 243. doi: 10.3390/md22060243 |
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2024 Journal Article Goondansamycins A–H: Benzenoid Ansamycins from an Australian volcanic crater soil-derived Actinomadura sp. S4S-00069B08Han, Jianying, Bernhardt, Paul V. and Capon, Robert J. (2024). Goondansamycins A–H: Benzenoid Ansamycins from an Australian volcanic crater soil-derived Actinomadura sp. S4S-00069B08. Journal of Natural Products, 87 (5), 1471-1478. doi: 10.1021/acs.jnatprod.4c00336 |
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2024 Journal Article Synthesis of steroidal inhibitors for Mycobacterium tuberculosisChurchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479 |
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2024 Journal Article Correction to “Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series’’Wijesinghe, Tharushi P., Kaya, Busra, Gonzálvez, Miguel A., Harmer, Jeffrey R., Gholam Azad, Mahan, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2024). Correction to “Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series’’. Journal of Medicinal Chemistry, 67 (8), 6893-6893. doi: 10.1021/acs.jmedchem.4c00714 |
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2024 Journal Article Macrocyclic Copper(II) Complexes as Catalysts for Electrochemically Mediated Atom TransferNaher, Masnun, Su, Chuyi, Harmer, Jeffrey R., Williams, Craig M. and Bernhardt, Paul V. (2024). Macrocyclic Copper(II) Complexes as Catalysts for Electrochemically Mediated Atom Transfer. Inorganic Chemistry, 63 (14), 6453-6464. doi: 10.1021/acs.inorgchem.4c00311 |
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2024 Journal Article Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnologyWilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539 |
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2024 Journal Article The (±)-5-Aza[1.0]triblattane skeleton via azetine cycloadditionSu, Chuyi, Dallaston, Madeleine A., Watson, Renée D., Fahrenhorst-Jones, Tyler, Cameron, Jacob P., Pierens, Gregory K., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2024). The (±)-5-Aza[1.0]triblattane skeleton via azetine cycloaddition. Organic Letters, 26 (14), 2827-2831. doi: 10.1021/acs.orglett.3c03655 |
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2024 Journal Article Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidationDharmasivam, Mahendiran, Kaya, Busra, Wijesinghe, Tharushi P., Richardson, Vera, Harmer, Jeffrey R., Gonzalvez, Miguel A., Lewis, William, Azad, Mahan Gholam, Bernhardt, Paul V. and Richardson, Des R. (2024). Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy-hemoglobin oxidation. Chemical Science, 15 (3), 974-990. doi: 10.1039/d3sc05723b |
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2024 Journal Article Reversible structural transformation of metastable lead-free organic–inorganic hybrid bismuth halide single crystalsZhang, Yurou, Ghasemi, Mehri, Wen, Xiaoming, Lee, Minwoo, Liu, Xiaoxia, Jiao, Yalong, Bernhardt, Paul V., Han, EQ, Lin, Tongen, Zhang, Bo Wei, Xu, Kaijie, Lee, Su-Min, Yun, Jae Sung, Yun, Jung-Ho and Wang, Lianzhou (2024). Reversible structural transformation of metastable lead-free organic–inorganic hybrid bismuth halide single crystals. Journal of Materials Chemistry A, 12 (42), 29152-29164. doi: 10.1039/d4ta04715j |
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2024 Journal Article Hyperstable alkenes: are they remarkably unreactive?Summersgill, Matthew D., Gahan, Lawrence R., Chow, Sharon, Pierens, Gregory K., Bernhardt, Paul V., Krenske, Elizabeth H. and Williams, Craig M. (2024). Hyperstable alkenes: are they remarkably unreactive?. Chemical Science, 15 (46), 19299-19306. doi: 10.1039/d4sc06697a |
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2024 Journal Article Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistanceKaya, Busra, Smith, Henry, Chen, Yanbing, Azad, Mahan Gholam, M. Russell, Tiffany, Richardson, Vera, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2024). Targeting lysosomes by design: novel N-acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistance. Chemical Science, 15 (37), 15109-15124. doi: 10.1039/d4sc04339a |
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2024 Journal Article X-ray absorption and emission spectroscopy of N<sub>2</sub>S<sub>2</sub> Cu(<scp>ii</scp>)/(<scp>iii</scp>) complexesGeoghegan, Blaise L., Bilyj, Jessica K., Bernhardt, Paul V., DeBeer, Serena and Cutsail, George E. (2024). X-ray absorption and emission spectroscopy of N2S2 Cu(ii)/(iii) complexes. Dalton Transactions, 53 (18), 7828-7838. doi: 10.1039/d4dt00085d |
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2024 Journal Article Rapid and stable complexation of the α-generators bismuth-212 and lead-212 with a tetraazamacrocyclic chelator bearing thiosemicarbazone pendant armsGrieve, Melyssa L., Davey, Patrick R. W. J., Bernhardt, Paul V., Forsyth, Craig M. and Paterson, Brett M. (2024). Rapid and stable complexation of the α-generators bismuth-212 and lead-212 with a tetraazamacrocyclic chelator bearing thiosemicarbazone pendant arms. Inorganic Chemistry Frontiers, 11 (21), 7307-7323. doi: 10.1039/d4qi01338g |
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2023 Journal Article Dilution accelerates crystallization: a negative-order kinetic coordination reaction induced by the competitive interplay of dissociation and complexationMeng, Peng, Connolly, Blake J. P., Anand, Ayusha, Wang, Yuting, Bernhardt, Paul V. and Xu, Jingsan (2023). Dilution accelerates crystallization: a negative-order kinetic coordination reaction induced by the competitive interplay of dissociation and complexation. CCS Chemistry, 5 (12), 2845-2854. doi: 10.31635/ccschem.023.202303095 |
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2023 Journal Article Redox characterization of the complex molybdenum enzyme formate dehydrogenase from Cupriavidus necatorHarmer, Jeffrey R., Hakopian, Sheron, Niks, Dimitri, Hille, Russ and Bernhardt, Paul V. (2023). Redox characterization of the complex molybdenum enzyme formate dehydrogenase from Cupriavidus necator. Journal of the American Chemical Society, 145 (47), 25850-25863. doi: 10.1021/jacs.3c10199 |
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2023 Journal Article Steric blockade of oxy-myoglobin oxidation by thiosemicarbazones: structure–activity relationships of the novel PPP4pT seriesWijesinghe, Tharushi P., Kaya, Busra, Gonzálvez, Miguel A., Harmer, Jeffrey R., Gholam Azad, Mahan, Bernhardt, Paul V., Dharmasivam, Mahendiran and Richardson, Des R. (2023). Steric blockade of oxy-myoglobin oxidation by thiosemicarbazones: structure–activity relationships of the novel PPP4pT series. Journal of Medicinal Chemistry, 66 (22), 15453-15476. doi: 10.1021/acs.jmedchem.3c01612 |
