Dr Jun Yan
Dr

Jun Yan

Email: 
Phone: 
+61 7 334 65077

Background

Dr Jun Yan is a molecular biologist, currently working in the field of neurological diseases. Dr Yan's research interest is cell signal transduction pathways invoved in mechanisms of the disease development.

Dr Jun Yan completed her postgraduate study at The University of Queensland, after which she undertook a postdoctoral position in Experimental Oncology laboratory in Department of Patholody, UQ and worked on Ras / Raf signalling pathway. In 2001 she joined the Neuroimmunology Research group in Department of Medicine, UQ, and works on neurological diseases, including autoimmune disease multiple sclerosis (MS), ischaemic stroke and amyotrophic lateral sclerosis (ALS) . She has been investigating NF-kB signal transduction pathway in MS and ALS, and cell immune responese to ischaemic stroke.

Availability

Dr Jun Yan is:
Available for supervision
Media expert

Fields of research

Clinical sciences Immunology Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Science, Peking University
  • Masters (Coursework) of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Jun Yan’s works on UQ eSpace

45 works between 1989 and 2020
All (45) Journal Article (33) Conference Publication (12)

1 - 20 of 45 works

2020

Journal Article

Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation

Yan, Jun, McCombe, Pamela A., Pender, Michael P. and Greer, Judith M. (2020). Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation. Journal of Clinical Medicine, 9 (8) 2534, 2534-13. doi: 10.3390/jcm9082534

Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation

2018

Journal Article

PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations

Cloake, Nancy, Yan, Jun, Aminian, Atefeh, Pender, Michael and Greer, Judith (2018). PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations. Journal of Clinical Medicine, 7 (10) 342, 342. doi: 10.3390/jcm7100342

PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations

2018

Journal Article

Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis

Yan, Jun, Winterford, Clay M., Catts, Vibeke S., Pat, Betty K., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2018). Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis. Journal of Neuroimmunology, 320, 111-116. doi: 10.1016/j.jneuroim.2018.04.002

Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis

2016

Journal Article

NF-kappa B pathways in the pathogenesis of multiple sclerosis and the therapeutic implications

Leibowitz, Saskia M. and Yan, Jun (2016). NF-kappa B pathways in the pathogenesis of multiple sclerosis and the therapeutic implications. Frontiers in Molecular Neuroscience, 9 (84) 84, 84. doi: 10.3389/fnmol.2016.00084

NF-kappa B pathways in the pathogenesis of multiple sclerosis and the therapeutic implications

2016

Journal Article

Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome

Yan, J., Greer, J. M. and McCombe, P. A. (2016). Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome. Journal of Neuroimmunology, 293, 22-27. doi: 10.1016/j.jneuroim.2016.02.001

Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome

2015

Journal Article

Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome

Chan, Adeline, Yan, Jun, Csurhes, Peter, Greer, Judith and McCombe, Pamela (2015). Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome. Journal of Neuroimmunology, 286, 42-47. doi: 10.1016/j.jneuroim.2015.06.013

Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome

2014

Journal Article

Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke

Yan, Jun, Liu, Jia, Greer, Judith M. and McCombe, Pamela A. (2014). Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke. Clinical and Experimental Neuroimmunology, 5 (2), 216-226. doi: 10.1111/cen3.12104

Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke

2014

Journal Article

Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke

Liu, Jia, Yan, Jun, Greer, Judith M., Read, Stephen J., Henderson, Robert D., Rose, Stephen E., Coulthard, Alan and McCombe, Pamela A. (2014). Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke. International Journal of Neuroscience, 124 (4), 271-280. doi: 10.3109/00207454.2013.837462

Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke

2014

Conference Publication

Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis

Yan, Jun, Greer, Judith, Mccombe, Pamela, Pender, Michael and Consortium, Anzgene (2014). Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis. 12th International Congress of Neuroimmunology (ISNI), Mainz, Germany, Nov 09-13, 2014. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.jneuroim.2014.08.141

Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis

2014

Conference Publication

PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations

Cloake, Nancy, Yan, Jun, Pender, Michael, Aminian, Atefeh and Greer, Judith (2014). PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2014.08.268

PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations

2013

Journal Article

A simple and reliable immunohistochemical method for colocalization of 2 antigens in the same cells of paraffin-embedded tissues

Yan, Jun, Catts, Vibeke S., Chan, Anthony and McCombe, Pamela A. (2013). A simple and reliable immunohistochemical method for colocalization of 2 antigens in the same cells of paraffin-embedded tissues. Applied Immunohistochemistry and Molecular Morphol, 21 (5), 471-477. doi: 10.1097/PAI.0b013e3182795710

A simple and reliable immunohistochemical method for colocalization of 2 antigens in the same cells of paraffin-embedded tissues

2013

Journal Article

Levels of interleukin 33 and soluble suppression of tumorigenicity 2 in acute ischemic stroke

Yan, Jun, Lin, Clement Y. H., Pfluger, Casey M. and McCombe, Pamela A. (2013). Levels of interleukin 33 and soluble suppression of tumorigenicity 2 in acute ischemic stroke. Clinical and Experimental Neuroimmunology, 4 (3), 339-347. doi: 10.1111/cen3.12067

Levels of interleukin 33 and soluble suppression of tumorigenicity 2 in acute ischemic stroke

2012

Journal Article

Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability

Yan, Jun, Greer, Judith M. and McCombe, Pamela A. (2012). Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability. Journal of Neuroimmunology, 246 (1-2), 78-84. doi: 10.1016/j.jneuroim.2012.02.013

Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability

2012

Journal Article

Frequency and function of regulatory T cells after ischaemic stroke in humans

Yan, Jun, Read, Stephen J., Henderson, Robert D., Hull, Renee, O'Sullivan, John D., McCombe, Pamela A. and Greer, Judith M. (2012). Frequency and function of regulatory T cells after ischaemic stroke in humans. Journal of Neuroimmunology, 243 (1-2), 89-94. doi: 10.1016/j.jneuroim.2011.12.019

Frequency and function of regulatory T cells after ischaemic stroke in humans

2012

Conference Publication

Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis

Yan, J., Pender, M.P., Liu, J., McCombe, P.A., Greer, J.M. and ANZgene Consortium (2012). Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.

Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis

2012

Conference Publication

Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke

McCombe, Pamela, Liu, Jia, Yan, Jun and Greer, Judith (2012). Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.

Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke

2012

Journal Article

Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis

Yan, Jun, Liu, Jia, Lin, Clement Yihao, Australia and New Zealand Multiple Sclerorsis Genetics Consortium, Csurhes, Peter A., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2012). Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis. International Journal of Molecular Sciences, 13 (10), 13667-13679. doi: 10.3390/ijms131013667

Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis

2011

Journal Article

Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke

Singh, P., Yan, J., Hull, R., Read, S., O'Sullivan, J., Henderson, R.D., Rose, S., Greer, J.M. and McCombe, P.A. (2011). Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke. Journal of the Neurological Sciences, 304 (1-2), 117-121. doi: 10.1016/j.jns.2011.01.025

Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke

2010

Journal Article

The effect of ageing on human lymphocyte subsets: comparison of males and females

Yan, Jun, Greer, Judith M., Hull, Renee, O'Sullivan, John D., Henderson, Robert D., Read, Stephen J. and McCombe, Pamela A. (2010). The effect of ageing on human lymphocyte subsets: comparison of males and females. Immunity & Ageing, 7 (4) 1742, 1-10. doi: 10.1186/1742-4933-7-4

The effect of ageing on human lymphocyte subsets: comparison of males and females

2010

Conference Publication

Immune response in acute ischaemic stroke

Badve, Monica S., Yan, J., Hull, R., Henderson, Robert, O’Sullivan, John D., Read, Stephen J., Wong, Andrew A. and McCombe, Pamela (2010). Immune response in acute ischaemic stroke. ANZAN Annual Scientific Meeting 2010, -, 2010. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jocn.2010.07.064

Immune response in acute ischaemic stroke

Current funding

  • 2023 - 2025
    Investigating effects of Evobrutinib on immune and non-immune cells in microglia-enhanced brain organoids
    Merck Group T/A Ares Trading SA
    Open grant

Past funding

  • 2021 - 2023
    Deriving immune-like cells, neuronal-like cells and brain organoids from iPSCs as a means of studying differential effects of NF-kB activation in MS
    Incubator Grant Scheme
    Open grant
  • 2020 - 2024
    Improving and validating a novel translational tool for research in multiple sclerosis
    NHMRC IDEAS Grants
    Open grant
  • 2011 - 2013
    NFKBIA mutations as a mechanism leading to constitutive activation of NF-kB in patients with primary progressive MS
    Multiple Sclerosis Research Australia
    Open grant
  • 2010 - 2011
    Do PLP1 mutations found in MS patients lead to the unfolded protein response and apoptosis of PLP-expressing cells?
    Multiple Sclerosis Research Australia
    Open grant
  • 2007 - 2009
    Mechanisms leading to constitutive activation of the transcription factor NF-kB in progressive multiple sclerosis
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    Investigation of the NF-KB Pathway In Immune Cells of Multiple Sclerosis Patients
    UQ Early Career Researcher
    Open grant
  • 2004 - 2006
    Investigation Of The Links Between 1kB And Chronic Inflammatory Responses In Patients With Multiple Sclerosis
    Multiple Sclerosis Research Australia
    Open grant

Availability

Dr Jun Yan is:
Available for supervision

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Supervision history

Current supervision

Enquiries

Contact Dr Jun Yan directly for media enquiries about:

  • Cancer research
  • Cell biology
  • Immunology
  • Molecular biology
  • Neuroimmunology

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