
Overview
Background
Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.
She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.
Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.
Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Tumour Immunology, The University of Queensland
- Foreign Fellow, American Association of Immunologists, American Association of Immunologists
- Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
- Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
- Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
- Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
- Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
- Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
- Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
- Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
- Board Member, Neuroimmunology Australia, Neuroimmunology Australia
Research interests
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Immunology of multiple sclerosis
My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.
Works
Search Professor Judith Greer’s works on UQ eSpace
2003
Book Chapter
Proteolipids in the nervous system
Greer, J. M. and Lees, M. B. (2003). Proteolipids in the nervous system. Encyclopedia of Neuroscience. (pp. _-_) edited by G. Adelman and B. H. Smith. Amsterdam: Elsevier Science.
2002
Journal Article
Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization
Becker, E. M., Greer, J. M., Ponka, P. and Richardson, D. R. (2002). Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization. Blood, 99 (10), 3813-3822. doi: 10.1182/blood.V99.10.3813
2002
Conference Publication
T cell responses to gangliosides in patients with inflammatory neuropathy
McCombe, P. A., Sullivan, A. A., Alizart, M. A., Csurhes, P. A., Greer, J. M. and Pender, M. P. (2002). T cell responses to gangliosides in patients with inflammatory neuropathy. Xth International Congress on Neuromuscular Diseases, Vancouver, Canada, 07-12 Jul 2002. Amsterda, The Netherlands: Elseiver. doi: 10.1016/S0022-510X(02)80069-7
2002
Conference Publication
Comparison of regulatory cell populations in patients with multiple sclerosis and controls
Yan, J., Rist, M. J., Dodson, M. J., Pender, M. P. and Greer, J. M. (2002). Comparison of regulatory cell populations in patients with multiple sclerosis and controls. Progress in MS Research, Sydney, 9-11 Oct, 2002.
2002
Conference Publication
Blood T-cell reactivity to gangliosides GM3 and GQ1b is increased in patients with primary progressive multiple sclerosis
Pender, M. P., Csurhes, P. A., Wolfe, N. P., Cameron, K. D., McCombe, P. A., Greer, J. M. and Good, M. F. (2002). Blood T-cell reactivity to gangliosides GM3 and GQ1b is increased in patients with primary progressive multiple sclerosis. 127th Annual Meeting of the American Neurological Association, New York City, NY, USA, October 12-16 2002. NEW YORK: WILEY-LISS.
2002
Conference Publication
Comparison of NF-kB in immune cells of multiple sclerosis patients and controls Society for Cytokines, Inflammation and Leukocytes
Yan, J., Inglis, H., Pender, M. P. and Greer, J. M. (2002). Comparison of NF-kB in immune cells of multiple sclerosis patients and controls Society for Cytokines, Inflammation and Leukocytes. 32nd Annual Scientific Meeting of the ASI, Brisbane, Qld, Australia, 8-12 December, 2002.
2000
Journal Article
Circulating antiganglioside antibodies are not associated with the development of progressive disease or cerebral atrophy in patients with multiple sclerosis - Reply
Sadatipour, B.T., Greer, J.M. and Pender, M.P. (2000). Circulating antiganglioside antibodies are not associated with the development of progressive disease or cerebral atrophy in patients with multiple sclerosis - Reply. Annals of Neurology, 47 (5), 685-685.
2000
Journal Article
Reply
Tayyebeh Sadatipour, B., Greer, Judith M. and Pender, Michael P. (2000). Reply. Annals of Neurology, 47 (5), 685-685. doi: 10.1002/1531-8249(200005)47:53.0.co;2-k
2000
Journal Article
Reply to letter by Giovanni et. al.
Sadatipour, B. T., Greer, J. M. and Pender, M. P. (2000). Reply to letter by Giovanni et. al.. Annals of Neurology, 47 (5), 685-685.
2000
Conference Publication
Inflammatory cell populations in rotatory experimental autoimmune encephalomyelitis
Muller, D., Pender, M. P. and Greer, J. M. (2000). Inflammatory cell populations in rotatory experimental autoimmune encephalomyelitis. Progress in Multiple Sclerosis Research 2000, Melbourne, 22-24 Nov, 2000. Melbourne: Multiple Sclerosis Australia.
2000
Journal Article
Early pregnancy factor suppresses experimental autoimmune encephalomyelitis induced in Lewis rats with myelin basic protein and in SJL/J mice with myelin proteolipid protein peptide 139-151
ZhangB, HarnessJ, Somodevilla-TorresMJ, HillyardNC, MouldAW, AlewoodD, LoveSG, AlewoodPF, GreerJM, CavanaghAC, McCombe, PA, MortonH and RPLisak (2000). Early pregnancy factor suppresses experimental autoimmune encephalomyelitis induced in Lewis rats with myelin basic protein and in SJL/J mice with myelin proteolipid protein peptide 139-151. Journal of the Neurological Sciences, 182 (1), 5-15. doi: 10.1016/S0022-510X(00)00432-9
2000
Conference Publication
Increased circulating anti-myelin antibodies in multiple sclerosis
Pender, M. P. and Greer, J. M. (2000). Increased circulating anti-myelin antibodies in multiple sclerosis. ANN Meeting, xx, xx. Leith Walkedinburgh, Scotland: Churchill Livingstone. doi: 10.1054/jocn.2000.0668
2000
Conference Publication
Enhancement of autoimmunity by thioacylated lipopeptides
Greer, J. M., Denis, B., Sobel, R. A. and Trifilieff, E. (2000). Enhancement of autoimmunity by thioacylated lipopeptides. 30th Annual Meeting of the Aust. Society for Immunology, UNSW, Sydney, 10-15 Dec, 2000. Sydney: Australasian Society for Immunology.
1999
Conference Publication
A detailed neuropathological analysis of a form of experimental autoimmune encephalomyelitis with predominant brainstem and cerebellar involvment
Muller, D., Greer, J. M. and Pender, M. P. (1999). A detailed neuropathological analysis of a form of experimental autoimmune encephalomyelitis with predominant brainstem and cerebellar involvment. ECTRIMS/ACTRIMS 99, Basel, Switzerland, 15 - 18 Sept, 1999. UK: Stockton Press.
1999
Conference Publication
Fluctuations in the frequencies of circulating myelin-reactive T cells in healthy subjects and patients with multiple sclerosis
Pender, M. P., Csurhes, P. A., Greer, J. M., Mowat, P. D., Henderson, R. D., Cameron, K. D., McCombe, P. A. and Good, M. F. (1999). Fluctuations in the frequencies of circulating myelin-reactive T cells in healthy subjects and patients with multiple sclerosis. ECTRIMS/ACTRIMS'99, Basel, Switzerland, 15 - 18 Sept, 1999. Basingstoke, England: Stockton Press.
1999
Conference Publication
Antibody against myelin proteolipid protein is involved in localization of demyelinated lesions to specific sites within the CNS
Greer, J. M. and Muller, D. (1999). Antibody against myelin proteolipid protein is involved in localization of demyelinated lesions to specific sites within the CNS. ECTRIMS/ACTRIMS 99, Basel, Switzerland, 15 - 18 Sept, 1999. UK: Stockton Press.
1998
Conference Publication
The frequency of circulating T cells reactive to PLP184-209 increases prior to MS relapse and development of new MR1 lesions
Cameron, K. D., Csurhes, P. A., Good, M. F., Greer, J. M., Henderson, R. D., McCombe, P. A., Mowat, P. D. and Pender, M. P. (1998). The frequency of circulating T cells reactive to PLP184-209 increases prior to MS relapse and development of new MR1 lesions. Fifth International Congress of the International Society of Neuroimmunology, Montreal, QC, Canada, 23-27 August 1998. doi: 10.1016/S0165-5728(98)91636-8
1996
Conference Publication
T-cell reactivity to peptides of proteolipid protein and myelin basic protein in multiple sclerosis
Pender, M. P., Greer, J. M., Csurhes, P. A., Cameron, K. D., McCombe, P. A. and Good, M. F. (1996). T-cell reactivity to peptides of proteolipid protein and myelin basic protein in multiple sclerosis. 121st Annual Meeting of the American Neurological Association, Miami, FL, U.S.A., 13-16 October 1996. BOSTON: LITTLE BROWN CO. doi: 10.1002/ana.410400326
1995
Conference Publication
Reactivity to myelin proteolipid protein in multiple sclerosis patients
Cameron, K., Csurhes, P., Greer, J., McCombe, P. and Pender, M. (1995). Reactivity to myelin proteolipid protein in multiple sclerosis patients. The 9th International Congress of Immunology, San Francisco, California, USA, 23-29 July 1995. San Francisco, California, USA: American Association of Immunologists and the International Union of Immunological Societies.
1995
Conference Publication
Expression of myelin proteolipid protein in oligodendrocytes and transfected cells
Lees, MB, Smith, FI, Dyer, CA, Greer, JM and Pakaski, M (1995). Expression of myelin proteolipid protein in oligodendrocytes and transfected cells. 2nd Stanford International Neuroscience Symposium, Beijing Peoples R China, Oct 19-22, 1993. AMSTERDAM: ELSEVIER SCIENCE PUBL B V.
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Judith Greer is:
- Not available for supervision
Supervision history
Current supervision
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Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
-
Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Principal Advisor
Other advisors: Professor Pamela McCombe
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Principal Advisor
Other advisors: Dr Aakanksha Dixit
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Principal Advisor
Completed supervision
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2022
Doctor Philosophy
Anti-Muscarinic Acetylcholine Receptor Antibodies in First Episode Psychosis
Principal Advisor
Other advisors: Professor James Scott
-
2022
Doctor Philosophy
Investigating the mechanism of action of a novel therapeutic derived from parasitic worms in animal models of multiple sclerosis
Principal Advisor
-
2015
Doctor Philosophy
Amino acid variants of myelin proteolipid protein: potential inducers of multiple sclerosis or potential means to a cure?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
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2013
Doctor Philosophy
Altered peptide ligands as therapeutic agents for a model of multiple sclerosis: Determining the signature of clinical efficacy
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Neuropathological and Neuroimmunological Studies of the Central Nervous System of Mice With Axial-Rotatory Experimental Autoimmune Encephalomyelitis
Principal Advisor
Other advisors: Emeritus Professor Michael Pender
-
2012
Doctor Philosophy
Immune dysregulation in schizophrenia: Do some cases of schizophrenia have an autoimmune basis?
Principal Advisor
Other advisors: Emeritus Professor Michael Pender, Professor Bryan Mowry
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2007
Doctor Philosophy
Development of immunomodulatory peptides for the treatment of the experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
Principal Advisor
-
2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Associate Advisor
Other advisors: Professor Pamela McCombe
-
2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Associate Advisor
Other advisors: Professor Pamela McCombe
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2003
Doctor Philosophy
MITOCHONDRIAL IRON METABOLISM AND THE ROLE OF FRATAXIN IN IRON AND HAEM METABOLISM
Associate Advisor
Media
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