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Associate Professor Judith Greer
Associate Professor

Judith Greer

Email: 
Phone: 
+61 7 334 66018

Overview

Background

Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.

She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.

Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.

Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).

Availability

Associate Professor Judith Greer is:
Not available for supervision

Fields of research

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy of Tumour Immunology, The University of Queensland
  • Foreign Fellow, American Association of Immunologists, American Association of Immunologists
  • Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
  • Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
  • Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
  • Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
  • Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
  • Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
  • Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
  • Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
  • Board Member, Neuroimmunology Australia, Neuroimmunology Australia

Research interests

  • Immunology of multiple sclerosis

    My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.

Works

Search Professor Judith Greer’s works on UQ eSpace

145 works between 1988 and 2023

21 - 40 of 145 works

Featured

1996

Journal Article

Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice

Encinas, JA, Lees, MB, Sobel, RA, Symonowicz, C, Greer, JM, Shovlin, CL, Weiner, HL, Seidman, CE, Seidman, JG and Kuchroo, VK (1996). Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. Journal of Immunology, 157 (5), 2186-2192.

Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice

Featured

1996

Journal Article

Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane

Greer, JM, Dyer, CA, Pakaski, M, Symonowicz, C and Lees, MB (1996). Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane. Neurochemical Research, 21 (4), 431-440. doi: 10.1007/BF02527707

Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane

Featured

1996

Journal Article

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein

Greer, JM, Sobel, RA, Sette, A, Southwood, S, Lees, MB and Kuchroo, VK (1996). Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. Journal of Immunology, 156 (1), 371-379.

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein

Featured

1995

Journal Article

An Altered Peptide Ligand Mediates Immune Deviation and Prevents Autoimmune Encephalomyelitis

Nicholson, LB, Greer, JM, Sobel, RA, Lees, MB and Kuchroo, VK (1995). An Altered Peptide Ligand Mediates Immune Deviation and Prevents Autoimmune Encephalomyelitis. Immunity, 3 (4), 397-405. doi: 10.1016/1074-7613(95)90169-8

An Altered Peptide Ligand Mediates Immune Deviation and Prevents Autoimmune Encephalomyelitis

Featured

1994

Journal Article

A Single Tcr Antagonist Peptide Inhibits Experimental Allergic Encephalomyelitis Mediated by a Diverse T-Cell Repertoire

Kuchroo, VK, Greer, JM, Kaul, D, Ishioka, G, Franco, A, Sette, A, Sobel, RA and Lees, MB (1994). A Single Tcr Antagonist Peptide Inhibits Experimental Allergic Encephalomyelitis Mediated by a Diverse T-Cell Repertoire. Journal of Immunology, 153 (7), 3326-3336.

A Single Tcr Antagonist Peptide Inhibits Experimental Allergic Encephalomyelitis Mediated by a Diverse T-Cell Repertoire

Featured

1994

Journal Article

Minireview - Autoimmune Responses to Myelin Proteolipid Protein

Sobel, RA, Greer, JM and Kuchroo, VK (1994). Minireview - Autoimmune Responses to Myelin Proteolipid Protein. Neurochemical Research, 19 (8), 915-921. doi: 10.1007/BF00968701

Minireview - Autoimmune Responses to Myelin Proteolipid Protein

Featured

1994

Journal Article

Immunolocalization of Proteolipid Protein Peptide 103-116 in Myelin

Sobel, RA, Greer, JM, Isaac, J, Fondren, G and Lees, MB (1994). Immunolocalization of Proteolipid Protein Peptide 103-116 in Myelin. Journal of Neuroscience Research, 37 (1), 36-43. doi: 10.1002/jnr.490370106

Immunolocalization of Proteolipid Protein Peptide 103-116 in Myelin

Featured

1993

Journal Article

Cytokines and Adhesion Molecules Contribute to the Ability of Myelin Proteolipid Protein-Specific T-Cell Clones to Mediate Experimental Allergic Encephalomyelitis

Kuchroo, VK, Martin, CA, Greer, JM, Ju, ST, Sobel, RA and Dorf, ME (1993). Cytokines and Adhesion Molecules Contribute to the Ability of Myelin Proteolipid Protein-Specific T-Cell Clones to Mediate Experimental Allergic Encephalomyelitis. Journal of Immunology, 151 (8), 4371-4382.

Cytokines and Adhesion Molecules Contribute to the Ability of Myelin Proteolipid Protein-Specific T-Cell Clones to Mediate Experimental Allergic Encephalomyelitis

Featured

1992

Journal Article

Identification And Characterization Of A Second Encephalitogenic Determinant Of Myelin Proteolipid Protein (Residues 178-191) For SJL Mice

Greer, J. M., Kuchroo, V. K., Sobel, R. A. and Lees, M. B. (1992). Identification And Characterization Of A Second Encephalitogenic Determinant Of Myelin Proteolipid Protein (Residues 178-191) For SJL Mice. Journal of Immunology, 149 (3), 783-788.

Identification And Characterization Of A Second Encephalitogenic Determinant Of Myelin Proteolipid Protein (Residues 178-191) For SJL Mice

2023

Journal Article

A long and winding road: the history of <i>Immunology &amp; Cell Biology</i> from 1936 to 1987

Greer, Judith M (2023). A long and winding road: the history of Immunology &amp; Cell Biology from 1936 to 1987. Immunology & Cell Biology, 101 (10), 891-895. doi: 10.1111/imcb.12704

A long and winding road: the history of <i>Immunology &amp; Cell Biology</i> from 1936 to 1987

2023

Journal Article

A centenary of service: 100 years of <i>Immunology &amp; Cell Biology</i>

Liston, Adrian, La Flamme, Anne C, Belz, Gabrielle T, Parish, Christopher R and Greer, Judith M (2023). A centenary of service: 100 years of Immunology &amp; Cell Biology. Immunology & Cell Biology, 101 (10), 882-890. doi: 10.1111/imcb.12700

A centenary of service: 100 years of <i>Immunology &amp; Cell Biology</i>

2023

Journal Article

An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models

Dixit, Aakanksha, Savage, Hannah S. and Greer, Judith M. (2023). An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models. Expert Opinion on Therapeutic Targets, 27 (7), 553-574. doi: 10.1080/14728222.2023.2236301

An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models

2023

Journal Article

100 years flashback

Greer, Judith M (2023). 100 years flashback. Immunology & Cell Biology, 101 (4), 278-280. doi: 10.1111/imcb.12639

100 years flashback

2022

Journal Article

Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis

McCombe, Pamela A., Hardy, Todd A., Nona, Robert J. and Greer, Judith M. (2022). Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis. Frontiers in Immunology, 13 1038411, 1-23. doi: 10.3389/fimmu.2022.1038411

Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis

2022

Journal Article

Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated

McCombe, Pamela A. and Greer, Judith M. (2022). Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated. Frontiers in Immunology, 13 1059833, 1-24. doi: 10.3389/fimmu.2022.1059833

Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated

2022

Journal Article

HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis

Nona, R. J., Greer, J. M., Henderson, R. D. and McCombe, P. A. (2022). HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 24 (1-2), 1-9. doi: 10.1080/21678421.2022.2078665

HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis

2020

Journal Article

Correlation between anti-myelin proteolipid protein (PLP) antibodies and disease severity in multiple sclerosis patients with PLP response-permissive HLA types

Greer, Judith M., Trifilieff, Elisabeth and Pender, Michael P. (2020). Correlation between anti-myelin proteolipid protein (PLP) antibodies and disease severity in multiple sclerosis patients with PLP response-permissive HLA types. Frontiers in Immunology, 11 1891, 1891. doi: 10.3389/fimmu.2020.01891

Correlation between anti-myelin proteolipid protein (PLP) antibodies and disease severity in multiple sclerosis patients with PLP response-permissive HLA types

2020

Journal Article

Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation

Yan, Jun, McCombe, Pamela A., Pender, Michael P. and Greer, Judith M. (2020). Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation. Journal of Clinical Medicine, 9 (8) 2534, 2534-13. doi: 10.3390/jcm9082534

Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation

2019

Journal Article

Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?

Ryan, Alexander E., Mowry, Bryan J., Kesby, James P., Scott, James G. and Greer, Judith M. (2019). Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?. Australian and New Zealand Journal of Psychiatry, 53 (11) ARTN 0004867419864438, 1-11. doi: 10.1177/0004867419864438

Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?

2019

Book Chapter

Sexual dimorphism in the immune system

McCombe, Pamela A. and Greer, Judith M. (2019). Sexual dimorphism in the immune system. The autoimmune diseases. (pp. 419-428) edited by Noel R. Rose and Ian R. Mackay. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-812102-3.00024-5

Sexual dimorphism in the immune system

Funding

Current funding

  • 2024 - 2026
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    United States Congressionally Directed Medical Research Programs - Multiple Sclerosis Research Program
    Open grant
  • 2023 - 2025
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    National Multiple Sclerosis Society-US
    Open grant
  • 2023 - 2027
    How does Epstein-Barr virus infection lead to multiple sclerosis?
    NHMRC MRFF CTAI and EPCDRI Multiple Sclerosis
    Open grant
  • 2023 - 2025
    Investigating effects of Evobrutinib on immune and non-immune cells in microglia-enhanced brain organoids
    Merck Group T/A Ares Trading SA
    Open grant
  • 2020 - 2024
    Assessing the effects of cladribine on vaccine recall responses in multiple sclerosis.
    Merck Healthcare KGaA
    Open grant

Past funding

  • 2021 - 2023
    Deriving immune-like cells, neuronal-like cells and brain organoids from iPSCs as a means of studying differential effects of NF-kB activation in MS
    Incubator Grant Scheme
    Open grant
  • 2020 - 2024
    Improving and validating a novel translational tool for research in multiple sclerosis
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2021
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies
    NHMRC Project Grant
    Open grant
  • 2019 - 2022
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies (NHMRC Project Grant led by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2018 - 2020
    Understanding how a parasite-derived peptide prevents immune mediated demyelination (NHMRC Project Grant led by the University of Technology Sydney)
    University of Technology Sydney
    Open grant
  • 2017
    Funding for salary of C. Pfluger and lab expenses
    Research Donation Generic
    Open grant
  • 2017 - 2019
    Does genetic variation in genes controlling pro-inflammatory immune responses modulate outcomes of MIS416 treatment in patients with multiple sclerosis?
    Wesley Medical Research Ltd
    Open grant
  • 2016 - 2021
    Investigating the aetiopathogenic role of autoantibodies against the M1 muscarinic acetylcholine receptor in patients with first episode of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Glutamate transporters as potential targets of autoimmune attack in multiple sclerosis
    National Multiple Sclerosis Society-US
    Open grant
  • 2016 - 2018
    Understanding the mechanisms by which parasite worms prevent multiple sclerosis (MSRA grant administered by UTS)
    University of Technology Sydney
    Open grant
  • 2015 - 2016
    Developing a xenograft mouse model for multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2014 - 2015
    Do antibodies against myelin proteolipid protein play a role in multiple sclerosis?
    Ochsner Clinic Foundation
    Open grant
  • 2014 - 2017
    Investigation of the functional role of antibodies against myelin proteolipid protein in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 2013
    T cells in stroke - part of the solution?
    Royal Brisbane and Women's Hospital
    Open grant
  • 2012 - 2013
    Treatment of Multiple Sclerosis with parasite immunomodulatory molecules
    University of Technology Sydney
    Open grant
  • 2012 - 2014
    Understanding the interplay between the spectrum of glial and neuronal autoantibodies and clinical outcome in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2011 - 2012
    Role of maternofetal chimerism in transferring susceptibility to MS
    National Multiple Sclerosis Society-US
    Open grant
  • 2011 - 2013
    Nature and timing of inflammation after acute ischaemic stroke
    National Heart Foundation of Australia
    Open grant
  • 2011 - 2013
    NFKBIA mutations as a mechanism leading to constitutive activation of NF-kB in patients with primary progressive MS
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2011
    Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2012
    Proteomic analysis of central nervous system inflammation in multiple sclerosis (ARC Linkage held by University of Adelaide)
    University of Adelaide
    Open grant
  • 2010 - 2012
    Molecular interactions underpinning lesion localization in multiple sclerosis.
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    Development of specific immunomodulatory agents for Multiple Sclerosis affecting the brainstem and cerebellum
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    The effects of pregnancy and the post-partum period on T cells, antibodies, and gene expression in EAE
    Multiple Sclerosis Research Australia
    Open grant
  • 2008 - 2012
    Immune Response to stroke
    Wesley Merdical Research
    Open grant
  • 2007 - 2009
    Mechanisms leading to constitutive activation of the transcription factor NF-kB in progressive multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2008
    Investigations In Multiple Sclerosis Patients With Coexistent Autoimmune Thyroid Disease
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    Studies on the functional role of antibodies in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2006
    Supplementary funding to advance development
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2002 - 2003
    Investigation of the mechanisms by which thiacylated lipopeptides enhance immune responses
    Multiple Sclerosis Research Australia
    Open grant
  • 2002 - 2003
    Is autoreactivity to myelin antigens regulated differently in multiple sclerosis and stroke?
    Multiple Sclerosis Research Australia
    Open grant
  • 2001 - 2002
    Studies on the disease process and potential therapeutic agents in multiple sclerosis
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2000 - 2005
    HLA type, B & T cell responses to myelin antigens, and lesion distribution
    National Multiple Sclerosis Society-US
    Open grant
  • 1999 - 2001
    Correlation Between Ganglioside-Specific Immune Responses and Disease Prograssion in Multiple Sclerosis
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Studies of T cell reactivity to myelin antigens in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 1995
    B and T cell reactivity to myelin/oligodendrocyte-specific protein in multiple sclerosis
    University of Queensland New Staff Research Grant
    Open grant
  • 1995
    Immune responses to central nervous system myelin antigens in multiple sclerosis
    Ramaciotti Foundation
    Open grant

Supervision

Availability

Associate Professor Judith Greer is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Investigation of the role of BTK and NF-kB signalling in CNS cells

    Principal Advisor

    Other advisors: Dr Jun Yan

  • Doctor Philosophy

    A novel humanized mouse model for multiple sclerosis

    Principal Advisor

    Other advisors: Dr Jun Yan, Dr Aakanksha Dixit

  • Doctor Philosophy

    The role of Epstein-Barr virus infection in multiple sclerosis

    Principal Advisor

    Other advisors: Professor Pamela McCombe

Completed supervision

Media

Enquiries

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