
Overview
Background
Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.
She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.
Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.
Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Tumour Immunology, The University of Queensland
- Foreign Fellow, American Association of Immunologists, American Association of Immunologists
- Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
- Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
- Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
- Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
- Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
- Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
- Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
- Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
- Board Member, Neuroimmunology Australia, Neuroimmunology Australia
Research interests
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Immunology of multiple sclerosis
My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.
Works
Search Professor Judith Greer’s works on UQ eSpace
Featured
1996
Journal Article
Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice
Encinas, JA, Lees, MB, Sobel, RA, Symonowicz, C, Greer, JM, Shovlin, CL, Weiner, HL, Seidman, CE, Seidman, JG and Kuchroo, VK (1996). Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. Journal of Immunology, 157 (5), 2186-2192.
Featured
1996
Journal Article
Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane
Greer, JM, Dyer, CA, Pakaski, M, Symonowicz, C and Lees, MB (1996). Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane. Neurochemical Research, 21 (4), 431-440. doi: 10.1007/BF02527707
Featured
1996
Journal Article
Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein
Greer, JM, Sobel, RA, Sette, A, Southwood, S, Lees, MB and Kuchroo, VK (1996). Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. Journal of Immunology, 156 (1), 371-379.
Featured
1995
Journal Article
An Altered Peptide Ligand Mediates Immune Deviation and Prevents Autoimmune Encephalomyelitis
Nicholson, LB, Greer, JM, Sobel, RA, Lees, MB and Kuchroo, VK (1995). An Altered Peptide Ligand Mediates Immune Deviation and Prevents Autoimmune Encephalomyelitis. Immunity, 3 (4), 397-405. doi: 10.1016/1074-7613(95)90169-8
Featured
1994
Journal Article
A Single Tcr Antagonist Peptide Inhibits Experimental Allergic Encephalomyelitis Mediated by a Diverse T-Cell Repertoire
Kuchroo, VK, Greer, JM, Kaul, D, Ishioka, G, Franco, A, Sette, A, Sobel, RA and Lees, MB (1994). A Single Tcr Antagonist Peptide Inhibits Experimental Allergic Encephalomyelitis Mediated by a Diverse T-Cell Repertoire. Journal of Immunology, 153 (7), 3326-3336.
Featured
1994
Journal Article
Minireview - Autoimmune Responses to Myelin Proteolipid Protein
Sobel, RA, Greer, JM and Kuchroo, VK (1994). Minireview - Autoimmune Responses to Myelin Proteolipid Protein. Neurochemical Research, 19 (8), 915-921. doi: 10.1007/BF00968701
Featured
1994
Journal Article
Immunolocalization of Proteolipid Protein Peptide 103-116 in Myelin
Sobel, RA, Greer, JM, Isaac, J, Fondren, G and Lees, MB (1994). Immunolocalization of Proteolipid Protein Peptide 103-116 in Myelin. Journal of Neuroscience Research, 37 (1), 36-43. doi: 10.1002/jnr.490370106
Featured
1993
Journal Article
Cytokines and Adhesion Molecules Contribute to the Ability of Myelin Proteolipid Protein-Specific T-Cell Clones to Mediate Experimental Allergic Encephalomyelitis
Kuchroo, VK, Martin, CA, Greer, JM, Ju, ST, Sobel, RA and Dorf, ME (1993). Cytokines and Adhesion Molecules Contribute to the Ability of Myelin Proteolipid Protein-Specific T-Cell Clones to Mediate Experimental Allergic Encephalomyelitis. Journal of Immunology, 151 (8), 4371-4382.
Featured
1992
Journal Article
Identification And Characterization Of A Second Encephalitogenic Determinant Of Myelin Proteolipid Protein (Residues 178-191) For SJL Mice
Greer, J. M., Kuchroo, V. K., Sobel, R. A. and Lees, M. B. (1992). Identification And Characterization Of A Second Encephalitogenic Determinant Of Myelin Proteolipid Protein (Residues 178-191) For SJL Mice. Journal of Immunology, 149 (3), 783-788.
2023
Journal Article
A long and winding road: the history of <i>Immunology & Cell Biology</i> from 1936 to 1987
Greer, Judith M (2023). A long and winding road: the history of Immunology & Cell Biology from 1936 to 1987. Immunology & Cell Biology, 101 (10), 891-895. doi: 10.1111/imcb.12704
2023
Journal Article
A centenary of service: 100 years of <i>Immunology & Cell Biology</i>
Liston, Adrian, La Flamme, Anne C, Belz, Gabrielle T, Parish, Christopher R and Greer, Judith M (2023). A centenary of service: 100 years of Immunology & Cell Biology. Immunology & Cell Biology, 101 (10), 882-890. doi: 10.1111/imcb.12700
2023
Journal Article
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models
Dixit, Aakanksha, Savage, Hannah S. and Greer, Judith M. (2023). An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models. Expert Opinion on Therapeutic Targets, 27 (7), 553-574. doi: 10.1080/14728222.2023.2236301
2023
Journal Article
100 years flashback
Greer, Judith M (2023). 100 years flashback. Immunology & Cell Biology, 101 (4), 278-280. doi: 10.1111/imcb.12639
2022
Journal Article
Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis
McCombe, Pamela A., Hardy, Todd A., Nona, Robert J. and Greer, Judith M. (2022). Sex differences in Guillain Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and experimental autoimmune neuritis. Frontiers in Immunology, 13 1038411, 1-23. doi: 10.3389/fimmu.2022.1038411
2022
Journal Article
Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated
McCombe, Pamela A. and Greer, Judith M. (2022). Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated. Frontiers in Immunology, 13 1059833, 1-24. doi: 10.3389/fimmu.2022.1059833
2022
Journal Article
HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis
Nona, R. J., Greer, J. M., Henderson, R. D. and McCombe, P. A. (2022). HLA and amyotrophic lateral sclerosis: a systematic review and meta-analysis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 24 (1-2), 1-9. doi: 10.1080/21678421.2022.2078665
2020
Journal Article
Correlation between anti-myelin proteolipid protein (PLP) antibodies and disease severity in multiple sclerosis patients with PLP response-permissive HLA types
Greer, Judith M., Trifilieff, Elisabeth and Pender, Michael P. (2020). Correlation between anti-myelin proteolipid protein (PLP) antibodies and disease severity in multiple sclerosis patients with PLP response-permissive HLA types. Frontiers in Immunology, 11 1891, 1891. doi: 10.3389/fimmu.2020.01891
2020
Journal Article
Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation
Yan, Jun, McCombe, Pamela A., Pender, Michael P. and Greer, Judith M. (2020). Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation. Journal of Clinical Medicine, 9 (8) 2534, 2534-13. doi: 10.3390/jcm9082534
2020
Book Chapter
Sexual dimorphism in the immune system
McCombe, Pamela A. and Greer, Judith M. (2020). Sexual dimorphism in the immune system. The autoimmune diseases. (pp. 419-428) edited by Noel R. Rose and Ian R. Mackay. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-812102-3.00024-5
2019
Journal Article
Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?
Ryan, Alexander E., Mowry, Bryan J., Kesby, James P., Scott, James G. and Greer, Judith M. (2019). Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia?. Australian and New Zealand Journal of Psychiatry, 53 (11) 0004867419864438, 1-11. doi: 10.1177/0004867419864438
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
-
Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Principal Advisor
Other advisors: Professor Pamela McCombe
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Other advisors: Dr Aakanksha Dixit
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Principal Advisor
Completed supervision
-
2022
Doctor Philosophy
Anti-Muscarinic Acetylcholine Receptor Antibodies in First Episode Psychosis
Principal Advisor
Other advisors: Professor James Scott
-
2022
Doctor Philosophy
Investigating the mechanism of action of a novel therapeutic derived from parasitic worms in animal models of multiple sclerosis
Principal Advisor
-
2015
Doctor Philosophy
Amino acid variants of myelin proteolipid protein: potential inducers of multiple sclerosis or potential means to a cure?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2013
Doctor Philosophy
Altered peptide ligands as therapeutic agents for a model of multiple sclerosis: Determining the signature of clinical efficacy
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Neuropathological and Neuroimmunological Studies of the Central Nervous System of Mice With Axial-Rotatory Experimental Autoimmune Encephalomyelitis
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Immune dysregulation in schizophrenia: Do some cases of schizophrenia have an autoimmune basis?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender, Professor Bryan Mowry
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2007
Doctor Philosophy
Development of immunomodulatory peptides for the treatment of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
Principal Advisor
-
2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2003
Doctor Philosophy
MITOCHONDRIAL IRON METABOLISM AND THE ROLE OF FRATAXIN IN IRON AND HAEM METABOLISM
Associate Advisor
Media
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