
Overview
Background
Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.
She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.
Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.
Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Tumour Immunology, The University of Queensland
- Foreign Fellow, American Association of Immunologists, American Association of Immunologists
- Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
- Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
- Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
- Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
- Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
- Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
- Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
- Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
- Board Member, Neuroimmunology Australia, Neuroimmunology Australia
Research interests
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Immunology of multiple sclerosis
My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.
Works
Search Professor Judith Greer’s works on UQ eSpace
2008
Conference Publication
Role of autoreactivity against myelin proteolipid protein in multiple sclerosis
Greer, Judith, Csurhes, Peter, Muller, Diane and Pender, Michael (2008). Role of autoreactivity against myelin proteolipid protein in multiple sclerosis. ISNI 2008: 9th International Congress of Neuroimmunology, Fort Worth, TX, U.S.A., October 26-30, 2008. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2008.08.001
2008
Conference Publication
Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis
Greer, Judith M. and Pender, Michael P. (2008). Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis. 11th Australasian Autoimmunity Workshop, Melbourne, VIC, Australia, 6 - 8 July 2007. London, United Kingdom: Academic Press. doi: 10.1016/j.jaut.2008.04.018
2007
Conference Publication
Increased population of activated T cells in patients after acute ischemic stroke
Yan, J., Greer, J. M., Cavanagh, H., Henderson, R., O'Sullivan, J., Read, S., Etherington, K. and McCombe, P. A. (2007). Increased population of activated T cells in patients after acute ischemic stroke. 37th Annual Scientific Meeting of the Australasian Society for Immunology, Sydney, Australia, 2-6 December 2007.
2006
Journal Article
Studies of HLA associations in male and female patients with Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
McCombe, Pamela A., Csurhes, Peter A. and Greer, Judith M. (2006). Studies of HLA associations in male and female patients with Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Journal of Neuroimmunology, 180 (1-2), 172-177. doi: 10.1016/j.jneuroim.2006.07.017
2006
Conference Publication
T-cell reactivity to myelin proteolipid protein drives the development of brainstem and cerebellar lesions in multiple sclerosis
Pender, M. P., Csurhes, P. A. and Greer, J. M. (2006). T-cell reactivity to myelin proteolipid protein drives the development of brainstem and cerebellar lesions in multiple sclerosis. 8th International Conference on Neuroimmunology, Nagoya, Japan, 15-19 October 2006. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.jneuroim.2006.07.002
2005
Journal Article
Increased Circulating T Cell Reactivity to GM1 Ganglioside in Patients with Guillain-Barre Syndrome
Csurhes, Peter A., Sullivan, Alice-Ann, Green, Kerryn, Greer, Judith M., Pender, Michael P. and McCombe, Pamela A. (2005). Increased Circulating T Cell Reactivity to GM1 Ganglioside in Patients with Guillain-Barre Syndrome. Journal of Clinical Neuroscience, 12 (4), 409-415. doi: 10.1016/j.jocn.2004.04.006
2005
Conference Publication
HLA-DR2 is associated with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in females, but not males
McCombe, P. A., Csurhes, P. A., Alizart, M. A. and Greer, J. M. (2005). HLA-DR2 is associated with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in females, but not males. 5th Annual Meeting of the Federation-of-Clinical-Immunology-Society, Boston, MA, U.S.A., 12-16 May 2005. Orlando, Florida: Academic Press.
2005
Conference Publication
Increased constitutive activation of NF-kappa B in patients with multiple sclerosis
Yan, J., Pat, B., Winterford, C., Inglis, F., Pender, M. P. and Greer, J. M. (2005). Increased constitutive activation of NF-kappa B in patients with multiple sclerosis. 5th Annual Meeting of the Federation of Clinical Immunology Society, Boston, MA, United States, 12-16 May 2005. SAN DIEGO: Academic Press.
2005
Conference Publication
Levels of constitutively activated NF-kB are increased and IB levels are decreased in T cells and macrophages from patients with multiple sclerosis
Yan, J., Pat, B., Winterford, C., Inglis, H. R., Pender, M. P. and Greer, J. M. (2005). Levels of constitutively activated NF-kB are increased and IB levels are decreased in T cells and macrophages from patients with multiple sclerosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, 29 November - 2 December 2005. Copenhagen, Denmark: Munksgaard. doi: 10.1111/j.1399-0039.2005.00523.x
2004
Journal Article
Chemokines and Chemokine Receptors: Potential Therapeutic Targets in Multiple Sclerosis
Muller, Diane M., Pender, Michael P. and Greer, Judith M. (2004). Chemokines and Chemokine Receptors: Potential Therapeutic Targets in Multiple Sclerosis. Current Drug Targets - Inflammation and Allergy, 3 (3), 279-290. doi: 10.2174/1568010043343732
2004
Journal Article
Effect Of Gender On T-Cell Proliferative Responses To Myelin Proteolipid Protein Antigens In Patients With Multiple Sclerosis And Controls
Greer, Judith M., Csurhes, Peter A., Pender, Michael P. and McCombe, Pamela A. (2004). Effect Of Gender On T-Cell Proliferative Responses To Myelin Proteolipid Protein Antigens In Patients With Multiple Sclerosis And Controls. Journal of Autoimmunity, 22 (4), 345-352. doi: 10.1016/j.jaut.2004.03.004
2004
Journal Article
Immunological properties of thiopalmitoylated lipopeptides
Greer, J. M. and Trifilieff, E. (2004). Immunological properties of thiopalmitoylated lipopeptides. Current Topics in Peptide & Protein Research, 6, 115-123.
2004
Conference Publication
Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis
Pender, M. P. and Greer, J. M. (2004). Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis. ECTRIMS 04, Vienna, 6-9 October, 2004. London, United Kingdom: Sage Publications.
2004
Conference Publication
Spreading of autoreactivity from antigens present in the thyroid gland to the spinal cord or vice versa: an alternative pathogenic mechanism in MS
Greer, J. M. and Pender, M. P. (2004). Spreading of autoreactivity from antigens present in the thyroid gland to the spinal cord or vice versa: an alternative pathogenic mechanism in MS. 7th International Congress of Neuroimmunology, Venice, 28th September - 2nd October, 2004. United Kingdom: Elsevier.
2004
Conference Publication
Clinical and immunological findings in patients with concurrent MS and autoimmune thyroid disease
Greer, J. M., Tan, K. M., Wolfe, N. P., Csurhes, P. A. and Pender, M. P. (2004). Clinical and immunological findings in patients with concurrent MS and autoimmune thyroid disease. ACTRIMS 03, San Francisco, 19 October, 2003. United Kingdom: Arnold.
2004
Journal Article
CXCL1, CXCL2 and CXCR2 are highly expressed in an axial rotatory model of experimental autoinamune encephalomyelitis with polymorphonuclear cell infiltration
Muller, D, Pender, M and Greer, JM (2004). CXCL1, CXCL2 and CXCR2 are highly expressed in an axial rotatory model of experimental autoinamune encephalomyelitis with polymorphonuclear cell infiltration. Multiple Sclerosis, 10, S97-S97.
2004
Conference Publication
CXCL1, CXCL2 and CXCR2 are highly expressed in an axial rotatory model of experimental autoimmune encephalomyelitis with polymorphonuclear cell infiltration
Muller, D. M., Pender, M. P. and Greer, J. M. (2004). CXCL1, CXCL2 and CXCR2 are highly expressed in an axial rotatory model of experimental autoimmune encephalomyelitis with polymorphonuclear cell infiltration. ECTRIMS 04, Vienna, 6 - 9 Oct, 2004. United Kingdom: Arnold.
2003
Journal Article
Solid-phase synthesis of a biotin-labelled thiopalmitoylated myelin proteolipid protein epitope and application in the study of uptake of antigen by macrophages
Nadège, Pfender, Erwann, GuŮin, Judith, Greer M. and Elisabeth, Trifilieff (2003). Solid-phase synthesis of a biotin-labelled thiopalmitoylated myelin proteolipid protein epitope and application in the study of uptake of antigen by macrophages. International Journal of Peptide Research and Therapeutics, 10 (5-6), 581-587. doi: 10.1007/s10989-004-3534-9
2003
Journal Article
Solid-phase synthesis of a biotin-labelled thiopalmitoylated myelin proteolipid protein epitope and application in the study of uptake of antigen by macrophages
Pfender, Nadège, Guénin, Erwann, Greer, Judith M. and Trifilieff, Elisabeth (2003). Solid-phase synthesis of a biotin-labelled thiopalmitoylated myelin proteolipid protein epitope and application in the study of uptake of antigen by macrophages. Letters in Peptide Science, 10 (5-6), 581-588. doi: 10.1007/BF02442591
2003
Journal Article
Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents
Becker, E. M., Lovejoy, D. B., Greer, J. M., Watts, R. and Richardson, D. R. (2003). Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents. British Journal of Pharmacology, 138 (5), 819-830. doi: 10.1038/sj.bjp.0705089
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Principal Advisor
Other advisors: Professor Pamela McCombe
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Other advisors: Dr Aakanksha Dixit
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Principal Advisor
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Completed supervision
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2022
Doctor Philosophy
Anti-Muscarinic Acetylcholine Receptor Antibodies in First Episode Psychosis
Principal Advisor
Other advisors: Professor James Scott
-
2022
Doctor Philosophy
Investigating the mechanism of action of a novel therapeutic derived from parasitic worms in animal models of multiple sclerosis
Principal Advisor
-
2015
Doctor Philosophy
Amino acid variants of myelin proteolipid protein: potential inducers of multiple sclerosis or potential means to a cure?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2013
Doctor Philosophy
Altered peptide ligands as therapeutic agents for a model of multiple sclerosis: Determining the signature of clinical efficacy
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Immune dysregulation in schizophrenia: Do some cases of schizophrenia have an autoimmune basis?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender, Professor Bryan Mowry
-
2012
Doctor Philosophy
Neuropathological and Neuroimmunological Studies of the Central Nervous System of Mice With Axial-Rotatory Experimental Autoimmune Encephalomyelitis
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2007
Doctor Philosophy
Development of immunomodulatory peptides for the treatment of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
Principal Advisor
-
2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2003
Doctor Philosophy
MITOCHONDRIAL IRON METABOLISM AND THE ROLE OF FRATAXIN IN IRON AND HAEM METABOLISM
Associate Advisor
Media
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