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Associate Professor Judith Greer
Associate Professor

Judith Greer

Email: 
Phone: 
+61 7 334 66018

Overview

Background

Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.

She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.

Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.

Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).

Availability

Associate Professor Judith Greer is:
Not available for supervision

Fields of research

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy of Tumour Immunology, The University of Queensland
  • Foreign Fellow, American Association of Immunologists, American Association of Immunologists
  • Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
  • Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
  • Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
  • Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
  • Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
  • Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
  • Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
  • Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
  • Board Member, Neuroimmunology Australia, Neuroimmunology Australia

Research interests

  • Immunology of multiple sclerosis

    My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.

Works

Search Professor Judith Greer’s works on UQ eSpace

145 works between 1988 and 2023

61 - 80 of 145 works

2014

Journal Article

Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia

Jones, Amanda L., Mowry, Bryan J., McLean, Duncan E., Mantzioris, Basil X., Pender, Michael P. and Greer, Judith M. (2014). Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia. Journal of Neuroimmunology, 269 (1-2), 68-75. doi: 10.1016/j.jneuroim.2014.02.008

Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia

2014

Journal Article

Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke

Yan, Jun, Liu, Jia, Greer, Judith M. and McCombe, Pamela A. (2014). Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke. Clinical and Experimental Neuroimmunology, 5 (2), 216-226. doi: 10.1111/cen3.12104

Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke

2014

Journal Article

Thiopalmitoylation of altered peptide ligands enhances their protective effects in an animal model of multiple sclerosis

Cloake, Nancy C., Beaino, Wissam, Trifilieff, Elisabeth and Greer, Judith M. (2014). Thiopalmitoylation of altered peptide ligands enhances their protective effects in an animal model of multiple sclerosis. Journal of Immunology, 192 (5), 2244-2251. doi: 10.4049/jimmunol.1301871

Thiopalmitoylation of altered peptide ligands enhances their protective effects in an animal model of multiple sclerosis

2014

Conference Publication

PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations

Cloake, Nancy, Yan, Jun, Pender, Michael, Aminian, Atefeh and Greer, Judith (2014). PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2014.08.268

PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations

2014

Journal Article

Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke

Liu, Jia, Yan, Jun, Greer, Judith M., Read, Stephen J., Henderson, Robert D., Rose, Stephen E., Coulthard, Alan and McCombe, Pamela A. (2014). Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke. International Journal of Neuroscience, 124 (4), 271-280. doi: 10.3109/00207454.2013.837462

Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke

2014

Conference Publication

Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis

Yan, Jun, Greer, Judith, Mccombe, Pamela, Pender, Michael and Consortium, Anzgene (2014). Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis. 12th International Congress of Neuroimmunology (ISNI), Mainz, Germany, Nov 09-13, 2014. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.jneuroim.2014.08.141

Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis

2014

Conference Publication

Thiopalmitoylated altered peptide ligands can successfully treat established disease in an animal model of multiple sclerosis

Cloake, Nancy, Trifilieff, Elisabeth and Greer, Judith (2014). Thiopalmitoylated altered peptide ligands can successfully treat established disease in an animal model of multiple sclerosis. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2014.08.586

Thiopalmitoylated altered peptide ligands can successfully treat established disease in an animal model of multiple sclerosis

2014

Book Chapter

Sexual dimorphism in the immune system

McCombe, Pamela A. and Greer, Judith M. (2014). Sexual dimorphism in the immune system. The Autoimmune Diseases. (pp. 319-328) edited by Ian R. Mackay and Noel R. Rose. San Diego, United States: Academic Press. doi: 10.1016/B978-0-12-384929-8.00024-1

Sexual dimorphism in the immune system

2013

Journal Article

Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis

Greer, Judith M. (2013). Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis. Multiple Sclerosis International, 2013 (151427), 1-16. doi: 10.1155/2013/151427

Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis

2012

Journal Article

Gene expression in the spinal cord in female Lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic proteins

Inglis, Hayley R., Greer, Judith M. and McCombe, Pamela A. (2012). Gene expression in the spinal cord in female Lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic proteins. PLoS One, 7 (11), e48555.1-e48555.15. doi: 10.1371/journal.pone.0048555

Gene expression in the spinal cord in female Lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic proteins

2012

Conference Publication

Gene expression in the spinal cord in MBP-EAE in pregnant and post-partum rats: implications for the effects of MS in pregnancy

Inglis, H., Greer, J. and McCombe, P. (2012). Gene expression in the spinal cord in MBP-EAE in pregnant and post-partum rats: implications for the effects of MS in pregnancy. 28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Lyon France, Oct 10-13, 2012. LONDON: SAGE PUBLICATIONS LTD.

Gene expression in the spinal cord in MBP-EAE in pregnant and post-partum rats: implications for the effects of MS in pregnancy

2012

Journal Article

Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects

Lill, Christina M., Liu, Tian, Schjeide, Brit-Marem, Roehr, Johannes T., Akkad, Denis A., Damotte, Vincent, Alcina, Antonio, Ortiz, Migual A., Arroyo, Rafa, Lopez de Lapuente, Aitzkoa, Blaschke, Paul, Winkelmann, Alexander, Gerdes, Lisa-Ann, Luessi, Felix, Fernadez, Oscar, Izquierdo, Guillermo, Antiguedad, Alfredo, Hoffjan, Sabine, Cournu-Reibeix, Isabelle, Gromoller, Silvana, Faber, Hans, Liebsch, Maria, Meissner, Esther, Chanvillard, Coralie, Touze, Emmanuel, Pico, Fernando, Corcia, Philippe, 19ANZgene Consortium, Bahlo, Melanie ... Zipp, Frauke (2012). Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. Journal of Medical Genetics, 49 (9), 558-562. doi: 10.1136/jmedgenet-2012-101175

Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects

2012

Journal Article

Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability

Yan, Jun, Greer, Judith M. and McCombe, Pamela A. (2012). Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability. Journal of Neuroimmunology, 246 (1-2), 78-84. doi: 10.1016/j.jneuroim.2012.02.013

Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability

2012

Journal Article

Frequency and function of regulatory T cells after ischaemic stroke in humans

Yan, Jun, Read, Stephen J., Henderson, Robert D., Hull, Renee, O'Sullivan, John D., McCombe, Pamela A. and Greer, Judith M. (2012). Frequency and function of regulatory T cells after ischaemic stroke in humans. Journal of Neuroimmunology, 243 (1-2), 89-94. doi: 10.1016/j.jneuroim.2011.12.019

Frequency and function of regulatory T cells after ischaemic stroke in humans

2012

Conference Publication

Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis

Yan, J., Pender, M.P., Liu, J., McCombe, P.A., Greer, J.M. and ANZgene Consortium (2012). Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.

Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis

2012

Conference Publication

Consistent patterns of clinical and laboratory findings in patients with co-existent autoimmune thyroid disease and autoimmune demyelinating disease in the central nervous system

Greer, Judith and Pender, Michael (2012). Consistent patterns of clinical and laboratory findings in patients with co-existent autoimmune thyroid disease and autoimmune demyelinating disease in the central nervous system. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.

Consistent patterns of clinical and laboratory findings in patients with co-existent autoimmune thyroid disease and autoimmune demyelinating disease in the central nervous system

2012

Conference Publication

Development of specific therapeutic agents for multiple sclerosis (MS)

Greer, J.M., Moxey, N.C., Pender, M.P. and Trifilieff, E. (2012). Development of specific therapeutic agents for multiple sclerosis (MS). Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.

Development of specific therapeutic agents for multiple sclerosis (MS)

2012

Conference Publication

Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?

Moxey, N. and Greer, J. (2012). Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.

Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?

2012

Conference Publication

Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke

McCombe, Pamela, Liu, Jia, Yan, Jun and Greer, Judith (2012). Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.

Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke

2012

Conference Publication

Quantitative analysis of the spinal cord CD4+T lymphocyte proteome in EAE

McColl, S.R., Turvey, M., Koudelka, T., Carroll, W., Bernard, C., Greer, J., Hoffmann, P. and MSRA Proteomics Platform (2012). Quantitative analysis of the spinal cord CD4+T lymphocyte proteome in EAE. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications. doi: 10.1177/1352458512440394

Quantitative analysis of the spinal cord CD4+T lymphocyte proteome in EAE

Funding

Current funding

  • 2024 - 2026
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    United States Congressionally Directed Medical Research Programs - Multiple Sclerosis Research Program
    Open grant
  • 2023 - 2025
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    National Multiple Sclerosis Society-US
    Open grant
  • 2023 - 2027
    How does Epstein-Barr virus infection lead to multiple sclerosis?
    NHMRC MRFF CTAI and EPCDRI Multiple Sclerosis
    Open grant
  • 2023 - 2025
    Investigating effects of Evobrutinib on immune and non-immune cells in microglia-enhanced brain organoids
    Merck Group T/A Ares Trading SA
    Open grant
  • 2020 - 2024
    Assessing the effects of cladribine on vaccine recall responses in multiple sclerosis.
    Merck Healthcare KGaA
    Open grant

Past funding

  • 2021 - 2023
    Deriving immune-like cells, neuronal-like cells and brain organoids from iPSCs as a means of studying differential effects of NF-kB activation in MS
    Incubator Grant Scheme
    Open grant
  • 2020 - 2024
    Improving and validating a novel translational tool for research in multiple sclerosis
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2021
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies
    NHMRC Project Grant
    Open grant
  • 2019 - 2022
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies (NHMRC Project Grant led by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2018 - 2020
    Understanding how a parasite-derived peptide prevents immune mediated demyelination (NHMRC Project Grant led by the University of Technology Sydney)
    University of Technology Sydney
    Open grant
  • 2017
    Funding for salary of C. Pfluger and lab expenses
    Research Donation Generic
    Open grant
  • 2017 - 2019
    Does genetic variation in genes controlling pro-inflammatory immune responses modulate outcomes of MIS416 treatment in patients with multiple sclerosis?
    Wesley Medical Research Ltd
    Open grant
  • 2016 - 2021
    Investigating the aetiopathogenic role of autoantibodies against the M1 muscarinic acetylcholine receptor in patients with first episode of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Glutamate transporters as potential targets of autoimmune attack in multiple sclerosis
    National Multiple Sclerosis Society-US
    Open grant
  • 2016 - 2018
    Understanding the mechanisms by which parasite worms prevent multiple sclerosis (MSRA grant administered by UTS)
    University of Technology Sydney
    Open grant
  • 2015 - 2016
    Developing a xenograft mouse model for multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2014 - 2015
    Do antibodies against myelin proteolipid protein play a role in multiple sclerosis?
    Ochsner Clinic Foundation
    Open grant
  • 2014 - 2017
    Investigation of the functional role of antibodies against myelin proteolipid protein in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 2013
    T cells in stroke - part of the solution?
    Royal Brisbane and Women's Hospital
    Open grant
  • 2012 - 2013
    Treatment of Multiple Sclerosis with parasite immunomodulatory molecules
    University of Technology Sydney
    Open grant
  • 2012 - 2014
    Understanding the interplay between the spectrum of glial and neuronal autoantibodies and clinical outcome in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2011 - 2012
    Role of maternofetal chimerism in transferring susceptibility to MS
    National Multiple Sclerosis Society-US
    Open grant
  • 2011 - 2013
    Nature and timing of inflammation after acute ischaemic stroke
    National Heart Foundation of Australia
    Open grant
  • 2011 - 2013
    NFKBIA mutations as a mechanism leading to constitutive activation of NF-kB in patients with primary progressive MS
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2011
    Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2012
    Proteomic analysis of central nervous system inflammation in multiple sclerosis (ARC Linkage held by University of Adelaide)
    University of Adelaide
    Open grant
  • 2010 - 2012
    Molecular interactions underpinning lesion localization in multiple sclerosis.
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    Development of specific immunomodulatory agents for Multiple Sclerosis affecting the brainstem and cerebellum
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    The effects of pregnancy and the post-partum period on T cells, antibodies, and gene expression in EAE
    Multiple Sclerosis Research Australia
    Open grant
  • 2008 - 2012
    Immune Response to stroke
    Wesley Merdical Research
    Open grant
  • 2007 - 2009
    Mechanisms leading to constitutive activation of the transcription factor NF-kB in progressive multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2008
    Investigations In Multiple Sclerosis Patients With Coexistent Autoimmune Thyroid Disease
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    Studies on the functional role of antibodies in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2006
    Supplementary funding to advance development
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2002 - 2003
    Investigation of the mechanisms by which thiacylated lipopeptides enhance immune responses
    Multiple Sclerosis Research Australia
    Open grant
  • 2002 - 2003
    Is autoreactivity to myelin antigens regulated differently in multiple sclerosis and stroke?
    Multiple Sclerosis Research Australia
    Open grant
  • 2001 - 2002
    Studies on the disease process and potential therapeutic agents in multiple sclerosis
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2000 - 2005
    HLA type, B & T cell responses to myelin antigens, and lesion distribution
    National Multiple Sclerosis Society-US
    Open grant
  • 1999 - 2001
    Correlation Between Ganglioside-Specific Immune Responses and Disease Prograssion in Multiple Sclerosis
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Studies of T cell reactivity to myelin antigens in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 1995
    B and T cell reactivity to myelin/oligodendrocyte-specific protein in multiple sclerosis
    University of Queensland New Staff Research Grant
    Open grant
  • 1995
    Immune responses to central nervous system myelin antigens in multiple sclerosis
    Ramaciotti Foundation
    Open grant

Supervision

Availability

Associate Professor Judith Greer is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    A novel humanized mouse model for multiple sclerosis

    Principal Advisor

    Other advisors: Dr Jun Yan, Dr Aakanksha Dixit

  • Doctor Philosophy

    The role of Epstein-Barr virus infection in multiple sclerosis

    Principal Advisor

    Other advisors: Professor Pamela McCombe

  • Doctor Philosophy

    Investigation of the role of BTK and NF-kB signalling in CNS cells

    Principal Advisor

    Other advisors: Dr Jun Yan

Completed supervision

Media

Enquiries

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