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Associate Professor Judith Greer
Associate Professor

Judith Greer

Email: 
Phone: 
+61 7 334 66018

Overview

Background

Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.

She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.

Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.

Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).

Availability

Associate Professor Judith Greer is:
Not available for supervision

Fields of research

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy of Tumour Immunology, The University of Queensland
  • Foreign Fellow, American Association of Immunologists, American Association of Immunologists
  • Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
  • Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
  • Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
  • Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
  • Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
  • Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
  • Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
  • Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
  • Board Member, Neuroimmunology Australia, Neuroimmunology Australia

Research interests

  • Immunology of multiple sclerosis

    My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.

Works

Search Professor Judith Greer’s works on UQ eSpace

145 works between 1988 and 2023

41 - 60 of 145 works

2018

Journal Article

PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations

Cloake, Nancy, Yan, Jun, Aminian, Atefeh, Pender, Michael and Greer, Judith (2018). PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations. Journal of Clinical Medicine, 7 (10) 342, 342. doi: 10.3390/jcm7100342

PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations

2018

Journal Article

Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis

Yan, Jun, Winterford, Clay M., Catts, Vibeke S., Pat, Betty K., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2018). Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis. Journal of Neuroimmunology, 320, 111-116. doi: 10.1016/j.jneuroim.2018.04.002

Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis

2018

Conference Publication

Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo

Bagert, Bridget, Greer, Judith, Savage, Hannah, Beasley, Shannon, Juba, Gracy and Pender, Michael (2018). Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo. AAN 70th Annual Meeting, Los Angeles, CA United States, 21-27 April 2018. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.90.15_supplement.s52.001

Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo

2018

Conference Publication

Antibodies Specific for Myelin Proteolipid Protein Can Inhibit Remyelination In Vivo

Bagert, Bridget A., Greer, Judith M., Savage, Hannah, Beasley, Shannon J., Juba, Gracy and Pender, Micahel P. (2018). Antibodies Specific for Myelin Proteolipid Protein Can Inhibit Remyelination In Vivo. ACTRIMS Forum, San Diego Ca, Feb 01-03, 2018. LONDON: SAGE PUBLICATIONS LTD.

Antibodies Specific for Myelin Proteolipid Protein Can Inhibit Remyelination In Vivo

2018

Conference Publication

Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo

Bagert, Bridget, Greer, Judith, Savage, Hannah, Beasley, Shannon, Juba, Gracy and Pender, Michael (2018). Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo. 70th Annual Meeting of the American Academy of Neurology (AAN), Los Angeles, California, 21-27 April 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo

2017

Journal Article

Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms

Dixit, Aakanksha, Tanaka, Akane, Greer, Judith M and Donnelly, Sheila (2017). Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms. International Journal of Molecular Sciences, 18 (10) 2141, 1-17. doi: 10.3390/ijms18102141

Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms

2017

Journal Article

Predicting the effects of potentially therapeutic modified peptides on polyclonal T cell populations in a mouse model of multiple sclerosis

Sauer, Evan L., Trifilieff, Elisabeth and Greer, Judith M. (2017). Predicting the effects of potentially therapeutic modified peptides on polyclonal T cell populations in a mouse model of multiple sclerosis. Journal of Neuroimmunology, 307, 18-26. doi: 10.1016/j.jneuroim.2017.03.011

Predicting the effects of potentially therapeutic modified peptides on polyclonal T cell populations in a mouse model of multiple sclerosis

2017

Journal Article

Reactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease

Greer, Judith M., Broadley, Simon and Pender, Michael P. (2017). Reactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease. Frontiers in Immunology, 8 (514) 514, 514. doi: 10.3389/fimmu.2017.00514

Reactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease

2017

Conference Publication

Using a parasite derived peptide to prevent immune-mediated demyelination

Donnelly, Sheila, Greer, Judith and Dixit, Aakanksha (2017). Using a parasite derived peptide to prevent immune-mediated demyelination. Progress in MS Research Conference, Sydney Australia, 11-13 October 2017. London, United Kingdom: Sage Publications.

Using a parasite derived peptide to prevent immune-mediated demyelination

2016

Journal Article

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

Lund, Maria E., Greer, Judith M., Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O'Brien, Bronwyn A., Dalton, John P. and Donnelly, Sheila (2016). A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis. Scientific Reports, 6 (1) 37789, 37789. doi: 10.1038/srep37789

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

2016

Journal Article

Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome

Yan, J., Greer, J. M. and McCombe, P. A. (2016). Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome. Journal of Neuroimmunology, 293, 22-27. doi: 10.1016/j.jneuroim.2016.02.001

Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome

2016

Conference Publication

Protection against development of a mouse model of multiple sclerosis by a parasite-derived 68-mer peptide

Dixit, A., Donnelly, S., Lund, M. A., Dalton, J. P. and Greer, J. M. (2016). Protection against development of a mouse model of multiple sclerosis by a parasite-derived 68-mer peptide. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200

Protection against development of a mouse model of multiple sclerosis by a parasite-derived 68-mer peptide

2016

Conference Publication

Functional effects of antibodies specific for myelin proteolipid protein in multiple sclerosis

Greer, J. M., Muller, D. M., Beasley, S. J., Trifilieff, E. and Pender, M. P. (2016). Functional effects of antibodies specific for myelin proteolipid protein in multiple sclerosis. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley.

Functional effects of antibodies specific for myelin proteolipid protein in multiple sclerosis

2015

Journal Article

Autoantibodies and their potential roles in diseases of the nervous system

Beasley, Shannon J. and Greer, Judith M. (2015). Autoantibodies and their potential roles in diseases of the nervous system. Clinical and Experimental Neuroimmunology, 6 (4), 370-386. doi: 10.1111/cen3.12269

Autoantibodies and their potential roles in diseases of the nervous system

2015

Journal Article

Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome

Chan, Adeline, Yan, Jun, Csurhes, Peter, Greer, Judith and McCombe, Pamela (2015). Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome. Journal of Neuroimmunology, 286, 42-47. doi: 10.1016/j.jneuroim.2015.06.013

Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome

2015

Journal Article

Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases

Sauer, Evan L., Cloake, Nancy C. and Greer, Judith M. (2015). Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases. International Reviews of Immunology, 34 (6), 460-485. doi: 10.3109/08830185.2015.1027822

Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases

2015

Journal Article

Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Brun, Susana, Beaino, Wissam, Kremer, Laurent, Taleb, Omar, Mensah-Nyagan, Ayikoe Guy, Lam, Chanh D., Greer, Judith M., de Seze, Jerome and Trifilieff, Elisabeth (2015). Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies. Journal of Neuroimmunology, 278, 1-10. doi: 10.1016/j.jneuroim.2014.11.022

Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

2015

Book Chapter

The role of HLA in MS susceptibility and phenotype

Greer, Judith M. (2015). The role of HLA in MS susceptibility and phenotype. Emerging and evolving topics in multiple sclerosis pathogenesis and treatments. (pp. 1-27) edited by Anne C. La Flamme and Jacqueline Monique Orian. Heidelberg, Germany: Springer. doi: 10.1007/7854_2014_357

The role of HLA in MS susceptibility and phenotype

2015

Conference Publication

Expression of glutamate transporter splice variants on oligodendrocytes in rat brain and in mixed glial cultures

Beasley, S., Lee, A., Greer, J. and Pow, D. (2015). Expression of glutamate transporter splice variants on oligodendrocytes in rat brain and in mixed glial cultures. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Expression of glutamate transporter splice variants on oligodendrocytes in rat brain and in mixed glial cultures

2014

Journal Article

Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis

Turvey, Michelle E., Koudelka, Tomas, Comerford, Iain, Greer, Judith M., Carroll, William, Bernard, Claude C. A., Hoffmann, Peter and McColl, Shaun R. (2014). Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis. Journal of Proteome Research, 13 (8), 3655-3670. doi: 10.1021/pr500158r

Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis

Funding

Current funding

  • 2024 - 2026
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    United States Congressionally Directed Medical Research Programs - Multiple Sclerosis Research Program
    Open grant
  • 2023 - 2025
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    National Multiple Sclerosis Society-US
    Open grant
  • 2023 - 2027
    How does Epstein-Barr virus infection lead to multiple sclerosis?
    NHMRC MRFF CTAI and EPCDRI Multiple Sclerosis
    Open grant
  • 2023 - 2025
    Investigating effects of Evobrutinib on immune and non-immune cells in microglia-enhanced brain organoids
    Merck Group T/A Ares Trading SA
    Open grant
  • 2020 - 2024
    Assessing the effects of cladribine on vaccine recall responses in multiple sclerosis.
    Merck Healthcare KGaA
    Open grant

Past funding

  • 2021 - 2023
    Deriving immune-like cells, neuronal-like cells and brain organoids from iPSCs as a means of studying differential effects of NF-kB activation in MS
    Incubator Grant Scheme
    Open grant
  • 2020 - 2024
    Improving and validating a novel translational tool for research in multiple sclerosis
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2021
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies
    NHMRC Project Grant
    Open grant
  • 2019 - 2022
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies (NHMRC Project Grant led by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2018 - 2020
    Understanding how a parasite-derived peptide prevents immune mediated demyelination (NHMRC Project Grant led by the University of Technology Sydney)
    University of Technology Sydney
    Open grant
  • 2017
    Funding for salary of C. Pfluger and lab expenses
    Research Donation Generic
    Open grant
  • 2017 - 2019
    Does genetic variation in genes controlling pro-inflammatory immune responses modulate outcomes of MIS416 treatment in patients with multiple sclerosis?
    Wesley Medical Research Ltd
    Open grant
  • 2016 - 2021
    Investigating the aetiopathogenic role of autoantibodies against the M1 muscarinic acetylcholine receptor in patients with first episode of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Glutamate transporters as potential targets of autoimmune attack in multiple sclerosis
    National Multiple Sclerosis Society-US
    Open grant
  • 2016 - 2018
    Understanding the mechanisms by which parasite worms prevent multiple sclerosis (MSRA grant administered by UTS)
    University of Technology Sydney
    Open grant
  • 2015 - 2016
    Developing a xenograft mouse model for multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2014 - 2015
    Do antibodies against myelin proteolipid protein play a role in multiple sclerosis?
    Ochsner Clinic Foundation
    Open grant
  • 2014 - 2017
    Investigation of the functional role of antibodies against myelin proteolipid protein in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 2013
    T cells in stroke - part of the solution?
    Royal Brisbane and Women's Hospital
    Open grant
  • 2012 - 2013
    Treatment of Multiple Sclerosis with parasite immunomodulatory molecules
    University of Technology Sydney
    Open grant
  • 2012 - 2014
    Understanding the interplay between the spectrum of glial and neuronal autoantibodies and clinical outcome in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2011 - 2012
    Role of maternofetal chimerism in transferring susceptibility to MS
    National Multiple Sclerosis Society-US
    Open grant
  • 2011 - 2013
    Nature and timing of inflammation after acute ischaemic stroke
    National Heart Foundation of Australia
    Open grant
  • 2011 - 2013
    NFKBIA mutations as a mechanism leading to constitutive activation of NF-kB in patients with primary progressive MS
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2011
    Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2012
    Proteomic analysis of central nervous system inflammation in multiple sclerosis (ARC Linkage held by University of Adelaide)
    University of Adelaide
    Open grant
  • 2010 - 2012
    Molecular interactions underpinning lesion localization in multiple sclerosis.
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    Development of specific immunomodulatory agents for Multiple Sclerosis affecting the brainstem and cerebellum
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    The effects of pregnancy and the post-partum period on T cells, antibodies, and gene expression in EAE
    Multiple Sclerosis Research Australia
    Open grant
  • 2008 - 2012
    Immune Response to stroke
    Wesley Merdical Research
    Open grant
  • 2007 - 2009
    Mechanisms leading to constitutive activation of the transcription factor NF-kB in progressive multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2008
    Investigations In Multiple Sclerosis Patients With Coexistent Autoimmune Thyroid Disease
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    Studies on the functional role of antibodies in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2006
    Supplementary funding to advance development
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2002 - 2003
    Investigation of the mechanisms by which thiacylated lipopeptides enhance immune responses
    Multiple Sclerosis Research Australia
    Open grant
  • 2002 - 2003
    Is autoreactivity to myelin antigens regulated differently in multiple sclerosis and stroke?
    Multiple Sclerosis Research Australia
    Open grant
  • 2001 - 2002
    Studies on the disease process and potential therapeutic agents in multiple sclerosis
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2000 - 2005
    HLA type, B & T cell responses to myelin antigens, and lesion distribution
    National Multiple Sclerosis Society-US
    Open grant
  • 1999 - 2001
    Correlation Between Ganglioside-Specific Immune Responses and Disease Prograssion in Multiple Sclerosis
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Studies of T cell reactivity to myelin antigens in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 1995
    B and T cell reactivity to myelin/oligodendrocyte-specific protein in multiple sclerosis
    University of Queensland New Staff Research Grant
    Open grant
  • 1995
    Immune responses to central nervous system myelin antigens in multiple sclerosis
    Ramaciotti Foundation
    Open grant

Supervision

Availability

Associate Professor Judith Greer is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    The role of Epstein-Barr virus infection in multiple sclerosis

    Principal Advisor

    Other advisors: Professor Pamela McCombe

  • Doctor Philosophy

    Investigation of the role of BTK and NF-kB signalling in CNS cells

    Principal Advisor

    Other advisors: Dr Jun Yan

  • Doctor Philosophy

    A novel humanized mouse model for multiple sclerosis

    Principal Advisor

    Other advisors: Dr Jun Yan, Dr Aakanksha Dixit

Completed supervision

Media

Enquiries

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