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Associate Professor Judith Greer
Associate Professor

Judith Greer

Email: 
Phone: 
+61 7 334 66018

Overview

Background

Judith Greer is an immunologist with a strong interest in the nervous system and autoimmune diseases affecting the nervous system.

She is a graduate of the University of Queensland, having completed her PhD on cancer immunology. She then undertook postdoctoral training at Harvard Medical School in the USA, during which time her interests shifted towards immune responses and interactions within the nervous system (neuroimmunology), an area in which she has worked ever since. She isa Principal Research Fellow at the UQ Centre for Clinical Research, located at the Royal Brisbane & Women's Hospital.

Her research is directly particularly towards trying to identify brain components that are targetted by the immune system in people with a variety of disorders, particularly multiple sclerosis (MS), which is traditionally thought to be an autoimmune disease, but also in psychosis, where we are now starting to understand that autoimmune targetting of the brain can play a role in some patients. She is interested in how the specificity of autoimmune responses within the nervous system relates to the symptoms experienced by patients, and in developing new ways to specifically turn off the damaging immune responses in the brain. Another focus of her research is to improve on pre-clinical models of MS, so as to enhance the translation of new therapeutic approaches for MS to the clinic.

Judith is also interested in research training, and held leadership positions in this area in the School of Medicine and the Faculty of Medicine at UQ from 2000 - 2023. She is also committed to improving the field of neuroimmunology, and has been a member of the International Advisory Board of the International Society for Neuroimmunology and is the Asia-Pacific representative for the Global Schools of Neuroimmunology. Judith co-founded a society, Neuroimmunology Australia, to better support those working in this field, and was Convenor and Chair of the 14th International Congress of Neuroimmunology, which was held in Brisbane in 2018 (the only time this congress has been held outside of the Northern Hemisphere).

Availability

Associate Professor Judith Greer is:
Not available for supervision

Fields of research

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy of Tumour Immunology, The University of Queensland
  • Foreign Fellow, American Association of Immunologists, American Association of Immunologists
  • Foreign Fellow, American Society for Neurochemistry, American Society for Neurochemistry
  • Board Member, Australian and New Zealand Society for Immunology, Australian and New Zealand Society for Immunology
  • Journal Editorial Board Member, Frontiers in Immunology, Frontiers in Immunology
  • Journal Editorial Board Member, Immunology & Cell Biology, Immunology & Cell Biology
  • Board Member, International Society of Neuroimmunology, International Society of Neuroimmunology
  • Journal Editorial Board Member, Journal of Clinical Medicine, Journal of Clinical Medicine
  • Journal Editorial Board Member, Journal of Immunology, Journal of Immunology
  • Journal Editorial Board Member, Journal of Neuroimmunology, Journal of Neuroimmunology
  • Board Member, Neuroimmunology Australia, Neuroimmunology Australia

Research interests

  • Immunology of multiple sclerosis

    My main research interest is in multiple sclerosis, an autoimmune disease affecting the central nervous system. I am interested in how we can determine the antigen specificity of the autoimmune response and how we might target this in a specific manner to treat the disease.

Works

Search Professor Judith Greer’s works on UQ eSpace

145 works between 1988 and 2023

1 - 20 of 145 works

2013

Journal Article

Female reproductive issues in multiple sclerosis

McCombe, Pamela A. and Greer, Judith M. (2013). Female reproductive issues in multiple sclerosis. Multiple Sclerosis Journal, 19 (4), 392-402. doi: 10.1177/1352458512452331

Female reproductive issues in multiple sclerosis

2012

Journal Article

The role of epigenetic mechanisms and processes in autoimmune disorders

Greer, Judith M. and McCombe, Pamela A. (2012). The role of epigenetic mechanisms and processes in autoimmune disorders. Biologics: Targets and Therapy, 6, 307-327. doi: 10.2147/BTT.S24067

The role of epigenetic mechanisms and processes in autoimmune disorders

2012

Journal Article

Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis

Yan, Jun, Liu, Jia, Lin, Clement Yihao, Australia and New Zealand Multiple Sclerorsis Genetics Consortium, Csurhes, Peter A., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2012). Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis. International Journal of Molecular Sciences, 13 (10), 13667-13679. doi: 10.3390/ijms131013667

Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis

2011

Journal Article

Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms

Greer, Judith M. and McCombe, Pamela A. (2011). Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms. Journal of Neuroimmunology, 234 (1-2), 7-18. doi: 10.1016/j.jneuroim.2011.03.003

Role of gender in multiple sclerosis: Clinical effects and potential molecular mechanisms

2008

Journal Article

Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis

Greer, Judith M., Csurhes, Peter A., Muller, Diane M. and Pender, Michael P. (2008). Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis. Journal of Immunology, 180 (9), 6402-6410. doi: 10.4049/jimmunol.180.9.6402

Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis

2008

Journal Article

Route of uptake of palmitoylated encephalitogenic peptides of myelin proteolipid protein by antigen-presenting cells: Importance of the type of bond between lipid chain and peptide and relevance to autoimmunity

Pfender, N., Grosch ,S., Roussell, G., Koch, M., Trifilieff, E. and Greer, Judith M. (2008). Route of uptake of palmitoylated encephalitogenic peptides of myelin proteolipid protein by antigen-presenting cells: Importance of the type of bond between lipid chain and peptide and relevance to autoimmunity. Journal of Immunology, 180 (3), 1398-1404. doi: 10.4049/jimmunol.180.3.1398

Route of uptake of palmitoylated encephalitogenic peptides of myelin proteolipid protein by antigen-presenting cells: Importance of the type of bond between lipid chain and peptide and relevance to autoimmunity

2007

Journal Article

Immunology of multiple sclerosis

Pender, Michael P. and Greer, Judith M. (2007). Immunology of multiple sclerosis. Current Allergy and Asthma Reports, 7 (4), 285-292. doi: 10.1007/s11882-007-0043-x

Immunology of multiple sclerosis

2005

Journal Article

The Presence of Glutamic Acid at Positions 71 or 74 in Pocket 4 of the HLA-DR beta 1 Chain is Associated with the Clinical Course of Multiple Sclerosis

Greer, J. M. and Pender, M. P. (2005). The Presence of Glutamic Acid at Positions 71 or 74 in Pocket 4 of the HLA-DR beta 1 Chain is Associated with the Clinical Course of Multiple Sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 76 (5), 656-662. doi: 10.1136/jnnp.2004.042168

The Presence of Glutamic Acid at Positions 71 or 74 in Pocket 4 of the HLA-DR beta 1 Chain is Associated with the Clinical Course of Multiple Sclerosis

2005

Journal Article

Blood-Brain Barrier Disruption And Lesion Localisation In Experimental Autoimmune Encephalomyelitis With Predominant Cerebellar And Brainstem Involvement

Muller, Diane M., Pender, Michael P. and Greer, Judith M. (2005). Blood-Brain Barrier Disruption And Lesion Localisation In Experimental Autoimmune Encephalomyelitis With Predominant Cerebellar And Brainstem Involvement. Journal of Neuroimmunology, 160 (1-2), 162-169. doi: 10.1016/j.jneuroim.2004.11.011

Blood-Brain Barrier Disruption And Lesion Localisation In Experimental Autoimmune Encephalomyelitis With Predominant Cerebellar And Brainstem Involvement

2005

Journal Article

Immune Dysregulation and Self-Reactivity in Schizophrenia: Do Some Cases of Schizophrenia Have an Autoimmune Basis?

Jones, Amanda L., Mowry, Bryan J., Pender, Michael P. and Greer, Judith M. (2005). Immune Dysregulation and Self-Reactivity in Schizophrenia: Do Some Cases of Schizophrenia Have an Autoimmune Basis?. Immunology and Cell Biology, 83 (1), 9-17. doi: 10.1111/j.1440-1711.2005.01305.x

Immune Dysregulation and Self-Reactivity in Schizophrenia: Do Some Cases of Schizophrenia Have an Autoimmune Basis?

2004

Journal Article

Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis

Pender, MP and Greer, JM (2004). Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis. Multiple Sclerosis, 10 (7032), S166-S166.

Increased circulating antibodies to an extracellular domain of myelin proteolipid protein in multiple sclerosis

2003

Journal Article

Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis

Pender, Michael P., Csurhes, Peter A., Wolfe, Nigel P., Hooper, Kaye D., Good, Michael F., McCombe, Pamela A. and Greer, Judith M. (2003). Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis. Journal of Clinical Neuroscience, 10 (1), 63-66. doi: 10.1016/S0967-5868(02)00270-9

Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis

2002

Journal Article

Myelin proteolipid protein - the first 50 years

Greer, Judith M. and Lees, Marjorie B. (2002). Myelin proteolipid protein - the first 50 years. International Journal of Biochemistry and Cell Biology, 34 (3), 211-215. doi: 10.1016/S1357-2725(01)00136-4

Myelin proteolipid protein - the first 50 years

2001

Journal Article

Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity

Greer, J. M., Denis, B., Sobel, R. A. and Trifilieff, E. (2001). Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity. Journal of Immunology, 166 (11), 6907-6913. doi: 10.4049/jimmunol.166.11.6907

Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity

2000

Journal Article

A Neuropathological Analysis Of Experimental Autoimmune Encephalomyelitis With Predominant Brain Stem And Cerebellar Involvement And Differences Between Active And Passive Induction

Muller, Diane M., Pender, Michael P. and Greer, Judith M. (2000). A Neuropathological Analysis Of Experimental Autoimmune Encephalomyelitis With Predominant Brain Stem And Cerebellar Involvement And Differences Between Active And Passive Induction. Acta Neuropathologica, 100 (2), 174-182. doi: 10.1007/s004019900163

A Neuropathological Analysis Of Experimental Autoimmune Encephalomyelitis With Predominant Brain Stem And Cerebellar Involvement And Differences Between Active And Passive Induction

2000

Journal Article

Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects

Pender, Michael P., Csurhes, Peter A., Greer, Judith M., Mowat, Paul D., Henderson, Robert D., Cameron, Kaye D., Purdie, David M., McCombe, Pamela A. and Good, Michael F. (2000). Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects. Journal of Immunology, 165 (9), 5322-5331. doi: 10.4049/jimmunol.165.9.5322

Surges of Increased T Cell Reactivity to an Encephalitogenic Region of Myelin Proteolipid Protein Occur More Often in Patients with Multiple Sclerosis than in Healthy Subjects

1998

Journal Article

Increased Circulating Antiganglioside Antibodies in Primary and Secondary Progressive Multiple Sclerosis

Sadatipour, B. Tayyebeh, Greer, Judith M. and Pender, Michael P. (1998). Increased Circulating Antiganglioside Antibodies in Primary and Secondary Progressive Multiple Sclerosis. Annals of Neurology, 44 (6), 980-983. doi: 10.1002/ana.410440621

Increased Circulating Antiganglioside Antibodies in Primary and Secondary Progressive Multiple Sclerosis

1997

Journal Article

Increased Immunoreactivity to Two Overlapping Peptides of Myelin Proteolipid Protein in Multiple Sclerosis

Greer, J. M., Csurhes, P. A., Cameron, K. D., McCombe, P. A., Good, M. F. and Pender, M. P. (1997). Increased Immunoreactivity to Two Overlapping Peptides of Myelin Proteolipid Protein in Multiple Sclerosis. Brain, 120 (8), 1447-1460. doi: 10.1093/brain/120.8.1447

Increased Immunoreactivity to Two Overlapping Peptides of Myelin Proteolipid Protein in Multiple Sclerosis

1997

Journal Article

Encephalitogenicity of murine, but not bovine, DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope

Greer, JM, Klinguer, C, Trifilieff, E, Sobel, RA and Lees, MB (1997). Encephalitogenicity of murine, but not bovine, DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope. Neurochemical Research, 22 (4), 541-547. doi: 10.1023/A:1027336516785

Encephalitogenicity of murine, but not bovine, DM20 in SJL mice is due to a single amino acid difference in the immunodominant encephalitogenic epitope

1997

Journal Article

Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein

Das, MP, Nicholson, LB, Greer, JM and Kuchroo, VK (1997). Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. Journal of Experimental Medicine, 186 (6), 867-876. doi: 10.1084/jem.186.6.867

Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein

Funding

Current funding

  • 2024 - 2026
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    United States Congressionally Directed Medical Research Programs - Multiple Sclerosis Research Program
    Open grant
  • 2023 - 2025
    Using a novel humanized mouse model to investigate how EBV infection at different ages potentiates development of CNS demyelinating disease
    National Multiple Sclerosis Society-US
    Open grant
  • 2023 - 2027
    How does Epstein-Barr virus infection lead to multiple sclerosis?
    NHMRC MRFF CTAI and EPCDRI Multiple Sclerosis
    Open grant
  • 2023 - 2025
    Investigating effects of Evobrutinib on immune and non-immune cells in microglia-enhanced brain organoids
    Merck Group T/A Ares Trading SA
    Open grant
  • 2020 - 2024
    Assessing the effects of cladribine on vaccine recall responses in multiple sclerosis.
    Merck Healthcare KGaA
    Open grant

Past funding

  • 2021 - 2023
    Deriving immune-like cells, neuronal-like cells and brain organoids from iPSCs as a means of studying differential effects of NF-kB activation in MS
    Incubator Grant Scheme
    Open grant
  • 2020 - 2024
    Improving and validating a novel translational tool for research in multiple sclerosis
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2021
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies
    NHMRC Project Grant
    Open grant
  • 2019 - 2022
    Identifying and treating patients with psychosis who are positive to anti-neuronal antibodies (NHMRC Project Grant led by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2018 - 2020
    Understanding how a parasite-derived peptide prevents immune mediated demyelination (NHMRC Project Grant led by the University of Technology Sydney)
    University of Technology Sydney
    Open grant
  • 2017
    Funding for salary of C. Pfluger and lab expenses
    Research Donation Generic
    Open grant
  • 2017 - 2019
    Does genetic variation in genes controlling pro-inflammatory immune responses modulate outcomes of MIS416 treatment in patients with multiple sclerosis?
    Wesley Medical Research Ltd
    Open grant
  • 2016 - 2021
    Investigating the aetiopathogenic role of autoantibodies against the M1 muscarinic acetylcholine receptor in patients with first episode of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Glutamate transporters as potential targets of autoimmune attack in multiple sclerosis
    National Multiple Sclerosis Society-US
    Open grant
  • 2016 - 2018
    Understanding the mechanisms by which parasite worms prevent multiple sclerosis (MSRA grant administered by UTS)
    University of Technology Sydney
    Open grant
  • 2015 - 2016
    Developing a xenograft mouse model for multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2014 - 2015
    Do antibodies against myelin proteolipid protein play a role in multiple sclerosis?
    Ochsner Clinic Foundation
    Open grant
  • 2014 - 2017
    Investigation of the functional role of antibodies against myelin proteolipid protein in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 2013
    T cells in stroke - part of the solution?
    Royal Brisbane and Women's Hospital
    Open grant
  • 2012 - 2013
    Treatment of Multiple Sclerosis with parasite immunomodulatory molecules
    University of Technology Sydney
    Open grant
  • 2012 - 2014
    Understanding the interplay between the spectrum of glial and neuronal autoantibodies and clinical outcome in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2011 - 2012
    Role of maternofetal chimerism in transferring susceptibility to MS
    National Multiple Sclerosis Society-US
    Open grant
  • 2011 - 2013
    Nature and timing of inflammation after acute ischaemic stroke
    National Heart Foundation of Australia
    Open grant
  • 2011 - 2013
    NFKBIA mutations as a mechanism leading to constitutive activation of NF-kB in patients with primary progressive MS
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2011
    Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2012
    Proteomic analysis of central nervous system inflammation in multiple sclerosis (ARC Linkage held by University of Adelaide)
    University of Adelaide
    Open grant
  • 2010 - 2012
    Molecular interactions underpinning lesion localization in multiple sclerosis.
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    Development of specific immunomodulatory agents for Multiple Sclerosis affecting the brainstem and cerebellum
    Multiple Sclerosis Research Australia
    Open grant
  • 2009 - 2011
    The effects of pregnancy and the post-partum period on T cells, antibodies, and gene expression in EAE
    Multiple Sclerosis Research Australia
    Open grant
  • 2008 - 2012
    Immune Response to stroke
    Wesley Merdical Research
    Open grant
  • 2007 - 2009
    Mechanisms leading to constitutive activation of the transcription factor NF-kB in progressive multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2008
    Investigations In Multiple Sclerosis Patients With Coexistent Autoimmune Thyroid Disease
    NHMRC Project Grant
    Open grant
  • 2005 - 2007
    Studies on the functional role of antibodies in multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005 - 2006
    Supplementary funding to advance development
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2002 - 2003
    Investigation of the mechanisms by which thiacylated lipopeptides enhance immune responses
    Multiple Sclerosis Research Australia
    Open grant
  • 2002 - 2003
    Is autoreactivity to myelin antigens regulated differently in multiple sclerosis and stroke?
    Multiple Sclerosis Research Australia
    Open grant
  • 2001 - 2002
    Studies on the disease process and potential therapeutic agents in multiple sclerosis
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2000 - 2005
    HLA type, B & T cell responses to myelin antigens, and lesion distribution
    National Multiple Sclerosis Society-US
    Open grant
  • 1999 - 2001
    Correlation Between Ganglioside-Specific Immune Responses and Disease Prograssion in Multiple Sclerosis
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Studies of T cell reactivity to myelin antigens in multiple sclerosis
    NHMRC Project Grant
    Open grant
  • 1995
    B and T cell reactivity to myelin/oligodendrocyte-specific protein in multiple sclerosis
    University of Queensland New Staff Research Grant
    Open grant
  • 1995
    Immune responses to central nervous system myelin antigens in multiple sclerosis
    Ramaciotti Foundation
    Open grant

Supervision

Availability

Associate Professor Judith Greer is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Investigation of the role of BTK and NF-kB signalling in CNS cells

    Principal Advisor

    Other advisors: Dr Jun Yan

  • Doctor Philosophy

    A novel humanized mouse model for multiple sclerosis

    Principal Advisor

    Other advisors: Dr Jun Yan, Dr Aakanksha Dixit

  • Doctor Philosophy

    The role of Epstein-Barr virus infection in multiple sclerosis

    Principal Advisor

    Other advisors: Professor Pamela McCombe

Completed supervision

Media

Enquiries

For media enquiries about Associate Professor Judith Greer's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au