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2019

Journal Article

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Huckins, Laura M., Dobbyn, Amanda, Ruderfer, Douglas M., Hoffman, Gabriel, Wang, Weiqing, Pardiñas, Antonio F., Rajagopal, Veera M., Als, Thomas D., T. Nguyen, Hoang, Girdhar, Kiran, Boocock, James, Roussos, Panos, Fromer, Menachem, Kramer, Robin, Domenici, Enrico, Gamazon, Eric R., Purcell, Shaun, Johnson, Jessica S., Shah, Hardik R., Klein, Lambertus L., Dang, Kristen K., Logsdon, Benjamin A., Mahajan, Milind C., Mangravite, Lara M., Toyoshiba, Hiroyoshi, Gur, Raquel E., Hahn, Chang-Gyu, Schadt, Eric, Lewis, David A. ... Stahl, Eli A. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51 (4), 659-674. doi: 10.1038/s41588-019-0364-4

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

2019

Journal Article

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Harold, Denise, Connolly, Siobhan, Riley, Brien P., Kendler, Kenneth S., McCarthy, Shane E., McCombie, William R., Richards, Alex, Owen, Michael J., O'Donovan, Michael C., Walters, James, Donnelly, Peter, Bates, Lesley, Barroso, Ines, Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Deloukas, Panos, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S., Mathew, Christopher G., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Trembath, Richard C., Viswanathan, Ananth C. ... Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180 (3), 223-231. doi: 10.1002/ajmg.b.32716

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

2019

Journal Article

Cumulative influence of parity-related genomic changes in multiple sclerosis

Mehta, Divya, Wani, Shivangi, Wallace, Leanne, Henders, Anjali K., Wray, Naomi R. and McCombe, Pamela A. (2019). Cumulative influence of parity-related genomic changes in multiple sclerosis. Journal of Neuroimmunology, 328, 38-49. doi: 10.1016/j.jneuroim.2018.12.004

Cumulative influence of parity-related genomic changes in multiple sclerosis

2019

Journal Article

Identification of common genetic risk variants for autism spectrum disorder

Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel ... Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431-444. doi: 10.1038/s41588-019-0344-8

Identification of common genetic risk variants for autism spectrum disorder

2019

Journal Article

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Howard, David M., Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Shirali, Masoud, Coleman, Jonathan R. I., Hagenaars, Saskia P., Ward, Joey, Wigmore, Eleanor M., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Xu, Eileen Y., Whalley, Heather C., Marioni, Riccardo E., Porteous, David J., Davies, Gail, Deary, Ian J., Hemani, Gibran, Berger, Klaus, Teismann, Henning, Rawal, Rajesh, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Domschke, Katharina, Tian, Chao, Hinds, David A. ... McIntosh, Andrew M. (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22 (3), 343-352. doi: 10.1038/s41593-018-0326-7

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

2019

Journal Article

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

Arnau-Soler, Aleix, Macdonald-Dunlop, Erin, Adams, Mark J., Clarke, Toni-Kim, MacIntyre, Donald J., Milburn, Keith, Navrady, Lauren, Hayward, Caroline, McIntosh, Andrew M., Thomson, Pippa A., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenscon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9 (1) 14. doi: 10.1038/s41398-018-0360-y

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

2019

Journal Article

Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome

Niarchou, Maria, Chawner, Samuel J. R. A., Fiksinski, Ania, Vorstman, Jacob A. S., Maeder, Johanna, Schneider, Maude, Eliez, Stephan, Armando, Marco, Pontillo, Maria, Vicari, Stefano, McDonald-McGinn, Donna M., Emanuel, Beverly S., Zackai, Elaine H., Bearden, Carrie E., Shashi, Vandana, Hooper, Stephen R., Owen, Michael J., Gur, Raquel E., Wray, Naomi R., van den Bree, Marianne B. M. and Thapar, Anita (2019). Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome. Schizophrenia Research, 204, 320-325. doi: 10.1016/j.schres.2018.07.044

Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome

2019

Journal Article

Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder

Trzaskowski, Maciej, Mehta, Divya, Peyrot, Wouter J., Hawkes, David, Davies, Daniel, Howard, David M., Kemper, Kathryn E., Sidorenko, Julia, Maier, Robert, Ripke, Stephan, Mattheisen, Manuel, Baune, Bernhard T., Grabe, Hans J., Heath, Andrew C., Jones, Lisa, Jones, Ian, Madden, Pamela A.F., McIntosh, Andrew M., Breen, Gerome, Lewis, Cathryn M., Børglum, Anders D., Sullivan, Patrick F., Martin, Nicholas G., Kendler, Kenneth S., Levinson, Douglas F. and Wray, Naomi R. (2019). Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (6), 439-447. doi: 10.1002/ajmg.b.32713

Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder

2019

Journal Article

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

Schork, Andrew J., Won, Hyejung, Appadurai, Vivek, Nudel, Ron, Gandal, Mike, Delaneau, Olivier, Revsbech Christiansen, Malene, Hougaard, David M., Bækved-Hansen, Marie, Bybjerg-Grauholm, Jonas, Giørtz Pedersen, Marianne, Agerbo, Esben, Bøcker Pedersen, Carsten, Neale, Benjamin M., Daly, Mark J., Wray, Naomi R., Nordentoft, Merete, Mors, Ole, Børglum, Anders D., Bo Mortensen, Preben, Buil, Alfonso, Thompson, Wesley K., Geschwind, Daniel H. and Werge, Thomas (2019). A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience, 22 (3), 353-361. doi: 10.1038/s41593-018-0320-0

A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment

2019

Journal Article

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

Foo, Jerome C., Streit, Fabian, Frank, Josef, Witt, Stephanie H., Treutlein, Jens, Baune, Bernhard T., Moebus, Susanne, Joeckel, Karl-Heinz, Forstner, Andreas J., Noethen, Markus M., Rietschel, Marcella, Sartorius, Alexander, Kranaster, Laura, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1), 35-45. doi: 10.1002/ajmg.b.32700

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

2019

Journal Article

Sleep disorders and risk of incident depression: a population case-control study

Byrne, Enda M., Timmerman, Allan, Wray, Naomi R. and Agerbo, Esben (2019). Sleep disorders and risk of incident depression: a population case-control study. Twin Research and Human Genetics, 22 (03) PII S1832427419000227, 140-146. doi: 10.1017/thg.2019.22

Sleep disorders and risk of incident depression: a population case-control study

2019

Journal Article

A polygenic resilience score moderates the genetic risk for schizophrenia

Hess, Jonathan L., Tylee, Daniel S., Mattheisen, Manuel, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Andreassen, Ole A, Arranz, Maria J, Bacanu, Silviu A, Bakker, Steven, Band, Gavin, Barroso, Ines, Begemann, Martin, Bellenguez, Céline, Belliveau, Richard A, Bender, Stephan, Bene, Judit, Bergen, Sarah E, Bevilacqua, Elizabeth, Bigdeli, Tim B, Black, Donald W, Blackburn, Hannah, Blackwell, Jenefer M, Blackwood, Douglas H R, Bramon, Elvira, Brown, Matthew A ... Glatt, Stephen J. (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry, 26 (3), 800-815. doi: 10.1038/s41380-019-0463-8

A polygenic resilience score moderates the genetic risk for schizophrenia

2018

Journal Article

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

Stevenson, Anna J., McCartney, Daniel L., Harris, Sarah E., Taylor, Adele M., Redmond, Paul, Starr, John M., Zhang, Qian, McRae, Allan F., Wray, Naomi R., Spires-Jones, Tara L., McColl, Barry W., McIntosh, Andrew M., Deary, Ian J. and Marioni, Riccardo E. (2018). Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing. Clinical Epigenetics, 10 (1) 159, 159. doi: 10.1186/s13148-018-0585-x

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

2018

Journal Article

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

Yap, Chloe X., Sidorenko, Julia, Wu, Yang, Kemper, Kathryn E., Yang, Jian, Wray, Naomi R., Robinson, Matthew R. and Visscher, Peter M. (2018). Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Nature Communications, 9 (1) 5407, 5407. doi: 10.1038/s41467-018-07862-y

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

2018

Journal Article

Identification of 55,000 replicated DNA methylation QTL

McRae, Allan F., Marioni, Riccardo E., Shah, Sonia, Yang, Jian, Powell, Joseph E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Bowdler, Lisa, Painter, Jodie N., Murphy, Lee, Martin, Nicholas G., Starr, John M., Wray, Naomi R., Deary, Ian J., Visscher, Peter M. and Montgomery, Grant W. (2018). Identification of 55,000 replicated DNA methylation QTL. Scientific Reports, 8 (1) 17605, 17605. doi: 10.1038/s41598-018-35871-w

Identification of 55,000 replicated DNA methylation QTL

2018

Journal Article

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Arnau-Soler, Aleix, Adams, Mark J., Hayward, Caroline, Thomson, Pippa A., Porteous, David, Campbell, Archie, Smith, Blair H., Black, Corri, Padmanabhan, Sandosh, McIntosh, Andrew, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13 (12) e0209160, e0209160. doi: 10.1371/journal.pone.0209160

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

2018

Journal Article

The association between neonatal vitamin D status and risk of schizophrenia

Eyles, Darryl W., Trzaskowski, Maciej, Vinkhuyzen, Anna A. E., Mattheisen, Manuel, Meier, Sandra, Gooch, Helen, Anggono, Victor, Cui, Xiaoying, Tan, Men Chee, Burne, Thomas H. J., Jang, Se Eun, Kvaskoff, David, Hougaard, David M., Nørgaard-Pedersen, Bent, Cohen, Arieh, Agerbo, Esben, Pedersen, Carsten B., Børglum, Anders D., Mors, Ole, Sah, Pankaj, Wray, Naomi R., Mortensen, Preben B. and McGrath, John J. (2018). The association between neonatal vitamin D status and risk of schizophrenia. Scientific Reports, 8 (1) 17692, 17692. doi: 10.1038/s41598-018-35418-z

The association between neonatal vitamin D status and risk of schizophrenia

2018

Journal Article

PPD ACT: an app-based genetic study of postpartum depression

Guintivano, Jerry, Krohn, Holly, Lewis, Carol, Byrne, Enda M., Henders, Anjali K., Ploner, Alexander, Kirk, Katherine, Martin, Nicholas G., Milgrom, Jeannette, Wray, Naomi R., Sullivan, Patrick F. and Meltzer-Brody, Samantha (2018). PPD ACT: an app-based genetic study of postpartum depression. Translational Psychiatry, 8 (1) 260, 260. doi: 10.1038/s41398-018-0305-5

PPD ACT: an app-based genetic study of postpartum depression

2018

Journal Article

Imprint of assortative mating on the human genome

Yengo, Loic, Robinson, Matthew R., Keller, Matthew C., Kemper, Kathryn E., Yang, Yuanhao, Trzaskowski, Maciej, Gratten, Jacob, Turley, Patrick, Cesarini, David, Benjamin, Daniel J., Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2018). Imprint of assortative mating on the human genome. Nature Human Behaviour, 2 (12), 948-954. doi: 10.1038/s41562-018-0476-3

Imprint of assortative mating on the human genome

2018

Journal Article

Erratum: Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness (Nature communications (2018) 9 1 (2537))

Yap, Chloe X., Sidorenko, Julia, Marioni, Riccardo E., Yengo, Loic, Wray, Naomi R. and Visscher, Peter M. (2018). Erratum: Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness (Nature communications (2018) 9 1 (2537)). Nature communications, 9 (1) 4953, 4953. doi: 10.1038/s41467-018-07400-w

Erratum: Author Correction: Misestimation of heritability and prediction accuracy of male-pattern baldness (Nature communications (2018) 9 1 (2537))