Overview
Background
Dr Jun Yan is a molecular biologist, currently working in the field of neurological diseases. Dr Yan's research interest is cell signal transduction pathways invoved in mechanisms of the disease development.
Dr Jun Yan completed her postgraduate study at The University of Queensland, after which she undertook a postdoctoral position in Experimental Oncology laboratory in Department of Patholody, UQ and worked on Ras / Raf signalling pathway. In 2001 she joined the Neuroimmunology Research group in Department of Medicine, UQ, and works on neurological diseases, including autoimmune disease multiple sclerosis (MS), ischaemic stroke and amyotrophic lateral sclerosis (ALS) . She has been investigating NF-kB signal transduction pathway in MS and ALS, and cell immune responese to ischaemic stroke.
Availability
- Dr Jun Yan is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, Peking University
- Masters (Coursework) of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Jun Yan’s works on UQ eSpace
2009
Journal Article
Immune activation in the peripheral blood of patients with acute ischemic stroke
Yan, Jun, Greer, Judith M., Etherington, Kellie, Cadigan, Greg P., Cavanagh, Helen, Henderson, Robert D., O'Sullivan, John D., Pandian, Jeyaraj D., Read, Stephen J. and McCombe, Pamela A. (2009). Immune activation in the peripheral blood of patients with acute ischemic stroke. Journal of Neuroimmunology, 206 (1-2), 112-117. doi: 10.1016/j.jneuroim.2008.11.001
2008
Journal Article
NF-kB, a potential therapeutic target for the treatment of multiple sclerosis
Yan, J. and Greer, Judith M. (2008). NF-kB, a potential therapeutic target for the treatment of multiple sclerosis. CNS & Neurological Disorders - Drug Targets, 7 (6), 536-557. doi: 10.2174/187152708787122941
2007
Conference Publication
Increased population of activated T cells in patients after acute ischemic stroke
Yan, J., Greer, J. M., Cavanagh, H., Henderson, R., O'Sullivan, J., Read, S., Etherington, K. and McCombe, P. A. (2007). Increased population of activated T cells in patients after acute ischemic stroke. 37th Annual Scientific Meeting of the Australasian Society for Immunology, Sydney, Australia, 2-6 December 2007.
2005
Conference Publication
Levels of constitutively activated NF-kB are increased and IB levels are decreased in T cells and macrophages from patients with multiple sclerosis
Yan, J., Pat, B., Winterford, C., Inglis, H. R., Pender, M. P. and Greer, J. M. (2005). Levels of constitutively activated NF-kB are increased and IB levels are decreased in T cells and macrophages from patients with multiple sclerosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, 29 November - 2 December 2005. Copenhagen, Denmark: Munksgaard. doi: 10.1111/j.1399-0039.2005.00523.x
2005
Conference Publication
Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas
Gobe, G., Li, J., Pat, B., Yan, J., Vesey, D., Johnson, D. and Nicol, D. (2005). Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, 4-8 September 2005, Carlton, Victoria. Blackwell Science: 1320-5358 (print); 1440-1797 (electronic). doi: 10.1111/j.1440-1797.2005.00461.x
2005
Conference Publication
Increased constitutive activation of NF-kappa B in patients with multiple sclerosis
Yan, J., Pat, B., Winterford, C., Inglis, F., Pender, M. P. and Greer, J. M. (2005). Increased constitutive activation of NF-kappa B in patients with multiple sclerosis. 5th Annual Meeting of the Federation of Clinical Immunology Society, Boston, MA, United States, 12-16 May 2005. SAN DIEGO: Academic Press.
2003
Conference Publication
Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas
Li, J., Pat, B., Yan, J., Vesey, D. A., Johnson, D. W., Nicol, D. and Gobe, G. C. (2003). Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas. 39th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, WA, Australia, 31 August- 3 September, 2003. Carlton South, Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1797.8.s3.1.x
2002
Conference Publication
Comparison of NF-kB in immune cells of multiple sclerosis patients and controls Society for Cytokines, Inflammation and Leukocytes
Yan, J., Inglis, H., Pender, M. P. and Greer, J. M. (2002). Comparison of NF-kB in immune cells of multiple sclerosis patients and controls Society for Cytokines, Inflammation and Leukocytes. 32nd Annual Scientific Meeting of the ASI, Brisbane, Qld, Australia, 8-12 December, 2002.
2002
Journal Article
The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase
Jaumot, M., Yan, J., Clyde-Smith, J., Sluimer, J. and Hancock, J. F. (2002). The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. Journal of Biological Chemistry, 277 (1), 272-278. doi: 10.1074/jbc.M108423200
2002
Conference Publication
Comparison of regulatory cell populations in patients with multiple sclerosis and controls
Yan, J., Rist, M. J., Dodson, M. J., Pender, M. P. and Greer, J. M. (2002). Comparison of regulatory cell populations in patients with multiple sclerosis and controls. Progress in MS Research, Sydney, 9-11 Oct, 2002.
2001
Journal Article
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity
Prior, Ian A., Harding, Angus, Yan, Jun, Sluimer, Judith, Parton, Robert G. and Hancock, John F. (2001). GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nature Cell Biology, 3 (4), 368-375. doi: 10.1038/35070050
2000
Journal Article
Escape from apoptosis after prolonged serum deprivation is associated with the regulation of the mitochondrial death pathway by Bcl-x(L)
Zhang, XJ, Yan, J, Cuttle, L, Endre, Z and Gobe, G (2000). Escape from apoptosis after prolonged serum deprivation is associated with the regulation of the mitochondrial death pathway by Bcl-x(L). Archives of Biochemistry and Biophysics, 277 (2), 487-493. doi: 10.1006/bbrc.2000.3699
2000
Journal Article
Defective radiation signal transduction in ataxia-telangiectasia cells
Yan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035.
2000
Journal Article
Escape from apoptosis after prolonged serum deprivation is associated with the regulation of the mitochondrial death pathway by Bcl-xL
Zhang, X., Yan, J., Cuttle, L., Endre, Z. H. and Gobe, G. C. (2000). Escape from apoptosis after prolonged serum deprivation is associated with the regulation of the mitochondrial death pathway by Bcl-xL. Biochemical & Biophysical Research Communications, 277 (2), 487-493. doi: 10.1006/bbrc.2000.3699
2000
Journal Article
Defective radiation signal transduction in ataxia-telangiectasia cells
Yan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. doi: 10.1080/09553000050111497
1998
Journal Article
Evidence of multiple transcription initiation and termination sites within the rDNA intergenic spacer and rRNA readthrough transcription in the urochordate Herdmania curvata
Degnan, Bernard M., Yan, Jun and Lavin, Martin F. (1998). Evidence of multiple transcription initiation and termination sites within the rDNA intergenic spacer and rRNA readthrough transcription in the urochordate Herdmania curvata. Molecular Marine Biology And Biotechnology, 7 (4), 294-302.
1998
Journal Article
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
Yan, J, Roy, S, Apolloni, A, Lane, A and Hancock, JF (1998). Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. Journal of Biological Chemistry, 273 (37), 24052-24056. doi: 10.1074/jbc.273.37.24052
1998
Journal Article
14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo
Roy, S., McPherson, R. A., Apolloni, A., Yan, J., Lane, A., Clyde-Smith, J. and Hancock, J. F. (1998). 14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Molecular and Cellular Biology, 18 (7), 3947-3955. doi: 10.1128/MCB.18.7.3947
1997
Journal Article
Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger
Roy, S, Lane, A, Yan, J, McPherson, R and Hancock, JF (1997). Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger. Journal of Biological Chemistry, 272 (32), 20139-20145. doi: 10.1074/jbc.272.32.20139
1997
Journal Article
Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells
Khanna, KK, Yan, J, Watters, D, Hobson, K, Beamish, H, Spring, K, Shiloh, Y, Gatti, RA and Lavin, MF (1997). Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells. Journal of Biological Chemistry, 272 (14), 9489-9495. doi: 10.1074/jbc.272.14.9489
Funding
Current funding
Past funding
Supervision
Availability
- Dr Jun Yan is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
A novel humanized mouse model for multiple sclerosis
Associate Advisor
Other advisors: Dr Aakanksha Dixit, Associate Professor Judith Greer
-
Doctor Philosophy
Investigation of the role of BTK and NF-kB signalling in CNS cells
Associate Advisor
Other advisors: Associate Professor Judith Greer
Media
Enquiries
Contact Dr Jun Yan directly for media enquiries about:
- Cancer research
- Cell biology
- Immunology
- Molecular biology
- Neuroimmunology
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