Female reproductive health preservation by Nictotinamide Adenine Dinucleotide (NAD+) and Sirtuin2 (SIRT2) (2016-2018)

Cancer treatment can be severely toxic to women's eggs. Increasing numbers of women who survive cancer therefore become infertile and prematurely deprived of hormonal support whilst still in their reproductive years. This project will use state-of-the-art techniques to interrogate newly uncovered pathways that can protect eggs from treatment-induced injury thereby greatly improving the quality of life for female cancer survivors.