Overview
Background
Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.
She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.
Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.
Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Tumour Immunology, The University of Queensland
- Foreign Fellow, American Association of Immunologists, American Association of Immunologists
- Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
- Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
- Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
- Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
- Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
- Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
- Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
- Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
- Board Member, Neuroimmunology Australia, Neuroimmunology Australia
Research interests
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Immunology of multiple sclerosis
My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.
Works
Search Professor Judith Greer’s works on UQ eSpace
2018
Journal Article
PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations
Cloake, Nancy, Yan, Jun, Aminian, Atefeh, Pender, Michael and Greer, Judith (2018). PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations. Journal of Clinical Medicine, 7 (10) 342, 342. doi: 10.3390/jcm7100342
2018
Journal Article
Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis
Yan, Jun, Winterford, Clay M., Catts, Vibeke S., Pat, Betty K., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2018). Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis. Journal of Neuroimmunology, 320, 111-116. doi: 10.1016/j.jneuroim.2018.04.002
2018
Conference Publication
Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo
Bagert, Bridget, Greer, Judith, Savage, Hannah, Beasley, Shannon, Juba, Gracy and Pender, Michael (2018). Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo. AAN 70th Annual Meeting, Los Angeles, CA United States, 21-27 April 2018. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.90.15_supplement.s52.001
2018
Conference Publication
Antibodies Specific for Myelin Proteolipid Protein Can Inhibit Remyelination In Vivo
Bagert, Bridget A., Greer, Judith M., Savage, Hannah, Beasley, Shannon J., Juba, Gracy and Pender, Micahel P. (2018). Antibodies Specific for Myelin Proteolipid Protein Can Inhibit Remyelination In Vivo. ACTRIMS Forum, San Diego Ca, Feb 01-03, 2018. LONDON: SAGE PUBLICATIONS LTD.
2018
Conference Publication
Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo
Bagert, Bridget, Greer, Judith, Savage, Hannah, Beasley, Shannon, Juba, Gracy and Pender, Michael (2018). Antibodies specific for myelin proteolipid protein can inhibit remyelination in vivo. 70th Annual Meeting of the American Academy of Neurology (AAN), Los Angeles, California, 21-27 April 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
2017
Journal Article
Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms
Dixit, Aakanksha, Tanaka, Akane, Greer, Judith M and Donnelly, Sheila (2017). Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms. International Journal of Molecular Sciences, 18 (10) 2141, 1-17. doi: 10.3390/ijms18102141
2017
Journal Article
Predicting the effects of potentially therapeutic modified peptides on polyclonal T cell populations in a mouse model of multiple sclerosis
Sauer, Evan L., Trifilieff, Elisabeth and Greer, Judith M. (2017). Predicting the effects of potentially therapeutic modified peptides on polyclonal T cell populations in a mouse model of multiple sclerosis. Journal of Neuroimmunology, 307, 18-26. doi: 10.1016/j.jneuroim.2017.03.011
2017
Journal Article
Reactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease
Greer, Judith M., Broadley, Simon and Pender, Michael P. (2017). Reactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease. Frontiers in Immunology, 8 (514) 514, 514. doi: 10.3389/fimmu.2017.00514
2017
Conference Publication
Using a parasite derived peptide to prevent immune-mediated demyelination
Donnelly, Sheila, Greer, Judith and Dixit, Aakanksha (2017). Using a parasite derived peptide to prevent immune-mediated demyelination. Progress in MS Research Conference, Sydney Australia, 11-13 October 2017. London, United Kingdom: Sage Publications.
2016
Journal Article
A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis
Lund, Maria E., Greer, Judith M., Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O'Brien, Bronwyn A., Dalton, John P. and Donnelly, Sheila (2016). A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis. Scientific Reports, 6 (1) 37789, 37789. doi: 10.1038/srep37789
2016
Journal Article
Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome
Yan, J., Greer, J. M. and McCombe, P. A. (2016). Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome. Journal of Neuroimmunology, 293, 22-27. doi: 10.1016/j.jneuroim.2016.02.001
2016
Conference Publication
Protection against development of a mouse model of multiple sclerosis by a parasite-derived 68-mer peptide
Dixit, A., Donnelly, S., Lund, M. A., Dalton, J. P. and Greer, J. M. (2016). Protection against development of a mouse model of multiple sclerosis by a parasite-derived 68-mer peptide. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
2016
Conference Publication
Functional effects of antibodies specific for myelin proteolipid protein in multiple sclerosis
Greer, J. M., Muller, D. M., Beasley, S. J., Trifilieff, E. and Pender, M. P. (2016). Functional effects of antibodies specific for myelin proteolipid protein in multiple sclerosis. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley.
2015
Journal Article
Autoantibodies and their potential roles in diseases of the nervous system
Beasley, Shannon J. and Greer, Judith M. (2015). Autoantibodies and their potential roles in diseases of the nervous system. Clinical and Experimental Neuroimmunology, 6 (4), 370-386. doi: 10.1111/cen3.12269
2015
Journal Article
Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome
Chan, Adeline, Yan, Jun, Csurhes, Peter, Greer, Judith and McCombe, Pamela (2015). Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome. Journal of Neuroimmunology, 286, 42-47. doi: 10.1016/j.jneuroim.2015.06.013
2015
Journal Article
Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases
Sauer, Evan L., Cloake, Nancy C. and Greer, Judith M. (2015). Taming the TCR: antigen-specific immunotherapeutic agents for autoimmune diseases. International Reviews of Immunology, 34 (6), 460-485. doi: 10.3109/08830185.2015.1027822
2015
Journal Article
Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies
Brun, Susana, Beaino, Wissam, Kremer, Laurent, Taleb, Omar, Mensah-Nyagan, Ayikoe Guy, Lam, Chanh D., Greer, Judith M., de Seze, Jerome and Trifilieff, Elisabeth (2015). Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies. Journal of Neuroimmunology, 278, 1-10. doi: 10.1016/j.jneuroim.2014.11.022
2015
Book Chapter
The role of HLA in MS susceptibility and phenotype
Greer, Judith M. (2015). The role of HLA in MS susceptibility and phenotype. Emerging and evolving topics in multiple sclerosis pathogenesis and treatments. (pp. 1-27) edited by Anne C. La Flamme and Jacqueline Monique Orian. Heidelberg, Germany: Springer. doi: 10.1007/7854_2014_357
2015
Conference Publication
Expression of glutamate transporter splice variants on oligodendrocytes in rat brain and in mixed glial cultures
Beasley, S., Lee, A., Greer, J. and Pow, D. (2015). Expression of glutamate transporter splice variants on oligodendrocytes in rat brain and in mixed glial cultures. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188
2014
Journal Article
Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis
Turvey, Michelle E., Koudelka, Tomas, Comerford, Iain, Greer, Judith M., Carroll, William, Bernard, Claude C. A., Hoffmann, Peter and McColl, Shaun R. (2014). Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis. Journal of Proteome Research, 13 (8), 3655-3670. doi: 10.1021/pr500158r
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Principal Advisor
Other advisors: Professor Pamela McCombe
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Principal Advisor
Other advisors: Dr Jun Yan
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Other advisors: Dr Jun Yan, Dr Aakanksha Dixit
Completed supervision
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2022
Doctor Philosophy
Anti-Muscarinic Acetylcholine Receptor Antibodies in First Episode Psychosis
Principal Advisor
Other advisors: Professor James Scott
-
2022
Doctor Philosophy
Investigating the mechanism of action of a novel therapeutic derived from parasitic worms in animal models of multiple sclerosis
Principal Advisor
-
2015
Doctor Philosophy
Amino acid variants of myelin proteolipid protein: potential inducers of multiple sclerosis or potential means to a cure?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2013
Doctor Philosophy
Altered peptide ligands as therapeutic agents for a model of multiple sclerosis: Determining the signature of clinical efficacy
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Neuropathological and Neuroimmunological Studies of the Central Nervous System of Mice With Axial-Rotatory Experimental Autoimmune Encephalomyelitis
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Immune dysregulation in schizophrenia: Do some cases of schizophrenia have an autoimmune basis?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender, Professor Bryan Mowry
-
2007
Doctor Philosophy
Development of immunomodulatory peptides for the treatment of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
Principal Advisor
-
2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Associate Advisor
Other advisors: Professor Pamela McCombe
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2003
Doctor Philosophy
MITOCHONDRIAL IRON METABOLISM AND THE ROLE OF FRATAXIN IN IRON AND HAEM METABOLISM
Associate Advisor
Media
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