
Overview
Background
Centre for Solar Biotechnology: Prof Ben Hankamer is the founding director of the Solar Biofuels Consortium (2007) and Centre for Solar Biotechnology (2016) which is focused on developing next generation microalgae systems. These systems are designed to tap into the huge energy resource of the sun (>2300x global energy demand) and capture CO2 to produce a wide-range of products. These include solar fuels (e.g. H2 from water, oil, methane and ethanol), foods (e.g. health foods) and high value products (e.g. vaccines produced in algae). Microalgae systems also support important eco-services such as water purification and CO2 sequestration. The Centre is being launched in 2016/2017 and includes approximately 30 teams with skills ranging from genome sequencing through to demonstration systems optimsation and accompanying techno-economis and life cycle analysis. The Centre teams have worked extensively with industry.
Structural Biology: The photosynthetic machinery is the biological interface of microalgae that taps into the huge energy resource of the sun, powers the biosphere and produces the atmospheric oxygen that supports life on Earth. My team uses high resolution single particle analysis and electron tomography to solve the intricate 3D architecture of the photosynthetic machinery to enable structure guided design of high efficiency microalgae cell lines and advanced artificial solar fuel systems.
Availability
- Professor Ben Hankamer is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Liverpool
- Masters (Coursework) of Science, University College London
- Doctor of Philosophy, University College London
Research interests
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The Structural Biology of Photosynthesis
Algae cells have evolved over ~3 billion years of natural selection to yield a diverse array of highly efficient, self-assembling, light-responsive membranes. These act as Nature’s solar interfaces, via which plants tap into the power of the sun. These interfaces contain nano-machinery to drive the photosynthetic light reactions which convert light from the sun into food, fuel and atmospheric oxygen to support life on Earth. This photosynthetic machinery is intricately arranged in 3D and has evolved to adjust dynamically (i.e. 4D: 3D & time) to changing light conditions to achieve optimal efficiency of solar energy conversion. Structural biology, in the form of cryo- electron microscopy, electron tomography, and single particle analysis therefore provide critical insights into this process and will increasingly facilitates structure guided design of new solar fuel systems.
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Micro-algae biotechnology
Algae tap into the power of the sun (> 2300 x total global energy demand) to produce biomass for CO2 water and nutrients. Consequently microalgae can be used for the following High value foods and pharmaceuticals: To develop algae based systems for the production of foods/nutraceuticals, vaccines, peptide therapeutics, novel antibiotics in algae. Reef protection/Bioremediation: To develop algae based bioremediation technologies (e.g. minimising nutrient runoff to the reef; phytomining). Solar Fuels: To develop economic algae based and bio-inspired solar fuel systems (e.g. solar power H2 from water for fuel cells).
Research impacts
The Challenge: The global economy is valued at ~$114 Tn pa and is powered by the $6 Tn energy sector. 80% of global energy is used as fuels (only ~20% as electricity).
By 2050, expansion of the human population to > 9 billion people and continued global economic growth, will necessitate 50% more energy (International Energy Agency), 70% more food (UN), 50% more fresh water (OECD) and CO2 emissions cuts of 80% (IPCC) to maintain political, social, fuel and climate security.
Microalgae systems sit at the nexus of this challenge. They are rapidly growing microscopic solar driven ‘cell factories’ which can capture sunlight and CO2 and can grow in saline/low grade water to reduce greenhouse gas emission and produce O2, clean water and biomass. Depending on the species and process used, this bimass can yield a wide range of products. At the high value end micoalgae can be used to produce pharmaeutical and health food products such as omega-3 fatty acids and anti-oxidants. As systems and economic efficiencies are improved they can supply much larger commodity markets including renewable fuels as well as bioplastics and ‘green-chemical’ feedstocks.
Australia is uniquely positioned to benefit from such work on tackling the challenge of delivering cost-competitive solar fuel systems. It has vast lands, abundant solar irradiation, saline water resources and excellent infrastructure.
Our parallel structural biology work is focused on generating detailed molecular blueprints of photosynthetic interfaces, refined over 3 billion years of evolution, and to apply these design principles to the development of high-efficiency algal and bio-inspired artificial solar fuel systems at pilot-scale. This will benefit society by reducing its reliance on fossil fuels, and provide the basis for sustainable, long-term economic development.
Works
Search Professor Ben Hankamer’s works on UQ eSpace
2016
Conference Publication
Structural characterization of dihydroorotase domain in yeast CAD multienzyme
Jeon, Yujung, Ross, Ian, Landsberg, Michael, Schultz, Ben, Hankamer, Ben and Kobe, Bostjan (2016). Structural characterization of dihydroorotase domain in yeast CAD multienzyme. 30th European Crystallographic Meeting, Basel, Switzerland, 28 August - 1 September 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273316096807
2016
Journal Article
Challenges and opportunities for hydrogen production from microalgae
Oey, Melanie, Sawyer, Anne Linda, Ross, Ian Lawrence and Hankamer, Ben (2016). Challenges and opportunities for hydrogen production from microalgae. Plant Biotechnology Journal, 14 (7), 1487-1499. doi: 10.1111/pbi.12516
2016
Journal Article
Multifactorial comparison of photobioreactor geometries in parallel microalgae cultivations
Wolf, J., Stephens, E., Steinbusch, S., Yarnold, J., Ross, I. L., Steinweg, C., Doebbe, A., Krolovitsch, C., Muller, S., Jakob, G., Kruse, O., Posten, C. and Hankamer, B. (2016). Multifactorial comparison of photobioreactor geometries in parallel microalgae cultivations. Algal Research, 15, 187-201. doi: 10.1016/j.algal.2016.02.018
2016
Journal Article
Prospects for photobiological hydrogen as a renewable energy
Ross, Ian L., Oey, Melanie, Stephens, Evan and Hankamer, Ben (2016). Prospects for photobiological hydrogen as a renewable energy. Current Biotechnology, 5, 1-19. doi: 10.2174/2211550105666160308202919
2016
Journal Article
Triggered exocytosis of the protozoan Tetrahymena as a source of bioflocculation and a controllable dewatering method for efficient harvest of microalgal cultures
Jakob, Gisela, Stephens, Evan, Feller, Rafael, Oey, Melanie, Hankamer, Ben and Ross, Ian L. (2016). Triggered exocytosis of the protozoan Tetrahymena as a source of bioflocculation and a controllable dewatering method for efficient harvest of microalgal cultures. Algal Research, 13, 148-158. doi: 10.1016/j.algal.2015.11.011
2016
Journal Article
Photoacclimation and productivity of Chlamydomonas reinhardtii grown in fluctuating light regimes which simulate outdoor algal culture conditions
Yarnold, Jennifer, Ross, Ian L. and Hankamer, Ben (2016). Photoacclimation and productivity of Chlamydomonas reinhardtii grown in fluctuating light regimes which simulate outdoor algal culture conditions. Algal Research: biology, biomass and biofuels, 13, 182-194. doi: 10.1016/j.algal.2015.11.001
2015
Journal Article
High-throughput screen for high performance microalgae strain selection and integrated media design
Wolf, Juliane, Ross, Ian L., Radzun, Khairul Adzfa, Jakob, Gisela, Stephens, Evan and Hankamer, Ben (2015). High-throughput screen for high performance microalgae strain selection and integrated media design. Algal Research, 11, 313-325. doi: 10.1016/j.algal.2015.07.005
2015
Journal Article
Functional similarities between heterogeneously and homogenously expressed MscL constructs
Chi, Gamma, Rohde, Paul R., Ridone, Pietro, Hankamer, Ben, Martinac, Boris and Landsberg, Michael J. (2015). Functional similarities between heterogeneously and homogenously expressed MscL constructs. European Biophysics Journal, 44 (7), 589-598. doi: 10.1007/s00249-015-1062-5
2015
Journal Article
Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and l-α-lysophosphatidylcholine
Foo, Alexander, Battle, Andrew R., Chi, Gamma, Hankamer, Ben, Landsberg, Michael J. and Martinac, Boris (2015). Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and l-α-lysophosphatidylcholine. European Biophysics Journal, 44 (7), 521-530. doi: 10.1007/s00249-015-1055-4
2015
Other Outputs
Biofloculation of microalgal populations
Ross, I. L., Jacob, G., Stephens, E. and Hankamer, B. (2015). Biofloculation of microalgal populations. 2015902422.
2015
Journal Article
Solution structure of the RNA-binding cold shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition
Sawyer, Anne L., Landsberg, Michael J., Ross, Ian L., Kruse, Olaf, Mobli, Mehdi and Hankamer, Ben (2015). Solution structure of the RNA-binding cold shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition. Biochemical Journal, 469 (1), 97-106. doi: 10.1042/BJ20150217
2015
Journal Article
Sulphur responsiveness of the Chlamydomonas reinhardtii LHCBM9 promoter
Sawyer, Anne L., Hankamer, Ben D. and Ross, Ian L. (2015). Sulphur responsiveness of the Chlamydomonas reinhardtii LHCBM9 promoter. Planta, 241 (5), 1287-1302. doi: 10.1007/s00425-015-2249-9
2015
Journal Article
Automated nutrient screening system enables high-throughput optimisation of microalgae production conditions
Radzun, Adzfa Radzun, Wolf, Juliane, Jakob, Gisela, Zhang, Eugene, Stephens, Evan, Ross, Ian and Hankamer, Ben (2015). Automated nutrient screening system enables high-throughput optimisation of microalgae production conditions. Biotechnology for Biofuels, 8 (1) 65, 65.1-65.17. doi: 10.1186/s13068-015-0238-7
2015
Book Chapter
Genetic engineering for microalgae strain improvement in relation to biocrude production systems
Stephens, Evan, Wolf, Juliane, Oey, Melanie, Zhang, Eugene, Hankamer, Ben and Ross, Ian L. (2015). Genetic engineering for microalgae strain improvement in relation to biocrude production systems. Biomass and biofuels from microalgae: advances in engineering and biology. (pp. 191-249) edited by Navid R. Moheimani, Mark P. McHenry, Karne de Boer and Parisa A. Bahri. Heidelberg, Germany: Springer. doi: 10.1007/978-3-319-16640-7_11
2014
Journal Article
Integration in microalgal bioprocess development: design of efficient, sustainable, and economic processes
Fresewinkel, Mark, Rosello, Rosa, Wilhelm, Christian, Kruse, Olaf, Hankamer, Ben and Posten, Clemens (2014). Integration in microalgal bioprocess development: design of efficient, sustainable, and economic processes. Engineering in Life Sciences, 14 (6), 560-573. doi: 10.1002/elsc.201300153
2014
Journal Article
Flow cytometry pulse width data enables rapid and sensitive estimation of biomass dry weight in the microalgae Chlamydomonas reinhardtii and Chlorella vulgaris
Chioccioli, Maurizio, Hankamer, Ben and Ross, Ian L. (2014). Flow cytometry pulse width data enables rapid and sensitive estimation of biomass dry weight in the microalgae Chlamydomonas reinhardtii and Chlorella vulgaris. PLoS One, 9 (5) e97269, e97269.1-e97269.12. doi: 10.1371/journal.pone.0097269
2014
Journal Article
Light-harvesting complex protein LHCBM9 is critical for photosystem II activity and hydrogen production in Chlamydomonas reinhardtii
Grewe, Sabrina, Ballottari, Matteo, Alcocer, Marcelo, D'Andrea, Cosimo, Blifernez-Klassen, Olga, Hankamer, Ben, Mussgnug, Jan H., Bassi, Roberto and Kruse, Olaf (2014). Light-harvesting complex protein LHCBM9 is critical for photosystem II activity and hydrogen production in Chlamydomonas reinhardtii. Plant Cell, 26 (4), 1598-1611. doi: 10.1105/tpc.114.124198
2014
Journal Article
Gateway-assisted vector construction to facilitate expression of foreign proteins in the chloroplast of single celled algae
Oey, Melanie, Ross, Ian L. and Hankamer, Ben (2014). Gateway-assisted vector construction to facilitate expression of foreign proteins in the chloroplast of single celled algae. PloS One, 9 (2) e86841, e86841. doi: 10.1371/journal.pone.0086841
2014
Journal Article
Bacterial mechanosensitive channels: models for studying mechanosensory transduction
Martinac, Boris, Nomura, Takeshi, Chi, Gamma, Petrov, Evgeny, Rohde, Paul R., Battle, Andrew R., Foo, Alexander, Constantine, Maryrose, Rothnagel, Rosalba, Carne, Sonia, Deplazes, Evelyne, Cornell, Bruce, Cranfield, Charles G., Hankamer, Ben and Landsberg, Michael J. (2014). Bacterial mechanosensitive channels: models for studying mechanosensory transduction. Antioxidants and Redox Signaling, 20 (6), 952-969. doi: 10.1089/ars.2013.5471
2013
Journal Article
Impact of procedural steps and cryopreservation agents in the cryopreservation of chlorophyte microalgae
Bui, Tony V. L., Ross, Ian L., Jakob, Gisela and Hankamer, Ben (2013). Impact of procedural steps and cryopreservation agents in the cryopreservation of chlorophyte microalgae. PloS One, 8 (11) e78668, e78668.1-e78668.9. doi: 10.1371/journal.pone.0078668
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ben Hankamer is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Isolation and purification of microalgae protein and omega-3 fatty acid for food applications
Principal Advisor
Other advisors: Dr Juliane Wolf, Dr Ian Ross
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Doctor Philosophy
Optimisation of microalgae-based fertiliser and plant bio-stimulants
Principal Advisor
Other advisors: Dr Juliane Wolf
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Doctor Philosophy
Investigating protein expression and secretion mechanisms in microalgae with a focus on significantly increasing the production of industrially relevant antibodies
Principal Advisor
Other advisors: Dr Ian Ross
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Doctor Philosophy
Cryo-EM studies of Photosystem II mutants
Principal Advisor
Other advisors: Dr Ian Ross
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Doctor Philosophy
Regulation of bioenergetic pathways in Clamydomonas reinhardtil: Control of linear and cyclic photosythetic electron transport and its implications on hydrogen production
Principal Advisor
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Doctor Philosophy
Regulation of bioenergetic pathways in Clamydomonas reinhardtil: Control of linear and cyclic photosythetic electron transport and its implications on hydrogen production
Principal Advisor
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Doctor Philosophy
Pipeline Development for Algae as a Viable Sustainable Dietary Protein Source to Support Human Nutrition
Principal Advisor
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Doctor Philosophy
Structure-guided optimisation of light-driven biomanufacture
Principal Advisor
Other advisors: Dr Ian Ross, Dr Farrah Blades
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Doctor Philosophy
Structure-guided optimisation of light-driven microalgae cell factories
Principal Advisor
Other advisors: Dr Ian Ross
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Doctor Philosophy
Digital simulation and model guided optimisation of light driven cell factories
Principal Advisor
Other advisors: Associate Professor Marcus Gallagher, Dr Juliane Wolf
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Doctor Philosophy
Pipeline Development for Algae as a Viable Sustainable Dietary Protein Source to Support Human Nutrition
Principal Advisor
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Doctor Philosophy
Light-driven biocatalytic cell factories
Principal Advisor
Other advisors: Dr Ian Ross, Professor Gary Schenk
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Doctor Philosophy
Enhancing microalgae harvesting and pigment extraction through novel methods: evaluation and optimization for sustainable biotechnological applications
Principal Advisor
Other advisors: Dr Juliane Wolf
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Doctor Philosophy
Closed Greenhouse Indoors Climate Simulation and Control
Associate Advisor
Other advisors: Dr Juliane Wolf, Emeritus Professor Hal Gurgenci
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Doctor Philosophy
Coupling of P450 ancestors with the photosynthetic machinery of Chlamydomonas reinhardtii for light-driven biocatalysis in vitro
Associate Advisor
Other advisors: Dr Ian Ross, Professor Elizabeth Gillam
Completed supervision
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2024
Doctor Philosophy
Integrated analyses of biomass production and pigment accumulation in cyanobacteria and microalgae
Principal Advisor
Other advisors: Dr Juliane Wolf
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2024
Doctor Philosophy
Solar-Driven P450 Biocatalysis: Tapping Photosynthetic Electrons to Power the Synthesis of High-Value Fine Chemicals
Principal Advisor
Other advisors: Dr Ian Ross, Dr Melanie Oey
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2023
Doctor Philosophy
Modelling microalgae based production of recombinant proteins under different scenarios
Principal Advisor
Other advisors: Dr Ian Ross, Dr Melanie Oey
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2022
Doctor Philosophy
Generation and characterisation of CRISPR - mediated LHCBM - Knockout Chlamydomonas reinhardtii strains
Principal Advisor
Other advisors: Dr Ian Ross
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2022
Doctor Philosophy
Techno-economic and life cycle analysis of multi-product microalgae biorefineries
Principal Advisor
Other advisors: Dr Ian Ross
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2022
Doctor Philosophy
The development of green microalgae as a biofertiliser and biostimulant to improve Spinacia oleracea crop quality and yield.
Principal Advisor
Other advisors: Professor Susanne Schmidt, Dr Juliane Wolf
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2020
Doctor Philosophy
Bioengineering high efficiency solar driven hydrogen production in the green alga Chlamydomonas reinhardtii
Principal Advisor
Other advisors: Dr Ian Ross
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2020
Doctor Philosophy
Analysis and optimisation of chloroplast recombinant protein expression in the green alga Chlamydomonas reinhardtii
Principal Advisor
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2020
Doctor Philosophy
Optimising microalgae production efficiency and key process parameters: light, nutrients and growth systems
Principal Advisor
Other advisors: Dr Juliane Wolf
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2019
Doctor Philosophy
Combined Techno-economic and Lifecycle Analysis of Renewable Fuel Production Systems
Principal Advisor
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2017
Doctor Philosophy
Biophysical and Structural Studies of Escherichia coli Mechanosensitive Channel of Large Conductance
Principal Advisor
Other advisors: Associate Professor Michael Landsberg
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2016
Doctor Philosophy
Developing 3D novel edge detection and particle picking tools for electron tomography
Principal Advisor
Other advisors: Associate Professor Michael Landsberg
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2016
Doctor Philosophy
Photosynthesis of microalgae in outdoor mass cultures and modelling its effects on biomass productivity for fuels, feeds and chemicals.
Principal Advisor
Other advisors: Dr Ian Ross
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2016
Doctor Philosophy
Enhanced microalgae growth and lipid production: A study of cytostatic inhibitors and glycerol assimilation
Principal Advisor
Other advisors: Dr Ian Ross
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2016
Doctor Philosophy
Scale-up cultivation of Australian algae New approaches to isolation, mid-scale cultivation and harvesting of Australian wild type algal strains
Principal Advisor
Other advisors: Dr Ian Ross, Dr Melanie Oey
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2015
Doctor Philosophy
Effective Scale Up of Microalgal Systems for the Production of Biomass and Biofuels
Principal Advisor
Other advisors: Dr Ian Ross
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2014
Doctor Philosophy
Developing automated high-throughput microalgal nutrient screening system
Principal Advisor
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2014
Doctor Philosophy
Cryopreservation, culture recovery and glucose induced Programmed cell death in Chlorophyte microalgae
Principal Advisor
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2014
Doctor Philosophy
Development of Novel Nanovalves for Liposomal Drug Delivery Based on Bacterial Mechanosensitive Channel of Large Conductance
Principal Advisor
Other advisors: Associate Professor Michael Landsberg
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2014
Doctor Philosophy
Multiple, Object-Oriented Segmentation Methods of Mammalian Cell Tomograms
Principal Advisor
Other advisors: Associate Professor Michael Landsberg
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2014
Doctor Philosophy
Regulation of light harvesting complex gene expression in Chlamydomonas reinhardtii
Principal Advisor
Other advisors: Dr Ian Ross
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2013
Doctor Philosophy
Exploring New Strategies For A More Accurate Estimation Of Microalgae Growth Rate And Light Harvesting Complexes Antennae Size
Principal Advisor
Other advisors: Dr Ian Ross
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2013
Doctor Philosophy
Multiscale analysis and optimisation of photosynthetic solar energy systems
Principal Advisor
Other advisors: Associate Professor Michael Landsberg, Professor Tom Stace
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2012
Doctor Philosophy
Developing metabolic fingerprinting strategies to decipher algal hydrogen production.
Principal Advisor
Other advisors: Dr Ian Ross
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2011
Doctor Philosophy
Commercialisation and Development of Integrated Microalgal Production Systems
Principal Advisor
Other advisors: Dr Ian Ross
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2008
Doctor Philosophy
Enhanced Filter Algorithms And Application Of Single Particle Analysis To The Study Of Ovine Atadenovirus
Principal Advisor
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Doctor Philosophy
ADVANCED ALGORITHMS, SOFTWARE AND APPLICATIONS IN SINGLE PARTICLE ANALYSIS
Principal Advisor
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2024
Doctor Philosophy
Coupling of P450 ancestors with the photosynthetic machinery of Chlamydomonas reinhardtii for light-driven biocatalysis in vitro
Associate Advisor
Other advisors: Dr Ian Ross, Professor Elizabeth Gillam
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2018
Doctor Philosophy
Structural characterisation of the eukaryotic CAD multienzyme complex
Associate Advisor
Other advisors: Associate Professor Michael Landsberg, Dr Ian Ross, Professor Bostjan Kobe
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2018
Doctor Philosophy
Structural characterisation of macromolecular complexes by cryo-electron microscopy
Associate Advisor
Other advisors: Associate Professor Michael Landsberg
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Media
Enquiries
Contact Professor Ben Hankamer directly for media enquiries about:
- algae
- algae biotechnology
- algae systems
- algal biofuels
- biodisesel
- biofuels
- Biofuels - microalgae
- bioreactors
- biotechnology
- climate change
- Crystallography
- Electron crystallography
- Electron microscopy
- Energy - clean
- hydrogen
- Life cycle analysis
- Microalgae biofuels
- Renewable energy
- Single particle analysis
- Solar fuels
- Structural biology
- Sustainable energy
- Techno-economic modelling
- X-ray crystallography
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