Overview
Background
Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.
She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.
Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.
Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Tumour Immunology, The University of Queensland
- Foreign Fellow, American Association of Immunologists, American Association of Immunologists
- Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
- Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
- Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
- Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
- Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
- Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
- Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
- Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
- Board Member, Neuroimmunology Australia, Neuroimmunology Australia
Research interests
-
Immunology of multiple sclerosis
My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.
Works
Search Professor Judith Greer’s works on UQ eSpace
2014
Journal Article
Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia
Jones, Amanda L., Mowry, Bryan J., McLean, Duncan E., Mantzioris, Basil X., Pender, Michael P. and Greer, Judith M. (2014). Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia. Journal of Neuroimmunology, 269 (1-2), 68-75. doi: 10.1016/j.jneuroim.2014.02.008
2014
Journal Article
Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke
Yan, Jun, Liu, Jia, Greer, Judith M. and McCombe, Pamela A. (2014). Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke. Clinical and Experimental Neuroimmunology, 5 (2), 216-226. doi: 10.1111/cen3.12104
2014
Journal Article
Thiopalmitoylation of altered peptide ligands enhances their protective effects in an animal model of multiple sclerosis
Cloake, Nancy C., Beaino, Wissam, Trifilieff, Elisabeth and Greer, Judith M. (2014). Thiopalmitoylation of altered peptide ligands enhances their protective effects in an animal model of multiple sclerosis. Journal of Immunology, 192 (5), 2244-2251. doi: 10.4049/jimmunol.1301871
2014
Conference Publication
PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations
Cloake, Nancy, Yan, Jun, Pender, Michael, Aminian, Atefeh and Greer, Judith (2014). PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2014.08.268
2014
Journal Article
Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke
Liu, Jia, Yan, Jun, Greer, Judith M., Read, Stephen J., Henderson, Robert D., Rose, Stephen E., Coulthard, Alan and McCombe, Pamela A. (2014). Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke. International Journal of Neuroscience, 124 (4), 271-280. doi: 10.3109/00207454.2013.837462
2014
Conference Publication
Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis
Yan, Jun, Greer, Judith, Mccombe, Pamela, Pender, Michael and Consortium, Anzgene (2014). Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis. 12th International Congress of Neuroimmunology (ISNI), Mainz, Germany, Nov 09-13, 2014. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.jneuroim.2014.08.141
2014
Conference Publication
Thiopalmitoylated altered peptide ligands can successfully treat established disease in an animal model of multiple sclerosis
Cloake, Nancy, Trifilieff, Elisabeth and Greer, Judith (2014). Thiopalmitoylated altered peptide ligands can successfully treat established disease in an animal model of multiple sclerosis. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2014.08.586
2014
Book Chapter
Sexual dimorphism in the immune system
McCombe, Pamela A. and Greer, Judith M. (2014). Sexual dimorphism in the immune system. The Autoimmune Diseases. (pp. 319-328) edited by Ian R. Mackay and Noel R. Rose. San Diego, United States: Academic Press. doi: 10.1016/B978-0-12-384929-8.00024-1
2013
Journal Article
Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis
Greer, Judith M. (2013). Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis. Multiple Sclerosis International, 2013 (151427), 1-16. doi: 10.1155/2013/151427
2012
Journal Article
Gene expression in the spinal cord in female Lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic proteins
Inglis, Hayley R., Greer, Judith M. and McCombe, Pamela A. (2012). Gene expression in the spinal cord in female Lewis rats with experimental autoimmune encephalomyelitis induced with myelin basic proteins. PLoS One, 7 (11), e48555.1-e48555.15. doi: 10.1371/journal.pone.0048555
2012
Conference Publication
Gene expression in the spinal cord in MBP-EAE in pregnant and post-partum rats: implications for the effects of MS in pregnancy
Inglis, H., Greer, J. and McCombe, P. (2012). Gene expression in the spinal cord in MBP-EAE in pregnant and post-partum rats: implications for the effects of MS in pregnancy. 28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis, Lyon France, Oct 10-13, 2012. LONDON: SAGE PUBLICATIONS LTD.
2012
Journal Article
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects
Lill, Christina M., Liu, Tian, Schjeide, Brit-Marem, Roehr, Johannes T., Akkad, Denis A., Damotte, Vincent, Alcina, Antonio, Ortiz, Migual A., Arroyo, Rafa, Lopez de Lapuente, Aitzkoa, Blaschke, Paul, Winkelmann, Alexander, Gerdes, Lisa-Ann, Luessi, Felix, Fernadez, Oscar, Izquierdo, Guillermo, Antiguedad, Alfredo, Hoffjan, Sabine, Cournu-Reibeix, Isabelle, Gromoller, Silvana, Faber, Hans, Liebsch, Maria, Meissner, Esther, Chanvillard, Coralie, Touze, Emmanuel, Pico, Fernando, Corcia, Philippe, 19ANZgene Consortium, Bahlo, Melanie ... Zipp, Frauke (2012). Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects. Journal of Medical Genetics, 49 (9), 558-562. doi: 10.1136/jmedgenet-2012-101175
2012
Journal Article
Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability
Yan, Jun, Greer, Judith M. and McCombe, Pamela A. (2012). Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability. Journal of Neuroimmunology, 246 (1-2), 78-84. doi: 10.1016/j.jneuroim.2012.02.013
2012
Journal Article
Frequency and function of regulatory T cells after ischaemic stroke in humans
Yan, Jun, Read, Stephen J., Henderson, Robert D., Hull, Renee, O'Sullivan, John D., McCombe, Pamela A. and Greer, Judith M. (2012). Frequency and function of regulatory T cells after ischaemic stroke in humans. Journal of Neuroimmunology, 243 (1-2), 89-94. doi: 10.1016/j.jneuroim.2011.12.019
2012
Conference Publication
Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis
Yan, J., Pender, M.P., Liu, J., McCombe, P.A., Greer, J.M. and ANZgene Consortium (2012). Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.
2012
Conference Publication
Consistent patterns of clinical and laboratory findings in patients with co-existent autoimmune thyroid disease and autoimmune demyelinating disease in the central nervous system
Greer, Judith and Pender, Michael (2012). Consistent patterns of clinical and laboratory findings in patients with co-existent autoimmune thyroid disease and autoimmune demyelinating disease in the central nervous system. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.
2012
Conference Publication
Development of specific therapeutic agents for multiple sclerosis (MS)
Greer, J.M., Moxey, N.C., Pender, M.P. and Trifilieff, E. (2012). Development of specific therapeutic agents for multiple sclerosis (MS). Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.
2012
Conference Publication
Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?
Moxey, N. and Greer, J. (2012). Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.
2012
Conference Publication
Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke
McCombe, Pamela, Liu, Jia, Yan, Jun and Greer, Judith (2012). Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.
2012
Conference Publication
Quantitative analysis of the spinal cord CD4+T lymphocyte proteome in EAE
McColl, S.R., Turvey, M., Koudelka, T., Carroll, W., Bernard, C., Greer, J., Hoffmann, P. and MSRA Proteomics Platform (2012). Quantitative analysis of the spinal cord CD4+T lymphocyte proteome in EAE. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications. doi: 10.1177/1352458512440394
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Other advisors: Dr Jun Yan, Dr Aakanksha Dixit
-
Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Principal Advisor
Other advisors: Professor Pamela McCombe
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Principal Advisor
Other advisors: Dr Jun Yan
Completed supervision
-
2022
Doctor Philosophy
Anti-Muscarinic Acetylcholine Receptor Antibodies in First Episode Psychosis
Principal Advisor
Other advisors: Professor James Scott
-
2022
Doctor Philosophy
Investigating the mechanism of action of a novel therapeutic derived from parasitic worms in animal models of multiple sclerosis
Principal Advisor
-
2015
Doctor Philosophy
Amino acid variants of myelin proteolipid protein: potential inducers of multiple sclerosis or potential means to a cure?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2013
Doctor Philosophy
Altered peptide ligands as therapeutic agents for a model of multiple sclerosis: Determining the signature of clinical efficacy
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Immune dysregulation in schizophrenia: Do some cases of schizophrenia have an autoimmune basis?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender, Professor Bryan Mowry
-
2012
Doctor Philosophy
Neuropathological and Neuroimmunological Studies of the Central Nervous System of Mice With Axial-Rotatory Experimental Autoimmune Encephalomyelitis
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2007
Doctor Philosophy
Development of immunomodulatory peptides for the treatment of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
Principal Advisor
-
2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2003
Doctor Philosophy
MITOCHONDRIAL IRON METABOLISM AND THE ROLE OF FRATAXIN IN IRON AND HAEM METABOLISM
Associate Advisor
Media
Enquiries
For media enquiries about Associate Professor Judith Greer's areas of expertise, story ideas and help finding experts, contact our Media team: